Happy #fluorescencefriday Our APOE4 mice showing blood vessels (magenta), amyloid (cyan) and microglia (yellow) by @shahrzadbahrampour.bsky.social and @arashsalah.bsky.social with the @mind-western.bsky.social we want to map the relationship between microglia and plaques with blood vessels
October 30, 2026 at 3:40 PM
Happy #fluorescencefriday Our APOE4 mice showing blood vessels (magenta), amyloid (cyan) and microglia (yellow) by @shahrzadbahrampour.bsky.social and @arashsalah.bsky.social with the @mind-western.bsky.social we want to map the relationship between microglia and plaques with blood vessels
¿Conoces la historia de Pío del Río Hortega?
Dos veces propuesto para el Premio Nobel y descubridor de la microglía (un tipo de células del cerebro).
Exiliado en Argentina por republicano y homosexual y muy desconocido para la mayoría de la población.
es.wikipedia.org/wiki/P%C3%AD...
Dos veces propuesto para el Premio Nobel y descubridor de la microglía (un tipo de células del cerebro).
Exiliado en Argentina por republicano y homosexual y muy desconocido para la mayoría de la población.
es.wikipedia.org/wiki/P%C3%AD...
Pío del Río Hortega - Wikipedia, la enciclopedia libre
es.wikipedia.org
November 1, 2026 at 6:49 AM
¿Conoces la historia de Pío del Río Hortega?
Dos veces propuesto para el Premio Nobel y descubridor de la microglía (un tipo de células del cerebro).
Exiliado en Argentina por republicano y homosexual y muy desconocido para la mayoría de la población.
es.wikipedia.org/wiki/P%C3%AD...
Dos veces propuesto para el Premio Nobel y descubridor de la microglía (un tipo de células del cerebro).
Exiliado en Argentina por republicano y homosexual y muy desconocido para la mayoría de la población.
es.wikipedia.org/wiki/P%C3%AD...
Wishing a happy 43rd birthday to Lithuanian neuroscientist Urtė Neniškytė. Her research has been central to discovering the role microglia play in the destruction of neurons during inflammation events, with promising future applications!
#WomenInSTEM #NeuroSky #BioSky 🧠
#WomenInSTEM #NeuroSky #BioSky 🧠
November 2, 2026 at 4:01 PM
Wishing a happy 43rd birthday to Lithuanian neuroscientist Urtė Neniškytė. Her research has been central to discovering the role microglia play in the destruction of neurons during inflammation events, with promising future applications!
#WomenInSTEM #NeuroSky #BioSky 🧠
#WomenInSTEM #NeuroSky #BioSky 🧠
Celebrating the 43rd birthday of Lithuanian neuroscientist Urtė Neniškytė. Here is an appreciation of the remarkable work that she has brought us this last decade on microglia and neuron death!
#WomenInSTEM #NeuroSky #Brain #Biology #HistSci
#WomenInSTEM #NeuroSky #Brain #Biology #HistSci
November 2, 2026 at 4:47 PM
Celebrating the 43rd birthday of Lithuanian neuroscientist Urtė Neniškytė. Here is an appreciation of the remarkable work that she has brought us this last decade on microglia and neuron death!
#WomenInSTEM #NeuroSky #Brain #Biology #HistSci
#WomenInSTEM #NeuroSky #Brain #Biology #HistSci
'(...) variant analysis of AD & identified 127 independent loci, of which 48 were new. We applied multiple methodologies to prioritize genes in each locus, many of which were linked to pathways previously implicated in AD, most notably immune processes, microglia function & amyloid catabolism'
Alzheimer’s disease genetics converges on microglial and neuronal dysregulation - Nature
A multi-ancestry study of Alzheimer’s disease identifies new risk loci and potential drug targets, implicates microglia and neurons, and reveals a larger common-variant contribution than previously es...
www.nature.com
November 2, 2026 at 5:49 PM
'(...) variant analysis of AD & identified 127 independent loci, of which 48 were new. We applied multiple methodologies to prioritize genes in each locus, many of which were linked to pathways previously implicated in AD, most notably immune processes, microglia function & amyloid catabolism'
A review indicates that lipid metabolism dysfunction in microglia accelerates brain aging. The article discusses the role of an aging gut microbiome in this process.
