#RNAExosome
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milofasken.bsky.social
Great work! #RNAExosome #Assembly #RNADecay #RNA #Mammalian

Hierarchical assembly and functional resilience of the mammalian RNA exosome
Tsimafei Navalayeu...Stefan L. Ameres
www.biorxiv.org/content/10.1...
www.biorxiv.org
March 19, 2025 at 3:25 PM
milofasken.bsky.social
#RNAExosome
www.cell.com/trends/cell-...
Precision in RNA degradation: helicases, ribosome and RNA polymerase stalling, and RNA modifications
Errors in transcription and RNA processing generate aberrant transcripts that can produce truncated, nonfunctional, or dominant-negative proteins. RNA surveillance pathways, centered on the RNA exosom...
www.cell.com
May 14, 2026 at 12:15 PM
milofasken.bsky.social
Congrats! #SSUprocessome #RNAExosome #rRNA

www.nature.com/articles/s41...
www.nature.com
October 31, 2025 at 10:59 AM
milofasken.bsky.social
Exollent! Congrats!
#RNAExosome #RNA

www.cell.com/cell-reports...
The RNA exosome maintains cellular RNA homeostasis by controlling transcript abundance in the brain
Higginson et al. present a cell-type-resolved atlas of RNA exosome dysfunction in the Drosophila brain, showing that pathogenic Rrp40 mutations disrupt RNA surveillance and neuronal integrity. This re...
www.cell.com
December 30, 2025 at 11:33 AM
milofasken.bsky.social
Nice work! #RNAExosome #RNA

link.springer.com/article/10.1...
Cellular assembly and functional resilience of the mammalian RNA exosome - The EMBO Journal
Most eukaryotic proteins assemble into multisubunit complexes that coordinate essential cellular functions, yet the principles governing their assembly and proteostatic control remain largely undefine...
link.springer.com
June 28, 2026 at 9:21 PM
milofasken.bsky.social
A tour de force. Wonderful stuff! Congrats!
#ncRNA #MALAT1 #RNAExosome #RNaseP #NEXT #DDX59 #RNADecay #RNA #RNAsky

www.nature.com/articles/s41...
Identification of human pathways acting on nuclear non-coding RNAs using the Mirror forward genetic approach - Nature Communications
Human pathways acting on nuclear ncRNAs have been refractory to forward genetics. Here, the authors develop a forward genetic approach that identifies such pathways and show DDX59 is required for mino...
www.nature.com
May 22, 2025 at 9:39 PM
milofasken.bsky.social
Cool!
#RNAExosome #RNA #RNAsky

www.nature.com/articles/s41...
4D structural biology–quantitative dynamics in the eukaryotic RNA exosome complex - Nature Communications
An integrated structural biology approach combining NMR, cryo-EM, X-ray crystallography and molecular dynamics simulations is implemented to characterise the conformational dynamics and interactions o...
www.nature.com
August 25, 2025 at 1:44 PM
milofasken.bsky.social
DIS is interesting!
#circRNA #Degradation #DIS3 #Ribonuclease #RNAExosome

www.sciencedirect.com/science/arti...
Degradation of circular RNA by the ribonuclease DIS3
Features of circular RNAs (circRNAs) produced by back-splicing of eukaryotic exon(s) make them resistant to degradation by linear RNA decay machinerie…
www.sciencedirect.com
February 19, 2025 at 2:11 PM
milofasken.bsky.social
#RNA #Condensate #RNAExosome #RNADecay

www.biorxiv.org/content/10.1...
RNA Dynamics Regulate Transcriptional Condensate Vivacity to Drive Gene Coordination
Transcriptional condensates (TCs), enriched with Mediator, orchestrate super-enhancer (SE)-driven gene expression critical for cell identity. However, how their dynamic physical properties shape trans...
www.biorxiv.org
June 13, 2025 at 5:49 PM
milofasken.bsky.social
#RNAExosome #RNA #Starvation
doi.org/10.1371/jour...
Inhibition of the nucleolar RNA exosome facilitates adaptation to starvation
Cells reallocate their limited energy for cellular maintenance in response to nutrient scarcity at the expense of other processes, but how this trade-off is achieved remains unknown. These authors sho...
doi.org
May 23, 2025 at 9:40 PM
milofasken.bsky.social
Interesting.
#rRNA #60S #RNAExosome #RNA #RNAsky

