#Targetome
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#Targetome
Cytoskeletal checkpoints, not molecular catalogs, may govern microglial aging: Pfn1 and Arpc4 loss trigger divergent senescence and synaptic deficits.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0035
#Microglia #Cytoskeleton #BrainAging #Dementia
September 21, 2026 at 12:28 AM
epigenometech.bsky.social
Epigenetics Update - Rapamycin targetome mining identifies RBBP7 as a druggable epigenetic vulnerability in hepatocellular carcinoma u.epigenome.us/jje91JhP

Bing Shan & Yaoyang Zhang (CAS) in Cell Chemical Biology

#Epigenetics #RBBP7 #Cancer #Rapamycin
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epigenometech.com
September 22, 2026 at 7:15 AM
mapjournals.bsky.social
#Targetome
An integrated framework unites target fishing, single-cell multi-omics, and AI reasoning into a closed-loop workflow for natural product target discovery.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0036
#TargetFishing #SingleCellOmics #AIDrugDiscovery
September 23, 2026 at 4:41 AM
biorxiv-molbio.bsky.social
Beyond microRNAs: Analysis of chimeric reads characterises the diverse targetome of AGO2-mediated regulation. https://www.biorxiv.org/content/10.1101/2023.08.24.554582v1
August 25, 2023 at 4:43 PM
michaelraissig.bsky.social
5/ Gene regulatory network analysis of the stomatal clusters identifies top transcription factors per clusters and could distinguish the targetome of co-expressed yet functionally distinct stomatal transcription factors BdMUTE and BdFAMA
November 5, 2025 at 12:32 PM
cp-cellchembiol.bsky.social
Online now! Online now! Rapamycin targetome mining identifies RBBP7 as a druggable epigenetic vulnerability in hepatocellular carcinoma #chembiol
Rapamycin targetome mining identifies RBBP7 as a druggable epigenetic vulnerability in hepatocellular carcinoma
Gao et al. identify RBBP7 as a rapamycin target that regulates histone H4 acetylation. Guided by this mechanism, they develop RBBP7-targeting peptides that suppress tumor growth and enhance the activity of HDAC inhibitors in liver cancer models.
dlvr.it
September 15, 2026 at 3:30 PM
mapjournals.bsky.social
#Targetome
AI pharmacophore-transcriptomic framework repurposes CBD for ischemic stroke via NRF2/BMAL1-mediated antioxidant and angiogenic effects.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0034
#DrugRepurposing #IschemicStroke
September 19, 2026 at 4:38 AM
travisfaust.bsky.social
Update: a Targetome commentary by Zhao, Agarwal & Bai discusses our Cell paper as part of a broader paradigm of glia–glia coordination—linking microglia–astrocyte signaling in synaptic pruning to cooperative glial mechanisms in processes such as myelination.

www.maxapress.com/article/doi/...
Glial Wnt dialogue controls synapses
www.maxapress.com
December 16, 2025 at 2:03 PM
mapjournals.bsky.social
#Targetome
Peroxisomes drive UCP1-independent heat via FASN-ACOX2 cycle, mmBCFA turnover. Cold redistributes FASN, coupling lipid synthesis to energy burn. 🌡️🔬
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0025-0006
#instaenergy #synthesis #energyburn
December 14, 2025 at 4:55 AM
mapjournals.bsky.social
#Targetome
AI-designed evodiamine derivative 8a targets gp130, halting tumor growth by 56%! Novel indolopyridine offers promising colorectal cancer therapy breakthrough.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0010
#cancertherapy #tumor #therapy
May 17, 2026 at 4:32 AM
mapjournals.bsky.social
#Targetome
New study in Nature Neuroscience reveals Fc effector function is crucial for lecanemab's amyloid clearance in Alzheimer's treatment.🧠✨
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0004
#alzheimer #naturelovers #neuroscience #effector
March 3, 2026 at 5:13 AM
mapjournals.bsky.social
#Targetome
Degradation-based protein profiling (DBPP) leverages PROTAC technology to convert binding events into amplified depletion signals, enabling target ID of elusive natural products.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0019
#DBPP #PROTAC #DrugDiscovery
July 1, 2026 at 12:35 AM
mapjournals.bsky.social
#Targetome
INKT cells uniquely bridge innate/adaptive immunity via CD1d/glycolipid recognition, offering promising off-the-shelf therapy for cancer/infections with low GVHD risk! 🧬💉
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0025-0010
#recognition #therapy #infections
January 30, 2026 at 3:26 AM
newphyt.bsky.social
HTD: a targetome #database for #plant #physiology and regulation in HPPD family

A #Letter by Mei et al. 👇

📖 nph.onlinelibrary.wiley.com/doi/10.1111/...

