We call these mechanism based sirtuin inhibitors SirTraps that trap the enzyme via this ADP ribose adduct onlinelibrary.wiley.com/doi/10.1002/... 2/
From Pharmacophore to Warhead: NAD+‐Targeting Triazoles as Mechanism‐Based Sirtuin Inhibitors
We report “Sirtuin Trapping Ligands” (SirTraps), mechanism-based 1,2,3-triazole inhibitors that hijack sirtuin (SIRT) catalysis to form covalent triazolium– or triazole–ADP-ribose (ADPR) adducts from...
onlinelibrary.wiley.com
November 2, 2025 at 1:20 PM
We call these mechanism based sirtuin inhibitors SirTraps that trap the enzyme via this ADP ribose adduct onlinelibrary.wiley.com/doi/10.1002/... 2/
July 1, 2025 at 1:51 AM
Sirtuin 3 as a Promising Target in Disease Therapy: Model Action and Drug Discovery
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
July 6, 2025 at 7:29 AM
Sirtuin 3 as a Promising Target in Disease Therapy: Model Action and Drug Discovery
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Sirtuin, this is a Wendy’s
March 3, 2026 at 2:54 AM
Sirtuin, this is a Wendy’s
In this paper, we demonstrate that the sirtuin SIRT6 can efficiently ADP-ribosylate histidine and tyrosine residues in proteins.
royalsocietypublishing.org/rsob/article...
royalsocietypublishing.org/rsob/article...
Histidine and tyrosine residues are targets for SIRT6 ADP-ribosylation activity
Abstract. SIRT6, a highly conserved member of the sirtuin family, plays a critical role in diverse cellular processes, including gene regulation, DNA damag
royalsocietypublishing.org
March 4, 2026 at 9:21 PM
In this paper, we demonstrate that the sirtuin SIRT6 can efficiently ADP-ribosylate histidine and tyrosine residues in proteins.
royalsocietypublishing.org/rsob/article...
royalsocietypublishing.org/rsob/article...
This was such a fun character to draw!
Character owned by artfight.net/~Sirtuin
#artfight #artfight2025
Character owned by artfight.net/~Sirtuin
#artfight #artfight2025
July 2, 2025 at 3:09 PM
This was such a fun character to draw!
Character owned by artfight.net/~Sirtuin
#artfight #artfight2025
Character owned by artfight.net/~Sirtuin
#artfight #artfight2025
Seems like our Sirtuin NanoBret qualifies us for Philosophy International Journal @simonhammann.bsky.social #academicspam
November 24, 2025 at 10:25 AM
Seems like our Sirtuin NanoBret qualifies us for Philosophy International Journal @simonhammann.bsky.social #academicspam
March 16, 2024 at 6:18 PM
In the hunt for more palatable ways to achieve the same lifespan-extending effects of caloric restriction, researchers are trying to identify the molecular mechanisms behind them. cen.acs.org/biological-c...
A bile acid may mimic caloric restriction
The molecule, known to be toxic at higher doses, may activate sirtuin signaling
cen.acs.org
December 21, 2024 at 1:32 PM
In the hunt for more palatable ways to achieve the same lifespan-extending effects of caloric restriction, researchers are trying to identify the molecular mechanisms behind them. cen.acs.org/biological-c...
The authors included RRIDs in their in Molecular Therapy paper! Thanks for making your methods matter! #methodsmatter #reproducibility #BetterScience
1,25D3 reprograms mitochondrial quality control via sirtuin and sensitizes glioblastoma to chemotherapy
Read the full paper: 1,25D3 reprograms mitochondrial quality control via sirtuin and sensitizes glioblastoma to chemotherapy
doi.org
October 1, 2026 at 7:01 AM
The authors included RRIDs in their in Molecular Therapy paper! Thanks for making your methods matter! #methodsmatter #reproducibility #BetterScience
Who, me? Eat a going-away-party cheesecake and publish a story on the positive health impacts of caloric restriction on the same day?
cen.acs.org/biological-c...
cen.acs.org/biological-c...
A bile acid may mimic caloric restriction
The molecule, known to be toxic at higher doses, may activate sirtuin signaling
cen.acs.org
December 18, 2024 at 9:18 PM
Who, me? Eat a going-away-party cheesecake and publish a story on the positive health impacts of caloric restriction on the same day?
cen.acs.org/biological-c...
cen.acs.org/biological-c...
