⠀⠀
⠀⠀ ⦇﹡⦈ ɑmon
❛ My 𝗻𝗮𝗺𝗲 is 𝗔𝗺𝗼𝗻, you
know what it means?
𝗧𝗵𝗲 𝗵𝗶𝗱𝗱𝗲𝗻 𝗼𝗻𝗲.❜
⤹ мαιɴ тнreαd.
Ꮺ ᴛʜᴇ sᴇᴄʀᴇᴛ ᴏғ ʟᴜᴄɪғᴇʀ.
twitter: @ THEHlDDENONE +
@ THEHIDDENS0N
⠀⠀ ⦇﹡⦈ ɑmon
❛ My 𝗻𝗮𝗺𝗲 is 𝗔𝗺𝗼𝗻, you
know what it means?
𝗧𝗵𝗲 𝗵𝗶𝗱𝗱𝗲𝗻 𝗼𝗻𝗲.❜
⤹ мαιɴ тнreαd.
Ꮺ ᴛʜᴇ sᴇᴄʀᴇᴛ ᴏғ ʟᴜᴄɪғᴇʀ.
twitter: @ THEHlDDENONE +
@ THEHIDDENS0N
October 8, 2026 at 12:04 PM
⠀⠀
⠀⠀ ⦇﹡⦈ ɑmon
❛ My 𝗻𝗮𝗺𝗲 is 𝗔𝗺𝗼𝗻, you
know what it means?
𝗧𝗵𝗲 𝗵𝗶𝗱𝗱𝗲𝗻 𝗼𝗻𝗲.❜
⤹ мαιɴ тнreαd.
Ꮺ ᴛʜᴇ sᴇᴄʀᴇᴛ ᴏғ ʟᴜᴄɪғᴇʀ.
twitter: @ THEHlDDENONE +
@ THEHIDDENS0N
⠀⠀ ⦇﹡⦈ ɑmon
❛ My 𝗻𝗮𝗺𝗲 is 𝗔𝗺𝗼𝗻, you
know what it means?
𝗧𝗵𝗲 𝗵𝗶𝗱𝗱𝗲𝗻 𝗼𝗻𝗲.❜
⤹ мαιɴ тнreαd.
Ꮺ ᴛʜᴇ sᴇᴄʀᴇᴛ ᴏғ ʟᴜᴄɪғᴇʀ.
twitter: @ THEHlDDENONE +
@ THEHIDDENS0N
i learned this real quick when i sent a draft aims page to a senior colleague and they asked me if it was already known that ERα can regulate gene expression. neuroscientists lol.
October 9, 2026 at 11:27 PM
i learned this real quick when i sent a draft aims page to a senior colleague and they asked me if it was already known that ERα can regulate gene expression. neuroscientists lol.
.·:*¨ ✘ sʟᴏᴀɴᴇ ᴍᴀɪʀɪ ✘ ¨*:·.
❝ Yoυ ɢoт мy вroтнer ĸιlled. He dιed ғor yoυ.❞
a mature & descriptive portrayal. adult themes ahead. MDNI. novella writer. friendly mun. dm to plot.
#FourthWingRP
another performance by #Cիαo𝚝icDivα
❝ Yoυ ɢoт мy вroтнer ĸιlled. He dιed ғor yoυ.❞
a mature & descriptive portrayal. adult themes ahead. MDNI. novella writer. friendly mun. dm to plot.
#FourthWingRP
another performance by #Cիαo𝚝icDivα
October 12, 2026 at 6:00 PM
.·:*¨ ✘ sʟᴏᴀɴᴇ ᴍᴀɪʀɪ ✘ ¨*:·.
❝ Yoυ ɢoт мy вroтнer ĸιlled. He dιed ғor yoυ.❞
a mature & descriptive portrayal. adult themes ahead. MDNI. novella writer. friendly mun. dm to plot.
