LIGR-Nue for the global mapping of the bacterial sRNA targetome in vivo https://www.biorxiv.org/content/10.64898/2026.11.09.765264v1
November 11, 2026 at 2:30 AM
LIGR-Nue for the global mapping of the bacterial sRNA targetome in vivo https://www.biorxiv.org/content/10.64898/2026.11.09.765264v1
#Targetome
A target-centered framework unifies CAR-T and TCR-T design across tumor specificity, shareability, abundance, and fitness dependence.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0050
#TCRT #Immunopeptidomics #AntigenEscape
A target-centered framework unifies CAR-T and TCR-T design across tumor specificity, shareability, abundance, and fitness dependence.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0050
#TCRT #Immunopeptidomics #AntigenEscape
November 3, 2026 at 2:36 AM
#Targetome
A target-centered framework unifies CAR-T and TCR-T design across tumor specificity, shareability, abundance, and fitness dependence.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0050
#TCRT #Immunopeptidomics #AntigenEscape
A target-centered framework unifies CAR-T and TCR-T design across tumor specificity, shareability, abundance, and fitness dependence.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0050
#TCRT #Immunopeptidomics #AntigenEscape
#Targetome
Chinese herbal medicine remodels the desmoplastic, immunosuppressive pancreatic tumor microenvironment, suppressing PDAC growth and enhancing efficacy of conventional therapies.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0049
#TumorMicroenvironment #ChineseHerb
Chinese herbal medicine remodels the desmoplastic, immunosuppressive pancreatic tumor microenvironment, suppressing PDAC growth and enhancing efficacy of conventional therapies.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0049
#TumorMicroenvironment #ChineseHerb
October 31, 2026 at 1:45 AM
#Targetome
Chinese herbal medicine remodels the desmoplastic, immunosuppressive pancreatic tumor microenvironment, suppressing PDAC growth and enhancing efficacy of conventional therapies.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0049
#TumorMicroenvironment #ChineseHerb
Chinese herbal medicine remodels the desmoplastic, immunosuppressive pancreatic tumor microenvironment, suppressing PDAC growth and enhancing efficacy of conventional therapies.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0049
#TumorMicroenvironment #ChineseHerb
#Targetome
Reframing MAFLD/MASH as disrupted lipid communication, this review maps organelle crosstalk and extracellular vesicle signaling as targetable nodes beyond neutral lipid accumulation.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0047
#MAFLD #MASH #Lipotoxicity
Reframing MAFLD/MASH as disrupted lipid communication, this review maps organelle crosstalk and extracellular vesicle signaling as targetable nodes beyond neutral lipid accumulation.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0047
#MAFLD #MASH #Lipotoxicity
October 28, 2026 at 3:54 AM
#Targetome
Reframing MAFLD/MASH as disrupted lipid communication, this review maps organelle crosstalk and extracellular vesicle signaling as targetable nodes beyond neutral lipid accumulation.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0047
#MAFLD #MASH #Lipotoxicity
Reframing MAFLD/MASH as disrupted lipid communication, this review maps organelle crosstalk and extracellular vesicle signaling as targetable nodes beyond neutral lipid accumulation.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0047
#MAFLD #MASH #Lipotoxicity
#Targetome
Reframing ischemic stroke as systemic disease, this review maps brain-gut-heart-liver-spleen-lung-kidney crosstalk and proposes combined therapies targeting central and peripheral organs.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0045
#IschemicStroke
Reframing ischemic stroke as systemic disease, this review maps brain-gut-heart-liver-spleen-lung-kidney crosstalk and proposes combined therapies targeting central and peripheral organs.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0045
#IschemicStroke
October 24, 2026 at 2:23 AM
#Targetome
Reframing ischemic stroke as systemic disease, this review maps brain-gut-heart-liver-spleen-lung-kidney crosstalk and proposes combined therapies targeting central and peripheral organs.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0045
#IschemicStroke
Reframing ischemic stroke as systemic disease, this review maps brain-gut-heart-liver-spleen-lung-kidney crosstalk and proposes combined therapies targeting central and peripheral organs.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0045
#IschemicStroke
#Targetome
Claudin-4 identified as the long-sought receptor for Bacteroides fragilis toxin: binding licenses E-cadherin cleavage, and soluble claudin-4 blunts epithelial damage in vivo.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0046
#GutMicrobiota #AntiVirulence
Claudin-4 identified as the long-sought receptor for Bacteroides fragilis toxin: binding licenses E-cadherin cleavage, and soluble claudin-4 blunts epithelial damage in vivo.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0046
#GutMicrobiota #AntiVirulence
October 21, 2026 at 2:20 AM
#Targetome