#LipidMetabolism #Microglia #Aging
#LipidMetabolism #Microglia #Aging
Newsletter sent weekly to thousands of subscribers
Source: Fight Aging!
realfeedapp.com
November 1, 2026 at 2:00 PM
A review indicates that lipid metabolism dysfunction in microglia accelerates brain aging. The article discusses the role of an aging gut microbiome in this process.
#LipidMetabolism #Microglia #Aging
#LipidMetabolism #Microglia #Aging
Microglia serve different roles in the 🧠, incl. stimulating neurogenesis, affecting immune responses. Here microglia from surface and cave🐟 morphotypes were compared to study how microglia shaped brain circuitry adaptations in cavefish. @jexpbiol.bsky.social journals.biologists.com/jeb/article/...
Evolved differences in microglial cell biology between surface and cave populations of Astyanax mexicanus
Microglia govern multiple aspects of brain architecture and function by eliminating dying neurons and glia, stimulating neurogenesis, refining neural connections, and orchestrating immune responses. T...
journals.biologists.com
October 29, 2026 at 2:05 PM
Microglia serve different roles in the 🧠, incl. stimulating neurogenesis, affecting immune responses. Here microglia from surface and cave🐟 morphotypes were compared to study how microglia shaped brain circuitry adaptations in cavefish. @jexpbiol.bsky.social journals.biologists.com/jeb/article/...
❗❗❗News︱Nature Communications
👏👏👏Prof. Xuejun Song’s team reports a novel mechanism for the loss of consciousness induced by anesthesia: microglia-dependent regulation of KCND2 in neurons of the hypothalamic paraventricular nucleus via PDGFB.
👇MORE
www.nature.com/articles/s41...
👏👏👏Prof. Xuejun Song’s team reports a novel mechanism for the loss of consciousness induced by anesthesia: microglia-dependent regulation of KCND2 in neurons of the hypothalamic paraventricular nucleus via PDGFB.
👇MORE
www.nature.com/articles/s41...
Microglia-dependent PDGFB regulation of neuronal KCND2 in the hypothalamic paraventricular nucleus determines propofol anesthesia induction - Nature Communications
Propofol anesthesia sensitivity largely depends on neuronal GABAA receptors. Here, the authors show that microglia-dependent PDGFB signaling controls propofol anesthesia induction by modulating KCND2 ...
www.nature.com
November 3, 2026 at 5:36 AM
❗❗❗News︱Nature Communications
👏👏👏Prof. Xuejun Song’s team reports a novel mechanism for the loss of consciousness induced by anesthesia: microglia-dependent regulation of KCND2 in neurons of the hypothalamic paraventricular nucleus via PDGFB.
👇MORE
www.nature.com/articles/s41...
👏👏👏Prof. Xuejun Song’s team reports a novel mechanism for the loss of consciousness induced by anesthesia: microglia-dependent regulation of KCND2 in neurons of the hypothalamic paraventricular nucleus via PDGFB.
👇MORE
www.nature.com/articles/s41...
Happy #FluorescenceFriday! 🔬✨ Fascinating work investigating the relationship between microglia, amyloid plaques, and blood vessels in APOE4 mice!
Happy #fluorescencefriday Our APOE4 mice showing blood vessels (magenta), amyloid (cyan) and microglia (yellow) by @shahrzadbahrampour.bsky.social and @arashsalah.bsky.social with the @mind-western.bsky.social we want to map the relationship between microglia and plaques with blood vessels
October 30, 2026 at 5:10 PM
Happy #FluorescenceFriday! 🔬✨ Fascinating work investigating the relationship between microglia, amyloid plaques, and blood vessels in APOE4 mice!
Microglia TREM1 promotes lipid droplet accumulation and microglia M1 polarization via NF-kappaB pathway to induce neuroinflammation-mediated central sensitization in chronic migraine
▶️ Read Full Paper
📚 Source: Neuroscience letters
👤 Creator: Jianchang Luo et al.
📅 Date: 2026-10-30
#MigrainePapertag/MigrainePaper" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#MigrainePaper
▶️ Read Full Paper
📚 Source: Neuroscience letters
👤 Creator: Jianchang Luo et al.
