N>460K #UKbiobank
TL: qPCR+Telseq (WGS, coverage-adjusted)➡️
PC1 TL surrogate; PC2 artefactual signal➡️
new GWAS common variants
ExWAS rare variants
Plasma Proteomics
#ClonalHematopoiesis driver genes
#NatureGenet 2024
www.nature.com/articles/s41...
N>460K #UKbiobank
TL: qPCR+Telseq (WGS, coverage-adjusted)➡️
PC1 TL surrogate; PC2 artefactual signal➡️
new GWAS common variants
ExWAS rare variants
Plasma Proteomics
#ClonalHematopoiesis driver genes
#NatureGenet 2024
www.nature.com/articles/s41...
https://doi.org/10.1038/s41598-022-10556-z #cognitivefunction #telomerelength #neuroprotection
https://doi.org/10.1038/s41598-022-10556-z #cognitivefunction #telomerelength #neuroprotection
#Senescence/#Aging features of Isogenic HGPS #hiPSC-#EndothelialCell vs #SmoothMuscleCell
#Progerin <
Nuclear deformation <
#Senescence >
#DNADamage ~
#TelomereLength <
#Shelterin
#SASP
#Heterochromatin loss ~
#EHJOpen 2022
academic.oup.com/ehjopen/arti...
#Senescence/#Aging features of Isogenic HGPS #hiPSC-#EndothelialCell vs #SmoothMuscleCell
#Progerin <
Nuclear deformation <
#Senescence >
#DNADamage ~
#TelomereLength <
#Shelterin
#SASP
#Heterochromatin loss ~
#EHJOpen 2022
academic.oup.com/ehjopen/arti...