curing cancer by adding a checksum nucleotide to the end of dna
July 12, 2026 at 2:39 AM
curing cancer by adding a checksum nucleotide to the end of dna
jev predicts nucleotide decay (ground truth on the right for comparison)
September 27, 2026 at 1:17 AM
jev predicts nucleotide decay (ground truth on the right for comparison)
oh, you're fascinated with genetics? name 3 nucleotide bases of DNA
October 11, 2024 at 1:12 AM
oh, you're fascinated with genetics? name 3 nucleotide bases of DNA
1 like = 1 nucleotide substitution in noncoding unannotated DNA of this fish
July 22, 2025 at 11:58 PM
1 like = 1 nucleotide substitution in noncoding unannotated DNA of this fish
Happy that our most recent paper on nucleotide excision repair mechanisms has now been published in Science Advances. This project was led by @natalia-mg.bsky.social and @callumhaste.bsky.social and focused on visualising early steps of the NER process by #cryoEM.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Visualization of stepwise derepression of TFIIH in global genome nucleotide excision repair
Cryogenic electron microscopy captures nucleotide excision repair complexes assembling on damaged DNA templates.
www.science.org
July 24, 2026 at 6:30 AM
Happy that our most recent paper on nucleotide excision repair mechanisms has now been published in Science Advances. This project was led by @natalia-mg.bsky.social and @callumhaste.bsky.social and focused on visualising early steps of the NER process by #cryoEM.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Your favourite #sequence database is also available on two other continents, together with tools such as #BLAST: www.insdc.org (International Nucleotide Sequence Database Collaboration) 🧪
International Nucleotide Sequence Database CollaborationInternational Nucleotide Sequence Database Collaboration
www.insdc.org
March 2, 2025 at 11:02 AM
Your favourite #sequence database is also available on two other continents, together with tools such as #BLAST: www.insdc.org (International Nucleotide Sequence Database Collaboration) 🧪
The beautiful, ever-expanding universe of viral proteins targeting nucleotide immune signals!
Paper by @reneechang.bsky.social in @cp-molcell.bsky.social on a nucleotide sponge www.cell.com/molecular-ce...
and preprint by @doudna-lab.bsky.social on viral nucleases www.biorxiv.org/content/10.1...
Paper by @reneechang.bsky.social in @cp-molcell.bsky.social on a nucleotide sponge www.cell.com/molecular-ce...
and preprint by @doudna-lab.bsky.social on viral nucleases www.biorxiv.org/content/10.1...
A widespread family of viral sponge proteins reveals specific inhibition of nucleotide signals in anti-phage defense
Chang et al. discover anti-CBASS 4 (Acb4), a family of viral sponges that inhibits
bacterial immunity by sequestering nucleotide immune signals. Acb4 homologs in phages
that infect hosts across all ma...
www.cell.com
August 22, 2025 at 9:02 PM
The beautiful, ever-expanding universe of viral proteins targeting nucleotide immune signals!
Paper by @reneechang.bsky.social in @cp-molcell.bsky.social on a nucleotide sponge www.cell.com/molecular-ce...
and preprint by @doudna-lab.bsky.social on viral nucleases www.biorxiv.org/content/10.1...
Paper by @reneechang.bsky.social in @cp-molcell.bsky.social on a nucleotide sponge www.cell.com/molecular-ce...
and preprint by @doudna-lab.bsky.social on viral nucleases www.biorxiv.org/content/10.1...
We wrote a review on the free nucleotide pool as a central playground in human, bacterial, and plant immunity – now out in Nature Reviews in Immunology
www.nature.com/articles/s41...
Was fun to write this piece with Dina Hochhauser!
Here is a thread to explain the premises
1/
www.nature.com/articles/s41...
Was fun to write this piece with Dina Hochhauser!
