Sarah Heuer
@heuerwego.bsky.social
Postdoctoral researcher in the Young-Pearse lab studying the genetic mechanisms of Alzheimer’s disease using human-derived stem cell models. Avid cat lover. Opinions are my own.
Reposted by Sarah Heuer
New TYP lab paper out today in @pnas.org from former PhD student Zach Augur and postdoc @garrettfogo.bsky.social all about how astrocytic BAG3 coordinates Alzheimer's proteostasis proteins! Read all about it here: www.pnas.org/doi/10.1073/...
BAG3 coordinates astrocytic proteostasis of Alzheimer’s disease–linked proteins via proteasome, autophagy, and retromer interactions | PNAS
Bcl-2-associated athanogene 3 (BAG3) is a mediator of chaperone-assisted selective
autophagy, and in the brain, is most highly expressed in astrocy...
www.pnas.org
September 29, 2026 at 12:30 AM
New TYP lab paper out today in @pnas.org from former PhD student Zach Augur and postdoc @garrettfogo.bsky.social all about how astrocytic BAG3 coordinates Alzheimer's proteostasis proteins! Read all about it here: www.pnas.org/doi/10.1073/...
Reposted by Sarah Heuer
New TYP lab publication is out today! A phenomenal review by @heuerwego.bsky.social, Fasih Ahsan and Tracy providing a thorough overview of human cellular models to study AD lipid biology!
Human cellular models of the brain to study #lipid homeostasis in #AlzheimersDisease and related dementias
Sarah E. Heuer @heuerwego.bsky.social, Fasih M. Ahsan, Tracy L. Young-Pearse @typlab.bsky.social #ipscs
link.springer.com/article/10.1...
Sarah E. Heuer @heuerwego.bsky.social, Fasih M. Ahsan, Tracy L. Young-Pearse @typlab.bsky.social #ipscs
link.springer.com/article/10.1...
Human cellular models of the brain to study lipid homeostasis in Alzheimer’s disease and related dementias - Molecular Neurodegeneration
Alzheimer’s disease (AD) is a complex neurodegenerative disorder, and the leading cause of dementia worldwide, yet the availability of effective disease-modifying therapeutics remains limited, undersc...
link.springer.com
September 21, 2026 at 1:59 PM
New TYP lab publication is out today! A phenomenal review by @heuerwego.bsky.social, Fasih Ahsan and Tracy providing a thorough overview of human cellular models to study AD lipid biology!
Happy to share a new review article I wrote with Fasih Ahsan and Tracy Young-Pearse @typlab.bsky.social is out today in @molneurodegen.bsky.social! Here, we provide an overview of tools and findings leveraging human cellular models to study lipid biology in AD!
Human cellular models of the brain to study #lipid homeostasis in #AlzheimersDisease and related dementias
Sarah E. Heuer @heuerwego.bsky.social, Fasih M. Ahsan, Tracy L. Young-Pearse @typlab.bsky.social #ipscs
link.springer.com/article/10.1...
Sarah E. Heuer @heuerwego.bsky.social, Fasih M. Ahsan, Tracy L. Young-Pearse @typlab.bsky.social #ipscs
link.springer.com/article/10.1...
Human cellular models of the brain to study lipid homeostasis in Alzheimer’s disease and related dementias - Molecular Neurodegeneration
Alzheimer’s disease (AD) is a complex neurodegenerative disorder, and the leading cause of dementia worldwide, yet the availability of effective disease-modifying therapeutics remains limited, undersc...
link.springer.com
September 21, 2026 at 2:01 PM
Happy to share a new review article I wrote with Fasih Ahsan and Tracy Young-Pearse @typlab.bsky.social is out today in @molneurodegen.bsky.social! Here, we provide an overview of tools and findings leveraging human cellular models to study lipid biology in AD!
Reposted by Sarah Heuer
Congratulations to TYP lab postdoc @heuerwego.bsky.social on being awarded a F32 NRSA Postdoctoral Fellowship through the NIA, titled "Identifying the cellular consequences of ABCA7 genetic risk in Alzheimer's disease." Looking forward to more amazing findings from Dr. Heuer's work!
