Mitochondrial fatty acid oxidation drives senescence 👩🔬🧪🔬🥼. #ageing #senescence #mitochondria #senescent 👇👇👇
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Mitochondrial fatty acid oxidation drives senescence
Nuclear DNA damage activates fatty acid–fueled mitochondrial energy metabolism to induce cellular senescence, a hallmark of aging.
www.science.org
November 26, 2024 at 12:03 AM
Mitochondrial fatty acid oxidation drives senescence 👩🔬🧪🔬🥼. #ageing #senescence #mitochondria #senescent 👇👇👇
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
November 23, 2024 at 6:03 AM
CellAge
Database of Cell #Senescence Genes
genomics.senescence.info/cells/
279 Senescence-associated genes
869 Longevity-associated genes
A multidimensional systems biology analysis of cellular senescence in aging & disease
#GenomeBiology 2020
genomebiology.biomedcentral.com/articles/10....
Database of Cell #Senescence Genes
genomics.senescence.info/cells/
279 Senescence-associated genes
869 Longevity-associated genes
A multidimensional systems biology analysis of cellular senescence in aging & disease
#GenomeBiology 2020
genomebiology.biomedcentral.com/articles/10....
January 20, 2025 at 1:26 PM
CellAge
Database of Cell #Senescence Genes
genomics.senescence.info/cells/
279 Senescence-associated genes
869 Longevity-associated genes
A multidimensional systems biology analysis of cellular senescence in aging & disease
#GenomeBiology 2020
genomebiology.biomedcentral.com/articles/10....
Database of Cell #Senescence Genes
genomics.senescence.info/cells/
279 Senescence-associated genes
869 Longevity-associated genes
A multidimensional systems biology analysis of cellular senescence in aging & disease
#GenomeBiology 2020
genomebiology.biomedcentral.com/articles/10....
Interleukin-23 receptor as a biomarker for aging and potential link to senolytic therapy
www.nature.com/articles/s43...
www.nature.com/articles/s43...
IL-23R is a senescence-linked circulating and tissue biomarker of aging - Nature Aging
Using mouse and human plasma, Carver et al. identify factors that are altered with age and test which are reverted by a panel of genetic and pharmacological senolytic interventions in aged mice. They ...
www.nature.com
December 10, 2024 at 3:32 PM
Interleukin-23 receptor as a biomarker for aging and potential link to senolytic therapy
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Long associated with aging, senescent cells can promote health and have physiological roles.
Learn more in this #SciencePerspective: scim.ag/40tp4nx
Learn more in this #SciencePerspective: scim.ag/40tp4nx
Cellular senescence in normal physiology
Long associated with aging, senescent cells can promote health and have physiological roles
scim.ag
January 8, 2025 at 4:15 PM
Long associated with aging, senescent cells can promote health and have physiological roles.
Learn more in this #SciencePerspective: scim.ag/40tp4nx
Learn more in this #SciencePerspective: scim.ag/40tp4nx
Senescent cell identification SenCID
#MachineLearning
52 transcriptomic datasets; 30 cell types▶️6 #Senescence modules
Single-cell senescence trajectories in multi-tissue Aging & Diseases
SMCs "have high basal senescence score"😬
@cp-cellmetabolism.bsky.social 2024
www.cell.com/cell-metabol...
#MachineLearning
52 transcriptomic datasets; 30 cell types▶️6 #Senescence modules
Single-cell senescence trajectories in multi-tissue Aging & Diseases
SMCs "have high basal senescence score"😬
@cp-cellmetabolism.bsky.social 2024
www.cell.com/cell-metabol...
January 22, 2025 at 12:49 PM
Senescent cell identification SenCID
#MachineLearning
52 transcriptomic datasets; 30 cell types▶️6 #Senescence modules
Single-cell senescence trajectories in multi-tissue Aging & Diseases
SMCs "have high basal senescence score"😬
@cp-cellmetabolism.bsky.social 2024
www.cell.com/cell-metabol...
#MachineLearning
52 transcriptomic datasets; 30 cell types▶️6 #Senescence modules
Single-cell senescence trajectories in multi-tissue Aging & Diseases
SMCs "have high basal senescence score"😬
@cp-cellmetabolism.bsky.social 2024
www.cell.com/cell-metabol...
New important publication in #LongCovid & #MECFS!
After a viral infection, cells lining our blood vessels can become damaged and enter senescence, similar to accelerated aging. These cells are not healthy, but they also don’t disappear. Instead, they send out constant stress & inflammatory signals.
After a viral infection, cells lining our blood vessels can become damaged and enter senescence, similar to accelerated aging. These cells are not healthy, but they also don’t disappear. Instead, they send out constant stress & inflammatory signals.
