We are proud to be a founding contributor to lipidinteractome.org, a repository developed by @tafesselab.bsky.social & Schultz lab to increase accessibility to proteomics data from multi-functionalized lipid analogs! Check out the website & preprint: arxiv.org/abs/2507.23101 #lipidtime
The Lipid Interactome Repository – Lipid Interactome Repository
lipidinteractome.org
August 5, 2025 at 1:06 PM
We are proud to be a founding contributor to lipidinteractome.org, a repository developed by @tafesselab.bsky.social & Schultz lab to increase accessibility to proteomics data from multi-functionalized lipid analogs! Check out the website & preprint: arxiv.org/abs/2507.23101 #lipidtime
Mapping and engineering the human cell–cell interactome - @uclasamueli.bsky.social www.nature.com/articles/s41...
Mapping and engineering the human cell–cell interactome - Nature Biotechnology
Di Carlo and colleagues discuss technologies required to map and engineer the human cell–cell interactome and the therapeutic avenues such an atlas could unlock.
www.nature.com
June 24, 2026 at 3:47 PM
Mapping and engineering the human cell–cell interactome - @uclasamueli.bsky.social www.nature.com/articles/s41...
We have started a project trying to predic the interactions/structures of all yeast protein pairs using an AlphaFold pooling approach. We are making the current dataset open and we welcome collaborations.
www.evocellnet.com/2026/03/mapp...
www.evocellnet.com/2026/03/mapp...
Mapping the yeast atructural interactome with AlphaFold3: an open call for collaboration
We are excited to announce the early-stage release of our S. cerevisiae structural interactome mapping project. Using AlphaFold3 (AF3), w...
www.evocellnet.com
March 4, 2026 at 10:36 AM
We have started a project trying to predic the interactions/structures of all yeast protein pairs using an AlphaFold pooling approach. We are making the current dataset open and we welcome collaborations.
www.evocellnet.com/2026/03/mapp...
www.evocellnet.com/2026/03/mapp...
Our paper on The Lipid Interactome is now published, and the database is open:
lipidinteractome.org
@ohsummi.bsky.social @ohsunews.bsky.social
@nadlerlab.bsky.social @jeremybaskin.bsky.social
Please RT to spread the word.
doi.org/10.1093/bioi...
The Lipid Interactome: an interactive and open access platform for exploring cellular lipid–protein interactions
AbstractSummary. Lipid–protein interactions play essential roles in cellular signaling and membrane dynamics, yet their systematic characterization has lon
doi.org
February 24, 2026 at 2:41 PM
Our paper on The Lipid Interactome is now published, and the database is open:
lipidinteractome.org
@ohsummi.bsky.social @ohsunews.bsky.social
@nadlerlab.bsky.social @jeremybaskin.bsky.social
Please RT to spread the word.
doi.org/10.1093/bioi...
Proteome-wide identification of the druggable CRBN interactome - @labthoma.bsky.social @fmiscience.bsky.social www.nature.com/articles/s41...
Proteome-wide identification of the druggable CRBN interactome - Nature Biotechnology
The latent interactions of molecular glue degraders are identified proteome-wide.
www.nature.com
August 13, 2026 at 2:53 PM
Proteome-wide identification of the druggable CRBN interactome - @labthoma.bsky.social @fmiscience.bsky.social www.nature.com/articles/s41...
I am excited to share some of my PhD work on the motile cilia interactome revealed by XL/MS with @jbwallingford.bsky.social @edwardmarcotte.bsky.social Ophelia Papoulas, Chanjae Lee, David Taylor, and @builab.bsky.social www.cell.com/developmenta...
December 16, 2024 at 2:44 PM
I am excited to share some of my PhD work on the motile cilia interactome revealed by XL/MS with @jbwallingford.bsky.social @edwardmarcotte.bsky.social Ophelia Papoulas, Chanjae Lee, David Taylor, and @builab.bsky.social www.cell.com/developmenta...
[Resources]
#AlphaFold protein and PPI prediction databases
1️⃣ Predictomes (genome maintenance & H2A/H2b) predictomes.org
2️⃣ Flypredictome www.flyrnai.org/tools/fly_pr...
3️⃣ Human interactome prodata.swmed.edu/humanPPI
4️⃣ BFVD (viral proteins) bfvd.steineggerlab.workers.dev
1/2
#AlphaFold protein and PPI prediction databases
1️⃣ Predictomes (genome maintenance & H2A/H2b) predictomes.org
2️⃣ Flypredictome www.flyrnai.org/tools/fly_pr...