Pre-ribosomal WDR74 module coordinates the early and late pre-rRNA processing stages for the NVL2-mediated regulation of 60S ribosome biogenesis

www.sciencedirect.com/science/arti...
January 6, 2025 at 4:44 PM
milofasken.bsky.social
#Dis3 #Rloop #RBP #RNAExosome #RNA

journals.plos.org/plosgenetics...
Cellular imbalance of specific RNA binding proteins associates with harmful R-loops
Author summary R-loops are three-stranded structures formed by a DNA-RNA hybrid and the displaced ssDNA. The accumulation of R-loops damages the genome, highlighting the need for their tight regulatio...
journals.plos.org
July 7, 2025 at 11:59 PM
milofasken.bsky.social
Look at DIS! #DIS3 #RNAExosome #PlasmaCells

www.nature.com/articles/s41...
DIS3 licenses B cells for plasma cell differentiation in humans - Cellular & Molecular Immunology
Cellular & Molecular Immunology - DIS3 licenses B cells for plasma cell differentiation in humans
www.nature.com
November 25, 2025 at 8:28 PM
milofasken.bsky.social
Interesting! #RNAExosome #RNA
#EXOSC10 -mediated pre- #tRNA #surveillance safeguards #neuron survival
Yoshinori Nishimoto, Xin Yang, Richard I. Gregory

www.biorxiv.org/content/10.1...
www.biorxiv.org
June 24, 2025 at 5:52 PM
milofasken.bsky.social
Nice work from Sean Johnson on "The Molecular Mechanisms of RNA Processing in the TRAMP RNA Surveillance Complex presented today at #RNASociety #Emory GA RNA Salon! @rnasociety.bsky.social #RNA #TRAMP #RNAExosome #RNADecay #Mtr4

www.pnas.org/doi/10.1073/...
TRAMP assembly alters the conformation and RNA binding of Mtr4 and Trf4-Air2 | PNAS
The TRAMP complex contains two enzymatic activities essential for RNA processing upstream of the nuclear exosome. Within TRAMP, RNA is 3′ polyadeny...
www.pnas.org
April 18, 2025 at 6:42 PM
milofasken.bsky.social
#RNAExosome #Rrp6 #RNAProcessing #Splicing #UPR #UnfoldedProteinResponse #BuddingYeast

academic.oup.com/nar/article/...
RNA exosome-driven RNA processing instructs the duration of the unfolded protein response
Abstract. Upon stresses, cellular compartments initiate adaptive programs meant to restore homeostasis. Dedicated to the resolution of transient perturbati
academic.oup.com
March 4, 2025 at 8:24 PM
milofasken.bsky.social
Tour de force stuff!

#SSU #Processome #RNAExosome

www.biorxiv.org/content/10.1...
Helicase-mediated mechanism of SSU processome maturation and disassembly
Eukaryotic ribosomal small subunit (SSU) assembly requires the SSU processome, a nucleolar precursor containing the RNA chaperone U3 snoRNA. The underlying molecular mechanisms of SSU processome matur...
www.biorxiv.org
October 18, 2025 at 3:44 PM
milofasken.bsky.social
#EXOSC10 #RNAExosome #RNA

academic.oup.com/brain/advanc...
EXOSC10 haploinsufficiency causes primary microcephaly by derepression of Sonic hedgehog signalling
Ulmke et al. show that mutations in EXOSC10 cause microcephaly. In mice, loss of Exosc10 leads to premature differentiation of neural progenitor cells, dis
academic.oup.com
October 28, 2025 at 3:23 PM
milofasken.bsky.social
#NEXT story to read! Cheers!
#RNAExosome
www.cell.com/cell-reports...
Nuclear exosome targeting complex safeguards hematopoietic stem cell self-renewal and genomic integrity through resolving R loops
R loops form during transcription, threatening the genomic stability of hematopoietic stem cells (HSCs) and lymphoma cells. Pan et al. report that ZCCHC8 safeguards the genome integrity and self-renew...
www.cell.com
December 10, 2025 at 12:07 PM
milofasken.bsky.social
Nice!
#RNAExosome #Structure #Review #RNADecay #RNA #RNAsky