January 14, 2026 at 3:31 PM
New important publication in #LongCovid & #MECFS!
After a viral infection, cells lining our blood vessels can become damaged and enter senescence, similar to accelerated aging. These cells are not healthy, but they also don’t disappear. Instead, they send out constant stress & inflammatory signals.
After a viral infection, cells lining our blood vessels can become damaged and enter senescence, similar to accelerated aging. These cells are not healthy, but they also don’t disappear. Instead, they send out constant stress & inflammatory signals.
Join us on June 23-24th in Paris, to explore the fascinating world of senescence and aging! #COSTAction; #senescence; #aging
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I am happy to announce with @hanli-pasteur.bsky.social that we'll organise a summer school titled "Senescence from Cell Cultures to Humans through Model Organisms" in Paris, Fr on June 23-24, 2025
Aimed at 2nd and 3rd year PhD student + postdocs
Submit your provisional project tinyurl.com/2uhfzxbp
Aimed at 2nd and 3rd year PhD student + postdocs
Submit your provisional project tinyurl.com/2uhfzxbp
February 27, 2025 at 3:53 PM
Join us on June 23-24th in Paris, to explore the fascinating world of senescence and aging! #COSTAction; #senescence; #aging
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Inferring organ aging, hallmark of aging and senescence scores from blood and facial photographs
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Inferring organ aging, hallmark of aging and senescence scores from blood and facial photographs
Aging progresses asynchronously across organs, motivating the development of organ-resolved aging clocks. Direct assessment of organ aging in living humans, however, is largely impractical. Here, we c...
www.biorxiv.org
October 1, 2026 at 1:39 PM
Inferring organ aging, hallmark of aging and senescence scores from blood and facial photographs
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Peripheral sensory (DRG) neurons exhibit senescence in aging and pain-inducing injury; elimination of senescent cells improved nociceptive behaviors in injured mice
@laurenjdonovan.bsky.social @vivtawfik-mdphd.bsky.social @stanfordmedicine.bsky.social
www.nature.com/articles/s41...
@laurenjdonovan.bsky.social @vivtawfik-mdphd.bsky.social @stanfordmedicine.bsky.social
www.nature.com/articles/s41...
Aging and injury drive neuronal senescence in the dorsal root ganglia - Nature Neuroscience
The authors describe a susceptibility of the peripheral nervous system to neuronal senescence with age or injury relevant for sensory dysfunction, such as chronic pain.
www.nature.com
May 14, 2025 at 2:41 PM
Peripheral sensory (DRG) neurons exhibit senescence in aging and pain-inducing injury; elimination of senescent cells improved nociceptive behaviors in injured mice
@laurenjdonovan.bsky.social @vivtawfik-mdphd.bsky.social @stanfordmedicine.bsky.social
www.nature.com/articles/s41...
@laurenjdonovan.bsky.social @vivtawfik-mdphd.bsky.social @stanfordmedicine.bsky.social
www.nature.com/articles/s41...
Could targeting LSD1 be a novel strategy to decrease senescence, organ aging, and hair graying? doi.org/10.1172/JCI1...
Zhang et al. demonstrate LSD1 as a key regulator of DNA damage-induced senescence and organ aging and highlights it as a promising therapeutic target.
Zhang et al. demonstrate LSD1 as a key regulator of DNA damage-induced senescence and organ aging and highlights it as a promising therapeutic target.
September 30, 2026 at 3:03 PM
Could targeting LSD1 be a novel strategy to decrease senescence, organ aging, and hair graying? doi.org/10.1172/JCI1...
Zhang et al. demonstrate LSD1 as a key regulator of DNA damage-induced senescence and organ aging and highlights it as a promising therapeutic target.
Zhang et al. demonstrate LSD1 as a key regulator of DNA damage-induced senescence and organ aging and highlights it as a promising therapeutic target.
| T ê t e - à -t ê t e |
Senescence ; referring to the process of aging and deterioration of function in living organisms. It can refer to the aging of cells or the aging of the entire organism - deterioration with age.
@stillframes.bsky.social @eastcoastkin-ac.bsky.social #photography
Senescence ; referring to the process of aging and deterioration of function in living organisms. It can refer to the aging of cells or the aging of the entire organism - deterioration with age.
@stillframes.bsky.social @eastcoastkin-ac.bsky.social #photography
June 20, 2025 at 10:01 PM
| T ê t e - à -t ê t e |
Senescence ; referring to the process of aging and deterioration of function in living organisms. It can refer to the aging of cells or the aging of the entire organism - deterioration with age.
@stillframes.bsky.social @eastcoastkin-ac.bsky.social #photography
Senescence ; referring to the process of aging and deterioration of function in living organisms. It can refer to the aging of cells or the aging of the entire organism - deterioration with age.