You might know 1,2,3-triazoles as stable linkers in medicinal chemistry. Have a look on a twist on triazoles in our latest publication in #AngewandteChemie
We report a new class of 1,2,3-triazole sirtuin inhibitors that
display unexpected reactivity with formation of an ADP adduct from NAD+ 1/
We report a new class of 1,2,3-triazole sirtuin inhibitors that
display unexpected reactivity with formation of an ADP adduct from NAD+ 1/
November 2, 2025 at 1:17 PM
You might know 1,2,3-triazoles as stable linkers in medicinal chemistry. Have a look on a twist on triazoles in our latest publication in #AngewandteChemie
We report a new class of 1,2,3-triazole sirtuin inhibitors that
display unexpected reactivity with formation of an ADP adduct from NAD+ 1/
We report a new class of 1,2,3-triazole sirtuin inhibitors that
display unexpected reactivity with formation of an ADP adduct from NAD+ 1/
New preprint from a collaboration with the Schutkowski group @unihalle.bsky.social @uni-freiburg.de . Alkyl branching in acyl lysines slows down deacylation by the NAD+ dependent Sirt2 to result in super potent enzyme inhibitors #sirtuin @chemrxivbot.bsky.social chemrxiv.org/doi/full/10.... 1/
Alkyl-Branched Acyl-Lysine Peptides as Potent Cell-Permeable Slow-Substrate Inhibitors of SIRT2 | ChemRxiv
Sirtuin 2 (SIRT2) is a nicotinamide adenine dinucleotide (NAD+)-dependent lysine deacylase implicated in cancer and neurodegeneration. Here, we report acyl-lysine peptide inhibitors bearing methyl-branched or cyclopropyl-modified acyl chains with low-...
chemrxiv.org
April 29, 2026 at 6:58 AM
New preprint from a collaboration with the Schutkowski group @unihalle.bsky.social @uni-freiburg.de . Alkyl branching in acyl lysines slows down deacylation by the NAD+ dependent Sirt2 to result in super potent enzyme inhibitors #sirtuin @chemrxivbot.bsky.social chemrxiv.org/doi/full/10.... 1/
By studying Sirtuin 5 (Sirt5) in mice, researchers discovered a key mechanism linking mitochondrial health to bone strength, offering new hope for treating osteoporosis.👇
#Sirt5 #osteoporosis #bone
@brjournal.bsky.social
www.nature.com/articles/s41...
#Sirt5 #osteoporosis #bone
@brjournal.bsky.social
www.nature.com/articles/s41...
November 28, 2025 at 3:28 AM
By studying Sirtuin 5 (Sirt5) in mice, researchers discovered a key mechanism linking mitochondrial health to bone strength, offering new hope for treating osteoporosis.👇
#Sirt5 #osteoporosis #bone
@brjournal.bsky.social
www.nature.com/articles/s41...
#Sirt5 #osteoporosis #bone
@brjournal.bsky.social
www.nature.com/articles/s41...
A new study investigated how the sirtuin SIRT6 protects against proteostasis-related brain 🧠 disorders by limiting protein production.
lifespan.io/news/how-a-s...
By: Josh Conway
lifespan.io/news/how-a-s...
By: Josh Conway
How a Sirtuin Protects Against Brain Diseases
The sirtuin SIRT6 protects against proteostasis-related brain disorders by maintaining the function of nucleoli and limiting protein production.
lifespan.io
February 23, 2026 at 8:54 PM
A new study investigated how the sirtuin SIRT6 protects against proteostasis-related brain 🧠 disorders by limiting protein production.
lifespan.io/news/how-a-s...
By: Josh Conway
lifespan.io/news/how-a-s...
By: Josh Conway
Sirtuin 2 inhibits global protein synthesis via Rheb-GTPase degradation
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Sirtuin 2 inhibits global protein synthesis via Rheb-GTPase degradation - EMBO Reports
Increased global protein synthesis is associated with the development and progression of several aging-related diseases and disorders. Strategies like calorie restriction and pharmacological inhibitio...
link.springer.com
March 30, 2026 at 8:33 PM
Sirtuin 2 inhibits global protein synthesis via Rheb-GTPase degradation
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Our Paper 'Efficient Crystallization of Apo Sirt2 for Small-Molecule Soaking and Structural Analysis of Ligand Interactions' is out in J Med Chem @acs.org pubs.acs.org/doi/10.1021/... 1/
Efficient Crystallization of Apo Sirt2 for Small-Molecule Soaking and Structural Analysis of Ligand Interactions
The selectivity pocket is a key binding site for inhibitors of the NAD+-dependent lysine deacylase Sirtuin 2 (Sirt2), a promising drug target in diseases like cancer. While small-molecule soaking can ...
pubs.acs.org
June 13, 2025 at 11:04 AM
Our Paper 'Efficient Crystallization of Apo Sirt2 for Small-Molecule Soaking and Structural Analysis of Ligand Interactions' is out in J Med Chem @acs.org pubs.acs.org/doi/10.1021/... 1/
#TesticularAging #Sirtuin
Aging-like testes phenotypes in 3.5-mo Sirt1+/-🐭
⏫Seminiferous tubule degeneration
⏫Spermiation failure
⏬Sperm count
⏬Spermatozoa membrane/acrosome integrity
⏬Male fertility
+Testes Proteomics
#Andrology 2026
onlinelibrary.wiley.com/doi/10.1111/...
