Excited to share our new paper, now published in Nature Cell Biology! 🎉
We asked a fundamental question in cell biology: How do cells maintain polarity while migrating? Especially how do cancer cells navigate confined spaces?
www.nature.com/articles/s41556-026-01981-1
We asked a fundamental question in cell biology: How do cells maintain polarity while migrating? Especially how do cancer cells navigate confined spaces?
www.nature.com/articles/s41556-026-01981-1
CD44 restricts EGFR mobility to polarize cytoskeletal signalling modules driving bleb-based migration - Nature Cell Biology
Jha et al. show that the transmembrane protein CD44 restricts EGFR mobility to maintain an EGFR–PI3K–Rac gradient during bleb-based cell migration.
www.nature.com
July 7, 2026 at 1:09 PM
Excited to share our new paper, now published in Nature Cell Biology! 🎉
We asked a fundamental question in cell biology: How do cells maintain polarity while migrating? Especially how do cancer cells navigate confined spaces?
www.nature.com/articles/s41556-026-01981-1
We asked a fundamental question in cell biology: How do cells maintain polarity while migrating? Especially how do cancer cells navigate confined spaces?
www.nature.com/articles/s41556-026-01981-1
Trying something new: For our recent preprint:
Fast label-free live imaging reveals key roles of flow dynamics and CD44-HA interaction in cancer cell arrest on endothelial monolayers
www.biorxiv.org/content/10.1...
I made an online presentation:
www.beautiful.ai/player/-ODGe...
Fast label-free live imaging reveals key roles of flow dynamics and CD44-HA interaction in cancer cell arrest on endothelial monolayers
www.biorxiv.org/content/10.1...
I made an online presentation:
www.beautiful.ai/player/-ODGe...
Fast label-free live imaging reveals key roles of flow dynamics and CD44-HA interaction in cancer cell arrest on endothelial monolayers
Get started with Beautiful.ai today.
www.beautiful.ai
December 4, 2024 at 12:36 PM
Trying something new: For our recent preprint:
Fast label-free live imaging reveals key roles of flow dynamics and CD44-HA interaction in cancer cell arrest on endothelial monolayers
www.biorxiv.org/content/10.1...
I made an online presentation:
www.beautiful.ai/player/-ODGe...
Fast label-free live imaging reveals key roles of flow dynamics and CD44-HA interaction in cancer cell arrest on endothelial monolayers
www.biorxiv.org/content/10.1...
I made an online presentation:
www.beautiful.ai/player/-ODGe...
Nature research paper: Fibroblastic reticular cells direct the initiation of T cell responses via CD44
go.nature.com/4qxGBXl
go.nature.com/4qxGBXl
Fibroblastic reticular cells direct the initiation of T cell responses via CD44 - Nature
CD44 expressed by fibroblastic reticular cells in secondary lymphoid organs regulates trafficking of dendritic cells, and thus has an essential role in the priming of T cells and the adaptive immune response.
go.nature.com
January 27, 2026 at 9:08 AM
Nature research paper: Fibroblastic reticular cells direct the initiation of T cell responses via CD44
go.nature.com/4qxGBXl
go.nature.com/4qxGBXl
CD44 links glial activation to metabolic dysfunction in Alzheimer's disease
www.sciencedirect.com
September 21, 2026 at 6:25 AM
CD44 links glial activation to metabolic dysfunction in Alzheimer's disease
This is interesting, when CD44 pulls in hyaluronan, it can also bring in bound iron, increasing intracellular iron, which may then reinforce CD44 expression.
CD44 regulates epigenetic plasticity by mediating iron endocytosis - Nature Chemistry
CD44 is a cell-surface adhesion receptor associated with many biological processes that rely on cellular plasticity. Now, CD44 has been shown to mediate endocytosis of iron-bound hyaluronates. Further...
www.nature.com
May 10, 2026 at 8:33 AM
This is interesting, when CD44 pulls in hyaluronan, it can also bring in bound iron, increasing intracellular iron, which may then reinforce CD44 expression.
