“Virologist Vincent Racaniello titled one of his articles: “Tcells will save us from COVID-19.”
But what if COVID wears down Tcells in people who get it, and does so increasingly with each reinfection?”
A must read from @thetyee.ca
#CovidFallout
#LongCovid
#TCells
But what if COVID wears down Tcells in people who get it, and does so increasingly with each reinfection?”
A must read from @thetyee.ca
#CovidFallout
#LongCovid
#TCells
I paid close attention to AJ Leonardi in the other place. Right from the get go he hammered on about T cell damage.
So many people tried to discredit him (looking at you Zeynap). But I believe his observations have substance. #ImmunityLost
Great read from @thetyee.ca
thetyee.ca/Analysis/202...
So many people tried to discredit him (looking at you Zeynap). But I believe his observations have substance. #ImmunityLost
Great read from @thetyee.ca
thetyee.ca/Analysis/202...
What If COVID Reinfections Wear Down Our Immunity? | The Tyee
Dr. Anthony Leonardi is a lightning rod for debate. If he’s right, this pandemic poses a greater threat than widely assumed.
thetyee.ca
January 24, 2025 at 5:25 PM
“Virologist Vincent Racaniello titled one of his articles: “Tcells will save us from COVID-19.”
But what if COVID wears down Tcells in people who get it, and does so increasingly with each reinfection?”
A must read from @thetyee.ca
#CovidFallout
#LongCovid
#TCells
But what if COVID wears down Tcells in people who get it, and does so increasingly with each reinfection?”
A must read from @thetyee.ca
#CovidFallout
#LongCovid
#TCells
Exciting to see this out in its final form! Wonderful work led by @probablycarmen.bsky.social. Want to know why protrusions are better at initiating immune signaling in #Tcells? Look no further. Link to Carmen’s 🧵 on the preprint bsky.app/profile/prob...
Revised role for actin-rich protrusions in T-cell activation:
@franbottanelli.bsky.social @probablycarmen.bsky.social et al reframe them as sites of enhanced receptor activation by exclusion & clustering dynamics, rather than pre-enrichment of signaling components
link.springer.com/article/10.1...
@franbottanelli.bsky.social @probablycarmen.bsky.social et al reframe them as sites of enhanced receptor activation by exclusion & clustering dynamics, rather than pre-enrichment of signaling components
link.springer.com/article/10.1...
T-cell protrusions enable fast, localised initiation of chimeric antigen receptor signalling - The EMBO Journal
Actin-rich protrusions densely cover the surface of T cells and are well characterised for their role in migration. Recent studies have uncovered their contribution to antigen surveillance and immune ...
link.springer.com
April 21, 2026 at 4:52 PM
Exciting to see this out in its final form! Wonderful work led by @probablycarmen.bsky.social. Want to know why protrusions are better at initiating immune signaling in #Tcells? Look no further. Link to Carmen’s 🧵 on the preprint bsky.app/profile/prob...
So much gratitude to Dr. AJ Leonardi for his time & sitting down with @theresisters.bsky.social on our podcast “No Ostriching Here.” to talk about TCells.
January 22, 2026 at 8:40 PM
So much gratitude to Dr. AJ Leonardi for his time & sitting down with @theresisters.bsky.social on our podcast “No Ostriching Here.” to talk about TCells.
Rapid and precise quantification of lymphocyte iron content by single cell inductively coupled plasma mass spectrometry https://www.biorxiv.org/content/10.1101/2024.11.11.623006v1
Rapid and precise quantification of lymphocyte iron content by single cell inductively coupled plasma mass spectrometry https://www.biorxiv.org/content/10.1101/2024.11.11.623006v1
Metals facilitate catalysis during cellular metabolism, but heterogeneity of metal content at single
www.biorxiv.org
November 15, 2024 at 12:58 PM
For those of you who do not know, I've been HIV+ for 16 yrs. 2 years ago, my TCells fell to the threshold, now I have AIDS
Now MAGA want 2 take away my meds because of their religious liberty.