@stillframes.bsky.social @eastcoastkin-ac.bsky.social #photography
Our latest is now out in @nataging.nature.com giving reason to celebrate! Led by talented Spiros Palikyras, it improves our preprint (posted 2 years ago!) dissecting the mechanism and functional consequences of CTCF clustering upon senescence commitment of human cells.
www.nature.com/articles/s43...
www.nature.com/articles/s43...
Senescent cells cluster CTCF on nuclear speckles to instruct an alternative splicing program - Nature Aging
Palikyras and colleagues investigate chromatin reorganization upon senescence induction, reporting that components of nuclear speckles coordinate chromatin rewiring and a senescence-associated splicin...
www.nature.com
July 21, 2026 at 10:04 AM
Our latest is now out in @nataging.nature.com giving reason to celebrate! Led by talented Spiros Palikyras, it improves our preprint (posted 2 years ago!) dissecting the mechanism and functional consequences of CTCF clustering upon senescence commitment of human cells.
www.nature.com/articles/s43...
www.nature.com/articles/s43...
🧪Progress made in building a senescence atlas to help map #aging and develop strategies to combat the detrimental effects that contribute to disease and distinct natural aging. Are senolytics the answer, if senescence is a defence against cancer? @cellpress.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
June 13, 2026 at 4:28 PM
🧪Progress made in building a senescence atlas to help map #aging and develop strategies to combat the detrimental effects that contribute to disease and distinct natural aging. Are senolytics the answer, if senescence is a defence against cancer? @cellpress.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
"In the context of #senescence, #zebrafish have been reported to age in a telomere-dependent manner with shortening #telomeres with #age, a feature which is seen in humans but not widely observed in laboratory mice."
Go Fish! 🐟 #Aging
www.nature.com/articles/s41...
Go Fish! 🐟 #Aging
www.nature.com/articles/s41...
Emerging insights in senescence: pathways from preclinical models to therapeutic innovations - npj Aging
npj Aging - Emerging insights in senescence: pathways from preclinical models to therapeutic innovations
www.nature.com
November 25, 2024 at 3:16 PM
"In the context of #senescence, #zebrafish have been reported to age in a telomere-dependent manner with shortening #telomeres with #age, a feature which is seen in humans but not widely observed in laboratory mice."
Go Fish! 🐟 #Aging
www.nature.com/articles/s41...
Go Fish! 🐟 #Aging
www.nature.com/articles/s41...
Like, here's a paper using stem cells in primates in China. The reality of this stuff is that the US will fall behind in biotech among other work while China (and likely India) will boom in terms of research going forward
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
Senescence-resistant human mesenchymal progenitor cells counter aging in primates
Genetically engineered senescence-resistant human mesenchymal progenitor cells can
reduce aging markers and improve tissue and cognitive functions in aged macaques,
highlighting their potential as a r...
www.cell.com
November 21, 2025 at 3:27 PM
Like, here's a paper using stem cells in primates in China. The reality of this stuff is that the US will fall behind in biotech among other work while China (and likely India) will boom in terms of research going forward
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
Welcome to all of our 89th Symposium: Senescence and Aging attendees! #cshlsymp25
May 29, 2025 at 7:15 PM
Welcome to all of our 89th Symposium: Senescence and Aging attendees! #cshlsymp25
🧬 Human stem cells delay aging in monkeys
Scientists gave older monkeys special human stem cells built to resist aging. The treatment improved brain function, reduced inflammation, and even boosted reproductive health, without side effects.
🔗 www.cell.com/cell/abstrac...
#SciComm #Aging 🧪
Scientists gave older monkeys special human stem cells built to resist aging. The treatment improved brain function, reduced inflammation, and even boosted reproductive health, without side effects.
🔗 www.cell.com/cell/abstrac...
#SciComm #Aging 🧪
Senescence-resistant human mesenchymal progenitor cells counter aging in primates
Genetically engineered senescence-resistant human mesenchymal progenitor cells can
reduce aging markers and improve tissue and cognitive functions in aged macaques,
highlighting their potential as a r...
www.cell.com
July 13, 2025 at 8:23 PM
🧬 Human stem cells delay aging in monkeys
Scientists gave older monkeys special human stem cells built to resist aging. The treatment improved brain function, reduced inflammation, and even boosted reproductive health, without side effects.
🔗 www.cell.com/cell/abstrac...
#SciComm #Aging 🧪
Scientists gave older monkeys special human stem cells built to resist aging. The treatment improved brain function, reduced inflammation, and even boosted reproductive health, without side effects.
🔗 www.cell.com/cell/abstrac...
#SciComm #Aging 🧪
Is age just a number? Who knows?
