#EXOSC10
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milofasken.bsky.social
#EXOSC10 #RNAExosome #RNA

academic.oup.com/brain/advanc...
EXOSC10 haploinsufficiency causes primary microcephaly by derepression of Sonic hedgehog signalling
Ulmke et al. show that mutations in EXOSC10 cause microcephaly. In mice, loss of Exosc10 leads to premature differentiation of neural progenitor cells, dis
academic.oup.com
October 28, 2025 at 3:23 PM
milofasken.bsky.social
Interesting! #RNAExosome #RNA
#EXOSC10 -mediated pre- #tRNA #surveillance safeguards #neuron survival
Yoshinori Nishimoto, Xin Yang, Richard I. Gregory

www.biorxiv.org/content/10.1...
www.biorxiv.org
June 24, 2025 at 5:52 PM
care-beyondlimits.bsky.social
Ever feel like research papers are written in another language?
​Our CEO is breaking down the latest EXOSC10 genetic discovery for the Microcephaly community.
​Learn why this "Recycling Center" gene is a huge win for personalized care in 2026. Read the article👇

www.linkedin.com/posts/activi...
Research Spotlight: The EXOSC10 Discovery | Lenah Mukai
Did you know a genetic breakthrough in late 2025 is changing how we understand brain development in Microcephaly? In this week's edition of Research Spotlight: The EXOSC10 Discovery I’m breaking down...
www.linkedin.com
January 19, 2026 at 6:56 AM
sciencex.bsky.social
Mutations in the EXOSC10 gene have been identified as a genetic cause of primary microcephaly, linking disrupted RNA degradation to abnormal brain development and altered Sonic hedgehog signaling.
Previously unknown genetic cause of microcephaly identified
Microcephaly is a congenital malformation that leads to a significantly reduced brain size and is often accompanied by developmental delay.
medicalxpress.com
October 28, 2025 at 6:56 PM
ruhr-uni-bochum.de
Die Mikrozephalie ist eine angeborene Fehlbildung, die zu einer verringerten Gehirngröße und motorischen und geistigen Einschränkungen führt. Mutationen im Gen EXOSC10 verursachen sie.
Neue genetische Ursache für Mikrozephalie entdeckt
Forschende entschlüsseln, wie ein RNA-abbauendes Enzym die Größe und Struktur des Gehirns steuert.
news.rub.de
October 29, 2025 at 8:29 AM
rridrobot.bsky.social
The authors included RRIDs in their in Biology of Reproduction paper! We value the author's support of reproducibility. #accelerateopenscience #methodsmatter #OpenScience
RNA exosome component EXOSC10 variants identified in a patient with premature ovarian insufficiency
Read the full paper: RNA exosome component EXOSC10 variants identified in a patient with premature ovarian insufficiency
doi.org
April 18, 2026 at 7:03 AM
bild.bsky.social
EXOSC10 genindeki mutasyonlar RNA yıkımını bozar, Shh sinyal iletimini aşırı aktive eder ve beyin gelişiminde mikrosefali hastalığına neden olur.
New Genetic Cause of Microcephaly Identified
Researchers uncover how a key RNA-processing factor safeguards proper brain development.
news.rub.de
October 29, 2025 at 12:28 PM
milofasken.bsky.social
rnajournal.cshlp.org/content/earl...
Genetic and genomic approaches to explore roles for the conserved 3’-5’ exoribonuclease EXOSC10 in normal and malignant cells
A monthly journal publishing high-quality, peer-reviewed research on all topics related to RNA and its metabolism in all organisms
rnajournal.cshlp.org
February 27, 2026 at 9:12 PM
rnajournal.bsky.social
We interpret global and targeted mouse Exosc10 deletion phenotypes in the context of the gene’s clinical potential as a prognostic cancer biomarker and explore its transcriptional regulatory network bit.ly/41IYUOj
July 9, 2026 at 4:52 PM
franmartinezgr.bsky.social
EXOSC10 haploinsufficiency causes primary microcephaly by derepression of Sonic hedgehog signalling #RareDisease #Genetics #morbidgene academic.oup.com/brain/advanc...
EXOSC10 haploinsufficiency causes primary microcephaly by derepression of Sonic hedgehog signalling
Ulmke et al. show that mutations in EXOSC10 cause microcephaly. In mice, loss of Exosc10 leads to premature differentiation of neural progenitor cells, dis
academic.oup.com
October 27, 2025 at 6:18 PM
fly-broadcast.bsky.social
RNA exosome component EXOSC10 variants identified in a patient with premature ovarian insufficiency
#Drosophila
RNA exosome component EXOSC10 variants identified in a patient with premature ovarian insufficiency #Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
January 30, 2026 at 5:23 AM
fly-broadcast.bsky.social
RNA exosome component EXOSC10 variants identified in a patient with premature ovarian insufficiency
#Drosophila
RNA exosome component EXOSC10 variants identified in a patient with premature ovarian insufficiency #Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
January 29, 2026 at 7:23 PM
diseasegenes.bsky.social
New finding from FranMartinezGr on Twitter/X! ift.tt/85GBUwR

EXOSC10 haploinsufficiency causes primary microcephaly by derepression of Sonic hedgehog signalling #RareDisease #Genetics #morbidgene
t.co
October 28, 2025 at 8:02 AM
biorxiv-molbio.bsky.social
EXOSC10-mediated pre-tRNA surveillance safeguards neuron survival https://www.biorxiv.org/content/10.1101/2025.06.19.660564v1
June 20, 2025 at 4:17 AM
biorxivpreprint.bsky.social
EXOSC10-mediated pre-tRNA surveillance safeguards neuron survival https://www.biorxiv.org/content/10.1101/2025.06.19.660564v1
June 20, 2025 at 4:17 AM
asapbio.bsky.social
From the National Institute of Diabetes and Digestive and Kidney Diseases:

EXOSC10 sculpts the transcriptome during the growth-to-maturation transition in mouse oocytes

www.biorxiv.org/content/10.1...
EXOSC10 sculpts the transcriptome during the growth-to-maturation transition in mouse oocytes
Growing mammalian oocytes accumulate substantial amounts of RNA, most of which is degraded during subsequent meiotic maturation. The growth-to-maturation transition begins with germinal vesicle or nuc...
www.biorxiv.org
February 7, 2025 at 3:05 PM