I will try to do a tweetorial about this paper when I have more energy but this is really important data. It looks (tentatively, preliminarily) that COVID-19 mRNA vaccines might significantly enhance the effectiveness of cancer immunotherapy (subject to many caveats).
SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade
Nature - mRNA vaccines targeting SARS-CoV-2 also sensitize tumours to immune checkpoint inhibitors.
rdcu.be
October 25, 2025 at 5:53 PM
#medsky#pedsky#idsky#immunosky 🧪
In the midst of all of the scary headlines recently, I thought I could take a moment to share a bit of good news: for the first time in history, a malaria vaccine with >90% efficacy seems to be within reach!
Here’s why that’s a really big deal for EVERYONE 🧵
In the midst of all of the scary headlines recently, I thought I could take a moment to share a bit of good news: for the first time in history, a malaria vaccine with >90% efficacy seems to be within reach!
Here’s why that’s a really big deal for EVERYONE 🧵
A Single-Dose Breakthrough: PfSPZ-LARC Vaccines Offer Transformative Protection Against Malaria – Sanaria
sanaria.com
February 13, 2025 at 1:23 PM
#medsky#pedsky#idsky#immunosky 🧪
In the midst of all of the scary headlines recently, I thought I could take a moment to share a bit of good news: for the first time in history, a malaria vaccine with >90% efficacy seems to be within reach!
Here’s why that’s a really big deal for EVERYONE 🧵
In the midst of all of the scary headlines recently, I thought I could take a moment to share a bit of good news: for the first time in history, a malaria vaccine with >90% efficacy seems to be within reach!
Here’s why that’s a really big deal for EVERYONE 🧵
Kids, don’t do grants. #AcademicSky #ImmunoSky
October 18, 2023 at 10:42 AM
Kids, don’t do grants. #AcademicSky #ImmunoSky
Looks like Kennedy is continuing his campaign to cut vaccine access by stealth by targeting Aluminium salts- these are adjuvants which are added to some vaccines to stimulate the immune system-quick explainer 🧪 #ImmunoSky 🧵
August 4, 2025 at 8:17 AM
Looks like Kennedy is continuing his campaign to cut vaccine access by stealth by targeting Aluminium salts- these are adjuvants which are added to some vaccines to stimulate the immune system-quick explainer 🧪 #ImmunoSky 🧵
Infectious disease as art. Revealing label-free imaging of Borrelia burgdorferi. #MicroSky #ImmunoSky #ChronicIlnness #Lyme
The never before seen Borrelia burgdorferi caught in the act of making trouble in our mouse model of borrelia infection-associated chronic illness. I feel so grateful to get to collaborate with Kunzan Liu (who took these sunning images), and Sixian You who makes the invisible visible.
November 28, 2024 at 2:38 AM
Infectious disease as art. Revealing label-free imaging of Borrelia burgdorferi. #MicroSky #ImmunoSky #ChronicIlnness #Lyme
Recent paper (Nature)-why are males more vulnerable to severe infections (ex acute #COVID), while females suffer more from autoimmunity (SLE, MS etc and also #LongCovid)? X/Y or hormones? We study adaptation of immune systems in gender-affirming testosterone treatment: nature.com/articles/s41...
Immune system adaptation during gender-affirming testosterone treatment - Nature
Examination of immunological changes in transgender individuals undergoing gender-affirming testosterone treatment reveals sex hormone-regulated pathways in humans and explains sex-divergent responses...
nature.com
November 17, 2024 at 7:09 AM
A Bone Marrow Organoid (BMO) that allows us to study hematopoiesis in vitro.
Blue: nuclei (DAPI)
Orange: endothelial cells (CD31)
#fluorescencefriday #immunosky
Blue: nuclei (DAPI)
Orange: endothelial cells (CD31)
#fluorescencefriday #immunosky
December 13, 2024 at 9:21 PM
A Bone Marrow Organoid (BMO) that allows us to study hematopoiesis in vitro.