If this happens. I die
This shit is real for millions of us
#USDemocracy
www.vox.com/explain-it-t...
Now MAGA want 2 take away my meds because of their religious liberty.
If this happens. I die
This shit is real for millions of us
#USDemocracy
www.vox.com/explain-it-t...
Have we cured AIDS?
The global fight against HIV is at a perilous tipping point.
www.vox.com
January 22, 2025 at 3:34 PM
For those of you who do not know, I've been HIV+ for 16 yrs. 2 years ago, my TCells fell to the threshold, now I have AIDS
Now MAGA want 2 take away my meds because of their religious liberty.
If this happens. I die
This shit is real for millions of us
#USDemocracy
www.vox.com/explain-it-t...
Now MAGA want 2 take away my meds because of their religious liberty.
If this happens. I die
This shit is real for millions of us
#USDemocracy
www.vox.com/explain-it-t...
Out now in #Science #Immunology: a fantastic new study looking at #CD8 #TCells that are broadly cross-reactive to diverse #influenza strains from the Kedzierska & Rossjohn labs!
Timely study by Katherine Kedzierska and Jamie Rossjohn and colleagues defining key structural features of #Tcell binding to circulating #influenza strains from 1918 to ~present #ImmunoSky www.science.org/doi/10.1126/...
Molecular determinants of cross-strain influenza A virus recognition by αβ T cell receptors
TCR-peptide-HLA ternary structures define molecular mechanisms of TCR cross-reactivity toward natural influenza variants.
www.science.org
February 7, 2025 at 8:03 PM
Out now in #Science #Immunology: a fantastic new study looking at #CD8 #TCells that are broadly cross-reactive to diverse #influenza strains from the Kedzierska & Rossjohn labs!
🎆 Happy new year and our first 2026 issue is out!
Cover: #epiblast development
👉Perspective: biological clocks
👉Review: #mitosis #CellDeath #inflammation
🔬 #chromatin #cancer #Bcells #Tcells #autophagy #organoids #mechanobiology #TranscriptionFactors #Xist & more!
www.nature.com/ncb/volumes/...
Cover: #epiblast development
👉Perspective: biological clocks
👉Review: #mitosis #CellDeath #inflammation
🔬 #chromatin #cancer #Bcells #Tcells #autophagy #organoids #mechanobiology #TranscriptionFactors #Xist & more!
www.nature.com/ncb/volumes/...
January 16, 2026 at 8:18 AM
🎆 Happy new year and our first 2026 issue is out!
Cover: #epiblast development
👉Perspective: biological clocks
👉Review: #mitosis #CellDeath #inflammation
🔬 #chromatin #cancer #Bcells #Tcells #autophagy #organoids #mechanobiology #TranscriptionFactors #Xist & more!
www.nature.com/ncb/volumes/...
Cover: #epiblast development
👉Perspective: biological clocks
👉Review: #mitosis #CellDeath #inflammation
🔬 #chromatin #cancer #Bcells #Tcells #autophagy #organoids #mechanobiology #TranscriptionFactors #Xist & more!
www.nature.com/ncb/volumes/...
Insights: Sajiki et al. @arakilab.bsky.social (rupress.org/jem/article/...) show that long-lived naive #CD8 #Tcells accrue tonic #TCR signaling during homeostasis, driving their differentiation into functionally superior effectors. From Hee Yeun Won & Jung-Hyun Park: rupress.org/jem/article/...
September 25, 2026 at 4:30 PM
Insights: Sajiki et al. @arakilab.bsky.social (rupress.org/jem/article/...) show that long-lived naive #CD8 #Tcells accrue tonic #TCR signaling during homeostasis, driving their differentiation into functionally superior effectors. From Hee Yeun Won & Jung-Hyun Park: rupress.org/jem/article/...
