#HepatocelluarCarcinoma
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Molecular Medicine - Journal
Article in Press: Metabolism-guided precision oncology in hepatocellular carcinoma: vascular, stromal and immune crosstalk | #MolecularMedicine #HepatocelluarCarcinoma #HCC #Metabolomics link.springer.com/article/10.1...
Fig. 6 Therapeutic strategies targeting metabolic–vascular interactions in HCC. This schematic summarizes therapeutic concepts that arise from metabolism–vascular crosstalk in HCC. The figure is organized into four modules: tumor-intrinsic metabolic targets, endothelial cell metabolism and angiogenesis, stromal and myeloid targeting, and rational combination strategies. Tumor-intrinsic metabolic interventions include inhibition of lactate production, lactate transport, glycolytic enzymes, glutamine metabolism, fatty-acid oxidation, and lactylation-associated signaling. Endothelial-directed strategies include anti-VEGF/VEGFR therapies, PFKFB3 inhibition, and modulation of endothelial barrier function. Stromal and myeloid strategies include TAM repolarization, lactylation-related targeting, TGF-β inhibition, CAF modulation, and periostin blockade. The combination module illustrates how metabolic interventions may be paired with anti-angiogenic therapy or PD-1/PD-L1 blockade to enhance vascular normalization and anti-tumor immunity. Approved anti-angiogenic and immunecheckpoint therapies are shown as established clinical backbones, whereas metabolic, stromal, lactylation-associated, and CAF/TAM-directed strategies should be interpreted as investigational or preclinical candidates for biomarker-enriched testing rather than as established treatment options. Approved agents are shown in solid blue boxes, whereas investigational and preclinical strategies are shown in gray boxes with dashed outlines.
September 16, 2026 at 6:49 PM