📅 Date: 2026-10-30
#MigrainePapertag/MigrainePaper" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#MigrainePaper
Microglia TREM1 promotes lipid droplet accumulation and microglia M1 polarization via NF-kappaB pathway to induce neuroinflammation-mediated central sensitization in chronic migraine
CONCLUSION: TREM1 promotes microglial LDs accumulation and M1 polarization via the NF-κB pathway to induce neuroinflammation-mediated central sensitization in CM.
pubmed.ncbi.nlm.nih.gov
October 31, 2026 at 3:41 AM
Microglia TREM1 promotes lipid droplet accumulation and microglia M1 polarization via NF-kappaB pathway to induce neuroinflammation-mediated central sensitization in chronic migraine
▶️ Read Full Paper
📚 Source: Neuroscience letters
👤 Creator: Jianchang Luo et al.
📅 Date: 2026-10-30
#MigrainePapertag/MigrainePaper" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#MigrainePaper
▶️ Read Full Paper
📚 Source: Neuroscience letters
👤 Creator: Jianchang Luo et al.
📅 Date: 2026-10-30
#MigrainePapertag/MigrainePaper" class="hover:underline text-blue-600 dark:text-sky-400 no-card-link">#MigrainePaper
1/n
Out today in @Nature: our Alzheimer’s disease GWAS of ~2.8M people (~184k cases). We find 48 new loci, ~3x higher SNP-heritability, enrichment in genes up-regulated in microglia and down-regulated in neurons, and we release public summary statistics. www.nature.com/articles/s41...
Out today in @Nature: our Alzheimer’s disease GWAS of ~2.8M people (~184k cases). We find 48 new loci, ~3x higher SNP-heritability, enrichment in genes up-regulated in microglia and down-regulated in neurons, and we release public summary statistics. www.nature.com/articles/s41...
Alzheimer’s disease genetics converges on microglial and neuronal dysregulation - Nature
A multi-ancestry study of Alzheimer’s disease identifies new risk loci and potential drug targets, implicates microglia and neurons, and reveals a larger common-variant contribution than previously es...
www.nature.com
October 28, 2026 at 5:08 PM
1/n
Out today in @Nature: our Alzheimer’s disease GWAS of ~2.8M people (~184k cases). We find 48 new loci, ~3x higher SNP-heritability, enrichment in genes up-regulated in microglia and down-regulated in neurons, and we release public summary statistics. www.nature.com/articles/s41...
Out today in @Nature: our Alzheimer’s disease GWAS of ~2.8M people (~184k cases). We find 48 new loci, ~3x higher SNP-heritability, enrichment in genes up-regulated in microglia and down-regulated in neurons, and we release public summary statistics. www.nature.com/articles/s41...
🎨 We merge science and art in our #PicOfTheMonth at @geneticsub.bsky.social
🔬This image shows a zebrafish larvae injured brain. Neurons are labelled in cyan and macrophages/microglia in magenta
📸 by Carmen de Sena
🔬This image shows a zebrafish larvae injured brain. Neurons are labelled in cyan and macrophages/microglia in magenta
📸 by Carmen de Sena
October 30, 2026 at 12:24 PM
🎨 We merge science and art in our #PicOfTheMonth at @geneticsub.bsky.social
🔬This image shows a zebrafish larvae injured brain. Neurons are labelled in cyan and macrophages/microglia in magenta
📸 by Carmen de Sena
🔬This image shows a zebrafish larvae injured brain. Neurons are labelled in cyan and macrophages/microglia in magenta
📸 by Carmen de Sena
RRIDs were included in this in Brain Research Bulletin paper. RRIDs improve reproducibility in scientific research. #RRID #methodsmatter #OpenScience
Apelin-13 exerts neuroprotection through activation of APJ/mTORC2 axis in microglia after Intracerebral Hemorrhage in mice
Read the full paper: Apelin-13 exerts neuroprotection through activation of APJ/mTORC2 axis in microglia after Intracerebral Hemorrhage in mice
doi.org
October 31, 2026 at 7:00 AM
RRIDs were included in this in Brain Research Bulletin paper. RRIDs improve reproducibility in scientific research. #RRID #methodsmatter #OpenScience
Dysfunction of lipid metabolism and lysosomal capacity: at the core of microglial aging?
www.frontiersin.org/journals/agi...
www.frontiersin.org/journals/agi...