I am still kinda new on BlueSky. Interested in #IBD, #Tcells, #TCR ? I would kindly appreciate Reposts! :-)
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
June 19, 2026 at 8:56 AM
I am still kinda new on BlueSky. Interested in #IBD, #Tcells, #TCR ? I would kindly appreciate Reposts! :-)
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
First day of #ATCR25 in Antwerp: done ☑️ 🤩
Picture of Antwerp city station
#immunology #TCRrepertoire #Tcells #research
Picture of Antwerp city station
#immunology #TCRrepertoire #Tcells #research
May 27, 2025 at 4:06 PM
First day of #ATCR25 in Antwerp: done ☑️ 🤩
Picture of Antwerp city station
#immunology #TCRrepertoire #Tcells #research
Picture of Antwerp city station
#immunology #TCRrepertoire #Tcells #research
Very honoured to be hosting Prof @kischober.bsky.social at Unravelling T cell recogition webinar series @imm.ox.ac.uk Kilian will present his latest work exploring how EBV-reactive T cells may contribute to CNS autoimmunity in multiple sclerosis. Join me.
#TCells #Immunology #MultipleSclerosis #EBV
#TCells #Immunology #MultipleSclerosis #EBV
September 21, 2026 at 2:30 PM
Very honoured to be hosting Prof @kischober.bsky.social at Unravelling T cell recogition webinar series @imm.ox.ac.uk Kilian will present his latest work exploring how EBV-reactive T cells may contribute to CNS autoimmunity in multiple sclerosis. Join me.
#TCells #Immunology #MultipleSclerosis #EBV
#TCells #Immunology #MultipleSclerosis #EBV
It’s been a little while since we shared this, so for those who think #Tcells really are the best cell just like us, we’ve got the starter pack for you 🧪#immunosky
go.bsky.app/8B5P25c
go.bsky.app/8B5P25c
January 26, 2025 at 6:50 PM
It’s been a little while since we shared this, so for those who think #Tcells really are the best cell just like us, we’ve got the starter pack for you 🧪#immunosky
go.bsky.app/8B5P25c
go.bsky.app/8B5P25c
So far in March, we've featured papers on:
• how inflammatory #ILC2 migrate
• engineering #CAR-TCells to restore #checkpoint sensitivity
• capturing the earliest events of #TCell #development
• how certain dietary antigens recognized by #Tregs help mediate #OralTolerance
New content every week!
• how inflammatory #ILC2 migrate
• engineering #CAR-TCells to restore #checkpoint sensitivity
• capturing the earliest events of #TCell #development
• how certain dietary antigens recognized by #Tregs help mediate #OralTolerance
New content every week!
The March 2026 issue of #ScienceImmunology is out!
This month's cover highlights how intestinal regulatory T cells in mice recognize food-derived antigens such as the maize protein αZein and suppress immune responses to them.
Learn about this research and more: https://scim.ag/4rL6F1I
This month's cover highlights how intestinal regulatory T cells in mice recognize food-derived antigens such as the maize protein αZein and suppress immune responses to them.
Learn about this research and more: https://scim.ag/4rL6F1I
March 13, 2026 at 7:37 PM
So far in March, we've featured papers on:
• how inflammatory #ILC2 migrate
• engineering #CAR-TCells to restore #checkpoint sensitivity
• capturing the earliest events of #TCell #development
• how certain dietary antigens recognized by #Tregs help mediate #OralTolerance
New content every week!
• how inflammatory #ILC2 migrate
• engineering #CAR-TCells to restore #checkpoint sensitivity
• capturing the earliest events of #TCell #development
• how certain dietary antigens recognized by #Tregs help mediate #OralTolerance
New content every week!
