In systemic lupus erythematosus, aberrant splicing in neutrophils generates novel peptides that are presented on MHC I, driving CD4+ and CD8+ T cell activation, clonal expansion and IgG autoantibody responses, establishing neoantigen-driven autoimmune immunity.

Most cancer deaths are not caused by the original tumor, but by metastases, which form when cancer cells leave the original tumor and spread to other organs.

A recent report by Deygas et al. shows how neutrophils navigate narrow skin capillaries without slowing down. They squeeze through tiny channels while maintaining velocity, a feat that neutrophils, but not other immune cells, seem to possess. This spotlight highlights these findings and discusses why neutrophils patrol these narrow spots.

Dietary state during a narrow temporal window can durably reprogram disease trajectory.

Read the full paper: Tumor-associated neutrophils and macrophages differentially affect T cell biology in the head and neck cancer tumor microenvironment

Dengue virus (DV) infection triggers profound alterations in host immune responses, yet the transcriptomic reprogramming of innate immune cells during disease progression remains incompletely understood. Here, we demonstrated that Dengue virus serotype 2 (DV-2) infection transcriptionally reprograms host neutrophils, establishing an immunosuppressive microenvironment that facilitates pathogenesis. Through scRNA transcriptomic profiling of bone marrow and spleen cells from the DV-2-infected AG129 mouse model, we delineated a distinct neutrophil signature that shows dynamic shifts in immature and activated populations over the course of dengue infection. We also characterized a specific Ly6Glow subpopulation, notably Fibrinogen-like protein 2 (FGL2)-expressing subsets, that appeared with disease progression. Serum FGL2 levels were significantly elevated in both DV-2-infected mice and human dengue-positive patients. Furthermore, treatment of splenocytes with FGL2 or FGL2-enriched neutrophil secretomes suppressed T cell functional activity and promoted an immunosuppressive phenotype. Together, these findings reveal how DV-2-driven neutrophil reprogramming shapes an immunosuppressive network, highlighting the importance of studying FGL2-expressing neutrophil subsets to understand dengue immunopathogenesis.

Neutrophils concentrate vitamin C at 80 times plasma levels, with saturation achieved at approximately 200 mg daily in healthy individuals.

In systemic lupus erythematosus, aberrant splicing in neutrophils generates novel peptides that are presented on MHC I, driving CD4+ and CD8+ T cell activation, clonal expansion and IgG autoantibody r...