#FourthWingRP
another performance by #Cիαo𝚝icDivα
❝ Yoυ ɢoт мy вroтнer ĸιlled. He dιed ғor yoυ.❞
a mature & descriptive portrayal. adult themes ahead. MDNI. novella writer. friendly mun. dm to plot.
#FourthWingRP
another performance by #Cիαo𝚝icDivα
Peroxisome quality control is gated by a dynamic ATF6α-ABCD3 tether www.biorxiv.org/content/10.6...
Peroxisome quality control is gated by a dynamic ATF6α-ABCD3 tether
The endoplasmic reticulum (ER) coordinates protein folding and lipid biosynthesis, while peroxisomes govern fatty-acid catabolism and redox balance. However, little is known about the mechanisms by wh...
www.biorxiv.org
October 7, 2026 at 1:32 PM
Peroxisome quality control is gated by a dynamic ATF6α-ABCD3 tether www.biorxiv.org/content/10.6...
Targeting the IRE1α/XBP1 pathway in type 2 diabetes mellitus: from ER stress signaling to therapeutic opportunity#Drosophilaa
Targeting the IRE1α/XBP1 pathway in type 2 diabetes mellitus: from ER stress signaling to therapeutic opportunity
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
October 8, 2026 at 10:23 PM
Targeting the IRE1α/XBP1 pathway in type 2 diabetes mellitus: from ER stress signaling to therapeutic opportunity#Drosophilaa
SRSF3 plays a key role in liver cancer sex disparity by facilitating hepatocyte expression of ERα and FOXA @PNAS.org
SRSF3 plays a key role in liver cancer sex disparity by facilitating hepatocyte expression of ERα and FOXA
Proceedings of the National Academy of Sciences, Volume 123, Issue 40, October 2026.
SignificanceConditional Srsf3 KO from mouse liver hepatocytes or mammary glands revealed that Srsf3 is tumor-suppressive in development of DEN-induced liver cancer but oncogenic in Erbb2-mammary tumorigenesis by differential regulation of different set of ...
dlvr.it
October 12, 2026 at 11:19 AM
SRSF3 plays a key role in liver cancer sex disparity by facilitating hepatocyte expression of ERα and FOXA @PNAS.org
The authors included RRIDs in their in Cell Communication and Signaling paper! We value the author's support of reproducibility. #ReproducibleResearch #methodsmatter #accelerateopenscience
The natural L370F ERα variant confers endocrine resistance and sensitivity to ATRA in metastatic breast cancer cells
Read the full paper: The natural L370F ERα variant confers endocrine resistance and sensitivity to ATRA in metastatic breast cancer cells
doi.org
October 9, 2026 at 7:04 AM
The authors included RRIDs in their in Cell Communication and Signaling paper! We value the author's support of reproducibility. #ReproducibleResearch #methodsmatter #accelerateopenscience
From MBoC: Could a cellular cleanup process contribute to the spread of α-synuclein?
New research links RTN3L-mediated ER-phagy to α-synuclein secretion, offering insight into a pathway relevant to Parkinson’s disease.
https://www.molbiolcell.org/doi/10.1091/mbc.E26-03-0138
New research links RTN3L-mediated ER-phagy to α-synuclein secretion, offering insight into a pathway relevant to Parkinson’s disease.
https://www.molbiolcell.org/doi/10.1091/mbc.E26-03-0138
October 5, 2026 at 1:05 PM
From MBoC: Could a cellular cleanup process contribute to the spread of α-synuclein?
New research links RTN3L-mediated ER-phagy to α-synuclein secretion, offering insight into a pathway relevant to Parkinson’s disease.
https://www.molbiolcell.org/doi/10.1091/mbc.E26-03-0138
New research links RTN3L-mediated ER-phagy to α-synuclein secretion, offering insight into a pathway relevant to Parkinson’s disease.
https://www.molbiolcell.org/doi/10.1091/mbc.E26-03-0138
The Golgi helps mito fusion. Trans-Golgi vesicles rich in PI(3,4)P2 are recruited to mito fusion sites marked by ER and mitofusin. Without the class II PI3-kinases that make this lipid (PI3K-C2α and β), fusion stalls and mitos fragment, and mice lacking both in cardiomyocytes develop heart failure.
