Cövid papers Insomnia
And REM Behaviour Disorder
#5
( Don't look up... A different meaning for the astute Neurologists)
doi.org/10.1093/slee...
Advance access publication 5 January 2024
And REM Behaviour Disorder
#5
( Don't look up... A different meaning for the astute Neurologists)
doi.org/10.1093/slee...
Advance access publication 5 January 2024
Comorbid neurotrauma increases neurodegenerative-relevant cognitive, motor, and autonomic dysfunction in patients with rapid eye movement sleep behavior disorder: a substudy of the North American Prodromal Synucleinopathy Consortium
AbstractStudy Objectives. Rapid eye movement sleep behavior disorder (RBD) is strongly associated with phenoconversion to an overt synucleinopathy, e.g. Pa
doi.org
November 22, 2024 at 5:35 AM
Cövid papers Insomnia
And REM Behaviour Disorder
#5
( Don't look up... A different meaning for the astute Neurologists)
doi.org/10.1093/slee...
Advance access publication 5 January 2024
And REM Behaviour Disorder
#5
( Don't look up... A different meaning for the astute Neurologists)
doi.org/10.1093/slee...
Advance access publication 5 January 2024
👻 #fluorescencefriday weird microglia (yellow) in a model of synucleinopathy courtesy Anoosha Attaran
October 31, 2025 at 11:30 AM
👻 #fluorescencefriday weird microglia (yellow) in a model of synucleinopathy courtesy Anoosha Attaran
Nature research paper: Intestinal macrophages modulate synucleinopathy along the gut–brain axis
go.nature.com/4rg6DOI
go.nature.com/4rg6DOI
Intestinal macrophages modulate synucleinopathy along the gut–brain axis - Nature
Muscularis macrophages, housekeepers of enteric nervous system integrity and intestinal homeostasis, modulate α-synuclein pathology and neurodegeneration in models of Parkinson’s disease, and understanding the accompanying mechanisms could pave the way for early-stage biomarkers.
go.nature.com
February 4, 2026 at 7:48 AM
Nature research paper: Intestinal macrophages modulate synucleinopathy along the gut–brain axis
go.nature.com/4rg6DOI
go.nature.com/4rg6DOI
Large Muscle Movements During Sleep Across the Synucleinopathy Spectrum: A Polysomnographic Study of Isolated REM Sleep Behavior Disorder and Parkinson’s Disease academic.oup.com/sleep/articl...
Large Muscle Movements During Sleep Across the Synucleinopathy Spectrum: A Polysomnographic Study of Isolated REM Sleep Behavior Disorder and Parkinson’s Disease
This study suggests that the nocturnal motor phenotype of synucleinopathy is broader than REM sleep without atonia and conventional PLMS measures alone. By
academic.oup.com
July 12, 2026 at 9:52 PM
Large Muscle Movements During Sleep Across the Synucleinopathy Spectrum: A Polysomnographic Study of Isolated REM Sleep Behavior Disorder and Parkinson’s Disease academic.oup.com/sleep/articl...
Intestinal macrophages modulate synucleinopathy along the gut–brain axis www.nature.com/articles/s41...
Intestinal macrophages modulate synucleinopathy along the gut–brain axis - Nature
Muscularis macrophages, housekeepers of enteric nervous system integrity and intestinal homeostasis, modulate α-synuclein pathology and neurodegeneration in models of Parkinson’s disease, and understa...
www.nature.com
February 2, 2026 at 9:22 AM
Intestinal macrophages modulate synucleinopathy along the gut–brain axis www.nature.com/articles/s41...
Quickly googling "synucleinopathy clinic annual gross" in between patients
August 14, 2023 at 4:52 PM
Quickly googling "synucleinopathy clinic annual gross" in between patients
We are looking for motivated post docs. Projects on Alzheimer’s and Synucleinopathy. New mouse models, combined lightsheet/15.2T MRI and high throughput cognitive testing using touchscreens. Perfect for a recent graduate in Neurosciences or related field. Come work with us in 🇨🇦 👊😀🧪 please share.
February 5, 2025 at 1:53 AM
We are looking for motivated post docs. Projects on Alzheimer’s and Synucleinopathy. New mouse models, combined lightsheet/15.2T MRI and high throughput cognitive testing using touchscreens. Perfect for a recent graduate in Neurosciences or related field. Come work with us in 🇨🇦 👊😀🧪 please share.
North American Prodromal Synucleinopathy study: protocol for a multi-site, longitudinal, observational study of idiopathic/isolated rapid eye movement sleep behavior disorder
academic.oup.com/sleepadvance...
academic.oup.com/sleepadvance...