Some say “yes.” Others suff’ring the woes
Of senescence will wage
A war against age,
To disguise the “gifts” aging bestows.
Happy Age Is Just A Number Day! (March 22)
#Aging #LimerickSunday #Limerick #Limericks #Rhyme #Poetry #MicroPoetry #LightVerse #Verse #Poems
Some say “yes.” Others suff’ring the woes
Of senescence will wage
A war against age,
To disguise the “gifts” aging bestows.
Happy Age Is Just A Number Day! (March 22)
#Aging #LimerickSunday #Limerick #Limericks #Rhyme #Poetry #MicroPoetry #LightVerse #Verse #Poems
March 22, 2026 at 7:11 PM
Is age just a number? Who knows?
Some say “yes.” Others suff’ring the woes
Of senescence will wage
A war against age,
To disguise the “gifts” aging bestows.
Happy Age Is Just A Number Day! (March 22)
#Aging #LimerickSunday #Limerick #Limericks #Rhyme #Poetry #MicroPoetry #LightVerse #Verse #Poems
Some say “yes.” Others suff’ring the woes
Of senescence will wage
A war against age,
To disguise the “gifts” aging bestows.
Happy Age Is Just A Number Day! (March 22)
#Aging #LimerickSunday #Limerick #Limericks #Rhyme #Poetry #MicroPoetry #LightVerse #Verse #Poems
🎥 #AgingShort:
Abstract #Video about the #Research paper, titled "Selective targeting of cancer and senescence via shared metabolic shifts extends lifespan of old mice.”
@qb3-berkeley.bsky.social @ucberkeleyofficial.bsky.social
🔗 https://bit.ly/4hcw9Tq
#Aging #Longevity #Cancer #Senescence #OA
Abstract #Video about the #Research paper, titled "Selective targeting of cancer and senescence via shared metabolic shifts extends lifespan of old mice.”
@qb3-berkeley.bsky.social @ucberkeleyofficial.bsky.social
🔗 https://bit.ly/4hcw9Tq
#Aging #Longevity #Cancer #Senescence #OA
October 2, 2026 at 6:00 PM
🎥 #AgingShort:
Abstract #Video about the #Research paper, titled "Selective targeting of cancer and senescence via shared metabolic shifts extends lifespan of old mice.”
@qb3-berkeley.bsky.social @ucberkeleyofficial.bsky.social
🔗 https://bit.ly/4hcw9Tq
#Aging #Longevity #Cancer #Senescence #OA
Abstract #Video about the #Research paper, titled "Selective targeting of cancer and senescence via shared metabolic shifts extends lifespan of old mice.”
@qb3-berkeley.bsky.social @ucberkeleyofficial.bsky.social
🔗 https://bit.ly/4hcw9Tq
#Aging #Longevity #Cancer #Senescence #OA
🧬 Specialised cells slow aging in monkeys
A new study found that modified human cells helped older monkeys stay healthier for nearly a year, reducing signs of aging and boosting memory and fertility.
🔗 www.cell.com/cell/fulltex...
#SciComm 🧪 #Ageing
A new study found that modified human cells helped older monkeys stay healthier for nearly a year, reducing signs of aging and boosting memory and fertility.
🔗 www.cell.com/cell/fulltex...
#SciComm 🧪 #Ageing
Senescence-resistant human mesenchymal progenitor cells counter aging in primates
Genetically engineered senescence-resistant human mesenchymal progenitor cells can
reduce aging markers and improve tissue and cognitive functions in aged macaques,
highlighting their potential as a r...
www.cell.com
September 12, 2025 at 4:52 AM
🧬 Specialised cells slow aging in monkeys
A new study found that modified human cells helped older monkeys stay healthier for nearly a year, reducing signs of aging and boosting memory and fertility.
🔗 www.cell.com/cell/fulltex...
#SciComm 🧪 #Ageing
A new study found that modified human cells helped older monkeys stay healthier for nearly a year, reducing signs of aging and boosting memory and fertility.
🔗 www.cell.com/cell/fulltex...
#SciComm 🧪 #Ageing
I'm afraid I don't have time to do a full explainer on this, but here's an short excerpt from my textbook, and a link to helpful context about the evolutionary theory of senescence: www.nature.com/scitable/kno...
Williams's arguments have held up all too well over the intervening years.
Williams's arguments have held up all too well over the intervening years.
January 24, 2025 at 7:57 PM
I'm afraid I don't have time to do a full explainer on this, but here's an short excerpt from my textbook, and a link to helpful context about the evolutionary theory of senescence: www.nature.com/scitable/kno...
Williams's arguments have held up all too well over the intervening years.
Williams's arguments have held up all too well over the intervening years.