Second day of the #EFMCISCB2023 conference starting now in Basel. It's been a fantastic combination of MedChem and ChemBio talks so far!
If you are around, come find me today at poster 56 to hear about #sirtuin sensors.
If you are around, come find me today at poster 56 to hear about #sirtuin sensors.
November 17, 2023 at 7:44 AM
Second day of the #EFMCISCB2023 conference starting now in Basel. It's been a fantastic combination of MedChem and ChemBio talks so far!
If you are around, come find me today at poster 56 to hear about #sirtuin sensors.
If you are around, come find me today at poster 56 to hear about #sirtuin sensors.
New preprint from a collaboration with the Schutkowski group @unihalle.bsky.social @uni-freiburg.de . Alkyl branching in acyl lysines slows down deacylation by the NAD+ dependent Sirt2 to result in super potent enzyme inhibitors #sirtuin @chemrxivbot.bsky.social chemrxiv.org/doi/full/10.... 1/
Alkyl-Branched Acyl-Lysine Peptides as Potent Cell-Permeable Slow-Substrate Inhibitors of SIRT2 | ChemRxiv
Sirtuin 2 (SIRT2) is a nicotinamide adenine dinucleotide (NAD+)-dependent lysine deacylase implicated in cancer and neurodegeneration. Here, we report acyl-lysine peptide inhibitors bearing methyl-branched or cyclopropyl-modified acyl chains with low-...
chemrxiv.org
April 29, 2026 at 6:58 AM
New preprint from a collaboration with the Schutkowski group @unihalle.bsky.social @uni-freiburg.de . Alkyl branching in acyl lysines slows down deacylation by the NAD+ dependent Sirt2 to result in super potent enzyme inhibitors #sirtuin @chemrxivbot.bsky.social chemrxiv.org/doi/full/10.... 1/
#TesticularAging #Sirtuin
Aging-like testes phenotypes in 3.5-mo Sirt1+/-🐭
⏫Seminiferous tubule degeneration
⏫Spermiation failure
⏬Sperm count
⏬Spermatozoa membrane/acrosome integrity
⏬Male fertility
+Testes Proteomics
#Andrology 2026
onlinelibrary.wiley.com/doi/10.1111/...
Aging-like testes phenotypes in 3.5-mo Sirt1+/-🐭
⏫Seminiferous tubule degeneration
⏫Spermiation failure
⏬Sperm count
⏬Spermatozoa membrane/acrosome integrity
⏬Male fertility
+Testes Proteomics
#Andrology 2026
onlinelibrary.wiley.com/doi/10.1111/...
June 11, 2026 at 8:48 PM
#TesticularAging #Sirtuin
Aging-like testes phenotypes in 3.5-mo Sirt1+/-🐭
⏫Seminiferous tubule degeneration
⏫Spermiation failure
⏬Sperm count
⏬Spermatozoa membrane/acrosome integrity
⏬Male fertility
+Testes Proteomics
#Andrology 2026
onlinelibrary.wiley.com/doi/10.1111/...
Aging-like testes phenotypes in 3.5-mo Sirt1+/-🐭
⏫Seminiferous tubule degeneration
⏫Spermiation failure
⏬Sperm count
⏬Spermatozoa membrane/acrosome integrity
⏬Male fertility
+Testes Proteomics
#Andrology 2026
onlinelibrary.wiley.com/doi/10.1111/...
Michael Weyand et al.: Potential 14-3-3 binding sites in sirtuins reveal extended phosphosite-recognition modes ##Sirtuin##Phosphopeptides##Regulation@unibt...##IUCrhttps://journals.iucr.org/paper?S2053230X25010908
Potential 14-3-3 binding sites in sirtuins reveal extended phosphosite-recognition modes
Identification, binding measurements and structure determination of human sirtuin phosphopeptides in complex with human adapter protein 14-3-3σ reveal variations among tight binders and suggest extended binding modes.
journals.iucr.org
December 19, 2025 at 1:00 AM
Michael Weyand et al.: Potential 14-3-3 binding sites in sirtuins reveal extended phosphosite-recognition modes ##Sirtuin##Phosphopeptides##Regulation@unibt...##IUCrhttps://journals.iucr.org/paper?S2053230X25010908
Potential 14-3-3 binding sites in sirtuins were identfied and the interactions of peptides representing phosphorylation sites in sirtuin 3 and sirtuin 1 with 14-3-3 proteins were characterized #Sirtuin #Phosphopeptides #Regulation doi.org/10.1107/S205...
February 16, 2026 at 2:47 PM
Potential 14-3-3 binding sites in sirtuins were identfied and the interactions of peptides representing phosphorylation sites in sirtuin 3 and sirtuin 1 with 14-3-3 proteins were characterized #Sirtuin #Phosphopeptides #Regulation doi.org/10.1107/S205...