October 11, 2026 at 1:03 PM
The Golgi helps mito fusion. Trans-Golgi vesicles rich in PI(3,4)P2 are recruited to mito fusion sites marked by ER and mitofusin. Without the class II PI3-kinases that make this lipid (PI3K-C2α and β), fusion stalls and mitos fragment, and mice lacking both in cardiomyocytes develop heart failure.
A review by Claudia Bellucci et al. examines the structural & functional consequences of germline ERα point mutations identified in estrogen insensitivity syndrome (EIS) & compares their functional consequences with somatic ERα point mutations in breast cancer.
🔗 doi.org/10.1530/JOE-26-0117
🔗 doi.org/10.1530/JOE-26-0117
![[Journal of Endocrinology logo]
Estrogen insensitivity syndrome: the ‘Upside Down’ of ESR1 mutations
Claudia Bellucci, Manuela Cipolletti,
Sergio Vulterini, Filippo Acconcia
[Journal of Endocrinology journal cover]](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:jhvxskrjpwmdig3viycotbxa/bafkreidibs6ynhgw2gh7puda7im5rqxxsyx364zqxh4bfwven2nwvagmge)
October 6, 2026 at 8:06 AM
A review by Claudia Bellucci et al. examines the structural & functional consequences of germline ERα point mutations identified in estrogen insensitivity syndrome (EIS) & compares their functional consequences with somatic ERα point mutations in breast cancer.
🔗 doi.org/10.1530/JOE-26-0117
🔗 doi.org/10.1530/JOE-26-0117
From Cancer Research: Imlunestrant in ESR1 Wild-Type and Mutant Breast Cancer doi.org/10.1158/0008...
Imlunestrant Is an Oral, Brain-Penetrant Selective Estrogen Receptor Degrader with Potent Antitumor Activity in ESR1 Wild-Type and Mutant Breast Cancer
Imlunestrant, a next-generation, brain-penetrant oral ERα degrader, displays potent activity in ESR1 wild-type and mutant breast cancer, enhances combination activity with standard-of-care agents, and...
doi.org
October 6, 2026 at 3:54 PM
From Cancer Research: Imlunestrant in ESR1 Wild-Type and Mutant Breast Cancer doi.org/10.1158/0008...
In JLR press| Loss of ceramide synthases 5 and 6 exacerbate myristate-induced colonic IRE1α activation.
Learn more:
www.jlr.org/article/...
#JLipidRes
Learn more:
www.jlr.org/article/...
#JLipidRes
October 2, 2026 at 2:58 PM
In JLR press| Loss of ceramide synthases 5 and 6 exacerbate myristate-induced colonic IRE1α activation.
Learn more:
www.jlr.org/article/...
#JLipidRes
Learn more:
www.jlr.org/article/...
#JLipidRes
Synthesis of substituted oxabicyclic phenol derivatives with increased affinity and activity for the classical estrogen receptor ERα https://www.biorxiv.org/content/10.64898/2026.09.25.754525v1
October 2, 2026 at 2:00 AM
Synthesis of substituted oxabicyclic phenol derivatives with increased affinity and activity for the classical estrogen receptor ERα https://www.biorxiv.org/content/10.64898/2026.09.25.754525v1
Synthesis of substituted oxabicyclic phenol derivatives with increased affinity and activity for the classical estrogen receptor ERα https://www.biorxiv.org/content/10.64898/2026.09.25.754525v1
October 2, 2026 at 2:00 AM
Synthesis of substituted oxabicyclic phenol derivatives with increased affinity and activity for the classical estrogen receptor ERα https://www.biorxiv.org/content/10.64898/2026.09.25.754525v1
MEMO1–ERα interaction may occur independent of Y537 phosphorylation which differs from MEMO1-ErbB2 binding #micropublication #biology #data #caltechlibrary #Escherichiacoli #Biochemistry #Computationa https://micropublication.org/journals/biology/micropub-biology-002363
September 29, 2026 at 6:40 PM
MEMO1–ERα interaction may occur independent of Y537 phosphorylation which differs from MEMO1-ErbB2 binding #micropublication #biology #data #caltechlibrary #Escherichiacoli #Biochemistry #Computationa https://micropublication.org/journals/biology/micropub-biology-002363
Take home message: ERα+ neurons in the POA, and estrogen signaling within these cells, contributes to reductions in temperature and its rhythmicity during pregnancy. These temp changes may help moms protect fetuses from too much heat and provide metabolic stability (7/9).
