#LandmarkRevisit

Deep learning enables genetic analysis of the human thoracic aorta

Still fascinated by the aortic diameter gene lists🤠generated by @jamespirruccello.com

#NatGenet 2022
www.nature.com/articles/s41...

SVIL/archvillin in SMC

#JCellSci 2004
journals.biologists.com/jcs/article/...

#LandmarkRevisit
#Zebrafish

Endothelial TGFβ signaling instructs #SmoothMuscleCell development in the cardiac outflow tract (& ventral, not dorsal, aorta)

alk5-/-🐟▶️ OFT dilation & endothelial leakage (& rupture)

EC Matrisome governs SMC organization

#eLife 2022
elifesciences.org/articles/57603