Frontiers | Dysfunction of lipid metabolism and lysosomal capacity: at the core of microglial aging?
As primary immune cells of the central nervous system (CNS), microglia maintain immune surveillance, inflammation regulation, cell interactions and debris cl...
www.frontiersin.org
November 2, 2026 at 1:32 PM
Dysfunction of lipid metabolism and lysosomal capacity: at the core of microglial aging?
www.frontiersin.org/journals/agi...
www.frontiersin.org/journals/agi...
Vertical lollipop timeline listing years down the side, with bar length showing annual publications on microglial senescence in neurodegeneration research.
#MicroglialSenescence #Neuroinflammation #AlzheimerDisease #DiseaseAssociatedMicroglia #Bibliometrics #NeurodegenerationResearch #Gliobiology
#MicroglialSenescence #Neuroinflammation #AlzheimerDisease #DiseaseAssociatedMicroglia #Bibliometrics #NeurodegenerationResearch #Gliobiology
![Figure: Microglial senescence papers have climbed steeply since 2000
I am sharing a bibliometric view of how the literature linking microglia, ageing or senescence, and neurodegeneration has developed. The chart is a vertical year-ladder lollipop timeline: each year from 2000 to 2025 is a rung, stem length is proportional to the annual PubMed record count, and the peak year is accented.
Data come from PubMed (NCBI E-utilities) using microglia[tiab] AND (senescence[tiab] OR senescent[tiab] OR aging[tiab] OR ageing[tiab]) AND (neurodegeneration[tiab] OR Alzheimer[tiab]), yielding 1,658 records in total, and these counts reflect indexing and query wording, not research effort or quality.
The series begins at 3 records in 2000 and reaches 197 in 2025, which is also the peak year. That corresponds to a 65.7-fold increase, with a mean annual growth of 18.2%. The rise is steady rather than driven by a single outlier year, which is why the ladder form is useful: the lengthening stems make the cumulative shift readable without smoothing.
The increase is temporally associated with a broader conceptual shift in the field. Microglia are increasingly described in terms of replicative exhaustion, CDKN2A-linked cell cycle arrest, the senescence-associated secretory phenotype, impaired phagocytic clearance and altered lipid handling, alongside disease-associated microglial states. Whether these descriptions converge on a single senescent phenotype or reflect partially overlapping activation programmes is not something this record count can resolve. The query also captures papers that use ageing as a covariate rather than as a mechanistic variable, so precision for true senescence studies is likely imperfect.
Open questions for colleagues: how should keyword-based retrieval be reconciled with marker-based definitions of senescent microglia, and would restricting to title or abstract mentions of specific effectors change the trajectory?](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:cmhgqrx4smzujdep5355m3rb/bafkreigvtghn6mco6k437ax53tbtka5cuuh4ku5paq3qv7odx6zjbeqp64)
![Figure: Microglial senescence papers have climbed steeply since 2000
I am sharing a bibliometric view of how the literature linking microglia, ageing or senescence, and neurodegeneration has developed. The chart is a vertical year-ladder lollipop timeline: each year from 2000 to 2025 is a rung, stem length is proportional to the annual PubMed record count, and the peak year is accented.
Data come from PubMed (NCBI E-utilities) using microglia[tiab] AND (senescence[tiab] OR senescent[tiab] OR aging[tiab] OR ageing[tiab]) AND (neurodegeneration[tiab] OR Alzheimer[tiab]), yielding 1,658 records in total, and these counts reflect indexing and query wording, not research effort or quality.
The series begins at 3 records in 2000 and reaches 197 in 2025, which is also the peak year. That corresponds to a 65.7-fold increase, with a mean annual growth of 18.2%. The rise is steady rather than driven by a single outlier year, which is why the ladder form is useful: the lengthening stems make the cumulative shift readable without smoothing.
