Nature Reviews Neurology, Published online: 26 October 2026; doi:10.1038/s41582-026-01272-1Neuroimmunology breakthroughs have been fuelled by studies in animal models. In this Review, the International Society of Neuroimmunology White Paper Task Force describes animal models that can be used to study neuroimmunological aspects of neurological disease and provide guidance on how to optimize use of animal models to gain insight into neuroimmunological mechanisms.

Human brain cellular xenograft (HBCX) models are emerging as a system to study human brain physiology and pathology in vivo. Mancuso and colleagues discuss how HBCXs enable in vivo interrogation of human-specific brain cell biology, neuroimmunology, disease modeling, and genetic risk and their potential for functional genomics, therapeutic discovery, and preclinical assessment of cell-based therapies for central nervous system disorders.

Nature Reviews Neurology, Published online: 26 October 2026; doi:10.1038/s41582-026-01272-1Neuroimmunology breakthroughs have been fuelled by studies in animal models. In this Review, the International Society of Neuroimmunology White Paper Task Force describes animal models that can be used to study neuroimmunological aspects of neurological disease and provide guidance on how to optimize use of animal models to gain insight into neuroimmunological mechanisms.

The brain can literally tell the immune system when to stand down. The inflammatory reflex—mediated by the vagus nerve—allow… #Clinicalneuroscience #Immuneregulation #Inflammatoryreflex #Neuroimmunology #Rheumatoidarthritis

Researchers uncover how sensory nerves help regulate allergic inflammation and pain in eosinophilic esophagitis.

Neuroimmunology Market growth is projected to reach 8.7 USD billion, at a 6.18% CAGR by driving industry size, share, top company analysis, segments research, trends and forecast report 2025 to 2035