Validate User
academic.oup.com
March 16, 2026 at 8:57 PM
North American Prodromal Synucleinopathy study: protocol for a multi-site, longitudinal, observational study of idiopathic/isolated rapid eye movement sleep behavior disorder
academic.oup.com/sleepadvance...
academic.oup.com/sleepadvance...
Sex differences in animal models are continually understudies!
Stephanie Tullo had a ⭐ observation on sex diffs in pathological propagation, survival, and atrophy in a model of synucleinopathy! An investigation with MRI, behaviour, and cool analytical methods
www.nature.com/articles/s42...
Stephanie Tullo had a ⭐ observation on sex diffs in pathological propagation, survival, and atrophy in a model of synucleinopathy! An investigation with MRI, behaviour, and cool analytical methods
www.nature.com/articles/s42...
Female mice exhibit resistance to disease progression despite early pathology in a transgenic mouse model inoculated with alpha-synuclein fibrils - Communications Biology
Sex differences in a mouse model of synucleinopathy reveals female resilience to disease progression despite early brain pathology, contrasting with accelerated disease in male mice after alpha-synucl...
www.nature.com
February 26, 2025 at 10:46 AM
Sex differences in animal models are continually understudies!
Stephanie Tullo had a ⭐ observation on sex diffs in pathological propagation, survival, and atrophy in a model of synucleinopathy! An investigation with MRI, behaviour, and cool analytical methods
www.nature.com/articles/s42...
Stephanie Tullo had a ⭐ observation on sex diffs in pathological propagation, survival, and atrophy in a model of synucleinopathy! An investigation with MRI, behaviour, and cool analytical methods
www.nature.com/articles/s42...
Note that there can be diminished perception of orthostatic hypotension - relating to habituation, this study also finding less awareness in alpha-synucleinopathy www.ahajournals.org/doi/full/10.... #dysautonomia
November 13, 2024 at 5:22 AM
Note that there can be diminished perception of orthostatic hypotension - relating to habituation, this study also finding less awareness in alpha-synucleinopathy www.ahajournals.org/doi/full/10.... #dysautonomia
New collaboration with @mallarchak.bsky.social Sex differences in synucleinopathy www.nature.com/articles/s42...
Female mice exhibit resistance to disease progression despite early pathology in a transgenic mouse model inoculated with alpha-synuclein fibrils - Communications Biology
Sex differences in a mouse model of synucleinopathy reveals female resilience to disease progression despite early brain pathology, contrasting with accelerated disease in male mice after alpha-synucl...
www.nature.com
February 26, 2025 at 3:26 AM
New collaboration with @mallarchak.bsky.social Sex differences in synucleinopathy www.nature.com/articles/s42...
Synaptic vesicle-omics in mice captures signatures of aging & synucleinopathy; Synaptic changes in mice lacking α-synuclein suggest that loss of α-synuclein function contributes to synaptic dysfunction
www.nature.com/articles/s41...
www.nature.com/articles/s41...
May 3, 2025 at 12:20 PM
Synaptic vesicle-omics in mice captures signatures of aging & synucleinopathy; Synaptic changes in mice lacking α-synuclein suggest that loss of α-synuclein function contributes to synaptic dysfunction
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Cerebellar α-synucleinopathy contributes to Parkinsonian gait and balance impairment in mouse models #NeuroDegeneration 🧪🧠
https://link.springer.com/10.1186/s40478-026-02432-6
https://link.springer.com/10.1186/s40478-026-02432-6
September 24, 2026 at 7:03 AM
Cerebellar α-synucleinopathy contributes to Parkinsonian gait and balance impairment in mouse models #NeuroDegeneration 🧪🧠
https://link.springer.com/10.1186/s40478-026-02432-6
https://link.springer.com/10.1186/s40478-026-02432-6
The authors included RRIDs in their in Parkinsonism & Related Disorders paper! We value the author's support of reproducibility. #OpenScience #reproducibility #ReproducibleResearch
Disease Course Map progression markers transfer from isolated REM sleep behavior disorder to non-RBD prodromal alpha-synucleinopathy: a PPMI study of 1,499 participants
Read the full paper: Disease Course Map progression markers transfer from isolated REM sleep behavior disorder to non-RBD prodromal alpha-synucleinopathy: a PPMI study of 1,499 participants
doi.org
September 25, 2026 at 7:01 AM
The authors included RRIDs in their in Parkinsonism & Related Disorders paper! We value the author's support of reproducibility. #OpenScience #reproducibility #ReproducibleResearch
Key findings of critical new research in #Parkinsons and #Alzheimers disease -with corrected conclusions.