RESEARCH | Guo, Li, Wu et al.(Soochow U)
A signaling axis promoting glycolysis in colorectal cancer cells, driving extracellular lactylation of CD44 & impairing T cell anti-tumor action🧪
A signaling axis promoting glycolysis in colorectal cancer cells, driving extracellular lactylation of CD44 & impairing T cell anti-tumor action🧪
Extracellular CD44 lactylation impairs CD8+ T cell function in KRAS-mutant colorectal cancer - Nature Metabolism
TRIP6 phosphorylation triggers a signalling cascade that promotes glycolysis in KRAS-mutant colorectal cancer cells. The resulting lactate accumulation drives extracellular lactylation of CD44 on CD8⁺ T cells, thereby compromising their anti-tumour activity.
dlvr.it
May 10, 2026 at 6:02 PM
RESEARCH | Guo, Li, Wu et al.(Soochow U)
A signaling axis promoting glycolysis in colorectal cancer cells, driving extracellular lactylation of CD44 & impairing T cell anti-tumor action🧪
A signaling axis promoting glycolysis in colorectal cancer cells, driving extracellular lactylation of CD44 & impairing T cell anti-tumor action🧪
A new #ScienceImmunology study demonstrates that T helper 17 cells upregulate CD44 and S1PR4 to transform into disease-promoting exTH17 cells in the synovium, which matches findings from human patients with rheumatoid arthritis. https://scim.ag/4nH90bi
TH17 cells converted into exTH17 cells sustain rheumatoid-like IL-17–independent inflammatory arthritis
ExTH17 cells drive IL-17–independent chronic SKG arthritis in mice through up-regulation of CD44 and S1PR4 and cross-talk with FLS.
scim.ag
November 12, 2025 at 8:47 PM
A new #ScienceImmunology study demonstrates that T helper 17 cells upregulate CD44 and S1PR4 to transform into disease-promoting exTH17 cells in the synovium, which matches findings from human patients with rheumatoid arthritis. https://scim.ag/4nH90bi
Fibroblastic reticular cells direct the initiation of T cell responses via CD44 @nature.com @the-de-lab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
January 21, 2026 at 6:06 PM
Fibroblastic reticular cells direct the initiation of T cell responses via CD44 @nature.com @the-de-lab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
CD44枚売って1,250円。積み重ね大事。なんせ元々300枚近くあった訳やしな。
September 21, 2025 at 6:02 AM
CD44枚売って1,250円。積み重ね大事。なんせ元々300枚近くあった訳やしな。
☕Jha et al. show that the transmembrane protein CD44 restricts EGFR mobility to maintain an EGFR–PI3K–Rac gradient during bleb-based cell migration.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
CD44 restricts EGFR mobility to polarize cytoskeletal signalling modules driving bleb-based migration - Nature Cell Biology
Jha et al. show that the transmembrane protein CD44 restricts EGFR mobility to maintain an EGFR–PI3K–Rac gradient during bleb-based cell migration.
www.nature.com
July 29, 2026 at 1:28 PM
☕Jha et al. show that the transmembrane protein CD44 restricts EGFR mobility to maintain an EGFR–PI3K–Rac gradient during bleb-based cell migration.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
CD44 is involved in cell adhesion, migration & signaling.
It is key in inflammation and immune diseases & cancer.
Good news: most commercial CD44 antibodies are highly specific and work well for:
• Western blot
• Immunofluorescence
• Flow cytometry
Full report: zenodo.org/records/1562...
It is key in inflammation and immune diseases & cancer.
Good news: most commercial CD44 antibodies are highly specific and work well for:
• Western blot
• Immunofluorescence
• Flow cytometry
Full report: zenodo.org/records/1562...
November 14, 2025 at 8:06 AM
CD44 is involved in cell adhesion, migration & signaling.
It is key in inflammation and immune diseases & cancer.
Good news: most commercial CD44 antibodies are highly specific and work well for:
• Western blot
• Immunofluorescence
• Flow cytometry
Full report: zenodo.org/records/1562...
It is key in inflammation and immune diseases & cancer.
Good news: most commercial CD44 antibodies are highly specific and work well for:
• Western blot
• Immunofluorescence
• Flow cytometry
Full report: zenodo.org/records/1562...
