#ClonalHematopoiesis
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bloodgenes.bsky.social
Wow!! 🔥🔥 CDK4/6 inhibition prevents selection of #ClonalHematopoiesis with DNA-damage repair mutations after chemotherapy! Awesome presentation from Irenaeus Chan from @kellybolton.bsky.social lab! #ASH25
December 7, 2025 at 8:28 PM
thekinglab.bsky.social
First post on BlueSky! We are celebrating a fabulous seed grant Frieda Zimmer MD earned to support her new studies in #clonalhematopoiesis. Excited for the collaborative work to come!
November 25, 2024 at 10:27 PM
chiraagkapadia.bsky.social
Delighted to share my PhD thesis work is now published in @nature.com! This study tracks the journey of blood stem cells in aging mice, examining how the clonal dynmics of blood production change over time. A short 🧵1/n #aging #stemcells #clonalhematopoiesis
www.nature.com/articles/s41...
Clonal dynamics and somatic evolution of haematopoiesis in mouse - Nature
Isolating and studying haematopoietic stem cells in young and aged mice demonstrates evolutionary processes related to blood production and provides a framework for interpreting future work using labo...
www.nature.com
March 6, 2025 at 1:58 PM
natcellbio.nature.com
🏖️Our August issue's out!
Cover: profiling #atherosclerosis

👉Reviews: #imaging membrane contact sites; #lysosomes in #aging; #nucleotide #metabolism
🔬: #ClonalHematopoiesis #PRC2 #embryogenesis #ferroptosis #cancer #neurobiology #intestine #vesicles & more!

www.nature.com/ncb/volumes/...
August 10, 2026 at 4:19 PM
haoyin.bsky.social
Human Lineage tracing with Somatic Mutation👺 (Blood vs Brain)

Passenger-Assisted Clone Tracking (PACT)

Myeloid cells contribute to 26%🥸 of Microglia (not oligodendrocyte/neuron) pool in aged 👤🧠(w/o driver genes of #ClonalHematopoiesis)

#Nature 2026
www.nature.com/articles/s41...
September 4, 2026 at 3:01 PM
emmamgroarke.bsky.social
Amazing talk from Fernanda Gutierrez-Rodrigues showing our lab’s work on #ClonalHematopoiesis over 10+ years after IST. We saw long-term clonal persistence of ASXL1 and PIGA. #ASH24 @ash-hematology.bsky.social
December 7, 2024 at 6:40 PM
emmamgroarke.bsky.social
Excited to see this work on #clonalhematopoiesis in #telomere disorders led by @daria-babushok.bsky.social @pennmedicine.bsky.social in @jclinical-invest.bsky.social - ATM mutations commonly observed. ATM-dependent DDR from telomere dysfunction key in disease pathogenesis www.jci.org/articles/vie...
April 7, 2025 at 6:38 PM
natcellbio.nature.com
☕ @trowbridgelab.bsky.social & co propose that Dnmt3a-mutant hematopoietic cells induce mesenchymal stromal cell #senescence. Removal of senescent non-hematopoietic cells reduces Dnmt3a-mutant #hematopoiesis. #ClonalHematopoiesis
www.nature.com/articles/s41...
Stromal cell senescence augments haematopoietic cell fitness in clonal haematopoiesis - Nature Cell Biology
Mistry et al. propose that Dnmt3a-mutant haematopoietic cells induce mesenchymal stromal cell senescence. Removal of senescent non-haematopoietic cells reduces Dnmt3a-mutant haematopoiesis.
www.nature.com
August 10, 2026 at 10:31 AM
smckinneyfreeman.bsky.social
@ganuzalab.bsky.social
Exciting new work from my former trainee, Mikel Ganuza, now running his own excellent team. Congrats!
#HSCs #clonalhematopoiesis
#science

www.nature.com/articles/s41...
A CADASIL NOTCH3 mutation leads to clonal hematopoiesis and expansion of Dnmt3a-R878H hematopoietic clones - Leukemia
Leukemia - A CADASIL NOTCH3 mutation leads to clonal hematopoiesis and expansion of Dnmt3a-R878H hematopoietic clones
www.nature.com
January 29, 2025 at 4:30 AM
emmamgroarke.bsky.social
Very nice talk from Austin Kulasekararaj from King’s College London on #ClonalHematopoiesis from the the EBMT RACE trial. #BMFsm #ASH24 @ash-hematology.bsky.social
December 7, 2024 at 6:42 PM
kprummel.bsky.social
🚨 Excited to share our paper 📢 @natcomms.nature.com
We reveal how inflammation reshapes the human #bonemarrow niche 🦴, home of 🩸 stem cells, in the context of #clonalhematopoiesis and #myelodysplasia

An amazing journey with fantastic colleagues and collaborators, thank you all!

shorturl.at/ad0st
November 19, 2025 at 8:12 PM
mskdeptofmed.bsky.social
Research co-led by MSK scientists found a gene variant that may reduce the risk of developing certain #bloodcancers associated with #clonalhematopoiesis. Learn more about how @mskcancercenter.bsky.social is leading the way in CH research and treatment.

Also check out our CH clinic: bit.ly/49szicf
mskcancercenter.bsky.social Memorial Sloan Kettering Cancer Center @mskcancercenter.bsky.social · Jan 6
Scientists have known for decades that there are gene mutations that increase your risk of developing cancer. But there is also a genetic variant that could reduce the risk of developing certain #bloodcancers, according to new research co-led by scientists from MSK.

