Second day of the #EFMCISCB2023 conference starting now in Basel. It's been a fantastic combination of MedChem and ChemBio talks so far!
If you are around, come find me today at poster 56 to hear about #sirtuin sensors.
If you are around, come find me today at poster 56 to hear about #sirtuin sensors.
November 17, 2023 at 7:44 AM
Second day of the #EFMCISCB2023 conference starting now in Basel. It's been a fantastic combination of MedChem and ChemBio talks so far!
If you are around, come find me today at poster 56 to hear about #sirtuin sensors.
If you are around, come find me today at poster 56 to hear about #sirtuin sensors.
Excited that I could present some of our work @led3hub.bsky.social today at #EFMCISCB2023. Including our work on identifying ligandable cysteines in pathogenic bacteria and developing covalent probes for diverse amino acids. Photo by Josef Braun. doi.org/10.26434/che...
November 16, 2023 at 11:07 AM
Excited that I could present some of our work @led3hub.bsky.social today at #EFMCISCB2023. Including our work on identifying ligandable cysteines in pathogenic bacteria and developing covalent probes for diverse amino acids. Photo by Josef Braun. doi.org/10.26434/che...
Grateful for the opportunity today to share our team's #GlycoTime efforts on developing CTL antagonists @ EFMC International Symposium on Chemical Biology #EFMCISCB2023 (and thanks to colleague Peter for the 📸!)
November 18, 2023 at 5:27 PM
Grateful for the opportunity today to share our team's #GlycoTime efforts on developing CTL antagonists @ EFMC International Symposium on Chemical Biology #EFMCISCB2023 (and thanks to colleague Peter for the 📸!)
Congratulations, Gonçalo Bernardes, on winning the EFMC-WuXi AppTec Award for Excellence in Chemical Biology at #EFMCISCB2023! He gave an inspiring award lecture on his group's work in the field of translational chemical biology.
November 18, 2023 at 3:46 PM
Congratulations, Gonçalo Bernardes, on winning the EFMC-WuXi AppTec Award for Excellence in Chemical Biology at #EFMCISCB2023! He gave an inspiring award lecture on his group's work in the field of translational chemical biology.
#EFMCISCB2023 is off to a great start with an insightful lecture by John Tallarico from the Novartis Institutes of Biomedical Research talking about the importance of chemical biology in the pharmaceutical industry. Exciting applications to proximity-inducing small molecules.
November 16, 2023 at 8:35 AM
#EFMCISCB2023 is off to a great start with an insightful lecture by John Tallarico from the Novartis Institutes of Biomedical Research talking about the importance of chemical biology in the pharmaceutical industry. Exciting applications to proximity-inducing small molecules.
Interesting talk by @SebastianDeindl at #EFMCISCB2023. He talked about his group's exciting work on single molecule fluorescence technologies to study the dynamics of the nucleosome. www.nature.com/articles/s41...
Spatiotemporally controlled generation of NTPs for single-molecule studies - Nature Chemical Biology
A new method for controlling NTP-driven reactions in single-molecule experiments via the local generation of NTPs (LAGOON) markedly increases the measurement throughput and enables single-turnover obs...
www.nature.com
November 17, 2023 at 2:38 PM
Interesting talk by @SebastianDeindl at #EFMCISCB2023. He talked about his group's exciting work on single molecule fluorescence technologies to study the dynamics of the nucleosome. www.nature.com/articles/s41...
Day 2 of #EFMCISCB2023 is under way in #Basel! (didn't have to travel far for this one 😉)
Fantastic networking opportunities & program ... although needing 😴😴😴
Fantastic networking opportunities & program ... although needing 😴😴😴
November 17, 2023 at 10:51 AM
Day 2 of #EFMCISCB2023 is under way in #Basel! (didn't have to travel far for this one 😉)
Fantastic networking opportunities & program ... although needing 😴😴😴
Fantastic networking opportunities & program ... although needing 😴😴😴
Interesting talk by Rita Petracca at #EFMCISCB2023. She talked about her group's research on better understanding biological systems with chemical tools. Innovative insights into studying posttranslational modifications with new chemistry. www.uu.nl/staff/RPetra...
November 18, 2023 at 2:42 PM
Interesting talk by Rita Petracca at #EFMCISCB2023. She talked about her group's research on better understanding biological systems with chemical tools. Innovative insights into studying posttranslational modifications with new chemistry. www.uu.nl/staff/RPetra...
Great virtual talk by Alice Ting at #EFMCISCB2023. She talked about her group's amazing research into innovative proximity labeling approaches to study the direct environment of various proteins. Exciting insights e.g. into studying protein trafficking. doi.org/10.1016/j.ce...
November 16, 2023 at 4:44 PM
Great virtual talk by Alice Ting at #EFMCISCB2023. She talked about her group's amazing research into innovative proximity labeling approaches to study the direct environment of various proteins. Exciting insights e.g. into studying protein trafficking. doi.org/10.1016/j.ce...