Blue: nuclei (DAPI)
Orange: endothelial cells (CD31)
#fluorescencefriday #immunosky
Blue: nuclei (DAPI)
Orange: endothelial cells (CD31)
#fluorescencefriday #immunosky
Working on immunometabolism? Or looking for people who do? Then here’s the starter pack for you! 😊 #Immunosky
go.bsky.app/MvxkA4Q
go.bsky.app/MvxkA4Q
November 24, 2024 at 1:35 PM
Working on immunometabolism? Or looking for people who do? Then here’s the starter pack for you! 😊 #Immunosky
go.bsky.app/MvxkA4Q
go.bsky.app/MvxkA4Q
So happy to (finally!!) announce that our paper studying synovial tissue dendritic cells in joint health and rheumatoid arthritis is now out in Immunity! 🚨 doi.org/10.1016/j.im...
November 27, 2024 at 9:37 PM
I haven't seen a starter pack of immunologists, so I created one. Apologies if I overlooked folks. #ImmunoSky 🧪⚕️
go.bsky.app/PY5tCas
go.bsky.app/PY5tCas
October 1, 2024 at 5:05 PM
I haven't seen a starter pack of immunologists, so I created one. Apologies if I overlooked folks. #ImmunoSky 🧪⚕️
go.bsky.app/PY5tCas
go.bsky.app/PY5tCas
#Medsky #IDsky #immunosky #publichealth #Science improving & saving life . A novel dual antibody Treatment can be effective against all #SarsCoV2 variants
THIS IS HUGE! Researchers at Stanford University have developed a dual-antibody treatment that remains effective against ALL SARS-CoV-2 variants by targeting a less-mutable part of the virus. This breakthrough could lead to longer-lasting therapies that OUTPACE viral evolution. 🧪🧵⬇️
March 9, 2025 at 8:12 PM
#Medsky #IDsky #immunosky #publichealth #Science improving & saving life . A novel dual antibody Treatment can be effective against all #SarsCoV2 variants
"P. aeruginosa subverts mucosal immunity and establishes a self-sustaining immunopathological loop, offering potential targets for #CF precision therapies."
really interesting - may have analogies in other infections too
#MicroSky #ImmunoSky #IDSky
really interesting - may have analogies in other infections too
#MicroSky #ImmunoSky #IDSky
Pseudomonas aeruginosa induces the generation of pathogenic IFNγ+Th17 cells that promote lung damage and chronic inflammation in cystic fibrosis
www.nature.com/articles/s41... @natmicrobiol.nature.com
www.nature.com/articles/s41... @natmicrobiol.nature.com
September 28, 2026 at 6:55 AM
"P. aeruginosa subverts mucosal immunity and establishes a self-sustaining immunopathological loop, offering potential targets for #CF precision therapies."
really interesting - may have analogies in other infections too
#MicroSky #ImmunoSky #IDSky
really interesting - may have analogies in other infections too
#MicroSky #ImmunoSky #IDSky
Last week the 2025 GRC Immunology of Fungal Infections concluded. Thanks to @lableibundgut.bsky.social and @fungalspore.bsky.social for chairing this extraordinary meeting. See you in 2027
January 27, 2025 at 10:49 PM
#Medsky🧪 #immunosky #IDSky The arc of vaccine progress spans centuries, from early, risky inoculations to today’s rapid, advanced technologies like mRNA. This evolution has saved hundreds of millions of lives & eradicated diseases like smallpox.
August 28, 2025 at 11:10 PM
#Medsky🧪 #immunosky #IDSky The arc of vaccine progress spans centuries, from early, risky inoculations to today’s rapid, advanced technologies like mRNA. This evolution has saved hundreds of millions of lives & eradicated diseases like smallpox.
I wrote a review of James Watson's obituary by CSHL: liorpachter.wordpress.com/2025/11/08/r...
Review of Cold Spring Harbor Laboratory’s Obituary for Dr. James Watson
James Watson, who described himself as “not a racist in a conventional way”, has died at the age of 97. Below is a review of an obituary for Dr. James Watson published by Cold Spring Ha…
liorpachter.wordpress.com
November 9, 2025 at 2:18 AM
🚨 this is a huge problem 🚨
More proof that this isn’t about individual choice -they are actively hindering the availability of safe and effective vaccines.
#immunosky #medsky 🧪
More proof that this isn’t about individual choice -they are actively hindering the availability of safe and effective vaccines.