Here is a thread to explain the premises
1/
Manipulation of the nucleotide pool in human, bacterial and plant immunity - Nature Reviews Immunology
Modification of the nucleotide pool is emerging as key to innate immunity in animals, plants and bacteria. This Review explains how immune pathways conserved from bacteria to humans manipulate the nuc...
www.nature.com
July 30, 2025 at 6:05 AM
We wrote a review on the free nucleotide pool as a central playground in human, bacterial, and plant immunity – now out in Nature Reviews in Immunology
www.nature.com/articles/s41...
Was fun to write this piece with Dina Hochhauser!
Here is a thread to explain the premises
1/
www.nature.com/articles/s41...
Was fun to write this piece with Dina Hochhauser!
Here is a thread to explain the premises
1/
AlphaFold Atlas: an exhaustive database of every nucleotide variant in the human body, and its effects as predicted by Google’s models
available for free
deepmind.google/blog/alphage...
available for free
deepmind.google/blog/alphage...
AlphaGenome Atlas: Molecular predictions for 9 Billion human DNA variants
Explore AlphaGenome Atlas, a catalogue predicting the molecular effects and AVI scores for 9 billion single-nucleotide variants across the human genome.
deepmind.google
September 8, 2026 at 5:47 PM
AlphaFold Atlas: an exhaustive database of every nucleotide variant in the human body, and its effects as predicted by Google’s models
available for free
deepmind.google/blog/alphage...
available for free
deepmind.google/blog/alphage...
Read my review with @soreklab.bsky.social on the nucleotide pool as a central playground in antiviral immunity across humans, bacteria and plants! 🧍♀️🦠🌿
& how viruses overcome these nucleotide-based immune mechanisms 🗡️
www.nature.com/articles/s41...
& how viruses overcome these nucleotide-based immune mechanisms 🗡️
www.nature.com/articles/s41...
Manipulation of the nucleotide pool in human, bacterial and plant immunity - Nature Reviews Immunology
Modification of the nucleotide pool is emerging as key to innate immunity in animals, plants and bacteria. This Review explains how immune pathways conserved from bacteria to humans manipulate the nuc...
www.nature.com
July 29, 2025 at 7:12 PM
Read my review with @soreklab.bsky.social on the nucleotide pool as a central playground in antiviral immunity across humans, bacteria and plants! 🧍♀️🦠🌿
& how viruses overcome these nucleotide-based immune mechanisms 🗡️
www.nature.com/articles/s41...
& how viruses overcome these nucleotide-based immune mechanisms 🗡️
www.nature.com/articles/s41...
The PhD work of @bboumard.bsky.social officially out in print! Happy to share this issue with our downstairs colleagues in the BDD @frelab.bsky.social @robinjournot.bsky.social
www.cell.com/developmenta...
www.cell.com/developmenta...
Cell-type-specific nucleotide sharing through gap junctions impacts sensitivity to replication stress in Drosophila
Boumard et al. demonstrate gap-junction-dependent tissue-scale nucleotide sharing,
which impacts cellular sensitivity to perturbation of nucleotide homeostasis and replication
stress. Drosophila wing ...
www.cell.com
October 7, 2025 at 6:43 AM
The PhD work of @bboumard.bsky.social officially out in print! Happy to share this issue with our downstairs colleagues in the BDD @frelab.bsky.social @robinjournot.bsky.social
www.cell.com/developmenta...
www.cell.com/developmenta...
So the fact that it might be named after the one nucleotide base which distinguishes the primordial soup from the Now seems, all things considered, very appropriate.
September 28, 2026 at 4:26 AM
So the fact that it might be named after the one nucleotide base which distinguishes the primordial soup from the Now seems, all things considered, very appropriate.
Nucleotide
August 6, 2025 at 5:41 AM
Nucleotide
@jevbot.bsky.social which nucleotide is your favorite, and why?
September 25, 2026 at 9:11 PM
@jevbot.bsky.social which nucleotide is your favorite, and why?
Our interdisciplinary collaboration with Stephanie Kath-Schorr group characterizes Thio-pRib-AMP, an enhanced derivative of a natural plant nucleotide immune second messenger. Thio-pRib-AMP leaf spray increases plant disease resistance.
