Discussed this at JC. Very nice experiments. The PHC1/2/3 degron results were interesting: no Polycomb bodies, yet some interactions remain among Polycomb target loci. To me, Polycomb bodies could be both sites of Polycomb target interactions AND clusters of self-interacting cPRC1. Not either/or.
(1/9) Excited to share my preprint on Polycomb 3D chromatin interactions from my postdoc with @andersshansen.bsky.social!
We were surprised to find that canonical PRC1 doesn't seem to be the only contributor to these interactions:
www.biorxiv.org/content/10.6...
We were surprised to find that canonical PRC1 doesn't seem to be the only contributor to these interactions:
www.biorxiv.org/content/10.6...
November 13, 2026 at 4:15 AM
Discussed this at JC. Very nice experiments. The PHC1/2/3 degron results were interesting: no Polycomb bodies, yet some interactions remain among Polycomb target loci. To me, Polycomb bodies could be both sites of Polycomb target interactions AND clusters of self-interacting cPRC1. Not either/or.
Thank you! I agree - an interesting (and maybe difficult to answer) question is how often is a Polycomb body a cluster of cPRC1 vs just enriched binding, how often do they contain Polycomb target loci, and how often are both of those true? I expect this may change by cell type/CBX expression too.
November 13, 2026 at 4:57 PM
Thank you! I agree - an interesting (and maybe difficult to answer) question is how often is a Polycomb body a cluster of cPRC1 vs just enriched binding, how often do they contain Polycomb target loci, and how often are both of those true? I expect this may change by cell type/CBX expression too.
We also review comparative genomic studies suggesting that the relative contributions of Polycomb- and DNA-methylation-mediated silencing have diversified throughout plant evolution.
November 13, 2026 at 10:49 AM
We also review comparative genomic studies suggesting that the relative contributions of Polycomb- and DNA-methylation-mediated silencing have diversified throughout plant evolution.
In this review, we explore emerging evidence for the interplay between DNA methylation and Polycomb-mediated repression in plants, and discuss potential mechanisms underlying their interactions.
November 13, 2026 at 10:49 AM
In this review, we explore emerging evidence for the interplay between DNA methylation and Polycomb-mediated repression in plants, and discuss potential mechanisms underlying their interactions.
We're hiring! Join my research group @ceitec.eu
🎓 1 PhD position (4 years)
🧪 1 Postdoc position
Investigate Polycomb protein function in 🌱Arabidopsis as part of a newly funded JUNIOR STAR project!
🔗 Links in the replies 👇
🔁 Please share!
🎓 1 PhD position (4 years)
🧪 1 Postdoc position
Investigate Polycomb protein function in 🌱Arabidopsis as part of a newly funded JUNIOR STAR project!
🔗 Links in the replies 👇
🔁 Please share!
November 10, 2026 at 10:16 AM
We're hiring! Join my research group @ceitec.eu
🎓 1 PhD position (4 years)
🧪 1 Postdoc position
Investigate Polycomb protein function in 🌱Arabidopsis as part of a newly funded JUNIOR STAR project!
🔗 Links in the replies 👇
🔁 Please share!
🎓 1 PhD position (4 years)
🧪 1 Postdoc position
Investigate Polycomb protein function in 🌱Arabidopsis as part of a newly funded JUNIOR STAR project!
🔗 Links in the replies 👇
🔁 Please share!
Indeed, an interesting and difficult question. I am sure these questions matter not just for Polycomb bodies, but also for other forms of bodies/condensates/granules/etc. in biology. Great work!
November 14, 2026 at 9:22 PM
Indeed, an interesting and difficult question. I am sure these questions matter not just for Polycomb bodies, but also for other forms of bodies/condensates/granules/etc. in biology. Great work!
We propose that DNA methylation, Polycomb repression and the interplay between these two major epigenetic pathways define a continuum of transposable element (TE) silencing states that may shift during development and across generations.