Claudin-4 identified as the long-sought receptor for Bacteroides fragilis toxin: binding licenses E-cadherin cleavage, and soluble claudin-4 blunts epithelial damage in vivo.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0046
#GutMicrobiota #AntiVirulence
Claudin-4 identified as the long-sought receptor for Bacteroides fragilis toxin: binding licenses E-cadherin cleavage, and soluble claudin-4 blunts epithelial damage in vivo.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0046
#GutMicrobiota #AntiVirulence
#Targetome
H3 receptor trials failed because signaling varies by splice variant, synapse side and brain circuit; the review argues for spatiotemporally precise, not systemic, intervention.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0044
#H3Receptor #Neuropharmacology
H3 receptor trials failed because signaling varies by splice variant, synapse side and brain circuit; the review argues for spatiotemporally precise, not systemic, intervention.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0044
#H3Receptor #Neuropharmacology
October 17, 2026 at 3:09 AM
#Targetome
H3 receptor trials failed because signaling varies by splice variant, synapse side and brain circuit; the review argues for spatiotemporally precise, not systemic, intervention.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0044
#H3Receptor #Neuropharmacology
H3 receptor trials failed because signaling varies by splice variant, synapse side and brain circuit; the review argues for spatiotemporally precise, not systemic, intervention.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0044
#H3Receptor #Neuropharmacology
A study published in Targetome identifies frequent annual exposure to genetically relevant medications and a small core gene set that warrants further evaluation for targeted pharmacogenomic testing.
#Geriatric #Pharmacogenomics
Details: doi.org/10.48130/tar...
#Geriatric #Pharmacogenomics
Details: doi.org/10.48130/tar...
October 15, 2026 at 4:21 PM
A study published in Targetome identifies frequent annual exposure to genetically relevant medications and a small core gene set that warrants further evaluation for targeted pharmacogenomic testing.
#Geriatric #Pharmacogenomics
Details: doi.org/10.48130/tar...
#Geriatric #Pharmacogenomics
Details: doi.org/10.48130/tar...
A study published in Targetome reports that acetylcholine signaling in the dorsal striatum links receptor-mediated neuronal protection with modulation of a striatum–substantia nigra circuit to improve cognitive performance.
#Vascular dementia
Details: doi.org/10.48130/tar...
#Vascular dementia
Details: doi.org/10.48130/tar...
October 15, 2026 at 4:23 PM
A study published in Targetome reports that acetylcholine signaling in the dorsal striatum links receptor-mediated neuronal protection with modulation of a striatum–substantia nigra circuit to improve cognitive performance.
#Vascular dementia
Details: doi.org/10.48130/tar...
#Vascular dementia
Details: doi.org/10.48130/tar...
#Targetome
Monocrotaline's reactive metabolite covalently modifies platelet IP receptor and PTEN, driving pulmonary hypertension; selexipag and rosiglitazone counteract vascular remodeling in rats.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0048
#PyrrolizidineAlkaloids
Monocrotaline's reactive metabolite covalently modifies platelet IP receptor and PTEN, driving pulmonary hypertension; selexipag and rosiglitazone counteract vascular remodeling in rats.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0048
#PyrrolizidineAlkaloids
October 14, 2026 at 5:48 PM
#Targetome
Monocrotaline's reactive metabolite covalently modifies platelet IP receptor and PTEN, driving pulmonary hypertension; selexipag and rosiglitazone counteract vascular remodeling in rats.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0048
#PyrrolizidineAlkaloids
Monocrotaline's reactive metabolite covalently modifies platelet IP receptor and PTEN, driving pulmonary hypertension; selexipag and rosiglitazone counteract vascular remodeling in rats.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0048
#PyrrolizidineAlkaloids
#Targetome
Retrospective analysis: 20.2% of Chinese older adults filled 2+ CPIC level-A drugs yearly; CYP2C19, SLCO1B1, CYP2C9 dominate coverage.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0043
#Pharmacogenomics #Polypharmacy #Geriatrics
Retrospective analysis: 20.2% of Chinese older adults filled 2+ CPIC level-A drugs yearly; CYP2C19, SLCO1B1, CYP2C9 dominate coverage.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0043
#Pharmacogenomics #Polypharmacy #Geriatrics
October 12, 2026 at 6:38 PM
#Targetome
Retrospective analysis: 20.2% of Chinese older adults filled 2+ CPIC level-A drugs yearly; CYP2C19, SLCO1B1, CYP2C9 dominate coverage.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0043
#Pharmacogenomics #Polypharmacy #Geriatrics
Retrospective analysis: 20.2% of Chinese older adults filled 2+ CPIC level-A drugs yearly; CYP2C19, SLCO1B1, CYP2C9 dominate coverage.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0043
#Pharmacogenomics #Polypharmacy #Geriatrics
A study published in Targetome on 11 August 2026 reports that CLP290 improved locomotion and induced coordinated neural and metabolic adaptations without restoring dystrophin expression.