3️⃣ Human interactome prodata.swmed.edu/humanPPI
4️⃣ BFVD (viral proteins) bfvd.steineggerlab.workers.dev
1/2
July 30, 2025 at 11:25 AM
[Resources]
#AlphaFold protein and PPI prediction databases
1️⃣ Predictomes (genome maintenance & H2A/H2b) predictomes.org
2️⃣ Flypredictome www.flyrnai.org/tools/fly_pr...
3️⃣ Human interactome prodata.swmed.edu/humanPPI
4️⃣ BFVD (viral proteins) bfvd.steineggerlab.workers.dev
1/2
#AlphaFold protein and PPI prediction databases
1️⃣ Predictomes (genome maintenance & H2A/H2b) predictomes.org
2️⃣ Flypredictome www.flyrnai.org/tools/fly_pr...
3️⃣ Human interactome prodata.swmed.edu/humanPPI
4️⃣ BFVD (viral proteins) bfvd.steineggerlab.workers.dev
1/2
Interactome mapping has been stuck at a few hundred baits over months. HIP-MS changes the regime: ~10,000 pulldowns/week at 500 samples/day, fully automated. A new era for interactomics — and a precursor to high-throughput proteomics writ large. 📄 doi.org/10.64898/202...
HIP-MS: An ultra-high-throughput, sensitive, and versatile affinity enrichment platform for static and dynamic interactome profiling
Although protein-protein interactions govern virtually all cellular processes, systematic interactome mapping by affinity enrichment mass spectrometry (AE-MS) is constrained by manual sample preparati...
doi.org
June 11, 2026 at 3:03 PM
Interactome mapping has been stuck at a few hundred baits over months. HIP-MS changes the regime: ~10,000 pulldowns/week at 500 samples/day, fully automated. A new era for interactomics — and a precursor to high-throughput proteomics writ large. 📄 doi.org/10.64898/202...
First up this morning, @fredhutch.org's translational researcher Dr. Kevin Cheung talking about the #metastatic "interactome" in #lobular #breastcancer #CanSky #ILCSymposium #bcsm @lobularbca.bsky.social @elbcc-2018.bsky.social @lobularbcuk.bsky.social
September 24, 2026 at 3:32 PM
First up this morning, @fredhutch.org's translational researcher Dr. Kevin Cheung talking about the #metastatic "interactome" in #lobular #breastcancer #CanSky #ILCSymposium #bcsm @lobularbca.bsky.social @elbcc-2018.bsky.social @lobularbcuk.bsky.social
Wow! – and with an appropriately all-encompassing title: 'Computing the human interactome'
I anticipate lots of searching for favourite proteins
Link to our work on the unknome: interactome can suggest function of unknown proteins
www.biorxiv.org/content/10.1...
I anticipate lots of searching for favourite proteins
Link to our work on the unknome: interactome can suggest function of unknown proteins
www.biorxiv.org/content/10.1...
Computing the Human Interactome
Protein-protein interactions (PPI) are essential for biological function. Recent advances in coevolutionary analysis and Deep Learning (DL) based protein structure prediction have enabled comprehensiv...
www.biorxiv.org
October 2, 2024 at 4:23 PM
Wow! – and with an appropriately all-encompassing title: 'Computing the human interactome'
I anticipate lots of searching for favourite proteins
Link to our work on the unknome: interactome can suggest function of unknown proteins
www.biorxiv.org/content/10.1...
I anticipate lots of searching for favourite proteins
Link to our work on the unknome: interactome can suggest function of unknown proteins
www.biorxiv.org/content/10.1...
A new study from our group, led by Iris Eisermann, of the septin interactome during appressorium development, revealing many new interactors and significantly widening the biological function of septins in fungal pathogenesis. 👇
@thesainsburylab.bsky.social
@thesainsburylab.bsky.social
A stage-resolved map of dynamic septin interactions required for infection by the rice blast fungus https://www.biorxiv.org/content/10.64898/2026.04.02.716073v1
April 7, 2026 at 10:52 AM
A new study from our group, led by Iris Eisermann, of the septin interactome during appressorium development, revealing many new interactors and significantly widening the biological function of septins in fungal pathogenesis. 👇
@thesainsburylab.bsky.social
@thesainsburylab.bsky.social
Cilia alert! Stoked for our new paper in Dev. Cell! Our cross-linking mass spec interactome for motile cilia provides some cool new insights into motile ciliopathy. Helmed by @computingcaitie.bsky.social, read her fantastic Bluetorial below (👇)!
www.cell.com/developmenta...
www.cell.com/developmenta...
