#TCellExhaustion
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mjnabuurs.bsky.social
We’re loving being back on the mic!

@theresisters.bsky.social have had convos with guests of all stripes, and this one with Anthony Leonardi does not disappoint!

What a fascinating - and very kind - human he seems to be.

#TCellExhaustion
#MakeYourNoise
#ArtsAndScience
#GoodHumaning
January 17, 2026 at 3:29 AM
castltrastondrs.medsky.network
#MedSky🧪 #IDSky #Immunosky #publichealth Very interesting study Persistent antigen stimulation, as in cancer and chronic
infections, results in #Tcellexhaustion (TEX) a state of
impaired effector functions.
December 14, 2024 at 7:38 PM
castltrastondrs.medsky.network
#Medsky🧪 #IDsky #immunosky #Publichealth
#Tcellexhaustion (a terminal state of immune dysfunction characterized by impaired proliferation & effector functions, diminished cytokine secretion & sustained expression of inhibitory receptors) .
November 15, 2025 at 3:06 PM
willemg.bsky.social
New research links #MECFS to T cell exhaustion—immune cells worn out from chronic activation. This isn’t “just fatigue,” it’s a biological crisis. We need urgent investment in ME/CFS research and real answers for millions suffering. #pwME #TcellExhaustion #ScienceMatters
May 26, 2025 at 8:53 PM
willemg.bsky.social
Honored to share our latest paper on T-Cell Exhaustion's role in Post-Acute Infection Syndromes, now features YouTube!
Watch here: www.youtube.com/watch?v=WSNV...
#Immunology #TCellExhaustion #LongCOVID #ImmuneDysfunction #MedicalResearch #HealthcareInnovation #Qeios
LinkedIn
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lnkd.in
July 12, 2025 at 7:31 AM
stacespace.bsky.social
I read the med journal on T-Cell exhaustion. Then, these two trailblazers who research and treat make the time to produce a podcast. Thank you. #ChronicIllness #Immunology #Virology #Microbiology #Neuroscience #TCellExhaustion #Autoimmune
January 5, 2025 at 7:57 PM
christinamt.bsky.social
Excited to share my first post & see the second part of my PhD work published! Our study on mTNBC highlights that baseline clonal expansion of dysfunctional CD8 cells is linked to better response to chemoimmunotherapy.
More here: www.sciencedirect.com/science/arti...

#CD8 #TCellExhaustion #TNBC
Continuous replenishment of the dysfunctional CD8 T cell axis is associated with response to chemoimmunotherapy in advanced breast cancer
Chemotherapy combined with immune checkpoint blockade has shown clinical activity in breast cancer. Response, however, occurs in only a low proportion…
www.sciencedirect.com
March 10, 2025 at 5:54 PM
castltrastondrs.medsky.network
#COVID are characterized by #Tcellexhaustion, which impairs immune surveillance & ⏫️ susceptibility to infections & adverse events such as myocardial infarctions, septic shock & ARDS

www.frontiersin.org/journals/imm...

www.frontiersin.org/journals/imm...

www.sciencedirect.com/science/arti...
Frontiers | Immunodiagnosis — the promise of personalized immunotherapy
Immunotherapy showed remarkable efficacy in several cancer types. However, the majority of patients do not benefit from immunotherapy. Evaluating tumor heter...
www.frontiersin.org
December 7, 2025 at 8:01 AM
castltrastondrs.medsky.network
#Medsky🧪 #oncosky #Immunosky #publichealth these studies demonstrate that #Tcell mitochondrial health is tightly linked to immune fitness and that active aldehydes derived from metabolic dysfunction in the tumor microenvironment damage mitochondria and drive #Tcellexhaustion.
February 8, 2026 at 5:45 AM
epigenometech.bsky.social
Epigenetics Review - Epigenetic regulation of T cell exhaustion in cancer go.nature.com/4ohBOrZ

Ben Youngblood (St. Jude Children's Research Hospital) reporting in Nat Rev Cancer

#Epigenetics #Review #TCellExhaustion #Cancer
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High-resolution insights without cell sorting; epigenometech.com
Epigenetic regulation of T cell exhaustion in cancer - Nature Reviews Cancer
Transcriptional and epigenetic mechanisms governing T cell exhaustion substantially impact immunotherapy effectiveness. In this Review, Kang et al. outline epigenetic regulatory programmes that i...
go.nature.com
November 3, 2025 at 9:01 AM
alicefrolov.bsky.social
Sharing a new data visualization exploring the phenotypic reprogramming of exhausted CD8+ T cells following PD-1 axis blockade.