#MDX mice #KCC2
Details: doi.org/10.48130/tar...
#MDX mice #KCC2
Details: doi.org/10.48130/tar...
October 10, 2026 at 2:03 PM
A study published in Targetome on 11 August 2026 reports that CLP290 improved locomotion and induced coordinated neural and metabolic adaptations without restoring dystrophin expression.
#MDX mice #KCC2
Details: doi.org/10.48130/tar...
#MDX mice #KCC2
Details: doi.org/10.48130/tar...
A Targetome study shows both saponin preparations share neuroprotection against ischemic brain injury, yet preferentially target vascular-cytoskeletal and mitochondrial-metabolic pathways, respectively.
#Spatial-seq #Spatial transcriptomics
Details: doi.org/10.48130/tar...
#Spatial-seq #Spatial transcriptomics
Details: doi.org/10.48130/tar...
October 10, 2026 at 10:29 AM
A Targetome study shows both saponin preparations share neuroprotection against ischemic brain injury, yet preferentially target vascular-cytoskeletal and mitochondrial-metabolic pathways, respectively.
#Spatial-seq #Spatial transcriptomics
Details: doi.org/10.48130/tar...
#Spatial-seq #Spatial transcriptomics
Details: doi.org/10.48130/tar...
#Targetome
Huperzine A restores striatal acetylcholine homeostasis and recruits a GABAergic circuit to improve cognition in vascular dementia mice.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0042
#VascularDementia #HuperzineA #NeuralCircuit
Huperzine A restores striatal acetylcholine homeostasis and recruits a GABAergic circuit to improve cognition in vascular dementia mice.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0042
#VascularDementia #HuperzineA #NeuralCircuit
October 8, 2026 at 6:35 PM
#Targetome
Huperzine A restores striatal acetylcholine homeostasis and recruits a GABAergic circuit to improve cognition in vascular dementia mice.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0042
#VascularDementia #HuperzineA #NeuralCircuit
Huperzine A restores striatal acetylcholine homeostasis and recruits a GABAergic circuit to improve cognition in vascular dementia mice.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0042
#VascularDementia #HuperzineA #NeuralCircuit
#Targetome
Immunosenescence destabilizes the bone marrow immune niche in osteoporosis; natural products may reprogram microenvironmental targets.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0040
#Osteoporosis #Immunosenescence #BoneMarrow #NaturalProducts
Immunosenescence destabilizes the bone marrow immune niche in osteoporosis; natural products may reprogram microenvironmental targets.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0040
#Osteoporosis #Immunosenescence #BoneMarrow #NaturalProducts
October 4, 2026 at 10:30 AM
#Targetome
Immunosenescence destabilizes the bone marrow immune niche in osteoporosis; natural products may reprogram microenvironmental targets.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0040
#Osteoporosis #Immunosenescence #BoneMarrow #NaturalProducts
Immunosenescence destabilizes the bone marrow immune niche in osteoporosis; natural products may reprogram microenvironmental targets.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0040
#Osteoporosis #Immunosenescence #BoneMarrow #NaturalProducts
#Targetome
Spatial-seq 2.0 maps how Panax notoginseng versus ginseng saponins differently protect brain regions after acute ischemic stroke.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0038
#Panax #Stroke #SpatialTranscriptomics #Neuroprotection
Spatial-seq 2.0 maps how Panax notoginseng versus ginseng saponins differently protect brain regions after acute ischemic stroke.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0038
#Panax #Stroke #SpatialTranscriptomics #Neuroprotection
October 2, 2026 at 10:22 AM
#Targetome
Spatial-seq 2.0 maps how Panax notoginseng versus ginseng saponins differently protect brain regions after acute ischemic stroke.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0038
#Panax #Stroke #SpatialTranscriptomics #Neuroprotection
Spatial-seq 2.0 maps how Panax notoginseng versus ginseng saponins differently protect brain regions after acute ischemic stroke.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0038
#Panax #Stroke #SpatialTranscriptomics #Neuroprotection
Great talk by Hui Ye at the @chembiotalks.bsky.social!
