We are looking for a human MALAT1 overexpression plasmid.
Does any of you kind people have it?
Does any of you kind people have it?
April 17, 2026 at 12:45 PM
We are looking for a human MALAT1 overexpression plasmid.
Does any of you kind people have it?
Does any of you kind people have it?
We also revealed that the use of MALAT1 expression as a surrogate for nuclear content is a promising solution, particularly when raw intronic data is unavailable.
5/8
5/8
December 3, 2024 at 8:38 AM
We also revealed that the use of MALAT1 expression as a surrogate for nuclear content is a promising solution, particularly when raw intronic data is unavailable.
5/8
5/8
Finally something the reads wasted on those damn Malat1 transcripts are good for 🙏
December 3, 2024 at 10:09 AM
Finally something the reads wasted on those damn Malat1 transcripts are good for 🙏
Keep an eye to your sc dataset, 1)are there two clusters of same cell type one with and the other without #MALAT1 expression?
2)extreme values of #MALAT1 or #intronic reads is bad, null values indicate citosolic debris and extreme high values bare nuclei (dying/damaged cell)
2)extreme values of #MALAT1 or #intronic reads is bad, null values indicate citosolic debris and extreme high values bare nuclei (dying/damaged cell)
December 4, 2024 at 2:33 PM
Nuanced MALAT1 functions revealed
PVT1 and MALAT1 Upregulation Correlates with Immune Checkpoints and Outcomes in African American Lung Cancer https://www.medrxiv.org/content/10.1101/2025.04.06.25325323v1
April 8, 2025 at 7:31 AM
Nuanced MALAT1 functions revealed
Overheard in lab…
"What's the biological equivalent of the "unadorned aluminum pole" for Festivus?"
"MALAT1"
"What's the biological equivalent of the "unadorned aluminum pole" for Festivus?"
"MALAT1"
December 18, 2024 at 2:43 PM
Overheard in lab…
"What's the biological equivalent of the "unadorned aluminum pole" for Festivus?"
"MALAT1"
"What's the biological equivalent of the "unadorned aluminum pole" for Festivus?"
"MALAT1"
METTL3 regulates α-KG-dependent mitophagy and apoptosis in nucleus pulposus cells through the MALAT1/miR-23c/IDH1 axis
METTL3 regulates α-KG-dependent mitophagy and apoptosis in nucleus pulposus cells through the MALAT1/miR-23c/IDH1 axis
Wu et al. reveal that METTL3-mediated m6A modification downregulates the lncRNA MALAT1, which sponges miR-23c to elevate IDH1 expression and α-ketoglutarate production. This axis promotes mitophagy and alleviates oxidative stress, thereby protecting against intervertebral disc degeneration.
dlvr.it
January 19, 2026 at 3:38 PM
METTL3 regulates α-KG-dependent mitophagy and apoptosis in nucleus pulposus cells through the MALAT1/miR-23c/IDH1 axis
Bağışıklık tepkilerindeki cinsiyete özgü farklılıklar bir genden kaynaklanıyor olabilir.
York'tan araştırmacılar Malat1 adlı bir genin kadın bağışıklık hücrelerinin işlevini değiştirdiğini ancak erkek hücrelerinin bundan etkilenmediğini keşfetti.
York'tan araştırmacılar Malat1 adlı bir genin kadın bağışıklık hücrelerinin işlevini değiştirdiğini ancak erkek hücrelerinin bundan etkilenmediğini keşfetti.
Malat1 regulates female Th2 cell cytokine expression through controlling early differentiation and response to IL-2
Abstract. Identifying cell intrinsic regulators of immune sexual dimorphism is critical for treatment of several immunopathologies. We show that Malat1 is
academic.oup.com
August 30, 2025 at 8:43 AM
Bağışıklık tepkilerindeki cinsiyete özgü farklılıklar bir genden kaynaklanıyor olabilir.
York'tan araştırmacılar Malat1 adlı bir genin kadın bağışıklık hücrelerinin işlevini değiştirdiğini ancak erkek hücrelerinin bundan etkilenmediğini keşfetti.
York'tan araştırmacılar Malat1 adlı bir genin kadın bağışıklık hücrelerinin işlevini değiştirdiğini ancak erkek hücrelerinin bundan etkilenmediğini keşfetti.
Now online! Nuclear speckle proteins form intrinsic and MALAT1-dependent microphases
Nuclear speckle proteins form intrinsic and MALAT1-dependent microphases
In nuclear speckles, sequence-encoded inter-domain attractive and repulsive interactions drive proteins to form hierarchical structures, including size-limited microphases, clusters of microphases, micron-scale double emulsions in protein mixtures, and microphases stabilized by preferential and protein-specific binding to the lncRNA MALAT1.
dlvr.it
December 19, 2025 at 3:59 PM
Now online! Nuclear speckle proteins form intrinsic and MALAT1-dependent microphases
Female Malat1-/- mice demonstrated altered Th2 cytokine expression, evidenced by a reduction in IL-10+ Th2 cells in both lung and spleen, while male Malat1-/- mice did not, revealing Malat1 as a novel determinant of immune sexual dimorphism. Read more: ow.ly/RgN050XQCz8.
Malat1 regulates female Th2 cell cytokine expression through controlling early differentiation and response to IL-2
Abstract. Identifying cell intrinsic regulators of immune sexual dimorphism is critical for treatment of several immunopathologies. We show that Malat1 is
ow.ly
December 31, 2025 at 2:28 PM
Female Malat1-/- mice demonstrated altered Th2 cytokine expression, evidenced by a reduction in IL-10+ Th2 cells in both lung and spleen, while male Malat1-/- mice did not, revealing Malat1 as a novel determinant of immune sexual dimorphism. Read more: ow.ly/RgN050XQCz8.