Just posted (bioRxiv): A novel #mechanobiology model revealing how #immune #Tcells combine a #nucleus as a #piston, an #uropod, and #microenvironment to power #amoeboid #cellmigration in #cellconfinement via a hydraulic cell engine. #CellBiophysics #ImmuneMigration
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
September 9, 2025 at 7:09 PM
Just posted (bioRxiv): A novel #mechanobiology model revealing how #immune #Tcells combine a #nucleus as a #piston, an #uropod, and #microenvironment to power #amoeboid #cellmigration in #cellconfinement via a hydraulic cell engine. #CellBiophysics #ImmuneMigration
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Keeping on the T cell theme! From June '24: At the moment of T cell activation, the presence, or lack, of nuclear envelope invaginations, which gather organelles, influences effector and memory fate decisions.
https://buff.ly/3ZzruBG
#Immunology #Tcells @science.org
https://buff.ly/3ZzruBG
#Immunology #Tcells @science.org
December 6, 2024 at 5:39 PM
Keeping on the T cell theme! From June '24: At the moment of T cell activation, the presence, or lack, of nuclear envelope invaginations, which gather organelles, influences effector and memory fate decisions.
https://buff.ly/3ZzruBG
#Immunology #Tcells @science.org
https://buff.ly/3ZzruBG
#Immunology #Tcells @science.org
#Medsky🧪 #IDsky #immunosky #publichealth @jidjournal.bsky.social
The long-term impact of #SARSCoV2 infection on #lymphocyte subsets in a cohort study of 40,537 patients
🔑 findings
- During the mass infection period, #Tcells, CD+ T cells, CD8+ T cells, NK cells & B cellsd significant ⏬️ vs to
The long-term impact of #SARSCoV2 infection on #lymphocyte subsets in a cohort study of 40,537 patients
🔑 findings
- During the mass infection period, #Tcells, CD+ T cells, CD8+ T cells, NK cells & B cellsd significant ⏬️ vs to
December 5, 2025 at 4:30 PM
#Medsky🧪 #IDsky #immunosky #publichealth @jidjournal.bsky.social
The long-term impact of #SARSCoV2 infection on #lymphocyte subsets in a cohort study of 40,537 patients
🔑 findings
- During the mass infection period, #Tcells, CD+ T cells, CD8+ T cells, NK cells & B cellsd significant ⏬️ vs to
The long-term impact of #SARSCoV2 infection on #lymphocyte subsets in a cohort study of 40,537 patients
🔑 findings
- During the mass infection period, #Tcells, CD+ T cells, CD8+ T cells, NK cells & B cellsd significant ⏬️ vs to
@theresisters.bsky.social got a chance to sit down with Dr. Anthony J. Leonardi to talk about Tcells, what they are, what they do & what happens to us when they get damaged. Stay tuned for the full episode of "No Ostriching Here." with Dr. AJ Leonardi. t.co/WJ5p2YLrtL
#womeninpodcasting
#womeninpodcasting
January 16, 2026 at 5:44 PM
@theresisters.bsky.social got a chance to sit down with Dr. Anthony J. Leonardi to talk about Tcells, what they are, what they do & what happens to us when they get damaged. Stay tuned for the full episode of "No Ostriching Here." with Dr. AJ Leonardi. t.co/WJ5p2YLrtL
#womeninpodcasting
#womeninpodcasting
T-cell #mechanobiology: how molecular forces shape immune function. New review from Judith Zubia-Aranburu, Lingxiao Zhang, and Mingdong Dong @au.dk:
rupress.org/jcb/article/...
#Biophysics #Immunology #Tcells
rupress.org/jcb/article/...
#Biophysics #Immunology #Tcells
May 28, 2026 at 1:30 PM
T-cell #mechanobiology: how molecular forces shape immune function. New review from Judith Zubia-Aranburu, Lingxiao Zhang, and Mingdong Dong @au.dk:
rupress.org/jcb/article/...
#Biophysics #Immunology #Tcells
rupress.org/jcb/article/...
#Biophysics #Immunology #Tcells
🧬 CD28 vs. TCR: not a one-size-fits-all signal.
New study by Cayman Williams et al. shows CD28 co-stimulation shapes naïve & memory CD4⁺ T cells differently - and can even act independently of TCR in memory cells.
📖 https://bit.ly/44MG7UD
##Tcells #Immunology
New study by Cayman Williams et al. shows CD28 co-stimulation shapes naïve & memory CD4⁺ T cells differently - and can even act independently of TCR in memory cells.