September 19, 2026 at 9:22 PM
Congratulations to TYP lab postdoc @heuerwego.bsky.social on being awarded a F32 NRSA Postdoctoral Fellowship through the NIA, titled "Identifying the cellular consequences of ABCA7 genetic risk in Alzheimer's disease." Looking forward to more amazing findings from Dr. Heuer's work!
Fun surprise to wake up to this morning: NoA that I have received an F32 fellowship from the NIA for work I proposed to identify the mechanisms of ABCA7 genetic risk factors in Alzheimer's disease! Excited to continue exploring this fascinating gene!
September 17, 2026 at 1:30 PM
Fun surprise to wake up to this morning: NoA that I have received an F32 fellowship from the NIA for work I proposed to identify the mechanisms of ABCA7 genetic risk factors in Alzheimer's disease! Excited to continue exploring this fascinating gene!
Congratulations Dr. Terzioglu!!! Absolutely crushed the defense!!
Congratulations to the Young-Pearse lab's newest doctor @gizemterzioglu.bsky.social on her successful PhD defense!!! We are so proud of her!!
August 29, 2026 at 2:03 PM
Congratulations Dr. Terzioglu!!! Absolutely crushed the defense!!
Reposted by Sarah Heuer
☕ @trowbridgelab.bsky.social & co propose that Dnmt3a-mutant hematopoietic cells induce mesenchymal stromal cell #senescence. Removal of senescent non-hematopoietic cells reduces Dnmt3a-mutant #hematopoiesis. #ClonalHematopoiesis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Stromal cell senescence augments haematopoietic cell fitness in clonal haematopoiesis - Nature Cell Biology
Mistry et al. propose that Dnmt3a-mutant haematopoietic cells induce mesenchymal stromal cell senescence. Removal of senescent non-haematopoietic cells reduces Dnmt3a-mutant haematopoiesis.
www.nature.com
August 10, 2026 at 10:31 AM
☕ @trowbridgelab.bsky.social & co propose that Dnmt3a-mutant hematopoietic cells induce mesenchymal stromal cell #senescence. Removal of senescent non-hematopoietic cells reduces Dnmt3a-mutant #hematopoiesis. #ClonalHematopoiesis
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Sarah Heuer
Tracy and our fabulous postdoc @kelliannealexa1.bsky.social both gave fantastic talks on their work using IPSC models to study vascular dysfunction in AD at the @jax.org Vascular Contributions to Cognitive Impairment workshop! Thank you to the organizers for such an amazing meeting!
May 1, 2026 at 11:45 PM
Tracy and our fabulous postdoc @kelliannealexa1.bsky.social both gave fantastic talks on their work using IPSC models to study vascular dysfunction in AD at the @jax.org Vascular Contributions to Cognitive Impairment workshop! Thank you to the organizers for such an amazing meeting!
Reposted by Sarah Heuer
Shout out to our fabulous postdoc @heuerwego.bsky.social who gave a great talk on her work leveraging iPSC models to uncover how genetic risk factors influence dysfunction in microglia in AD at the ACT Research Symposium hosted by the Kaiser Permanente Washington Health Research Institute! #ACT2026
May 1, 2026 at 7:49 PM
Shout out to our fabulous postdoc @heuerwego.bsky.social who gave a great talk on her work leveraging iPSC models to uncover how genetic risk factors influence dysfunction in microglia in AD at the ACT Research Symposium hosted by the Kaiser Permanente Washington Health Research Institute! #ACT2026
Very cool to have ABCA7-centric presentations from AD/PD featured by Alzforum, including the work presented by @typlab.bsky.social that I've been working on over the past few years!
www.alzforum.org/news/confere...
www.alzforum.org/news/confere...
Lipids, Lysosomes, and Plaques: How ABCA7 Nudges Up Alzheimer’s Risk | ALZFORUM
www.alzforum.org
April 12, 2026 at 11:59 PM
Very cool to have ABCA7-centric presentations from AD/PD featured by Alzforum, including the work presented by @typlab.bsky.social that I've been working on over the past few years!
www.alzforum.org/news/confere...
www.alzforum.org/news/confere...
Reposted by Sarah Heuer
New TYP lab publication from co-authors
Zach Augur and @garrettfogo.bsky.social
on deciphering the function of Optineurin in iPSC-derived Neurons and Astrocytes! This will be the first of 3 first-author publications from Zach's PhD thesis! link.springer.com/article/10.1...