#TcellExhaustion #CheckpointBlockade #TumorImmunology #CD8Tcells #AntiPD1 #Tpex #ImmuneCheckpoint #CancerImmunotherapy
Sharing a new data visualization exploring the phenotypic reprogramming of exhausted CD8+ T cells following PD-1 axis blockade. Figure: "Reprogramming exhausted CD8+ T cells with anti-PD-1 therapy" Subtitle: "Marker-defined transitions from terminal exhaustion toward progenitor/effector states after checkpoint blockade" The visualization employs a faceted marginal-distribution slope arrow design, functioning as a state-transition flow map. Each facet corresponds to a defined exhaustion-associated marker axis (TCF1, TOX, TIM-3, PD-1, GZMB, and Ki-67), with paired marginal distributions rendered pre- and post-treatment. Slope arrows connect the density centroids across conditions, encoding both the directionality and relative magnitude of population-level marker shifts. This approach was chosen to make explicit the differential mobilization of progenitor-exhausted (Tpex) versus terminally exhausted (Tex_term) subsets rather than collapsing the transition into a single trajectory summary. The simulated data are calibrated to reproduce trends consistent with the current literature. Under anti-PD-1, the TCF1+ TOX-intermediate progenitor compartment shows expansion accompanied by upward slope vectors in Ki-67 and GZMB, consistent with proliferative burst and reacquisition of effector potential. Concurrently, the TIM-3-high, TCF1-negative terminally differentiated fraction contracts, and its centroid displays limited displacement along the TCF1 axis, reflecting the constrained plasticity of terminally exhausted cells. This asymmetry underscores that checkpoint blockade preferentially acts on the Tpex reservoir rather than fully reverting terminal exhaustion, a distinction with direct implications for durability of response.
September 12, 2026 at 5:18 PM
alicefrolov.bsky.social
Sharing a visualization from a conceptual synthesis of the CD8+ T cell terminal exhaustion (Tex) program in tumor-infiltrating lymphocytes.

Figure: "Transcriptional and Epigenetic Architecture of CD8+ T Cell Exhaustion"

#TcellExhaustion #TumorImmunology #CD8Tcells #Epigenetics
Sharing a visualization from a conceptual synthesis of the CD8+ T cell terminal exhaustion (Tex) program in tumor-infiltrating lymphocytes. Figure: "Transcriptional and Epigenetic Architecture of CD8+ T Cell Exhaustion" Subtitle: "Relative feature intensity across the terminal exhaustion (Tex) program in tumor-infiltrating lymphocytes" The figure employs a radar bar-style plot in which each radial axis corresponds to a defining molecular feature of the terminal exhaustion state, with bar length encoding relative feature intensity on a normalized scale. Axes span the canonical inhibitory receptor module (PDCD1, HAVCR2, LAG3, TIGIT, CTLA4), the exhaustion-defining transcription factor TOX and its cofactor NR4A family members, alongside the progenitor-associated factor TCF7, which is depicted at low relative intensity to reflect the loss of stem-like potential upon terminal differentiation. Additional axes capture chromatin-level features, including the acquisition of exhaustion-specific accessible regulatory elements, EZH2-associated repressive marks at effector loci, and diminished accessibility at TCF7-dependent enhancers. Effector cytokine capacity (IFNG, TNF, IL2) and proliferative indices are rendered as attenuated, consistent with the hypofunctional terminal phenotype. The intent is to juxtapose transcriptional and epigenetic determinants within a single coordinate system, emphasizing that TOX-driven epigenetic commitment enforces a stable, largely irreversible chromatin landscape that constrains the response to checkpoint blockade. I want to state explicitly that the data plotted are simulated. The values do not derive from a specific experimental dataset; rather, they are constructed to illustrate a literature-grounded qualitative trend consistent with published single-cell RNA-seq and ATAC-seq characterizations of Tex populations. The figure is intended as a didactic and conceptual scaffold, not as primary evidence.
August 1, 2026 at 5:00 PM
alicefrolov.bsky.social
New Visualization: PD-1 Surface Expression Across CD8+ TIL Differentiation States

I am sharing a violin-style visualization intended to communicate a well-established mechanistic trend in tumor immunology.