Great talk by Beat Fierz at #EFMCISCB2023. He talked about his group's work on posttranslational modifications of chromatin and the cytoskeleton. Exciting applications of protein semi-synthesis and single molecule spectroscopy. www.nature.com/articles/s41...
Tubulin engineering by semi-synthesis reveals that polyglutamylation directs detyrosination - Nature...
Microtubules carry patterns of post-translational modifications that are important for the regulation of key cellular processes. Now a semi-synthetic method facilitates the production of tubulins with...
www.nature.com
November 18, 2023 at 2:23 PM
Great talk by Beat Fierz at #EFMCISCB2023. He talked about his group's work on posttranslational modifications of chromatin and the cytoskeleton. Exciting applications of protein semi-synthesis and single molecule spectroscopy. www.nature.com/articles/s41...
Amazing start to the second day of #EFMCISCB2023 with a great lecture by Claudia Hoebartner! She talked about her group's exciting work on developing (deoxy)ribozymes for detecting and manipulating RNA modifications. doi.org/10.1038/s415...
Site-specific RNA methylation by a methyltransferase ribozyme - Nature
A methyltransferase ribozyme, along with the small-molecule cofactor O6-methylguanine, is shown to catalyse the site-specific installation of 1-methyladenosine in various RNAs, providing insights into...
doi.org
November 17, 2023 at 8:50 AM
Amazing start to the second day of #EFMCISCB2023 with a great lecture by Claudia Hoebartner! She talked about her group's exciting work on developing (deoxy)ribozymes for detecting and manipulating RNA modifications. doi.org/10.1038/s415...
Great talk by Luca Laraia at #EFMCISCB2023. He talked about his group's work on understanding sterol metabolism using chemical biology tools including cool insights into squalene synthase degraders and stabilizers as well as into oxysterols. pubs.rsc.org/en/content/a...
Identification of non-conventional small molecule degraders and stabilizers of squalene synthase -...
pubs.rsc.org
November 17, 2023 at 4:39 PM
Great talk by Luca Laraia at #EFMCISCB2023. He talked about his group's work on understanding sterol metabolism using chemical biology tools including cool insights into squalene synthase degraders and stabilizers as well as into oxysterols. pubs.rsc.org/en/content/a...
Interesting talk by Tom Muir at #EFMCISCB2023. He talked about his group's impressive work on chemical approaches to study chromatin biology. Exciting insights into histone mutations and posttranslational modifications. www.jbc.org/article/S002...
Chemical Approaches for Studying Histone Modifications *
Histones form the protein core around which genomic DNA is wrapped in eukaryotic chromatin.
Numerous genetic studies have established that the structure and transcriptional state
of chromatin are clos...
www.jbc.org
November 18, 2023 at 1:22 PM
Interesting talk by Tom Muir at #EFMCISCB2023. He talked about his group's impressive work on chemical approaches to study chromatin biology. Exciting insights into histone mutations and posttranslational modifications. www.jbc.org/article/S002...
Very interesting talk by Slava Ziegler at #EFMCISCB2023. She talked about her group's work on using cell painting to narrow down the mechanism of action and cellular targets of bioactive compounds. www.cell.com/cell-chemica...
Morphological profiling by means of the Cell Painting assay enables identification of tubulin-target...
Akbarzadeh et al. employ the Cell Painting assay to identify small-molecule modulators
of microtubules in compound collections. They detect unanticipated tubulin-targeting
activity for several refere...
www.cell.com
November 17, 2023 at 11:20 AM
Very interesting talk by Slava Ziegler at #EFMCISCB2023. She talked about her group's work on using cell painting to narrow down the mechanism of action and cellular targets of bioactive compounds. www.cell.com/cell-chemica...
Great talk by Kim Bonger at #EFMCISCB2023. She talked about her group's exciting research on new tools to better understand biology including using THRONCAT to study newly synthesized proteins in cells. doi.org/10.1038/s414...
THRONCAT: metabolic labeling of newly synthesized proteins using a bioorthogonal threonine analog - ...
Incorporating bioorthogonally-modified amino acids into newly synthesized proteins allows studying the nascent proteome, but current methods often require special conditions or are toxic to cells. Her...
doi.org
November 19, 2023 at 9:30 AM
Great talk by Kim Bonger at #EFMCISCB2023. She talked about her group's exciting research on new tools to better understand biology including using THRONCAT to study newly synthesized proteins in cells. doi.org/10.1038/s414...
Now on: @stephanhacker2.bsky.social on exciting proteomics tool compound development! #EFMCISCB2023
November 16, 2023 at 10:32 AM
Now on: @stephanhacker2.bsky.social on exciting proteomics tool compound development! #EFMCISCB2023
Great talk by Dorothea Fiedler at #EFMCISCB2023. She talked about her group's work on inositol pyrophosphates and how they lead to protein pyrophosphorylation. Exciting proteomics techniques to detect pyrophosphorylation sites. www.biorxiv.org/content/10.1...