November 13, 2026 at 10:49 AM
We propose that DNA methylation, Polycomb repression and the interplay between these two major epigenetic pathways define a continuum of transposable element (TE) silencing states that may shift during development and across generations.
the lion does not concern himself with the Polycomb Repressive Complex
November 9, 2026 at 4:46 AM
the lion does not concern himself with the Polycomb Repressive Complex
PXD059191 🚨
Mutations in the two E3-ligases of the Polycomb Repressive Complex 1 (PRC1), RING1 and RNF2 in individuals with neurodevelopmental disorders and reveal distinct mechanisms by which PRC1 activity can be compromised.
🚨 New dataset alert! 🚨
Mutations in the two E3-ligases of the Polycomb Repressive Complex 1 (PRC1), RING1 and RNF2 in individuals with neurodevelopmental disorders and reveal distinct mechanisms by which PRC1 activity can be compromised.
🚨 New dataset alert! 🚨
November 14, 2026 at 3:00 PM
PXD059191 🚨
Mutations in the two E3-ligases of the Polycomb Repressive Complex 1 (PRC1), RING1 and RNF2 in individuals with neurodevelopmental disorders and reveal distinct mechanisms by which PRC1 activity can be compromised.
🚨 New dataset alert! 🚨
Mutations in the two E3-ligases of the Polycomb Repressive Complex 1 (PRC1), RING1 and RNF2 in individuals with neurodevelopmental disorders and reveal distinct mechanisms by which PRC1 activity can be compromised.
🚨 New dataset alert! 🚨
Postdoc position: www.ceitec.eu/postdoctoral...
Postdoctoral Researcher in Protein Biochemistry of Plant Epigenetic Regulators | CEITEC - výzkumné centrum
About this position:
We are looking for a postdoctoral researcher to investigate protein organizational properties of Arabidopsis Polycomb complexes that are involved in regulating ...
www.ceitec.eu
November 10, 2026 at 10:18 AM
Postdoc position: www.ceitec.eu/postdoctoral...
It also builds on our previous research published in Nature Com. (DNA methylation can either antagonize or promote Polycomb DOI: 10.1038/s41467-026-77108-9 ) and Genome Biology (transposable elements can switch between the two silencing states at the population level DOI: 10.1186/s13059-024-03466-6)
November 13, 2026 at 10:49 AM
It also builds on our previous research published in Nature Com. (DNA methylation can either antagonize or promote Polycomb DOI: 10.1038/s41467-026-77108-9 ) and Genome Biology (transposable elements can switch between the two silencing states at the population level DOI: 10.1186/s13059-024-03466-6)
🧬Structural basis for the inhibition of PRC2 by active transcription histone posttranslational modifications
⏰Published: 07 January 2025
📑Journal : @nature.com structural biology
🔗Study the paper www.nature.com/articles/s41... (1/n)
@epigenometech.bsky.social
@cancrepigenetic.bsky.social
⏰Published: 07 January 2025
📑Journal : @nature.com structural biology
🔗Study the paper www.nature.com/articles/s41... (1/n)
@epigenometech.bsky.social
@cancrepigenetic.bsky.social
Structural basis for the inhibition of PRC2 by active transcription histone posttranslational modifications - Nature Structural & Molecular Biology
Structures reveal that histone H3K36me3 and H3K4me3 modifications reduce Polycomb repressive complex 2 (PRC2) function through the inhibition of histone tail engagement and antagonistic binding to the...
www.nature.com
November 11, 2026 at 3:07 AM
🧬Structural basis for the inhibition of PRC2 by active transcription histone posttranslational modifications
⏰Published: 07 January 2025
📑Journal : @nature.com structural biology
🔗Study the paper www.nature.com/articles/s41... (1/n)
@epigenometech.bsky.social
@cancrepigenetic.bsky.social
⏰Published: 07 January 2025
📑Journal : @nature.com structural biology
🔗Study the paper www.nature.com/articles/s41... (1/n)
@epigenometech.bsky.social
@cancrepigenetic.bsky.social
Epigenetics Update - DCAF7 regulates hematopoietic stem cell function and differentiation through polycomb repressive complex 1 modulation www.nature.com/articles/s41...