September 22, 2026 at 4:37 PM
Take home message: ERα+ neurons in the POA, and estrogen signaling within these cells, contributes to reductions in temperature and its rhythmicity during pregnancy. These temp changes may help moms protect fetuses from too much heat and provide metabolic stability (7/9).
We wondered if pregnancy temp changes are linked to the medial preoptic area (MPO). We recorded the neural activity of ERα+ cells for many hours at night, and found that neural activity and temp are well synchronized in non-pregnant mice, but not in pregnant mice! (3/8)
September 22, 2026 at 4:37 PM
We wondered if pregnancy temp changes are linked to the medial preoptic area (MPO). We recorded the neural activity of ERα+ cells for many hours at night, and found that neural activity and temp are well synchronized in non-pregnant mice, but not in pregnant mice! (3/8)
What is estrogen signaling doing? To test the specific role of ERα, we knocked it out and found partial elevations in Tc in late pregnancy, but also increased 24- and 8-hour rhythmicity! Our cell/gene manipulations also had consequences for fetal development (including pre-term birth). (6/8)
September 22, 2026 at 4:37 PM
What is estrogen signaling doing? To test the specific role of ERα, we knocked it out and found partial elevations in Tc in late pregnancy, but also increased 24- and 8-hour rhythmicity! Our cell/gene manipulations also had consequences for fetal development (including pre-term birth). (6/8)
We knew that activating MPO ERα+ cells decreases temp in non-preg mice. So, we expected these neurons to be more active in pregnancy. However, electrophys data showed reduced firing. Unexpected, but we decided to test if they're essential for maternal temp changes using dreadds, and they are! (4/8)
September 22, 2026 at 4:37 PM
We knew that activating MPO ERα+ cells decreases temp in non-preg mice. So, we expected these neurons to be more active in pregnancy. However, electrophys data showed reduced firing. Unexpected, but we decided to test if they're essential for maternal temp changes using dreadds, and they are! (4/8)
The ER needs steady magnesium to fuel protein-making. When it drops, the machinery stalls. Proteins don't get made, or they misfold. The ER triggers an alarm (PERK–eIF2α pathway) that shuts down production to prevent damage.
September 18, 2026 at 1:00 PM
The ER needs steady magnesium to fuel protein-making. When it drops, the machinery stalls. Proteins don't get made, or they misfold. The ER triggers an alarm (PERK–eIF2α pathway) that shuts down production to prevent damage.
Preimplantation factor (PIF) links embryo-derived signaling to maternal pancreatic β-cell adaptation through an ERα-dependent pathway https://www.biorxiv.org/content/10.64898/2026.09.10.750557v1
September 16, 2026 at 4:02 AM
Preimplantation factor (PIF) links embryo-derived signaling to maternal pancreatic β-cell adaptation through an ERα-dependent pathway https://www.biorxiv.org/content/10.64898/2026.09.10.750557v1
Preimplantation factor (PIF) links embryo-derived signaling to maternal pancreatic β-cell adaptation through an ERα-dependent pathway https://www.biorxiv.org/content/10.64898/2026.09.10.750557v1
September 16, 2026 at 4:02 AM
Preimplantation factor (PIF) links embryo-derived signaling to maternal pancreatic β-cell adaptation through an ERα-dependent pathway https://www.biorxiv.org/content/10.64898/2026.09.10.750557v1