www.annualreviews.org/content/jour...
RNA-Degrading Exosome Complexes: Molecular Mechanisms and Structural Insights | Annual Reviews
The RNA exosome is a conserved multiprotein complex essential for 3′-to-5′ RNA degradation in eukaryotic cells. In the cytoplasm, the exosome participates in messenger RNA surveillance and decay, whil...
www.annualreviews.org
June 10, 2025 at 11:17 PM
milofasken.bsky.social
Cool! #MTR4 #RNADecay #RNA #RNAExosome
The #nuclear #exosome co-factor #MTR4 shapes the #transcriptome for #meiotic initiation

Li Zhang, Jianshu Wang, Zhidong Tang, Zhen Lin, Ruibao Su, Naijing Hu, Yao Tang, Gaoxiang Ge, Jing Fan, Ming-Han Tong, Yuanchao Xue, Yu Zhou & Hong Cheng
rdcu.be/ed5WM
The nuclear exosome co-factor MTR4 shapes the transcriptome for meiotic initiation
Nature Communications - Nuclear RNA decay regulates gene expression in cultured cells, but its role in animals is largely unclear. Here, authors found that the nuclear exosome co-factor MTR4...
rdcu.be
March 18, 2025 at 9:08 PM
milofasken.bsky.social
Interesting! #RNADecay #NEXT #PAXT #RNAExosome #RNA
www.nature.com/articles/s41...
RNA 3′end tailing safeguards cells against products of pervasive transcription termination - Nature Communications
Pervasive transcription generates numerous unadenylated RNAs, usually degraded by the NEXT/nuclear exosome pathway. Here, the authors show that, upon NEXT inactivation, these RNAs are removed by compe...
www.nature.com
December 2, 2024 at 2:25 PM
milofasken.bsky.social
Nice! #RNAExosome #Localization #BuddingYeast

New Insights into #nuclear #import and #nucleolar #localization of yeast #RNA #exosome #subunits

Valdir Gomes Neto...Carla C. Oliveira
www.biorxiv.org/content/10.1...
New Insights into nuclear import and nucleolar localization of yeast RNA exosome subunits
The RNA exosome is a multiprotein complex essential for RNA maturation and degradation. In budding yeast, a nine-subunit protein complex (Exo9) associated with Rrp44 forms Exo10 in the cytoplasm and, ...
www.biorxiv.org
March 11, 2025 at 3:28 PM
milofasken.bsky.social
Interesting!
#RNAExosome #EXOSC2 #RNADecay #RNAprocessing #Aging #Cancer

www.biorxiv.org/content/10.1...
Aging-dependent dysregulation of EXOSC2 is maintained in cancer as a dependency
Reprogramming of aged donor tissue cells into induced pluripotent stem cells (A-iPSC) preserved the epigenetic memory of aged-donor tissue, defined as genomic instability and poor tissue differentiati...
www.biorxiv.org
April 17, 2025 at 3:48 PM
milofasken.bsky.social
Interesting! #RNADecay #RNAExosome #RNA #ncRNA

Defining the roles of the #Integrator, #NEXT, and #nuclear #exosome complexes in #Drosophila #oogenesis
Yongjin Lee, Adriano Biasini, Cindy Tipping, Seong Hyeon Hong, Phillip Zamore

www.biorxiv.org/content/10.1...
Defining the roles of the Integrator, NEXT, and nuclear exosome complexes in Drosophila oogenesis
Nuclear RNA homeostasis depends on the balance of transcription, RNA processing, degradation, and transport between the nucleus and cytoplasm. RNA degradation directed by the Integrator, nuclear exoso...
www.biorxiv.org
March 13, 2025 at 3:24 PM