The increase is temporally associated with a broader conceptual shift in the field. Microglia are increasingly described in terms of replicative exhaustion, CDKN2A-linked cell cycle arrest, the senescence-associated secretory phenotype, impaired phagocytic clearance and altered lipid handling, alongside disease-associated microglial states. Whether these descriptions converge on a single senescent phenotype or reflect partially overlapping activation programmes is not something this record count can resolve. The query also captures papers that use ageing as a covariate rather than as a mechanistic variable, so precision for true senescence studies is likely imperfect.
Open questions for colleagues: how should keyword-based retrieval be reconciled with marker-based definitions of senescent microglia, and would restricting to title or abstract mentions of specific effectors change the trajectory?](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:cmhgqrx4smzujdep5355m3rb/bafkreidcirevdpfmsonmlna2t7k2smtmcrym7pr7xsz46xrlfdmicje67q)
November 2, 2026 at 5:35 PM
Vertical lollipop timeline listing years down the side, with bar length showing annual publications on microglial senescence in neurodegeneration research.
#MicroglialSenescence #Neuroinflammation #AlzheimerDisease #DiseaseAssociatedMicroglia #Bibliometrics #NeurodegenerationResearch #Gliobiology
#MicroglialSenescence #Neuroinflammation #AlzheimerDisease #DiseaseAssociatedMicroglia #Bibliometrics #NeurodegenerationResearch #Gliobiology
#HappyHalloween from the CISR on #FluorescenceFriday! Another fun activity working in a microscopy core is imaging random slides left behind. Looks like #microglia! Or are they spiders? Confocal, Z-stack MIP, 63x. 👻🎃🕷️🕸️☠️
October 30, 2026 at 4:50 PM
#HappyHalloween from the CISR on #FluorescenceFriday! Another fun activity working in a microscopy core is imaging random slides left behind. Looks like #microglia! Or are they spiders? Confocal, Z-stack MIP, 63x. 👻🎃🕷️🕸️☠️
How do #NeuralStemCells shape #microglial behavior?
This study reveals that CCN1 regulates microglial distribution and activation through region-specific CSF1 and IL2 signaling during #BrainDevelopment. #SpatialTranscriptomics
#GenesAndDiseases: doi.org/10.1016/j.ge...
This study reveals that CCN1 regulates microglial distribution and activation through region-specific CSF1 and IL2 signaling during #BrainDevelopment. #SpatialTranscriptomics
#GenesAndDiseases: doi.org/10.1016/j.ge...
November 2, 2026 at 6:29 AM
How do #NeuralStemCells shape #microglial behavior?
This study reveals that CCN1 regulates microglial distribution and activation through region-specific CSF1 and IL2 signaling during #BrainDevelopment. #SpatialTranscriptomics
#GenesAndDiseases: doi.org/10.1016/j.ge...
This study reveals that CCN1 regulates microglial distribution and activation through region-specific CSF1 and IL2 signaling during #BrainDevelopment. #SpatialTranscriptomics
#GenesAndDiseases: doi.org/10.1016/j.ge...
Mxd1-mediated transcriptional repression of FTO induces NLRP3-dependent pyroptosis in retinal microglia
Experimental cell research · Zhang et al.
doi.org/10.1016/j.yexcr.2026.115194
#RNAsky #RNAmods
Experimental cell research · Zhang et al.
doi.org/10.1016/j.yexcr.2026.115194
#RNAsky #RNAmods
Mxd1-mediated transcriptional repression of FTO induces NLRP3-dependent pyroptosis in retinal microglia
Experimental cell research · Zhang Y, Yang Y, Xu X.
doi.org
October 30, 2026 at 12:32 AM
Mxd1-mediated transcriptional repression of FTO induces NLRP3-dependent pyroptosis in retinal microglia
Experimental cell research · Zhang et al.
doi.org/10.1016/j.yexcr.2026.115194
#RNAsky #RNAmods
Experimental cell research · Zhang et al.
doi.org/10.1016/j.yexcr.2026.115194
#RNAsky #RNAmods
Excited to share our new manuscript showing how microglia adapt during chronic progressive demyelination
Check out the full story here:
www.nature.com/articles/s41...
Check out the full story here:
www.nature.com/articles/s41...