December 16, 2024 at 4:10 PM
Cilia alert! Stoked for our new paper in Dev. Cell! Our cross-linking mass spec interactome for motile cilia provides some cool new insights into motile ciliopathy. Helmed by @computingcaitie.bsky.social, read her fantastic Bluetorial below (👇)!
www.cell.com/developmenta...
www.cell.com/developmenta...
Chaperone isoform and interactome mapping reveals functional diversification of DNAJA2-DNAJA4 complexes via stress-regulated isoforms
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
Chaperone isoform and interactome mapping reveals functional diversification of DNAJA2-DNAJA4 complexes via stress-regulated isoforms
The human HSP70 chaperone network maintains cellular proteostasis through a diverse repertoire of HSP70s and co-chaperones. Here we examine alternative isoforms and co-chaperone hetero-complexes as ad...
www.biorxiv.org
September 25, 2026 at 7:17 AM
Chaperone isoform and interactome mapping reveals functional diversification of DNAJA2-DNAJA4 complexes via stress-regulated isoforms
www.biorxiv.org/content/10.6...
www.biorxiv.org/content/10.6...
🚨New preprint: There's this overlooked phospholipid with 3 acyl tails called NAPE that is made during ischemia. We identified its interactome & found it regulates lactate flux, suggesting metabolic functions in response to hypoxia. Congrats to Dylan Chiu! doi.org/10.26434/che... #lipidtime #chembio
March 6, 2025 at 3:15 PM
🚨New preprint: There's this overlooked phospholipid with 3 acyl tails called NAPE that is made during ischemia. We identified its interactome & found it regulates lactate flux, suggesting metabolic functions in response to hypoxia. Congrats to Dylan Chiu! doi.org/10.26434/che... #lipidtime #chembio
Live imaging and interactome analysis of Zika and chikungunya viral RNAs via dual-action aptamer tag
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com
September 21, 2026 at 12:48 PM
Live imaging and interactome analysis of Zika and chikungunya viral RNAs via dual-action aptamer tag
www.nature.com/articles/s41...
www.nature.com/articles/s41...
📢OUT TODAY @natgenet.nature.com
📰Genetic landscape of an in vivo protein interactome.
By Savandara Besse, Adrian W. R. Serohijos and colleagues.
⬇️
www.nature.com/articles/s41...
📰Genetic landscape of an in vivo protein interactome.
By Savandara Besse, Adrian W. R. Serohijos and colleagues.
⬇️
www.nature.com/articles/s41...
Genetic landscape of an in vivo protein interactome - Nature Genetics
This study uses budding yeast as a model system to link genetic variants with quantitative changes in protein–protein interaction strength under different environmental perturbations by leveraging a p...
www.nature.com
September 21, 2026 at 2:04 PM
📢OUT TODAY @natgenet.nature.com
📰Genetic landscape of an in vivo protein interactome.
By Savandara Besse, Adrian W. R. Serohijos and colleagues.
⬇️
www.nature.com/articles/s41...
📰Genetic landscape of an in vivo protein interactome.
By Savandara Besse, Adrian W. R. Serohijos and colleagues.
⬇️
www.nature.com/articles/s41...
📣 Publication alert: Our paper, “A guide to building the matrisome interactome: from computational predictions to experimental validation” is now published in @febsj.bsky.social!
📄 The paper is available in #OpenAccess at: doi.org/10.1111/febs...
#ECM #Matrisome #Interactome #SystemsBiology
📄 The paper is available in #OpenAccess at: doi.org/10.1111/febs...
#ECM #Matrisome #Interactome #SystemsBiology
November 25, 2025 at 2:10 AM
📣 Publication alert: Our paper, “A guide to building the matrisome interactome: from computational predictions to experimental validation” is now published in @febsj.bsky.social!
📄 The paper is available in #OpenAccess at: doi.org/10.1111/febs...
#ECM #Matrisome #Interactome #SystemsBiology
📄 The paper is available in #OpenAccess at: doi.org/10.1111/febs...