#LatestIssue
Figure 1: Construction pipelines of HPPD Targetome Database, depicting data collection, data processing, and database implementation.
March 7, 2025 at 4:30 PM
stephanhacker2.bsky.social
Amazing lecture by Hui Ye at #ISCPDD. She talked about her group’s exciting research into target responsive accessibility profiling (TRAP) to characterize the binding sites of covalent and non-covalent protein binders in complex environments using #ChemicalProteomics.
Chemoproteomic mapping of the glycolytic targetome in cancer cells
Nature Chemical Biology - A chemoproteomic approach is developed that examines changes in ligand binding-induced accessibility by globally labeling reactive proteinaceous lysines, revealing the...
www.nature.com
November 24, 2025 at 4:00 PM
mapjournals.bsky.social
#Targetome
Natural products as multi-target graft protectants: pairing nanocarrier delivery with machine perfusion to curb reperfusion injury in donor heart preservation.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0039
#HeartTransplant #GraftPreservation #Nanocarrier
September 17, 2026 at 4:36 AM
stephanhacker2.bsky.social
It will surely be an exciting talk about all of their amazing contributions to mapping cellular targets of small molecules e.g. using target-responsive accessibility profiling (TRAP). www.nature.com/articles/s41...
(2/2)
#ChemSky #ChemBio #ChemPro #ProteoProbes #ChemicalProteomics
Chemoproteomic mapping of the glycolytic targetome in cancer cells - Nature Chemical Biology
A chemoproteomic approach is developed that examines changes in ligand binding-induced accessibility by globally labeling reactive proteinaceous lysines, revealing the cellular targets of glycolytic i...
www.nature.com
June 30, 2026 at 8:53 AM
camronbryant.bsky.social
"New" paper from my lab identifying the baseline and methamphetamine-induced striatal RNA-binding targets of hnRNP H1. Glad to finally have this published! www.sciencedirect.com/science/arti...
The striatal heterogeneous nuclear ribonucleoprotein H1 mRNA targetome associated with methamphetamine administration and behavior
Methamphetamine addiction remains a major public health concern in the United States that has paralleled the opioid epidemic. Psychostimulant use diso…
www.sciencedirect.com
December 29, 2025 at 9:44 PM
transpread.bsky.social
A study published in Targetome reports a multilayered screening and validation strategy that identified CBD and linked its neurovascular protection to NRF2-dependent antioxidant activity and BMAL1-mediated angiogenesis.
#Drug repurposing #Deep learning
Details: doi.org/10.48130/tar...
September 18, 2026 at 3:58 AM
rridrobot.bsky.social
RRIDs were included in this in Cell Chemical Biology paper. RRIDs improve reproducibility in scientific research. #reproducibility #RRID #ReproducibleResearch
Rapamycin targetome mining identifies RBBP7 as a druggable epigenetic vulnerability in hepatocellular carcinoma
Read the full paper: Rapamycin targetome mining identifies RBBP7 as a druggable epigenetic vulnerability in hepatocellular carcinoma
doi.org
September 16, 2026 at 7:40 PM
transpread.bsky.social
A 2026 Targetome study by Xinzhi Wang’s team (China Pharmaceutical University) reports that celastrol suppresses CTSS-dependent autophagy impairment, promotes protective iNKT1 polarization, and reduces cholestasis and fibrosis.
#Mitophagy #Cathepsin S
Details: doi.org/10.48130/tar...
September 17, 2026 at 3:05 PM
melonisevil.bsky.social
In #epitransciptomics, there is a need to measure #RNA-#protein interactions which can be problematic from RNA conformational dynamics.
The in-solution measurement on #NanoTemper Monolith X means biomolecules retain conformations for these studies
#biophysics

www.tandfonline.com/doi/full/10....
Mechanistic studies on HNRNPA2B1 suggest binding but not selective recognition of m6A
HNRNPA2B1 contains two RRM domains and has been investigated for its possible role as an m6A reader protein. The targetome of HNRNPA2B1 was shown to overlap with the m6A methylation motif, but furt...
www.tandfonline.com
March 12, 2026 at 10:21 PM
mapjournals.bsky.social
#Targetome
CLDN18.2 emerges as a promising PDAC therapeutic target, with monoclonal antibodies, bispecific antibodies, CAR-T cell therapy, and antibody-drug conjugates showing clinical progress.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0033
#CLDN18.2 #TargetedTherapy
September 7, 2026 at 12:39 AM
transpread.bsky.social
A study published in Targetome reports that a thermosensitive microparticle-loaded gel sustained treprostinil exposure and improved hemodynamic and structural indicators of PAH in rats.
#Treprostinil #Microparticles
Details: doi.org/10.48130/tar...
August 29, 2026 at 12:52 PM
mapjournals.bsky.social
#Targetome
Cardiac mechanical load suppresses tumor growth via Nesprin-2-mediated LINC complex triggering H3K9me3 loss and growth-inhibitive chromatin remodeling.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0032
#Nesprin2 #MechanicalLoad #EpigeneticRemodeling
August 29, 2026 at 2:03 AM