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Nature Reviews Clinical Oncology, Published online: 21 September 2026; doi:10.1038/s41571-026-01203-5The extracellular matrix (ECM) has a role in all aspects of cancer progression and thus provides a rich source of potential tumour biomarkers and therapeutic targets. Nonetheless, early efforts at clinical translation have failed to provide ECM-specific clinical tools or therapies. In this Review, the authors describe novel technologies and how these are being leveraged to better inform our understanding of the role of the ECM in cancer development and progression as well as how this new knowledge and capabilities might lead to novel biomarkers and/or ECM-targeting therapies.

BRD2, via its ET tail, impairs iPSC generation in early reprogramming by maintaining the somatic transcription, especially, the somatic matrisome program, and by suppressing lipid biosynthesis. Lipid ...

The extracellular matrix (ECM) is a dynamic, complex network of proteins, collectively known as the 'matrisome’, which not only provides essential structural support to cells and tissues but also regu...

Spectrométrie de Masse Biologique et Protéomique/Biological Mass Spectrometry and Proteomics

Human cortical development involves dynamic changes in matrisome gene expression across cell types and developmental stages. Here, authors show that these changes reveal links to neurodevelopmental di...