#TumorImmunology #TCellExhaustion #DataVisualization #PD1 #FlowCytometry
New Visualization: PD-1 Surface Expression Across CD8+ TIL Differentiation States I am sharing a violin-style visualization intended to communicate a well-established mechanistic trend in tumor immunology. I want to state at the outset that the data displayed are simulated. They do not derive from a specific experiment or dataset; rather, they are constructed to illustrate a literature-grounded pattern for pedagogical and discussion purposes. Figure title: "PD-1 (PDCD1) Surface Expression Across Tumor-Infiltrating T Cell Differentiation States." Subtitle: "Single-cell flow cytometry of CD8+ TILs stratified by exhaustion program, before and after anti-PD-1 blockade." The plot stratifies CD8+ tumor-infiltrating lymphocytes along the canonical exhaustion trajectory: progenitor/stem-like (TCF1+, PD-1 intermediate), transitional intermediate, and terminally exhausted (TOX-high, TIM-3+, PD-1 high) subsets. Each violin depicts the distribution of PD-1 surface mean fluorescence intensity on a per-cell basis, with paired pre- and post-anti-PD-1 blockade conditions displayed side by side. The illustrated trend reflects consensus observations: surface PD-1 density increases monotonically across the differentiation continuum, peaking in the terminally exhausted compartment concomitant with TOX-driven epigenetic commitment. Following anti-PD-1 administration, measured surface PD-1 declines, consistent with epitope masking by therapeutic antibody and receptor internalization rather than a genuine reduction in PDCD1 transcription. This distinction is mechanistically important, as apparent downregulation by flow cytometry does not indicate reversal of the exhaustion program. I would welcome feedback on how best to annotate the epitope-competition caveat for readers less familiar with flow-based receptor occupancy artifacts. Discussion regarding preferred clonal gating strategies is also appreciated.
August 15, 2026 at 5:02 PM
atorchbearer.substack.com
Disulfide stress → disulfidptosis in CD8+ T cells? Big!

We explored similar redox targets in our recent Substack - cystine import, GSH, ferroptosis, and how to collapse tumor defense for <$20.

atorchbearer.substack.com/p/the-20-can...

Curious to hear from you!
#CancerCure #TCellExhaustion #Tumor
The $20 Cure That Terrifies Big Pharma
I Solved Cancer, Neuroinflammation, and Mitochondrial Dysfunction. Here’s the math, and the proof. Real data. Real images. Real results.
atorchbearer.substack.com
July 7, 2025 at 3:51 PM
psharmaphd.bsky.social
Amazing study from @RoychoudhuriLab highlighting the next-gen genetic manipulation to tweak the right amount of protein expression to enhance T cell function in cancers. Kudos to the authors.
Check it out : www.nature.com/articles/s41...

#tcellexhaustion #tcells
Fine-tuning BACH2 dosage balances stemness and effector function to enhance antitumor T cell therapy - Nature Immunology
One of three back-to-back papers to show dosage of BACH2 can modulate T cell differentiation and function and how we might apply this to enhance chimeric antigen receptor T cell therapies for cancer.
www.nature.com
January 21, 2026 at 8:01 PM
bionewscentral.com
Two companion studies show that #mezigdomide can reverse #TCellExhaustion and improve the effectiveness of #CARTCellTherapy and #BispecificAntibody treatments, which are already transforming the standard of care for #MultipleMyeloma.
#MyelomaImmunotherapy #MyelomaTreatment
Reversing T cell exhaustion improves effectiveness of myeloma immunotherapies – BioNews Central
Two companion studies show that mezigdomide can reverse T cell exhaustion and improve the effectiveness of CAR T-cell therapy and bispecific antibody treatments, which are already transforming the standard of care for multiple myeloma. ...
sbee.link
May 19, 2026 at 1:14 AM