Johanna Melo-Cardenas and John D. Crispino in Nat Commun
#Epigenetics #Chromatin #PRC1 #HSCs #StemCells
---
epigenometech.com
Johanna Melo-Cardenas and John D. Crispino in Nat Commun
#Epigenetics #Chromatin #PRC1 #HSCs #StemCells
---
epigenometech.com
November 6, 2026 at 4:11 PM
Epigenetics Update - DCAF7 regulates hematopoietic stem cell function and differentiation through polycomb repressive complex 1 modulation www.nature.com/articles/s41...
Johanna Melo-Cardenas and John D. Crispino in Nat Commun
#Epigenetics #Chromatin #PRC1 #HSCs #StemCells
---
epigenometech.com
Johanna Melo-Cardenas and John D. Crispino in Nat Commun
#Epigenetics #Chromatin #PRC1 #HSCs #StemCells
---
epigenometech.com
RRIDs were included in this in Science Advances paper. Thanks for making your methods matter! #BetterScience #accelerateopenscience #ReproducibleResearch
Widespread association of Polycomb complex–deposited histone H2A monoubiquitylation with enhancers and neuronal gene regulation
Read the full paper: Widespread association of Polycomb complex–deposited histone H2A monoubiquitylation with enhancers and neuronal gene regulation
doi.org
November 8, 2026 at 8:02 AM
RRIDs were included in this in Science Advances paper. Thanks for making your methods matter! #BetterScience #accelerateopenscience #ReproducibleResearch
🧬 Join us tomorrow for our Biology Seminar!
Dr. Steven DeLuca (Montana State University) will present “Developmental Gene Regulation through Polycomb Protein Polymerization.”
📅 Nov. 10 | 12 PM
📍 Room 8, Müller Lab
Hosted by Jesse Lasky.
See you there!
Dr. Steven DeLuca (Montana State University) will present “Developmental Gene Regulation through Polycomb Protein Polymerization.”
📅 Nov. 10 | 12 PM
📍 Room 8, Müller Lab
Hosted by Jesse Lasky.
See you there!
November 9, 2026 at 3:01 PM
🧬 Join us tomorrow for our Biology Seminar!
Dr. Steven DeLuca (Montana State University) will present “Developmental Gene Regulation through Polycomb Protein Polymerization.”
📅 Nov. 10 | 12 PM
📍 Room 8, Müller Lab
Hosted by Jesse Lasky.
See you there!
Dr. Steven DeLuca (Montana State University) will present “Developmental Gene Regulation through Polycomb Protein Polymerization.”
📅 Nov. 10 | 12 PM
📍 Room 8, Müller Lab
Hosted by Jesse Lasky.
See you there!
Polycomb Marked Promoter Methylation Gains in Aging and Cancer are Independent of Replication https://www.biorxiv.org/content/10.64898/2026.10.30.763235v1
November 3, 2026 at 8:48 AM
Polycomb Marked Promoter Methylation Gains in Aging and Cancer are Independent of Replication https://www.biorxiv.org/content/10.64898/2026.10.30.763235v1
Polycomb Marked Promoter Methylation Gains in Aging and Cancer are Independent of Replication https://www.biorxiv.org/content/10.64898/2026.10.30.763235v1
November 3, 2026 at 8:48 AM
Polycomb Marked Promoter Methylation Gains in Aging and Cancer are Independent of Replication https://www.biorxiv.org/content/10.64898/2026.10.30.763235v1
Proud of Alex Miller for his PhD work, and seeing it in Development, a journal I have read and re-read many classic papers on Hox genes and neural development.
#hox #polycomb #spinal
PHC2-dependent PRC1 assemblies stabilize motor neuron Hox codes journals.biologists.com/dev/article-...