1/7🧵
www.nature.com/articles/s41...
1/7🧵
www.nature.com/articles/s41...
Phosphorylated α-synuclein in CSF and plasma does not reflect synucleinopathy - npj Parkinson's Disease
npj Parkinson's Disease - Phosphorylated α-synuclein in CSF and plasma does not reflect synucleinopathy
www.nature.com
August 15, 2025 at 4:38 PM
Key findings of critical new research in #Parkinsons and #Alzheimers disease -with corrected conclusions.
1/7🧵
www.nature.com/articles/s41...
1/7🧵
www.nature.com/articles/s41...
Antagonizing Neuronal Toll-like Receptor 2 Prevents Synucleinopathy by Activating Autophagy
Antagonizing Neuronal Toll-like Receptor 2 Prevents Synucleinopathy by Activating Autophagy
(Cell Reports 13, 771–782; October 27, 2015)
dlvr.it
March 23, 2026 at 11:23 PM
Antagonizing Neuronal Toll-like Receptor 2 Prevents Synucleinopathy by Activating Autophagy
Product Citation 🍁
Researchers @westernu.ca utilized StressMarq's #AlphaSynuclein PFFs to create touchscreen cognitive tests that detect early stimulus-response learning deficits in a mouse model of #synucleinopathy.
Paper 🛶 https://go.nature.com/3LPaC5K
Product 🌲 https://bit.ly/2u9YHV2
Researchers @westernu.ca utilized StressMarq's #AlphaSynuclein PFFs to create touchscreen cognitive tests that detect early stimulus-response learning deficits in a mouse model of #synucleinopathy.
Paper 🛶 https://go.nature.com/3LPaC5K
Product 🌲 https://bit.ly/2u9YHV2
Impairment in stimulus-response learning as a cognitive biomarker in a model of synucleinopathy - Translational Psychiatry
Translating findings from preclinical assessments of cognitive function relevant to synucleinopathies into successful clinical trials poses significant challenges. In this study, we examined the effectiveness of human-relevant touchscreen cognitive a...
go.nature.com
February 11, 2026 at 12:09 AM
Product Citation 🍁
Researchers @westernu.ca utilized StressMarq's #AlphaSynuclein PFFs to create touchscreen cognitive tests that detect early stimulus-response learning deficits in a mouse model of #synucleinopathy.
Paper 🛶 https://go.nature.com/3LPaC5K
Product 🌲 https://bit.ly/2u9YHV2
Researchers @westernu.ca utilized StressMarq's #AlphaSynuclein PFFs to create touchscreen cognitive tests that detect early stimulus-response learning deficits in a mouse model of #synucleinopathy.
Paper 🛶 https://go.nature.com/3LPaC5K
Product 🌲 https://bit.ly/2u9YHV2
- REM Sleep Behaviour Disorder (RBD). RBD - highly correlated with α-synucleinopathy neurodegeneration, the underlying pathology of Parkinson's disease REM Sleep Behaviour Disorder (RBD). RBD is highly correlated with α-synucleinopathy neurodegeneration,
June 25, 2026 at 1:20 AM
- REM Sleep Behaviour Disorder (RBD). RBD - highly correlated with α-synucleinopathy neurodegeneration, the underlying pathology of Parkinson's disease REM Sleep Behaviour Disorder (RBD). RBD is highly correlated with α-synucleinopathy neurodegeneration,
New paper reports Helicobacter pylori infection & #Parkinsons -associated α-synuclein pathology drive parallel neurodegen. pathways in the substantia nigra; H. pylori infection doesn't exacerbate α-synucleinopathy
link.springer.com/article/10.1...
link.springer.com/article/10.1...
December 23, 2025 at 1:43 PM
New paper reports Helicobacter pylori infection & #Parkinsons -associated α-synuclein pathology drive parallel neurodegen. pathways in the substantia nigra; H. pylori infection doesn't exacerbate α-synucleinopathy
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Recent @pennngg.bsky.social grad Evan Gallagher identified a new molecule that might track the progression of neurodegenerative disorders.
PNK writer @kara-mcgaughey.bsky.social explains: www.upennglia.com/briefs/bib-p...
Follow @brainsinbriefs.bsky.social for more!
#neuroskyence #SciComm 🧪
PNK writer @kara-mcgaughey.bsky.social explains: www.upennglia.com/briefs/bib-p...
Follow @brainsinbriefs.bsky.social for more!