Pyrophosphoproteomics: extensive protein pyrophosphorylation revealed in human cell lines
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
November 18, 2023 at 1:52 PM
Great talk by Dorothea Fiedler at #EFMCISCB2023. She talked about her group's work on inositol pyrophosphates and how they lead to protein pyrophosphorylation. Exciting proteomics techniques to detect pyrophosphorylation sites. www.biorxiv.org/content/10.1...
Very exciting talk by Alberto Fernández-Tejada @afernandztejada at #EFMCISCB2023 @EuroMedChem. He talked about his group's research into vaccine adjuvants. Great insights e.g. into the mechanism of action and the SAR of saponins based on QS-21. www.nature.com/articles/s41...
Natural and synthetic carbohydrate-based vaccine adjuvants and their mechanisms of action - Nature R...
Carbohydrate adjuvants potentiate immune responses through diverse mechanisms. This Review highlights carbohydrate-based adjuvants, providing insights into structure–activity relationships and appli...
www.nature.com
November 18, 2023 at 10:47 AM
Very exciting talk by Alberto Fernández-Tejada @afernandztejada at #EFMCISCB2023 @EuroMedChem. He talked about his group's research into vaccine adjuvants. Great insights e.g. into the mechanism of action and the SAR of saponins based on QS-21. www.nature.com/articles/s41...
Great talk by Marc Vendrell at #EFMCISCB2023. He talked about his group's exciting work on fluorescent probes for biomedical applications. Interesting insights e.g. into cathepsin probes developed in collaboration with Martijn Verdoes. doi.org/10.1002/anie...
https://doi.org/10.1002/anie.202207508
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doi.org
November 18, 2023 at 9:10 AM
Great talk by Marc Vendrell at #EFMCISCB2023. He talked about his group's exciting work on fluorescent probes for biomedical applications. Interesting insights e.g. into cathepsin probes developed in collaboration with Martijn Verdoes. doi.org/10.1002/anie...
Interesting talk by Thomas Carell at #EFMCISCB2023. He talked about his group's research on studying and manipulating DNA base modifications such as 5-methylcytosine, 5-hydroxymethylcytosine and 5-carboxylcytosine. onlinelibrary.wiley.com/doi/10.1002/...
https://onlinelibrary.wiley.com/doi/10.1002/anie.201101547
Wiley Online Library requires cookies for authentication and use of other site features; therefore, cookies must be enabled to browse the site. Detailed information on how Wiley uses cookies can be fo...
onlinelibrary.wiley.com
November 18, 2023 at 8:40 AM
Interesting talk by Thomas Carell at #EFMCISCB2023. He talked about his group's research on studying and manipulating DNA base modifications such as 5-methylcytosine, 5-hydroxymethylcytosine and 5-carboxylcytosine. onlinelibrary.wiley.com/doi/10.1002/...
Great talk by Matthew Vander Heiden at #EFMCISCB2023. He talked about his group's impressive work on understanding cancer metabolism to improve drug discovery. Exciting insights into the importance of nutrients in the medium on screening outcomes. www.cell.com/cell-chemica...
Screening in serum-derived medium reveals differential response to compounds targeting metabolism
Drug response often differs between in vitro and in vivo conditions. Abbott et al.
examine how nutrient availability affects drug efficacy by screening compounds in
standard versus serum-derived me...
www.cell.com
November 17, 2023 at 3:49 PM
Great talk by Matthew Vander Heiden at #EFMCISCB2023. He talked about his group's impressive work on understanding cancer metabolism to improve drug discovery. Exciting insights into the importance of nutrients in the medium on screening outcomes. www.cell.com/cell-chemica...
Interesting talk by Dario Neri at #EFMCISCB2023. He talked about his group's impressive work on selectively targeting drugs to tumors using conjugates of antibodies with cytokines. Amazing to see the clinical successes of these conjugates.
November 16, 2023 at 3:40 PM
Interesting talk by Dario Neri at #EFMCISCB2023. He talked about his group's impressive work on selectively targeting drugs to tumors using conjugates of antibodies with cytokines. Amazing to see the clinical successes of these conjugates.
Great talk by Micah Niphakis of Lundbeck at #EFMCISCB2023. Interesting insights into the characteristics of approved covalent drugs.
November 16, 2023 at 11:34 AM
Great talk by Micah Niphakis of Lundbeck at #EFMCISCB2023. Interesting insights into the characteristics of approved covalent drugs.
Great talk by Marcus Bantscheff at #EFMCISCB2023. He talked about his group's work on drug target ID studies using a variety of methods including affinity-based proteome profiling, 2D thermal proteome profiling and residue-specific proteomics. doi.org/10.1021/acs....
November 16, 2023 at 9:29 AM
Great talk by Marcus Bantscheff at #EFMCISCB2023. He talked about his group's work on drug target ID studies using a variety of methods including affinity-based proteome profiling, 2D thermal proteome profiling and residue-specific proteomics. doi.org/10.1021/acs....