Zach Augur and @garrettfogo.bsky.social
on deciphering the function of Optineurin in iPSC-derived Neurons and Astrocytes! This will be the first of 3 first-author publications from Zach's PhD thesis! link.springer.com/article/10.1...
Optineurin deficiency disrupts phosphorylated tau proteostasis and clusterin expression in human neurons - Acta Neuropathologica Communications
Optineurin (OPTN) is an autophagy adaptor protein involved in selective autophagy, including aggrephagy and mitophagy. Pathogenic mutations in OPTN have also been linked to amyotrophic lateral scleros...
link.springer.com
September 8, 2025 at 2:13 PM
New TYP lab publication from co-authors
Zach Augur and @garrettfogo.bsky.social
on deciphering the function of Optineurin in iPSC-derived Neurons and Astrocytes! This will be the first of 3 first-author publications from Zach's PhD thesis! link.springer.com/article/10.1...
Zach Augur and @garrettfogo.bsky.social
on deciphering the function of Optineurin in iPSC-derived Neurons and Astrocytes! This will be the first of 3 first-author publications from Zach's PhD thesis! link.springer.com/article/10.1...
Reposted by Sarah Heuer
Huge congrats to @zacharyrmurphy.bsky.social selected as a 2025 Fujifilm Fellow at @harvard.edu 🎉
The Fujifilm Fellowship Program fully funds PhD students doing groundbreaking work in the life sciences!!
The Fujifilm Fellowship Program fully funds PhD students doing groundbreaking work in the life sciences!!
July 10, 2025 at 9:48 PM
Huge congrats to @zacharyrmurphy.bsky.social selected as a 2025 Fujifilm Fellow at @harvard.edu 🎉
The Fujifilm Fellowship Program fully funds PhD students doing groundbreaking work in the life sciences!!
The Fujifilm Fellowship Program fully funds PhD students doing groundbreaking work in the life sciences!!
Reposted by Sarah Heuer
Huge shoutout to our brilliant graduate student @gizemterzioglu.bsky.social for delivering a fantastic talk at the HMS Neurobiology Pizza Talk series! 🍕🧠 She highlighted exciting insights into how SHIP1 shapes microglial function at the intersection of intracellular trafficking and immune response.
June 13, 2025 at 6:26 PM
Huge shoutout to our brilliant graduate student @gizemterzioglu.bsky.social for delivering a fantastic talk at the HMS Neurobiology Pizza Talk series! 🍕🧠 She highlighted exciting insights into how SHIP1 shapes microglial function at the intersection of intracellular trafficking and immune response.
Reposted by Sarah Heuer
🧠 New study led by our talented graduate student Courtney Benoit, uncovers how the autism-linked gene POU3F2 supports brain development by promoting neural stem cell growth via Wnt signaling and key targets like ADNP and SOX13. Check it out here in Brain: academic.oup.com/brain/articl...
Validate User
academic.oup.com
June 13, 2025 at 10:43 AM
🧠 New study led by our talented graduate student Courtney Benoit, uncovers how the autism-linked gene POU3F2 supports brain development by promoting neural stem cell growth via Wnt signaling and key targets like ADNP and SOX13. Check it out here in Brain: academic.oup.com/brain/articl...
Reposted by Sarah Heuer
Highlights from our lab at the @keystonesymposia.bsky.social Neurodegeneration meeting!
@heuerwego.bsky.social delivered an excellent talk on ABCA7 loss and microglial dysfunction in Alzheimer’s
@alexlish.bsky.social presented a great poster on CLU and intercellular communication in Alzheimer’s
@heuerwego.bsky.social delivered an excellent talk on ABCA7 loss and microglial dysfunction in Alzheimer’s
@alexlish.bsky.social presented a great poster on CLU and intercellular communication in Alzheimer’s
June 12, 2025 at 9:15 PM
Highlights from our lab at the @keystonesymposia.bsky.social Neurodegeneration meeting!
@heuerwego.bsky.social delivered an excellent talk on ABCA7 loss and microglial dysfunction in Alzheimer’s
@alexlish.bsky.social presented a great poster on CLU and intercellular communication in Alzheimer’s
@heuerwego.bsky.social delivered an excellent talk on ABCA7 loss and microglial dysfunction in Alzheimer’s
@alexlish.bsky.social presented a great poster on CLU and intercellular communication in Alzheimer’s
Reposted by Sarah Heuer
New TYP lab publication led by PhD student @alexlish.bsky.social out today in @cp-cellreports.bsky.social! We present a reproducible neuron-astrocyte-microglia tri-culture model to better reproduce intercellular interactions in Alzheimer's disease. Read more here: www.cell.com/cell-reports...