Chronic progressive demyelination induces a microglial state with lysosomal dysfunction - Nature Neuroscience
Acute myelin injury responses are well defined, but microglia adaptations to chronic damage remain unclear. Mouse models reveal a chronic demyelination-associated microglial state marked by inflammati...
www.nature.com
October 27, 2026 at 4:23 PM
Excited to share our new manuscript showing how microglia adapt during chronic progressive demyelination
Check out the full story here:
www.nature.com/articles/s41...
Check out the full story here:
www.nature.com/articles/s41...
CD40 ligand and IFN-γ induce proinflammatory activity and microglia-mediated neurodegeneration in human stem cell models https://www.biorxiv.org/content/10.64898/2026.10.28.749776v1
November 3, 2026 at 2:18 PM
CD40 ligand and IFN-γ induce proinflammatory activity and microglia-mediated neurodegeneration in human stem cell models https://www.biorxiv.org/content/10.64898/2026.10.28.749776v1
Juliette Salvi, et al.: Postprandial hypertriglyceridemia activates microglia to promote satiety via an ASC dependent signaling https://hal.science/hal-05848538v1 [scco.neur]
November 3, 2026 at 3:01 AM
Juliette Salvi, et al.: Postprandial hypertriglyceridemia activates microglia to promote satiety via an ASC dependent signaling https://hal.science/hal-05848538v1 [scco.neur]
CD40 ligand and IFN-γ induce proinflammatory activity and microglia-mediated neurodegeneration in human stem cell models https://www.biorxiv.org/content/10.64898/2026.10.28.749776v1
November 3, 2026 at 2:18 PM
CD40 ligand and IFN-γ induce proinflammatory activity and microglia-mediated neurodegeneration in human stem cell models https://www.biorxiv.org/content/10.64898/2026.10.28.749776v1
🧬 Funded PhD: Editing the Alzheimer's Epigenome at the University of Exeter
Use CRISPR epigenome editing and iPSC-derived microglia to find which Alzheimer's-linked epigenetic changes actually drive disease.
⏰ Closes 5 Jan 2027
www.dementiaresearcher.nihr.ac.uk/job/phd-edit...
Use CRISPR epigenome editing and iPSC-derived microglia to find which Alzheimer's-linked epigenetic changes actually drive disease.
⏰ Closes 5 Jan 2027
www.dementiaresearcher.nihr.ac.uk/job/phd-edit...
PhD: Editing the Alzheimer’s Epigenome - Dementia Researcher
Funded MRC PhD at the University of Exeter using CRISPR epigenome editing and iPSC microglia to test which Alzheimer's epigenetic changes matter.
www.dementiaresearcher.nihr.ac.uk
October 30, 2026 at 4:54 PM
🧬 Funded PhD: Editing the Alzheimer's Epigenome at the University of Exeter
Use CRISPR epigenome editing and iPSC-derived microglia to find which Alzheimer's-linked epigenetic changes actually drive disease.
⏰ Closes 5 Jan 2027
www.dementiaresearcher.nihr.ac.uk/job/phd-edit...
Use CRISPR epigenome editing and iPSC-derived microglia to find which Alzheimer's-linked epigenetic changes actually drive disease.
⏰ Closes 5 Jan 2027
www.dementiaresearcher.nihr.ac.uk/job/phd-edit...
Alzheimer’s disease genetics converges on microglial and neuronal dysregulation www.nature.com/articles/s41...
Alzheimer’s disease genetics converges on microglial and neuronal dysregulation - Nature
A multi-ancestry study of Alzheimer’s disease identifies new risk loci and potential drug targets, implicates microglia and neurons, and reveals a larger common-variant contribution than previously es...
www.nature.com
October 28, 2026 at 5:19 PM
Alzheimer’s disease genetics converges on microglial and neuronal dysregulation www.nature.com/articles/s41...
→ What they did
Researchers investigated how lipid metabolism dysfunction affects microglia aging and reviewed data on how an aging gut microbiome may contribute to this process.
Researchers investigated how lipid metabolism dysfunction affects microglia aging and reviewed data on how an aging gut microbiome may contribute to this process.
November 1, 2026 at 2:00 PM
→ What they did
Researchers investigated how lipid metabolism dysfunction affects microglia aging and reviewed data on how an aging gut microbiome may contribute to this process.
Researchers investigated how lipid metabolism dysfunction affects microglia aging and reviewed data on how an aging gut microbiome may contribute to this process.