Aging-like testes phenotypes in 3.5-mo Sirt1+/-🐭
⏫Seminiferous tubule degeneration
⏫Spermiation failure
⏬Sperm count
⏬Spermatozoa membrane/acrosome integrity
⏬Male fertility
+Testes Proteomics
#Andrology 2026
onlinelibrary.wiley.com/doi/10.1111/...
June 11, 2026 at 8:48 PM
#TesticularAging #Sirtuin
Aging-like testes phenotypes in 3.5-mo Sirt1+/-🐭
⏫Seminiferous tubule degeneration
⏫Spermiation failure
⏬Sperm count
⏬Spermatozoa membrane/acrosome integrity
⏬Male fertility
+Testes Proteomics
#Andrology 2026
onlinelibrary.wiley.com/doi/10.1111/...
Aging-like testes phenotypes in 3.5-mo Sirt1+/-🐭
⏫Seminiferous tubule degeneration
⏫Spermiation failure
⏬Sperm count
⏬Spermatozoa membrane/acrosome integrity
⏬Male fertility
+Testes Proteomics
#Andrology 2026
onlinelibrary.wiley.com/doi/10.1111/...
Second day of the #EFMCISCB2023 conference starting now in Basel. It's been a fantastic combination of MedChem and ChemBio talks so far!
If you are around, come find me today at poster 56 to hear about #sirtuin sensors.
If you are around, come find me today at poster 56 to hear about #sirtuin sensors.
November 17, 2023 at 7:44 AM
Second day of the #EFMCISCB2023 conference starting now in Basel. It's been a fantastic combination of MedChem and ChemBio talks so far!
If you are around, come find me today at poster 56 to hear about #sirtuin sensors.
If you are around, come find me today at poster 56 to hear about #sirtuin sensors.
This always gets me rolling!
youtu.be/m4xIy1rlJKs?...
youtu.be/m4xIy1rlJKs?...
Just hook it to my veins
YouTube video by sirtuin
youtu.be
April 25, 2025 at 4:56 PM
This always gets me rolling!
youtu.be/m4xIy1rlJKs?...
youtu.be/m4xIy1rlJKs?...
Mishra, L., Mishra, M. (2024). Ribose-induced advanced glycation end products reduce the lifespan in Drosophila melanogaster by changing the redox state and down-regulating the Sirtuin genes. Biogerontology, 26(1):28 link.springer.com/article/10.1...
Ribose-induced advanced glycation end products reduce the lifespan in Drosophila melanogaster by changing the redox state and down-regulating the Sirtuin genes - Biogerontology
Advanced Glycation End (AGE) products are one such factor that accumulates during aging and age-related diseases. However, how exogenous AGE compounds cause aging is an area that needs to be explored....
link.springer.com
October 2, 2026 at 7:40 PM
Mishra, L., Mishra, M. (2024). Ribose-induced advanced glycation end products reduce the lifespan in Drosophila melanogaster by changing the redox state and down-regulating the Sirtuin genes. Biogerontology, 26(1):28 link.springer.com/article/10.1...
Gummy Twist Adopt 🫶
Watch out for the tails! They might bite 🫣
SB: 20$
MI: 5$
AB: 80$
Auction ends 48H after last bid
TOS: sirtuin-expand.carrd.co#tos
Likes and shares are appreciated 🥹
Watch out for the tails! They might bite 🫣
SB: 20$
MI: 5$
AB: 80$
Auction ends 48H after last bid
TOS: sirtuin-expand.carrd.co#tos
Likes and shares are appreciated 🥹
February 26, 2024 at 2:41 AM
Gummy Twist Adopt 🫶
Watch out for the tails! They might bite 🫣
SB: 20$
MI: 5$
AB: 80$
Auction ends 48H after last bid
TOS: sirtuin-expand.carrd.co#tos
Likes and shares are appreciated 🥹
Watch out for the tails! They might bite 🫣
SB: 20$
MI: 5$
AB: 80$
Auction ends 48H after last bid
TOS: sirtuin-expand.carrd.co#tos
Likes and shares are appreciated 🥹
Michael Weyand et al.: Potential 14-3-3 binding sites in sirtuins reveal extended phosphosite-recognition modes ##Sirtuin##Phosphopeptides##Regulation@unibt...##IUCrhttps://journals.iucr.org/paper?S2053230X25010908
Potential 14-3-3 binding sites in sirtuins reveal extended phosphosite-recognition modes
Identification, binding measurements and structure determination of human sirtuin phosphopeptides in complex with human adapter protein 14-3-3σ reveal variations among tight binders and suggest extended binding modes.
journals.iucr.org
December 19, 2025 at 1:00 AM
Michael Weyand et al.: Potential 14-3-3 binding sites in sirtuins reveal extended phosphosite-recognition modes ##Sirtuin##Phosphopeptides##Regulation@unibt...##IUCrhttps://journals.iucr.org/paper?S2053230X25010908