Learn more: bit.ly/4sIJ5DQ
January 7, 2026 at 7:33 PM
stemcellsciencenews.com
Huge congratulations to Dr. @benjaminwerner.bsky.social, @nvmp.bsky.social, @francescoterenzi.bsky.social, and collaborators! 👏

Check out the team's work! ⬇️:

#ClonalHematopoiesis
May 14, 2026 at 3:01 PM
krikirschner.bsky.social
We integrated data from 713 individuals across 3 longitudinal aging cohorts (2,341 observations total) and developed models to understand the dynamics of CH mutations over time. #CancerResearch #ClonalHematopoiesis
March 7, 2025 at 1:10 PM
castltrastondrs.medsky.network
#MedSky🧪#ImmunoSky #Cellbiology In #clonalhematopoiesis , HSPCs acquire somatic mutations that drive clone growth. Though CH occurs without overt hematological changes, it influences disease pathogenesis. From #Cancer to #CVD & the ramifications of CH
www.jci.org/articles/vie...
Clonal hematopoiesis is associated with numerous human diseases and conditions. Figure adapted from ref. 3 with permission. Highlight
October 1, 2024 at 8:20 PM
haoyin.bsky.social
Genetic Architecture of Human #TelomereLength 🤠
N>460K #UKbiobank

TL: qPCR+Telseq (WGS, coverage-adjusted)➡️
PC1 TL surrogate; PC2 artefactual signal➡️
new GWAS common variants
ExWAS rare variants
Plasma Proteomics
#ClonalHematopoiesis driver genes

#NatureGenet 2024
www.nature.com/articles/s41...
September 9, 2024 at 4:10 PM
nancygillis.bsky.social
Co-led with the always awesome @mingxiangteng.bsky.social with data from the #ORIENNetwork #AsterInsights and @moffittnews.bsky.social. #clonalhematopoiesis #CHIPsm
September 17, 2025 at 4:34 PM
nancygillis.bsky.social
#ClonalHematopoiesis / #CHIP is associated with worse survival in pts treated for solid cancers, but the evolutionary mechanisms driving differential CH dynamics are unknown. To get at this, we calculated therapeutic bottleneck sizes in pts treated for cancer.
September 3, 2025 at 11:51 AM
hemehub.bsky.social
🩸 Additional insights on prognostic scoring in Chronic Myelomonocytic Leukemia

#CMML #Hematology #HemeOnc #BoneMarrowFailure #Leukemia #HemeHub #MedicalEducation #MedEd #ChronicMyelomonocyticLeukemia #MyeloidMalignancies #HematologyEducation #ClonalHematopoiesis #MRD #iCPSS #Trisomy8
April 18, 2026 at 11:44 PM
hemehub.bsky.social
🚀💭Today’s questions!

Swipe to see the answers and explanations!

#CMML #ChronicMyelomonocyticLeukemia #Hematology #HemeOnc #MedEd #MedicalEducation #HematologyEducation #MyeloidNeoplasms #ClonalHematopoiesis #ASXL1 #TET2 #SRSF2 #BoneMarrowFailure #HemeCases #ClinicalHematology #HEMEHUB
April 11, 2026 at 9:49 PM
hemehub.bsky.social
🩸🔍First question of the month!

Swipe to see the answer and its explanation.

#CMML #ChronicMyelomonocyticLeukemia #Hematology #MyeloidNeoplasms #ClonalHematopoiesis #CHIP #TET2 #SRSF2 #ASXL1 #BoneMarrow #Monocytosis #FlowCytometry #HematologicMalignancies #HemeEd #HemeHub #BloodCancer
April 4, 2026 at 8:54 PM
hemehub.bsky.social
🩸Facts about Chronic Myelomonocytic Leukemia:

Disease Biology & Pathogenesis

#CMML #MDS #MPN #Hematology #HematologicMalignancies #ClonalHematopoiesis #CHIP #TET2 #SRSF2 #ASXL1 #MyeloidNeoplasms #MedEd #HemeEd #HemeHub #BloodCancer #MyeloidDisorders #ClinicalHematology
April 4, 2026 at 8:53 PM
jamacardiology.com
Among adults in two US biobanks, #ClonalHematopoiesis of indeterminate potential was associated with increased risk of incident #Pericarditis, but not #Myocarditis, supporting gene-driven inflammation as a therapeutic target.

ja.ma/4bw3Pqs
JAMA Cardiology 'Research Letter' on 'Clonal Hematopoiesis and Risk of Incident Pericarditis and Myocarditis in 2 US Biobank Cohorts' by Yash Pershad@1, Kun Zhao@1, J. Brett Heimlich, et al. Published Online: March 18, 2026.
March 20, 2026 at 4:00 PM
ufhealthcancer.bsky.social
Published in @jci.org, UF Health Cancer Center researchers have found that #ClonalHematopoiesis promotes #obesity and metabolic disease: go.ufl.edu/tbrz64w
Study finds hidden blood mutations spark obesity, diabetes and liver disease - UF Health
GAINESVILLE, Fla. — UF Health Cancer Center researchers have found a surprising culprit behind common health problems like obesity, diabetes and fatty liver…
go.ufl.edu
October 13, 2025 at 1:09 PM
castltrastondrs.medsky.network
#ClinicalReviews on #ClonalHematopoiesis
www.jci.org/review_serie...
October 1, 2024 at 8:22 PM