昨日、ポストにムソルグスキー『禿山の一夜』が流れてきてたので聴いてる。
リムスキー・コルサコフ編曲、ゲオルグ・ショルティ指揮ロンドン響、1966年キングズウェイ・ホール、ジョン・カルショウ（プロデューサー）、ゴードン・パリー，ケネス・ウィルキンソン（録音エンジニア）
リムスキー・コルサコフ編曲、ゲオルグ・ショルティ指揮ロンドン響、1966年キングズウェイ・ホール、ジョン・カルショウ（プロデューサー）、ゴードン・パリー，ケネス・ウィルキンソン（録音エンジニア）
August 25, 2024 at 6:24 AM
昨日、ポストにムソルグスキー『禿山の一夜』が流れてきてたので聴いてる。
リムスキー・コルサコフ編曲、ゲオルグ・ショルティ指揮ロンドン響、1966年キングズウェイ・ホール、ジョン・カルショウ（プロデューサー）、ゴードン・パリー，ケネス・ウィルキンソン（録音エンジニア）
リムスキー・コルサコフ編曲、ゲオルグ・ショルティ指揮ロンドン響、1966年キングズウェイ・ホール、ジョン・カルショウ（プロデューサー）、ゴードン・パリー，ケネス・ウィルキンソン（録音エンジニア）
RBPs redefine #RheumatoidArthritis (RA) pathogenesis.
Dysregulated RBPs drive splicing changes and enhanced FN1 CD44/CXCL12 CXCR4 signaling in RA #fibroblasts, offering new therapeutic targets. #medsky #Rheumatology
#AMM #OpenAccess: doi.org/10.15212/AMM...
Dysregulated RBPs drive splicing changes and enhanced FN1 CD44/CXCL12 CXCR4 signaling in RA #fibroblasts, offering new therapeutic targets. #medsky #Rheumatology
#AMM #OpenAccess: doi.org/10.15212/AMM...
September 23, 2026 at 4:22 PM
RBPs redefine #RheumatoidArthritis (RA) pathogenesis.
Dysregulated RBPs drive splicing changes and enhanced FN1 CD44/CXCL12 CXCR4 signaling in RA #fibroblasts, offering new therapeutic targets. #medsky #Rheumatology
#AMM #OpenAccess: doi.org/10.15212/AMM...
Dysregulated RBPs drive splicing changes and enhanced FN1 CD44/CXCL12 CXCR4 signaling in RA #fibroblasts, offering new therapeutic targets. #medsky #Rheumatology
#AMM #OpenAccess: doi.org/10.15212/AMM...
.🧬We looked for a CD44:SLC1A2 fusion in breast cancer. The data said no. Instead of shelving it, we published.
📢 Now out in @SpringerNature MCB: link.springer.com/article/10.1...
Negative results matter. Transparency matters. Proud of this one 🥳! #OpenScience
📢 Now out in @SpringerNature MCB: link.springer.com/article/10.1...
Negative results matter. Transparency matters. Proud of this one 🥳! #OpenScience
CD44 and SLC1A2 are commonly regulated but do not form a fusion transcript in ER+ breast cancer - Molecular and Cellular Biochemistry
Endocrine therapy (ET) is essential for managing ER+ HER2− breast cancer; however, resistance remains a significant clinical challenge. This study investigated whether CD44-SLC1A2 gene fusions, report...
link.springer.com
May 24, 2025 at 9:21 AM
.🧬We looked for a CD44:SLC1A2 fusion in breast cancer. The data said no. Instead of shelving it, we published.
📢 Now out in @SpringerNature MCB: link.springer.com/article/10.1...
Negative results matter. Transparency matters. Proud of this one 🥳! #OpenScience
📢 Now out in @SpringerNature MCB: link.springer.com/article/10.1...