She talked about the exciting projects of her group using her TRAP platform for the chemoproteomic profiling of ligand-protein interactions using reductive dimethylation.
www.nature.com/articles/s41...
#ChemBioTalks #ChemBio #ChemSky #Science
She talked about the exciting projects of her group using her TRAP platform for the chemoproteomic profiling of ligand-protein interactions using reductive dimethylation.
www.nature.com/articles/s41...
#ChemBioTalks #ChemBio #ChemSky #Science
Chemoproteomic mapping of the glycolytic targetome in cancer cells - Nature Chemical Biology
A chemoproteomic approach is developed that examines changes in ligand binding-induced accessibility by globally labeling reactive proteinaceous lysines, revealing the cellular targets of glycolytic i...
www.nature.com
September 29, 2026 at 11:26 AM
Great talk by Hui Ye at the @chembiotalks.bsky.social!
She talked about the exciting projects of her group using her TRAP platform for the chemoproteomic profiling of ligand-protein interactions using reductive dimethylation.
www.nature.com/articles/s41...
#ChemBioTalks #ChemBio #ChemSky #Science
She talked about the exciting projects of her group using her TRAP platform for the chemoproteomic profiling of ligand-protein interactions using reductive dimethylation.
www.nature.com/articles/s41...
#ChemBioTalks #ChemBio #ChemSky #Science
#Targetome
Respiratory chain complexes as programmable therapeutic nodes: beyond ATP bioenergetics toward context-dependent metabolic reprogramming.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0037
#RespiratoryChain #Mitochondria #MetabolicReprogramming #DrugDiscovery
Respiratory chain complexes as programmable therapeutic nodes: beyond ATP bioenergetics toward context-dependent metabolic reprogramming.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0037
#RespiratoryChain #Mitochondria #MetabolicReprogramming #DrugDiscovery
September 29, 2026 at 5:03 AM
#Targetome
Respiratory chain complexes as programmable therapeutic nodes: beyond ATP bioenergetics toward context-dependent metabolic reprogramming.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0037
#RespiratoryChain #Mitochondria #MetabolicReprogramming #DrugDiscovery
Respiratory chain complexes as programmable therapeutic nodes: beyond ATP bioenergetics toward context-dependent metabolic reprogramming.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0037
#RespiratoryChain #Mitochondria #MetabolicReprogramming #DrugDiscovery
#Targetome
CLP290-mediated KCC2 activation restores gait, inhibitory neurotransmission, and metabolic balance across the neuromuscular axis in dystrophic mice.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0041
#Duchenne #KCC2 #Neuromuscular #Metabolomics
CLP290-mediated KCC2 activation restores gait, inhibitory neurotransmission, and metabolic balance across the neuromuscular axis in dystrophic mice.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0041
#Duchenne #KCC2 #Neuromuscular #Metabolomics
September 27, 2026 at 4:44 AM
#Targetome
CLP290-mediated KCC2 activation restores gait, inhibitory neurotransmission, and metabolic balance across the neuromuscular axis in dystrophic mice.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0041
#Duchenne #KCC2 #Neuromuscular #Metabolomics
CLP290-mediated KCC2 activation restores gait, inhibitory neurotransmission, and metabolic balance across the neuromuscular axis in dystrophic mice.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0041
#Duchenne #KCC2 #Neuromuscular #Metabolomics
#Targetome
An integrated framework unites target fishing, single-cell multi-omics, and AI reasoning into a closed-loop workflow for natural product target discovery.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0036
#TargetFishing #SingleCellOmics #AIDrugDiscovery
An integrated framework unites target fishing, single-cell multi-omics, and AI reasoning into a closed-loop workflow for natural product target discovery.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0036
#TargetFishing #SingleCellOmics #AIDrugDiscovery
September 23, 2026 at 4:41 AM
#Targetome
An integrated framework unites target fishing, single-cell multi-omics, and AI reasoning into a closed-loop workflow for natural product target discovery.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0036
#TargetFishing #SingleCellOmics #AIDrugDiscovery
An integrated framework unites target fishing, single-cell multi-omics, and AI reasoning into a closed-loop workflow for natural product target discovery.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0036