#neuroskyence #SciComm 🧪
April 24, 2025 at 6:18 PM
Recent @pennngg.bsky.social grad Evan Gallagher identified a new molecule that might track the progression of neurodegenerative disorders.
PNK writer @kara-mcgaughey.bsky.social explains: www.upennglia.com/briefs/bib-p...
Follow @brainsinbriefs.bsky.social for more!
#neuroskyence #SciComm 🧪
PNK writer @kara-mcgaughey.bsky.social explains: www.upennglia.com/briefs/bib-p...
Follow @brainsinbriefs.bsky.social for more!
#neuroskyence #SciComm 🧪
⭐ New Products! StressMarq now offers Alpha Synuclein E83Q Mutant Monomers and Pre-formed Fibrils (SPR-538 & SPR-539). This rare missense variant promotes accelerated alpha synuclein aggregation, providing a valuable tool for synucleinopathy research.
🧪 Learn more: https://bit.ly/3TA3vSz
🧪 Learn more: https://bit.ly/3TA3vSz
September 23, 2026 at 7:16 PM
⭐ New Products! StressMarq now offers Alpha Synuclein E83Q Mutant Monomers and Pre-formed Fibrils (SPR-538 & SPR-539). This rare missense variant promotes accelerated alpha synuclein aggregation, providing a valuable tool for synucleinopathy research.
🧪 Learn more: https://bit.ly/3TA3vSz
🧪 Learn more: https://bit.ly/3TA3vSz
Our paper is finally out!
We position intestinal muscularis macrophages as early initiators of α-synuclein pathology and dopaminergic neurodegeneration in Parkinson’s models. They also drive local CD4⁺ T cell expansion, which subsequently migrates from gut to brain
www.nature.com/articles/s41...
We position intestinal muscularis macrophages as early initiators of α-synuclein pathology and dopaminergic neurodegeneration in Parkinson’s models. They also drive local CD4⁺ T cell expansion, which subsequently migrates from gut to brain
www.nature.com/articles/s41...
Intestinal macrophages modulate synucleinopathy along the gut–brain axis - Nature
Muscularis macrophages, housekeepers of enteric nervous system integrity and intestinal homeostasis, modulate α-synuclein pathology and neurodegeneration in models of Parkinson’s disease, and understa...
www.nature.com
January 28, 2026 at 7:25 PM
Our paper is finally out!
We position intestinal muscularis macrophages as early initiators of α-synuclein pathology and dopaminergic neurodegeneration in Parkinson’s models. They also drive local CD4⁺ T cell expansion, which subsequently migrates from gut to brain
www.nature.com/articles/s41...
We position intestinal muscularis macrophages as early initiators of α-synuclein pathology and dopaminergic neurodegeneration in Parkinson’s models. They also drive local CD4⁺ T cell expansion, which subsequently migrates from gut to brain
www.nature.com/articles/s41...
Cytotoxic T cell recognition of α-synuclein drives pathogenic immune responses in multiple system atrophy.
Cool paper on CD8 T cells and multiple system atrophy
doi.org/10.1073/pnas...
Cool paper on CD8 T cells and multiple system atrophy
doi.org/10.1073/pnas...
Cytotoxic T cell recognition of α-synuclein drives pathogenic immune responses in multiple system atrophy | PNAS
Multiple system atrophy (MSA) is a progressive neurologic disease, known as an α-synucleinopathy.
There are currently no effective disease-modifyin...
doi.org
April 1, 2026 at 1:12 PM
Cytotoxic T cell recognition of α-synuclein drives pathogenic immune responses in multiple system atrophy.
Cool paper on CD8 T cells and multiple system atrophy
doi.org/10.1073/pnas...
Cool paper on CD8 T cells and multiple system atrophy
doi.org/10.1073/pnas...
www.nature.com/articles/s41...
Beautiful work by a beautiful (and brilliant) friend! Congrats @soyonhonglab et
Beautiful work by a beautiful (and brilliant) friend! Congrats @soyonhonglab et
Intestinal macrophages modulate synucleinopathy along the gut–brain axis - Nature
Muscularis macrophages, housekeepers of enteric nervous system integrity and intestinal homeostasis, modulate α-synuclein pathology and neurodegeneration in models of Parkinson’s disease, and understa...
www.nature.com
January 30, 2026 at 4:42 AM
www.nature.com/articles/s41...
Beautiful work by a beautiful (and brilliant) friend! Congrats @soyonhonglab et
Beautiful work by a beautiful (and brilliant) friend! Congrats @soyonhonglab et