📖 https://bit.ly/44MG7UD
##Tcells #Immunology
July 6, 2025 at 1:16 PM
🧬 CD28 vs. TCR: not a one-size-fits-all signal.
New study by Cayman Williams et al. shows CD28 co-stimulation shapes naïve & memory CD4⁺ T cells differently - and can even act independently of TCR in memory cells.
📖 https://bit.ly/44MG7UD
##Tcells #Immunology
New study by Cayman Williams et al. shows CD28 co-stimulation shapes naïve & memory CD4⁺ T cells differently - and can even act independently of TCR in memory cells.
📖 https://bit.ly/44MG7UD
##Tcells #Immunology
So, a few months ago, I found out the HIV treatment I was on was no longer effective. My Tcells plummeted, and my viral load skyrocketed.
Today, I found out from my infectious disease doctor that my insurance has approved my expensive new treatment.
Pray this works or I'm pretty much fucked.
Today, I found out from my infectious disease doctor that my insurance has approved my expensive new treatment.
Pray this works or I'm pretty much fucked.
March 13, 2025 at 10:00 PM
So, a few months ago, I found out the HIV treatment I was on was no longer effective. My Tcells plummeted, and my viral load skyrocketed.
Today, I found out from my infectious disease doctor that my insurance has approved my expensive new treatment.
Pray this works or I'm pretty much fucked.
Today, I found out from my infectious disease doctor that my insurance has approved my expensive new treatment.
Pray this works or I'm pretty much fucked.
Immunologists have discovered that vaccine-induced T cells—white blood cells that destroy pathogens—can completely prevent viral infection to an extent previously unknown until now. These vax-prompted Tcells prevent infection w/out a 1st wave of neutralizing antibodies www.nature.com/articles/s41...
Vaccine-induced T cell responses control Orthoflavivirus challenge infection without neutralizing antibodies in humans - Nature Microbiology
The authors demonstrate the effectiveness of T cells in controlling acute viral infections, without neutralizing antibodies, by conducting an Orthoflavivirus vaccination and challenge study in humans.
www.nature.com
January 12, 2025 at 11:10 AM
Immunologists have discovered that vaccine-induced T cells—white blood cells that destroy pathogens—can completely prevent viral infection to an extent previously unknown until now. These vax-prompted Tcells prevent infection w/out a 1st wave of neutralizing antibodies www.nature.com/articles/s41...
We've worked on Hif deletion in CD4 #Tcells for an embarrassingly long time. We gave up and had to rederive the T conditional KO mice after we stumbled on a phenotype in # NK cells from these mice (1+ years after data acquisition)
It's been long, slow and fascinating. In a nutshell...
It's been long, slow and fascinating. In a nutshell...
HIF-1α+ CD4 T cells coordinate a tissue resident immune cell network in the lung https://www.biorxiv.org/content/10.1101/2025.06.13.659476v1
June 18, 2025 at 4:54 AM
We've worked on Hif deletion in CD4 #Tcells for an embarrassingly long time. We gave up and had to rederive the T conditional KO mice after we stumbled on a phenotype in # NK cells from these mice (1+ years after data acquisition)
It's been long, slow and fascinating. In a nutshell...
It's been long, slow and fascinating. In a nutshell...
Insights @jem.org: Sajiki et al. @arakilab.bsky.social (rupress.org/jem/article/...) show that long-lived naive #CD8 #Tcells accrue tonic TCR signaling during homeostasis, driving their differentiation into functionally superior effectors. By Hee Yeun Won & Jung-Hyun Park rupress.org/jem/article/...
September 25, 2026 at 5:15 PM
Insights @jem.org: Sajiki et al. @arakilab.bsky.social (rupress.org/jem/article/...) show that long-lived naive #CD8 #Tcells accrue tonic TCR signaling during homeostasis, driving their differentiation into functionally superior effectors. By Hee Yeun Won & Jung-Hyun Park rupress.org/jem/article/...