#TargetFishing #SingleCellOmics #AIDrugDiscovery
Epigenetics Update - Rapamycin targetome mining identifies RBBP7 as a druggable epigenetic vulnerability in hepatocellular carcinoma u.epigenome.us/jje91JhP
Bing Shan & Yaoyang Zhang (CAS) in Cell Chemical Biology
#Epigenetics #RBBP7 #Cancer #Rapamycin
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epigenometech.com
Bing Shan & Yaoyang Zhang (CAS) in Cell Chemical Biology
#Epigenetics #RBBP7 #Cancer #Rapamycin
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epigenometech.com
September 22, 2026 at 7:15 AM
Epigenetics Update - Rapamycin targetome mining identifies RBBP7 as a druggable epigenetic vulnerability in hepatocellular carcinoma u.epigenome.us/jje91JhP
Bing Shan & Yaoyang Zhang (CAS) in Cell Chemical Biology
#Epigenetics #RBBP7 #Cancer #Rapamycin
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epigenometech.com
Bing Shan & Yaoyang Zhang (CAS) in Cell Chemical Biology
#Epigenetics #RBBP7 #Cancer #Rapamycin
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epigenometech.com
#Targetome
Cytoskeletal checkpoints, not molecular catalogs, may govern microglial aging: Pfn1 and Arpc4 loss trigger divergent senescence and synaptic deficits.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0035
#Microglia #Cytoskeleton #BrainAging #Dementia
Cytoskeletal checkpoints, not molecular catalogs, may govern microglial aging: Pfn1 and Arpc4 loss trigger divergent senescence and synaptic deficits.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0035
#Microglia #Cytoskeleton #BrainAging #Dementia
September 21, 2026 at 12:28 AM
#Targetome
Cytoskeletal checkpoints, not molecular catalogs, may govern microglial aging: Pfn1 and Arpc4 loss trigger divergent senescence and synaptic deficits.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0035
#Microglia #Cytoskeleton #BrainAging #Dementia
Cytoskeletal checkpoints, not molecular catalogs, may govern microglial aging: Pfn1 and Arpc4 loss trigger divergent senescence and synaptic deficits.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0035
#Microglia #Cytoskeleton #BrainAging #Dementia
#Targetome
AI pharmacophore-transcriptomic framework repurposes CBD for ischemic stroke via NRF2/BMAL1-mediated antioxidant and angiogenic effects.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0034
#DrugRepurposing #IschemicStroke
AI pharmacophore-transcriptomic framework repurposes CBD for ischemic stroke via NRF2/BMAL1-mediated antioxidant and angiogenic effects.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0034
#DrugRepurposing #IschemicStroke
September 19, 2026 at 4:38 AM
#Targetome
AI pharmacophore-transcriptomic framework repurposes CBD for ischemic stroke via NRF2/BMAL1-mediated antioxidant and angiogenic effects.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0034
#DrugRepurposing #IschemicStroke
AI pharmacophore-transcriptomic framework repurposes CBD for ischemic stroke via NRF2/BMAL1-mediated antioxidant and angiogenic effects.
Details: https://www.maxapress.com/article/doi/10.48130/targetome-0026-0034
#DrugRepurposing #IschemicStroke
A study published in Targetome reports a multilayered screening and validation strategy that identified CBD and linked its neurovascular protection to NRF2-dependent antioxidant activity and BMAL1-mediated angiogenesis.
#Drug repurposing #Deep learning
Details: doi.org/10.48130/tar...
#Drug repurposing #Deep learning
Details: doi.org/10.48130/tar...
September 18, 2026 at 3:58 AM
A study published in Targetome reports a multilayered screening and validation strategy that identified CBD and linked its neurovascular protection to NRF2-dependent antioxidant activity and BMAL1-mediated angiogenesis.
#Drug repurposing #Deep learning
Details: doi.org/10.48130/tar...
#Drug repurposing #Deep learning
Details: doi.org/10.48130/tar...
A 2026 Targetome study by Xinzhi Wang’s team (China Pharmaceutical University) reports that celastrol suppresses CTSS-dependent autophagy impairment, promotes protective iNKT1 polarization, and reduces cholestasis and fibrosis.
#Mitophagy #Cathepsin S
Details: doi.org/10.48130/tar...
#Mitophagy #Cathepsin S
Details: doi.org/10.48130/tar...
September 17, 2026 at 3:05 PM
A 2026 Targetome study by Xinzhi Wang’s team (China Pharmaceutical University) reports that celastrol suppresses CTSS-dependent autophagy impairment, promotes protective iNKT1 polarization, and reduces cholestasis and fibrosis.
#Mitophagy #Cathepsin S
Details: doi.org/10.48130/tar...
#Mitophagy #Cathepsin S
Details: doi.org/10.48130/tar...