Check it out: doi.org/10.21203/rs....
Check it out: doi.org/10.21203/rs....
September 28, 2026 at 7:16 AM
Our interdisciplinary collaboration with Stephanie Kath-Schorr group characterizes Thio-pRib-AMP, an enhanced derivative of a natural plant nucleotide immune second messenger. Thio-pRib-AMP leaf spray increases plant disease resistance.
Check it out: doi.org/10.21203/rs....
Check it out: doi.org/10.21203/rs....
Damnit, that’s not how you calculate nucleotide diversity.
Without naming your job, tell me something you say over and over again at work.
"Where are your citations?"
"Where are your citations?"
Without naming your job, tell me something you say over and over again at work.
"No, you can't leave that here."
"No, you can't leave that here."
February 7, 2026 at 11:44 PM
Damnit, that’s not how you calculate nucleotide diversity.
The average nucleotide identity (ANI) underpins how we map microbial diversity, compare species, and connect genomes to ecology.
I wrote a short piece reflecting on the discovery and significance of this metric (and really enjoyed digging into the context and story behind it!) #microsky 🧬
I wrote a short piece reflecting on the discovery and significance of this metric (and really enjoyed digging into the context and story behind it!) #microsky 🧬
Average nucleotide identity — the backbone of modern ecological genomics - Nature Reviews Genetics
In this Journal Club, Luis Orellana recalls a 2005 publication by Konstantinidis and Tiedje that introduced average nucleotide identity as a sequence-based metric to determine the relatedness between ...
www.nature.com
October 30, 2025 at 9:11 PM
The average nucleotide identity (ANI) underpins how we map microbial diversity, compare species, and connect genomes to ecology.
I wrote a short piece reflecting on the discovery and significance of this metric (and really enjoyed digging into the context and story behind it!) #microsky 🧬
I wrote a short piece reflecting on the discovery and significance of this metric (and really enjoyed digging into the context and story behind it!) #microsky 🧬
Two major breakthroughs for the nucleotide immune signaling field in pre-print by @romihadary.bsky.social @soreklab.bsky.social www.biorxiv.org/content/10.1...
(1) Beautiful bioinformatic analyses reveal known viral nucleotide sponges are members of enormous protein families ubiquitous in phages
(1) Beautiful bioinformatic analyses reveal known viral nucleotide sponges are members of enormous protein families ubiquitous in phages
August 25, 2025 at 9:06 PM
Two major breakthroughs for the nucleotide immune signaling field in pre-print by @romihadary.bsky.social @soreklab.bsky.social www.biorxiv.org/content/10.1...
(1) Beautiful bioinformatic analyses reveal known viral nucleotide sponges are members of enormous protein families ubiquitous in phages
(1) Beautiful bioinformatic analyses reveal known viral nucleotide sponges are members of enormous protein families ubiquitous in phages
All those "biological truth" people can come and tell me how a gene works from nucleotide to regulation and then maybe I'll take them seriously.
January 20, 2025 at 7:10 AM
All those "biological truth" people can come and tell me how a gene works from nucleotide to regulation and then maybe I'll take them seriously.
Even better, this offers new hope to people suffering from other nucleotide repeat disorders — not just Huntington's disease.
In reporting this piece on the new trial for a Huntington's treatment, I was struck by one thing in particular:
The joy.
One of my sources wept for joy. He has spent his entire career studying this disease, he said it was the happiest day. www.sciencenews.org/article/hunt...
The joy.
One of my sources wept for joy. He has spent his entire career studying this disease, he said it was the happiest day. www.sciencenews.org/article/hunt...
Huntington's progression slowed by experimental gene therapy
An experimental gene therapy slowed Huntington’s by up to 75 percent in a small clinical trial. While not a cure, it may give patients longer lives.
www.sciencenews.org
September 28, 2025 at 7:37 PM
Even better, this offers new hope to people suffering from other nucleotide repeat disorders — not just Huntington's disease.