#hox #polycomb #spinal
PHC2-dependent PRC1 assemblies stabilize motor neuron Hox codes journals.biologists.com/dev/article-...
PHC2-dependent PRC1 assemblies stabilize motor neuron Hox codes
Polycomb Repressive Complexes PRC1 and PRC2 establish and maintain chromatin architectures critical for cell-type specific gene expression. In the developing spinal cord, PRC1 is essential for impleme...
journals.biologists.com
November 1, 2026 at 5:17 PM
Proud of Alex Miller for his PhD work, and seeing it in Development, a journal I have read and re-read many classic papers on Hox genes and neural development.
#hox #polycomb #spinal
PHC2-dependent PRC1 assemblies stabilize motor neuron Hox codes journals.biologists.com/dev/article-...
#hox #polycomb #spinal
PHC2-dependent PRC1 assemblies stabilize motor neuron Hox codes journals.biologists.com/dev/article-...
- "PHC2-dependent PRC1 assemblies stabilize Hox transcriptional boundaries and motor neuron segmental identities".
journals.biologists.com/dev/article-...
journals.biologists.com/dev/article-...
PHC2-dependent PRC1 assemblies stabilize motor neuron Hox codes
Polycomb Repressive Complexes PRC1 and PRC2 establish and maintain chromatin architectures critical for cell-type specific gene expression. In the developing spinal cord, PRC1 is essential for impleme...
journals.biologists.com
November 2, 2026 at 8:05 AM
- "PHC2-dependent PRC1 assemblies stabilize Hox transcriptional boundaries and motor neuron segmental identities".
journals.biologists.com/dev/article-...
journals.biologists.com/dev/article-...
RRIDs were included in this in eLife paper. Thanks for making your methods matter! #RRID #ReproducibleResearch #BetterScience
Nucleation-dependent propagation of Polycomb modifications emerges during the Drosophila maternal to zygotic transition
Read the full paper: Nucleation-dependent propagation of Polycomb modifications emerges during the Drosophila maternal to zygotic transition
doi.org
October 30, 2026 at 7:09 AM
RRIDs were included in this in eLife paper. Thanks for making your methods matter! #RRID #ReproducibleResearch #BetterScience
RRIDs were included in this in Nature Structural & Molecular Biology paper. Thanks for making your methods matter! #methodsmatter #ReproducibleResearch #OpenScience
Cryo-EM structure, enzymatic activity and genome targeting of canonical PRC1 - Nature Structural & Molecular Biology
Ciapponi et al. determine the cryo-electron microscopy structure of the canonical Polycomb repressive complex 1 holocomplex and show how its architecture coordinates complex assembly, H2A monoubiquitination and genomic targeting.
doi.org
October 30, 2026 at 7:08 AM
RRIDs were included in this in Nature Structural & Molecular Biology paper. Thanks for making your methods matter! #methodsmatter #ReproducibleResearch #OpenScience
Distinct functions of Nup93 paralogs in tumor growth and Polycomb-mediated repression of JAK/STAT signaling
#Drosophila
#Drosophila
Distinct functions of Nup93 paralogs in tumor growth and Polycomb-mediated repression of JAK/STAT signaling
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
October 25, 2026 at 8:23 AM
Distinct functions of Nup93 paralogs in tumor growth and Polycomb-mediated repression of JAK/STAT signaling
#Drosophila
#Drosophila
- "On how Polycomb domains are established during early embryogenesis".
Nucleation-dependent propagation of Polycomb modifications emerges during the Drosophila maternal to zygotic transition
Nucleation-dependent propagation of Polycomb modifications emerges during the Drosophila maternal to zygotic transition
Epigenomics and quantitative imaging are used to investigate the re-establishment of histone modifications associated with the Polycomb group of epigenetic regulators during the Drosophila maternal-to-zygotic...
buff.ly
October 24, 2026 at 8:03 AM
- "On how Polycomb domains are established during early embryogenesis".