#ComputationalOncology
LightNews LightNews
pranavgundla.bsky.social
Fantastic talk at the West German Cancer Center in Essen hosted by @ekocakavuk.bsky.social Had a great discussion with @roelverhaak.bsky.social about my project—gained valuable insights and feedback. Excited to keep pushing forward! #CancerResearch #ComputationalOncology
ekocakavuk.bsky.social Emre Kocakavuk @ekocakavuk.bsky.social · Feb 4
What an absolute pleasure to host my mentor @roelverhaak.bsky.social at our West German Cancer Center in Essen today. Fantastic talk in a packed room on #WorldCancerDay2025.
February 5, 2025 at 2:08 PM
carmonasfj.bsky.social
Open call for a Junior Group Leader position in #ComputationalOncology at Vall d'Hebron Institute of Oncology (VHIO) @vhio.bsky.social.

See details below and consider applying jobs.vhio.net/en/jobs/5412... #CancerResearch
2024-081-01 Junior Group Leader - VHIO
Under the leadership of Josep Tabernero, VHIO is an internationally recognized cancer center. Its multidisciplinary, collaborative model drives scientific progress and innovative cancer treatments.
jobs.vhio.net
January 9, 2025 at 6:38 PM
alicefrolov.bsky.social
Copy-Number Signature Architecture of Chromosomal Instability

#CancerGenomics #ChromosomalInstability #CopyNumberSignatures #MutationalSignatures #GenomeInstability #ComputationalOncology #Bioinformatics #DataVisualization
Copy-Number Signature Architecture of Chromosomal Instability I am sharing a visualization summarizing the relative contribution of 11 copy-number (CN) signatures associated with chromosomal instability (CIN) across a pan-cancer cohort. I want to state explicitly at the outset that the underlying data are simulated. The figure is not derived from a specific patient dataset; rather, it is constructed to illustrate a literature-grounded trend consistent with published CIN signature frameworks, and should be interpreted as a conceptual rather than empirical result. The plot adopts a radar bar-style format, with each of the 11 CIN signatures rendered as an angular segment whose radial length encodes its mean relative activity across the simulated cohort. This layout was chosen to emphasize the compositional structure of CIN etiologies within a single sample space, allowing simultaneous inspection of dominant and subdominant signature contributions. Mechanistically, these signatures are intended to reflect distinct genomic scars: impaired homologous recombination and replication stress producing tandem duplications and focal amplifications, defective mitotic segregation and whole-genome doubling generating chromosome-arm and whole-chromosome copy-number changes, and breakage-fusion-bridge cycles yielding characteristic segment-size and copy-number jump distributions. The simulated architecture recapitulates the expected skew, with a small number of signatures accounting for the majority of aggregate activity while lower-frequency signatures capture ecDNA-associated amplification and chromothripsis-like patterns. I offer this figure primarily as a communication and pedagogical aid for discussing how CN feature distributions - segment size, breakpoint count, copy-number state, and change-point magnitude - are decomposed into interpretable components.
August 19, 2026 at 10:52 PM
alicefrolov.bsky.social
Sharing a visualization from our ongoing modeling work on intratumoral oxygen dynamics and the HIF-1α-driven transcriptional response.

#TumorHypoxia #HIF1alpha #TumorMicroenvironment #Angiogenesis #OxygenSensing #VEGF #ComputationalOncology #CancerMetabolism
Sharing a visualization from our ongoing modeling work on intratumoral oxygen dynamics and the HIF-1α-driven transcriptional response. Figure: "Oxygen tension collapse drives coordinated hypoxia-angiogenesis program across the tumor radius" Subtitle: "Simulated intratumoral pO₂ gradient from vessel wall to necrotic core with HIF-target activation" The figure uses a horizon-style stacked area representation (layered oxygen-gradient contour strip) to render pO₂ as a function of radial distance from the perfused vessel wall toward the necrotic core. Each contour band encodes a discrete oxygen tension interval, with marker overlays indicating the activation thresholds of canonical HIF-1α target loci. I want to emphasize that the underlying data are simulated; the parameterization reflects diffusion-limited oxygen distributions consistent with published Krogh-cylinder estimates and the well-characterized ~100–200 µm diffusion limit. The central observation is the coordinated character of the transcriptional program along the radial axis. Proximal to the vessel wall, pO₂ remains above the threshold for prolyl hydroxylase domain (PHD/EGLN) activity, sustaining VHL-mediated HIF-1α degradation. As oxygen tension declines toward the intermediate perinecrotic zone, PHD activity becomes substrate-limited, HIF-1α escapes hydroxylation and proteasomal turnover, and it accumulates to drive HRE-dependent transcription. The marker overlays illustrate the staggered engagement of glycolytic effectors (SLC2A1, LDHA), pH-regulatory targets (CA9), and pro-angiogenic signaling (VEGFA) as the gradient steepens. The horizon-strip format was chosen deliberately to compress the steep radial pO₂ decay into a legible vertical encoding while preserving the coincidence between tension thresholds and target activation.
September 14, 2026 at 5:03 PM
sanoscience.bsky.social
Why haven’t we beaten cancer yet?
In the 4th episode of Twin Things Podcast, Dominik Czaplicki talks about cancer as an evolving ecosystem and the growing role of computational oncology.
🦻 www.youtube.com/watch?v=r6vc... #TwinThingsPodcast #computationaloncology #cancerresearch #digitaltwins
May 15, 2026 at 11:01 AM
iscb.bsky.social
Explore October's #ISCB Career Compass newsletter, including a featured #postdoc researcher opportunity in #computationaloncology, and an article on navigating workplace dynamics!

🧭Read more here: https://f.mtr.cool/xhlvdgnvuo
October 8, 2025 at 12:03 PM