#immunosky #medsky 🧪
Breaking: FDA's March meeting to select flu shot strains for 2025-2026 season has been canceled per email sent to committee members, a VRBPAC member told me. drug companies need about 6 months leeway to make shots in time for fall vax campaigns. #healthpolicy
February 27, 2025 at 3:02 AM
🚨 this is a huge problem 🚨
More proof that this isn’t about individual choice -they are actively hindering the availability of safe and effective vaccines.
#immunosky #medsky 🧪
More proof that this isn’t about individual choice -they are actively hindering the availability of safe and effective vaccines.
#immunosky #medsky 🧪
1/ The thymus is essential for T-cell maturation, protecting us from pathogens while ensuring tolerance to our own tissues. 🧬 This balance is maintained by the thymic epithelium, which, in mammals, birds, and bony fish, develops from the 3rd/4th pharyngeal pouches during embryogenesis.
December 8, 2024 at 2:30 PM
Infectious disease specialists keeping it social on #Bluesky - #IDSky getting some serious use over here!
#MedSky #pedsky #cardiosky #cansky #obgynsky #immunosky #episky #nephsky
#MedSky #pedsky #cardiosky #cansky #obgynsky #immunosky #episky #nephsky
May 8, 2025 at 10:28 AM
Infectious disease specialists keeping it social on #Bluesky - #IDSky getting some serious use over here!
#MedSky #pedsky #cardiosky #cansky #obgynsky #immunosky #episky #nephsky
#MedSky #pedsky #cardiosky #cansky #obgynsky #immunosky #episky #nephsky
A commensal-derived sugar protects against #obesity by regulating immunometabolism.
Clostridium immunis sugar lowers IL‑22 to boost visceral fat burning and counter obesity.
www.sciencedirect.com/science/arti... #microbiota #immunity #metabolism #MicroSky #ImmunoSky #MedSky
Clostridium immunis sugar lowers IL‑22 to boost visceral fat burning and counter obesity.
www.sciencedirect.com/science/arti... #microbiota #immunity #metabolism #MicroSky #ImmunoSky #MedSky
September 24, 2026 at 6:44 PM
A commensal-derived sugar protects against #obesity by regulating immunometabolism.
Clostridium immunis sugar lowers IL‑22 to boost visceral fat burning and counter obesity.
www.sciencedirect.com/science/arti... #microbiota #immunity #metabolism #MicroSky #ImmunoSky #MedSky
Clostridium immunis sugar lowers IL‑22 to boost visceral fat burning and counter obesity.
www.sciencedirect.com/science/arti... #microbiota #immunity #metabolism #MicroSky #ImmunoSky #MedSky
So excited to FINALLY be able to share exciting news from @lydiabeckeriii.bsky.social on our newly awarded MRC Centre of Research Excellence (MRC CoRE) in Exposome Immunology #ImmunoSky 🧪 🧵
July 16, 2025 at 8:35 AM
So excited to FINALLY be able to share exciting news from @lydiabeckeriii.bsky.social on our newly awarded MRC Centre of Research Excellence (MRC CoRE) in Exposome Immunology #ImmunoSky 🧪 🧵
I am part of an amazing immunology community in Manchester so I started a pack to help find us! Do reply if I missed you. #Immunosky
go.bsky.app/FwUMk1Q
go.bsky.app/FwUMk1Q
January 27, 2025 at 3:51 PM
I am part of an amazing immunology community in Manchester so I started a pack to help find us! Do reply if I missed you. #Immunosky
go.bsky.app/FwUMk1Q
go.bsky.app/FwUMk1Q
#MedSky🧪#IDSky #ImmunoSky #publichhealth This comprehensive study demonstrates that individuals receiving the full mRNA vaccination regimen, including the XBB.1.5 booster, have maximally effective neutralizing activity against recent strains of #SARSCoV2.
December 10, 2024 at 3:02 PM
#MedSky🧪#IDSky #ImmunoSky #publichhealth This comprehensive study demonstrates that individuals receiving the full mRNA vaccination regimen, including the XBB.1.5 booster, have maximally effective neutralizing activity against recent strains of #SARSCoV2.