Structures reveal that histone H3K36me3 and H3K4me3 modifications reduce Polycomb repressive complex 2 (PRC2) function through the inhibition of histone tail engagement and antagonistic binding to the...

In Arabidopsis, active cell division keeps bud precursor cells undifferentiated by removing H3 K27 trimethylation marks, countering PRC2 silencing of STM. Prolonged quiescence causes irreversible diff...

Polycomb Repressive Complexes PRC1 and PRC2 establish and maintain chromatin architectures critical for cell-type specific gene expression. In the developing spinal cord, PRC1 is essential for impleme...

The authors declare that they have no known competing financial interests or personal relationships that could influence the work reported in this study. Ethics statement Animal studies were conducted in accordance with ethical guidelines approved by the Animal Ethics Committee of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. The ethical approval number was 2132. Research involving human biological samples was conducted in compliance with the Declaration of Helsinki and approved by the Research Ethics Committee of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (Wuhan, China). The ethical approval number was S451. Consent for publication All participants provided written informed consent before their inclusion. The purpose of the research, the procedures involved, and any potential risks or benefits were thoroughly explained to each participant. Participants were informed of their right to withdraw from the study at any time without any consequences. The informed consent process complied with the ethical standards of the Research Ethics Committee of the Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (Wuhan, China). This article is published under an open access license. Please check the 'Copyright Information' section either on this page or in the PDF...

Polycomb Repressive Complexes PRC1 and PRC2 establish and maintain chromatin architectures critical for cell-type specific gene expression. In the developing spinal cord, PRC1 is essential for impleme...

Post-COVID status was associated with a lower score on the sample-derived diffusion-volume component pattern. The MLP showed numerically higher internal discrimination than logistic regression, while the between-model comparison remained statistically inconclusive. These findings highlight PRC2 as a …

PhD Project - UKRI BBSRC NEEDL DLA: Defining the Role of the PRC2 complex in Chromatin Regulation and Cell Viability under Hypoxia at Newcastle University, listed on FindAPhD.com

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