Astrocyte induction of disease-associated microglia is suppressed by acute exposure to fAD neurons in human iPSC triple cultures
Lish et al. present a co-culture system of iPSC-derived human microglia, astrocytes,
and neurons to investigate intercellular communication across different environmental
and genetic contexts. Transcr...
www.cell.com
June 5, 2025 at 12:49 AM
New TYP lab publication led by PhD student @alexlish.bsky.social out today in @cp-cellreports.bsky.social! We present a reproducible neuron-astrocyte-microglia tri-culture model to better reproduce intercellular interactions in Alzheimer's disease. Read more here: www.cell.com/cell-reports...
Reposted by Sarah Heuer
Huge congrats to our Master’s student Emma Karp for receiving the GBM Master Prize from the Society for Biochemistry and Molecular Biology! 🏆🧬
Emma earned it for her work in Biomedical Neurosciences at TUM! 🎓🧠
🔗 gbm-online.de/de/studium-k...
Emma earned it for her work in Biomedical Neurosciences at TUM! 🎓🧠
🔗 gbm-online.de/de/studium-k...
GBM-Masterpreis - Homepage der Gesellschaft für Biochemie und Molekularbiologie e.V.
gbm-online.de
May 30, 2025 at 11:06 AM
Huge congrats to our Master’s student Emma Karp for receiving the GBM Master Prize from the Society for Biochemistry and Molecular Biology! 🏆🧬
Emma earned it for her work in Biomedical Neurosciences at TUM! 🎓🧠
🔗 gbm-online.de/de/studium-k...
Emma earned it for her work in Biomedical Neurosciences at TUM! 🎓🧠
🔗 gbm-online.de/de/studium-k...
Honored to have been awarded the Martha Ondrey Junior Investigator Award for my postdoc work in @typlab.bsky.social!
With the support of Dr. Frank Ondrey, the RADC is pleased to present the Martha Ondrey Postdoctoral Prize to Sarah Heuer, PhD.
Dr. Heuer presented on leveraging human stem cells to elucidate how polygenic risk affects cellular state transitions & communication networks in AD.
Dr. Heuer presented on leveraging human stem cells to elucidate how polygenic risk affects cellular state transitions & communication networks in AD.
May 22, 2025 at 2:30 AM
Honored to have been awarded the Martha Ondrey Junior Investigator Award for my postdoc work in @typlab.bsky.social!
Reposted by Sarah Heuer
Big shoutout to our lab at the annual ROSMAP meeting in Chicago!
🎉 @heuerwego.bsky.social gave a great talk & won the Martha Ondrey Jr. Investigator Award 🏆
🧠 @gizemterzioglu.bsky.social crushed it with her presentation on SHIP1 & the inflammasome in microglia!
🎉 @heuerwego.bsky.social gave a great talk & won the Martha Ondrey Jr. Investigator Award 🏆
🧠 @gizemterzioglu.bsky.social crushed it with her presentation on SHIP1 & the inflammasome in microglia!
May 21, 2025 at 8:20 PM
Big shoutout to our lab at the annual ROSMAP meeting in Chicago!
🎉 @heuerwego.bsky.social gave a great talk & won the Martha Ondrey Jr. Investigator Award 🏆
🧠 @gizemterzioglu.bsky.social crushed it with her presentation on SHIP1 & the inflammasome in microglia!
🎉 @heuerwego.bsky.social gave a great talk & won the Martha Ondrey Jr. Investigator Award 🏆
🧠 @gizemterzioglu.bsky.social crushed it with her presentation on SHIP1 & the inflammasome in microglia!
Cool to see my PhD mentor’s work highlighted!!
What if a routine eye scan could tell a doctor if you were at risk of Alzheimer’s disease? At JAX, Gareth Howell is exploring how genetics shape the way our eyes—and brains—age.