Negative results matter. Transparency matters. Proud of this one 🥳! #OpenScience
CD44 and Ezrin restrict EGF receptor mobility to generate a novel spatial arrangement of cytoskeletal signaling modules driving bleb-based migration https://www.biorxiv.org/content/10.1101/2024.12.31.630838v1
January 1, 2025 at 8:30 PM
CD44 and Ezrin restrict EGF receptor mobility to generate a novel spatial arrangement of cytoskeletal signaling modules driving bleb-based migration https://www.biorxiv.org/content/10.1101/2024.12.31.630838v1
1/ An idea I'm kicking around:
The inhibitory neuron produces a large HMW-HA pericellular coat.
Astrocytes bind the HA coat through CD44 receptors.
The astrocyte mechanically probes the HA matrix through CD44.
The inhibitory neuron produces a large HMW-HA pericellular coat.
Astrocytes bind the HA coat through CD44 receptors.
The astrocyte mechanically probes the HA matrix through CD44.
March 13, 2026 at 8:20 AM
1/ An idea I'm kicking around:
The inhibitory neuron produces a large HMW-HA pericellular coat.
Astrocytes bind the HA coat through CD44 receptors.
The astrocyte mechanically probes the HA matrix through CD44.
The inhibitory neuron produces a large HMW-HA pericellular coat.
Astrocytes bind the HA coat through CD44 receptors.
The astrocyte mechanically probes the HA matrix through CD44.
ITGB1/FERMT1 mechanoactivation enhances CD44 characteristic stemness in oral squamous cell carcinoma via ubiquitin-dependent CK1α degradation
www.nature.com/articles/s41...
www.nature.com/articles/s41...
ITGB1/FERMT1 mechanoactivation enhances CD44 characteristic stemness in oral squamous cell carcinoma via ubiquitin-dependent CK1α degradation - Oncogene
Oncogene - ITGB1/FERMT1 mechanoactivation enhances CD44 characteristic stemness in oral squamous cell carcinoma via ubiquitin-dependent CK1α degradation
www.nature.com
March 15, 2025 at 8:30 AM
ITGB1/FERMT1 mechanoactivation enhances CD44 characteristic stemness in oral squamous cell carcinoma via ubiquitin-dependent CK1α degradation
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Fantastic new paper from @the-de-lab.bsky.social showing how the CMV m11 protein drives immune evasion by blocking CD44-dependent, FRC-mediated DC migration in the spleen, ultimately dampening antiviral CD8⁺ T cell priming @monashuniversity.bsky.social www.nature.com/articles/s41...
Fibroblastic reticular cells direct the initiation of T cell responses via CD44 - Nature
CD44 expressed by fibroblastic reticular cells in secondary lymphoid organs regulates trafficking of dendritic cells, and thus has an essential role in the priming of T cells and the adaptive immune r...
www.nature.com
January 23, 2026 at 4:03 AM
Fantastic new paper from @the-de-lab.bsky.social showing how the CMV m11 protein drives immune evasion by blocking CD44-dependent, FRC-mediated DC migration in the spleen, ultimately dampening antiviral CD8⁺ T cell priming @monashuniversity.bsky.social www.nature.com/articles/s41...
Function | New Article Alert! 🚨 #Endothelial #CD44 cleavage by #ADAM17 impairs shear stress #mechanotransduction. https://ow.ly/5lMX50Z83pg #T2D
June 10, 2026 at 1:30 PM
Function | New Article Alert! 🚨 #Endothelial #CD44 cleavage by #ADAM17 impairs shear stress #mechanotransduction. https://ow.ly/5lMX50Z83pg #T2D
This is a cool paper
"The targeting of CD44 by CMV reveals CD44 as a molecule that is essential to the functioning of the FRC network and uncovers a previously unrecognized stroma-based mechanism that is critical for the generation of effective T cell responses." #Immunology
"The targeting of CD44 by CMV reveals CD44 as a molecule that is essential to the functioning of the FRC network and uncovers a previously unrecognized stroma-based mechanism that is critical for the generation of effective T cell responses." #Immunology
Fibroblastic reticular cells direct the initiation of T cell responses via CD44 - Nature
CD44 expressed by fibroblastic reticular cells in secondary lymphoid organs regulates trafficking of dendritic cells, and thus has an essential role in the priming of T cells and the adaptive immune r...
