Karamanos, N. K. et al. A guide to the composition and functions of the extracellular matrix. FEBS J. 288, 6850–6912 (2021). Sahai, E. et al. A framework for advancing our understanding of cancer-associated fibroblasts. Nat. Rev. Cancer 20, 174–186 (2020). Kessenbrock, K., Plaks, V. & Werb, Z. Matrix metalloproteinases: regulators of the tumor microenvironment. Cell 141, 52–67 (2010). Anastassiades, O. T. & Pryce, D. M. Fibrosis as in indication of time in infiltrating breast cancer and its importance in prognosis. Br. J. Cancer 29, 232–239 (1974). Halvorsen, T. B. & Seim, E. Association between invasiveness, inflammatory reaction, desmoplasia and survival in colorectal cancer. J. Clin. Pathol. 42, 162–166 (1989). Barsky, S. H., Rao, C. N., Grotendorst, G. R. & Liotta, L. A. Increased content of type V collagen in desmoplasia of human breast carcinoma. Am. J. Pathol. 108, 276–283 (1982). Shimosato, Y. et al. Prognostic implications of fibrotic focus (scar) in small peripheral lung cancers. Am. J. Surg. Pathol. 4, 365–373 (1980). Winer, A., Adams, S. & Mignatti, P. Matrix metalloproteinase inhibitors in cancer therapy: turning past failures into future successes. Mol. Cancer Ther. 17, 1147–1155 (2018). Sparano, J. A. et al. Randomized phase III trial of marimastat versus placebo...

Nature Reviews Clinical Oncology, Published online: 21 September 2026; doi:10.1038/s41571-026-01203-5The extracellular matrix (ECM) has a role in all aspects of cancer progression and thus provides a rich source of potential tumour biomarkers and therapeutic targets. Nonetheless, early efforts at clinical translation have failed to provide ECM-specific clinical tools or therapies. In this Review, the authors describe novel technologies and how these are being leveraged to better inform our understanding of the role of the ECM in cancer development and progression as well as how this new knowledge and capabilities might lead to novel biomarkers and/or ECM-targeting therapies.

BRD2, via its ET tail, impairs iPSC generation in early reprogramming by maintaining the somatic transcription, especially, the somatic matrisome program, and by suppressing lipid biosynthesis. Lipid ...

Background The terms “regeneration” and “rejuvenation” in aesthetic medicine are used without standardized evidentiary criteria. This review quantified the gap between regenera...

The extracellular matrix (ECM) is a dynamic, complex network of proteins, collectively known as the 'matrisome’, which not only provides essential structural support to cells and tissues but also regu...

Spectrométrie de Masse Biologique et Protéomique/Biological Mass Spectrometry and Proteomics

Human cortical development involves dynamic changes in matrisome gene expression across cell types and developmental stages. Here, authors show that these changes reveal links to neurodevelopmental di...

Due to its limited symptoms, high-grade serous ovarian cancer (HGSOC) has frequently metastasized extensively throughout the peritoneal cavity prior to its diagnosis, resulting in an overall five-year...

The extracellular matrix (ECM) is made up of hundreds of proteins, including structural core ‘matrisome’ proteins, factors that associate with and regulate ECM architecture and dynamics, and ECM recep...

12 December 2024 - 3pm CET (8am US central / 2pm UK)- on Zoom Title: "The Matrisome Project: Tools and Resource to advance ECM research" Speaker: Assoc. Professor Alexandra Naba, University of Illinoi...