#medicine #genetics #research #science 🧪 🧬 🧠 #neuroskyence
#medicine #genetics #research #science 🧪 🧬 🧠 #neuroskyence
More than meets the eye
What if a routine eye scan could tell a doctor if you were at risk of Alzheimer’s disease? Gareth Howell is exploring how genetics shape the way our eyes—and brains—age. Jackson Laboratory
www.jax.org
May 21, 2025 at 2:06 PM
Cool to see my PhD mentor’s work highlighted!!
Emma has become such an impactful member of the lab and will truly be missed!! Big things ahead for this young neuroscientist!
A big day for the TYP lab! Master's student Emma successfully defended her incredible thesis work today where she's been working with @gizemterzioglu.bsky.social on studying how SHIP1 regulates lysosomal function in microglia. She will be missed!
May 14, 2025 at 11:21 PM
Emma has become such an impactful member of the lab and will truly be missed!! Big things ahead for this young neuroscientist!
Reposted by Sarah Heuer
Some TYP members attended the BIGG meeting at UMass on Monday, and had a great time presenting talks and posters! PhD student @gizemterzioglu.bsky.social & postdoc @kelliannealexa1.bsky.social gave amazing short talks, Master's student Emma & postdoc @heuerwego.bsky.social got great poster traffic!
May 14, 2025 at 10:00 PM
Some TYP members attended the BIGG meeting at UMass on Monday, and had a great time presenting talks and posters! PhD student @gizemterzioglu.bsky.social & postdoc @kelliannealexa1.bsky.social gave amazing short talks, Master's student Emma & postdoc @heuerwego.bsky.social got great poster traffic!
Reposted by Sarah Heuer
Thrilled to share my first first-author paper is out
@cp-neuron.bsky.social! We show that Alzheimer's disease protective CLU alleles upregulate CLU in response to neuropathology, dampening inflammatory signaling between microglia and astrocytes.
Read here www.sciencedirect.com/science/arti...
@cp-neuron.bsky.social! We show that Alzheimer's disease protective CLU alleles upregulate CLU in response to neuropathology, dampening inflammatory signaling between microglia and astrocytes.
Read here www.sciencedirect.com/science/arti...
CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density
Genetic studies implicate clusterin (CLU) in the pathogenesis of Alzheimer’s disease (AD), yet its precise molecular impact remains unclear. Through u…
www.sciencedirect.com
April 30, 2025 at 3:51 PM
Thrilled to share my first first-author paper is out
@cp-neuron.bsky.social! We show that Alzheimer's disease protective CLU alleles upregulate CLU in response to neuropathology, dampening inflammatory signaling between microglia and astrocytes.
Read here www.sciencedirect.com/science/arti...
@cp-neuron.bsky.social! We show that Alzheimer's disease protective CLU alleles upregulate CLU in response to neuropathology, dampening inflammatory signaling between microglia and astrocytes.
Read here www.sciencedirect.com/science/arti...
Reposted by Sarah Heuer
New TYP lab paper out today in @cp-neuron.bsky.social led by PhD student @alexlish.bsky.social! We took a deep dive into the mechanisms underlying CLU in AD using innovative iPSC, mouse, and human data approaches. Be sure to give it a read!
www.cell.com/neuron/abstr...
www.cell.com/neuron/abstr...
CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density
Lish et al. reveal that AD-protective CLU alleles enhance CLU upregulation in response
to accumulated neuropathology, thereby dampening inflammatory signaling between microglia
and astrocytes. Using s...
www.cell.com
April 30, 2025 at 3:56 PM
New TYP lab paper out today in @cp-neuron.bsky.social led by PhD student @alexlish.bsky.social! We took a deep dive into the mechanisms underlying CLU in AD using innovative iPSC, mouse, and human data approaches. Be sure to give it a read!
www.cell.com/neuron/abstr...
www.cell.com/neuron/abstr...
Reposted by Sarah Heuer
Harvard has set an example for other higher-ed institutions - rejecting an unlawful and ham-handed attempt to stifle academic freedom, while taking steps to make sure students can benefit from an environment of intellectual inquiry, rigorous debate and mutual respect. Let’s hope others follow suit.
April 15, 2025 at 3:52 AM
Harvard has set an example for other higher-ed institutions - rejecting an unlawful and ham-handed attempt to stifle academic freedom, while taking steps to make sure students can benefit from an environment of intellectual inquiry, rigorous debate and mutual respect. Let’s hope others follow suit.