How can an octopus edit their RNA? An introduction to A-to-I RNA editing in coleoid cephalopods (octopus, squid, cuttlefish) 🧪🐙🐡🧵
June 19, 2026 at 5:01 PM
How can an octopus edit their RNA? An introduction to A-to-I RNA editing in coleoid cephalopods (octopus, squid, cuttlefish) 🧪🐙🐡🧵
new preprint from our group & Antoine Hocher: www.biorxiv.org/content/10.1...
A fantastic collaboration with Antoine, with Jovana Kaljevic' initiated the collaboration and drives the project.
A fantastic collaboration with Antoine, with Jovana Kaljevic' initiated the collaboration and drives the project.
Versatile NTP recognition and domain fusions expand the functional repertoire of the ParB-CTPase fold beyond chromosome segregation
Nucleotide triphosphate (NTP)-dependent molecular switches regulate essential cellular processes by cycling between active and inactive states through nucleotide binding and hydrolysis. These mechanis...
www.biorxiv.org
October 11, 2025 at 11:36 AM
new preprint from our group & Antoine Hocher: www.biorxiv.org/content/10.1...
A fantastic collaboration with Antoine, with Jovana Kaljevic' initiated the collaboration and drives the project.
A fantastic collaboration with Antoine, with Jovana Kaljevic' initiated the collaboration and drives the project.
Wait, you mean you guys DON'T all think about how magnesium ion concentration affects DNA melting temperatures and nucleotide-dependent enzyme activity every day???
September 26, 2026 at 12:04 PM
Wait, you mean you guys DON'T all think about how magnesium ion concentration affects DNA melting temperatures and nucleotide-dependent enzyme activity every day???
Study: Mechanism of SARS-CoV-2 resistance to nucleotide analog-based antivirals.
Published: 13 January 2026
www.nature.com/articles/s41...
Published: 13 January 2026
www.nature.com/articles/s41...
Mechanism of SARS-CoV-2 resistance to nucleotide analog-based antivirals - Nature Communications
The coronavirus proofreading exoribonuclease (ExoN) is a major cause of viral resistance to nucleotide analog (NA) antivirals. Here, the authors reveal how different NAs are recognized by ExoN, sheddi...
www.nature.com
May 11, 2026 at 4:59 AM
Study: Mechanism of SARS-CoV-2 resistance to nucleotide analog-based antivirals.
Published: 13 January 2026
www.nature.com/articles/s41...
Published: 13 January 2026
www.nature.com/articles/s41...
"Nucleotidyltransferases and nucleotide-based second messengers"
Carina Baer de Oliveira Mann (@oliveiramann.bsky.social) gave an insightful talk on this topic at #Biochemistry2026.
febs.onlinelibrary.wiley.com/doi/full/10....
#Biochemistry #SecondMessenger #CyclicNucleotide
CC: @gdch.de
Carina Baer de Oliveira Mann (@oliveiramann.bsky.social) gave an insightful talk on this topic at #Biochemistry2026.
febs.onlinelibrary.wiley.com/doi/full/10....
#Biochemistry #SecondMessenger #CyclicNucleotide
CC: @gdch.de
March 18, 2026 at 9:31 AM
"Nucleotidyltransferases and nucleotide-based second messengers"
Carina Baer de Oliveira Mann (@oliveiramann.bsky.social) gave an insightful talk on this topic at #Biochemistry2026.
febs.onlinelibrary.wiley.com/doi/full/10....
#Biochemistry #SecondMessenger #CyclicNucleotide
CC: @gdch.de
Carina Baer de Oliveira Mann (@oliveiramann.bsky.social) gave an insightful talk on this topic at #Biochemistry2026.
febs.onlinelibrary.wiley.com/doi/full/10....
#Biochemistry #SecondMessenger #CyclicNucleotide
CC: @gdch.de