#ECM #Matrisome #Interactome #SystemsBiology
Evaluation of De Novo Deep Learning Models on the Protein-Sugar Interactome https://www.biorxiv.org/content/10.1101/2025.09.02.673778v1
September 7, 2025 at 12:48 AM
Evaluation of De Novo Deep Learning Models on the Protein-Sugar Interactome https://www.biorxiv.org/content/10.1101/2025.09.02.673778v1
Nuclear LC3 Interactome Profiling Identifies Clathrin Heavy Chain as a Mediator of Nuclear LC3 Translocation in Trabecular Meshwork Cells https://www.biorxiv.org/content/10.64898/2026.09.22.753497v1
September 23, 2026 at 1:30 PM
Nuclear LC3 Interactome Profiling Identifies Clathrin Heavy Chain as a Mediator of Nuclear LC3 Translocation in Trabecular Meshwork Cells https://www.biorxiv.org/content/10.64898/2026.09.22.753497v1
Excited to share that our research on the SCF E3 ubiquitin ligase interactome in plants is now published in New Phytologist and featured as the cover of the current issue! 🌱 @newphyt.bsky.social #ubiquitin #proteostasis
nph.onlinelibrary.wiley.com/share/CA8XRQ...
nph.onlinelibrary.wiley.com/share/CA8XRQ...
November 21, 2024 at 4:40 PM
Excited to share that our research on the SCF E3 ubiquitin ligase interactome in plants is now published in New Phytologist and featured as the cover of the current issue! 🌱 @newphyt.bsky.social #ubiquitin #proteostasis
nph.onlinelibrary.wiley.com/share/CA8XRQ...
nph.onlinelibrary.wiley.com/share/CA8XRQ...
me when I upregulate the frontotemporal neuroprotective matrices and activate downstream afferent interactome cascades
March 12, 2025 at 2:47 PM
me when I upregulate the frontotemporal neuroprotective matrices and activate downstream afferent interactome cascades
Recent Advances in Mass Spectrometry-based Protein Interactome Studies www.mcponline.org/ar...
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#proteomics #prot-paper
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#proteomics #prot-paper
November 28, 2024 at 4:20 PM
Recent Advances in Mass Spectrometry-based Protein Interactome Studies www.mcponline.org/ar...
---
#proteomics #prot-paper
---
#proteomics #prot-paper
Decoding the interactome for cyclic-di-AMP-producing enzyme diadenylate cyclase
-in #mSystems
journals.asm.org/doi/10.1128/...
-in #mSystems
journals.asm.org/doi/10.1128/...
Decoding the interactome for cyclic-di-AMP-producing enzyme diadenylate cyclase | mSystems
Mapping the DacA interactome reveals how environmental and intracellular cues tune
c-di-AMP signaling to control stress adaptation, ion balance, and virulence traits
in Streptococcus mutans. By identi...
journals.asm.org
June 4, 2026 at 10:15 AM
Decoding the interactome for cyclic-di-AMP-producing enzyme diadenylate cyclase
-in #mSystems
journals.asm.org/doi/10.1128/...
-in #mSystems
journals.asm.org/doi/10.1128/...
Have you published lipid-protein interactome data? Please let us know, we’d love to include it in the repository. The goal is to build a centralized hub for the scientific community.
Huge thanks to Gaelen Guzman, a graduate student/postdoc in the lab who built it from scratch.
Huge thanks to Gaelen Guzman, a graduate student/postdoc in the lab who built it from scratch.
August 12, 2025 at 2:13 PM
Have you published lipid-protein interactome data? Please let us know, we’d love to include it in the repository. The goal is to build a centralized hub for the scientific community.
Huge thanks to Gaelen Guzman, a graduate student/postdoc in the lab who built it from scratch.
Huge thanks to Gaelen Guzman, a graduate student/postdoc in the lab who built it from scratch.
Di Carlo and colleagues discuss technologies required to map and engineer the human cell–cell interactome and the therapeutic avenues such an atlas could unlock www.nature.com/articles/s41...
rdcu.be/fzyiv
rdcu.be/fzyiv
Mapping and engineering the human cell–cell interactome - Nature Biotechnology
Di Carlo and colleagues discuss technologies required to map and engineer the human cell–cell interactome and the therapeutic avenues such an atlas could unlock.
www.nature.com
August 13, 2026 at 3:30 AM
Di Carlo and colleagues discuss technologies required to map and engineer the human cell–cell interactome and the therapeutic avenues such an atlas could unlock www.nature.com/articles/s41...
rdcu.be/fzyiv
rdcu.be/fzyiv