www.nature.com
January 22, 2026 at 2:43 PM
This is a cool paper
"The targeting of CD44 by CMV reveals CD44 as a molecule that is essential to the functioning of the FRC network and uncovers a previously unrecognized stroma-based mechanism that is critical for the generation of effective T cell responses." #Immunology
"The targeting of CD44 by CMV reveals CD44 as a molecule that is essential to the functioning of the FRC network and uncovers a previously unrecognized stroma-based mechanism that is critical for the generation of effective T cell responses." #Immunology
El Mundo: 'Russia pronta ad attacchi con droni dal mare in Italia, Francia e Spagna'...
https://www.ansa.it/sito/notizie/mondo/2026/09/24/el-mundo-russia-pronta-ad-attacchi-con-droni-dal-mare-in-italia-francia_f3970154-cd44-45da-9d7a-0f7ce91c9725.html
https://www.ansa.it/sito/notizie/mondo/2026/09/24/el-mundo-russia-pronta-ad-attacchi-con-droni-dal-mare-in-italia-francia_f3970154-cd44-45da-9d7a-0f7ce91c9725.html
September 24, 2026 at 8:10 AM
El Mundo: 'Russia pronta ad attacchi con droni dal mare in Italia, Francia e Spagna'...
https://www.ansa.it/sito/notizie/mondo/2026/09/24/el-mundo-russia-pronta-ad-attacchi-con-droni-dal-mare-in-italia-francia_f3970154-cd44-45da-9d7a-0f7ce91c9725.html
https://www.ansa.it/sito/notizie/mondo/2026/09/24/el-mundo-russia-pronta-ad-attacchi-con-droni-dal-mare-in-italia-francia_f3970154-cd44-45da-9d7a-0f7ce91c9725.html
El Mundo: 'Russia pronta ad attacchi con droni dal mare in Italia, Francia e Spagna'...
https://www.ansa.it/sito/notizie/mondo/2026/09/24/el-mundo-russia-pronta-ad-attacchi-con-droni-dal-mare-in-italia-francia_f3970154-cd44-45da-9d7a-0f7ce91c9725.html
https://www.ansa.it/sito/notizie/mondo/2026/09/24/el-mundo-russia-pronta-ad-attacchi-con-droni-dal-mare-in-italia-francia_f3970154-cd44-45da-9d7a-0f7ce91c9725.html
September 24, 2026 at 5:25 AM
El Mundo: 'Russia pronta ad attacchi con droni dal mare in Italia, Francia e Spagna'...
https://www.ansa.it/sito/notizie/mondo/2026/09/24/el-mundo-russia-pronta-ad-attacchi-con-droni-dal-mare-in-italia-francia_f3970154-cd44-45da-9d7a-0f7ce91c9725.html
https://www.ansa.it/sito/notizie/mondo/2026/09/24/el-mundo-russia-pronta-ad-attacchi-con-droni-dal-mare-in-italia-francia_f3970154-cd44-45da-9d7a-0f7ce91c9725.html
Whenever we’ve run them the answer is always CD44…
November 15, 2024 at 1:47 PM
Whenever we’ve run them the answer is always CD44…
AGD1/USP10/METTL13 complexes enhance cancer stem cells proliferation and diminish the therapeutic effect of docetaxel via CD44 m6A modification in castration resistant #ProstateCancer
jeccr.biomedcentral.com/articles/10....
jeccr.biomedcentral.com/articles/10....
AGD1/USP10/METTL13 complexes enhance cancer stem cells proliferation and diminish the therapeutic effect of docetaxel via CD44 m6A modification in castration resistant prostate cancer - Journal of Exp...
Background Most patients with prostate cancer inevitably progress to castration-resistant prostate cancer (CRPC), at which stage chemotherapeutics like docetaxel become the first-line treatment. Howev...
jeccr.biomedcentral.com
January 21, 2025 at 11:56 AM
AGD1/USP10/METTL13 complexes enhance cancer stem cells proliferation and diminish the therapeutic effect of docetaxel via CD44 m6A modification in castration resistant #ProstateCancer
jeccr.biomedcentral.com/articles/10....
jeccr.biomedcentral.com/articles/10....