Structural basis of tRNA-like small RNA generated from MALAT1 and NEAT1
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Structural basis of NEAT1 lncRNA maturation and menRNA instability - Nature Structural & Molecular Biology
This study reveals the mechanisms of NEAT1 lncRNA maturation and menRNA biogenesis and uncovers an RNA-centric, riboswitch-like mechanism where menRNA drives its own conformational isomerization that ...
www.nature.com
November 18, 2024 at 4:42 PM
Structural basis of tRNA-like small RNA generated from MALAT1 and NEAT1
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Not checking nuclear markers like MALAT1 or intronic reads in your scRNA-seq data?🚨
We show their power to flag low-quality cells—even in top public datasets. It’s time to prioritize better QC for cleaner, more reliable genomics research!
Read more: bmcgenomics.biomedcentral.com/articles/10....
1/8
High content of nuclei-free low-quality cells in reference single-cell atlases: a call for more stringent quality control using nuclear fraction - BMC Genomics
The advent of droplet-based single-cell RNA-sequencing (scRNA-seq) has dramatically increased data throughput, enabling the release of a diverse array of tissue cell atlases to the public. However, we...
bmcgenomics.biomedcentral.com
December 3, 2024 at 8:38 AM
Not checking nuclear markers like MALAT1 or intronic reads in your scRNA-seq data?🚨
We show their power to flag low-quality cells—even in top public datasets. It’s time to prioritize better QC for cleaner, more reliable genomics research!
Read more: bmcgenomics.biomedcentral.com/articles/10....
1/8
What’s the difference between female and male Th cells? We have a new paper on this! The mighty Malat1 controls Th2 differentiation in female but not male cells.
Work by Mags Gwynne and Katie West
@jimmunol.bsky.social
doi.org/10.1093/jimm...
@york.ac.uk, @ybri-uoy.bsky.social, @hyms.ac.uk
Work by Mags Gwynne and Katie West
@jimmunol.bsky.social
doi.org/10.1093/jimm...
@york.ac.uk, @ybri-uoy.bsky.social, @hyms.ac.uk
Malat1 regulates female Th2 cell cytokine expression through controlling early differentiation and response to IL-2
Abstract. Identifying cell intrinsic regulators of immune sexual dimorphism is critical for treatment of several immunopathologies. We show that Malat1 is
doi.org
August 28, 2025 at 10:41 AM
What’s the difference between female and male Th cells? We have a new paper on this! The mighty Malat1 controls Th2 differentiation in female but not male cells.
Work by Mags Gwynne and Katie West
@jimmunol.bsky.social
doi.org/10.1093/jimm...
@york.ac.uk, @ybri-uoy.bsky.social, @hyms.ac.uk
Work by Mags Gwynne and Katie West
@jimmunol.bsky.social
doi.org/10.1093/jimm...
@york.ac.uk, @ybri-uoy.bsky.social, @hyms.ac.uk
A team from Universidad Andrés Bello (UNAB) used CRISPR to remove a tiny fragment of MALAT1 RNA, a molecule that plays a key role in gastric and breast cancer. By doing so, the researchers managed to destabilize the entire molecule and slow tumor progression.
Chilean scientists discover how to dismantle a key molecule in stomach and breast tumors
A team from Universidad Andrés Bello (UNAB) used CRISPR to remove a tiny fragment of MALAT1 RNA, a molecule that plays a key role in gastric and breast cancer. By doing so, the researchers managed to...
www.entnerd.com
September 24, 2026 at 12:35 PM
A team from Universidad Andrés Bello (UNAB) used CRISPR to remove a tiny fragment of MALAT1 RNA, a molecule that plays a key role in gastric and breast cancer. By doing so, the researchers managed to destabilize the entire molecule and slow tumor progression.
(5) To the meat of the story, POCA generated new views of proteins proximal to RNA targets like Malat1 and ITS1
May 6, 2026 at 12:07 AM
(5) To the meat of the story, POCA generated new views of proteins proximal to RNA targets like Malat1 and ITS1
Nuclear speckle associated RRM-containing proteins are block copolymers. They make size-limited, ordered microphases, tens of nm in size comprising tens of molecules. Speckles are likely clusters or emulsions of distinct microphases and not macrophases www.sciencedirect.com/science/arti...
Nuclear speckle proteins form intrinsic and MALAT1-dependent microphases
Pre-mRNA processing components in nuclear speckles encompass one or more folded RNA recognition motifs (RRMs) and disordered regions with specific seq…
www.sciencedirect.com
December 19, 2025 at 7:14 PM
Nuclear speckle associated RRM-containing proteins are block copolymers. They make size-limited, ordered microphases, tens of nm in size comprising tens of molecules. Speckles are likely clusters or emulsions of distinct microphases and not macrophases www.sciencedirect.com/science/arti...
#MetaAnalysis reveals that lncRNAs #MALAT1 and #MIAT show moderate diagnostic accuracy for #CoronaryArteryDisease, with MALAT1 also linked to prognosis. Findings highlight their potential but call for standardization in clinical validation. #Biomarker link.springer.com/article/10.1...
Diagnostic value of long noncoding RNAs MIAT and MALAT1 in coronary artery disease: a systematic review and diagnostic accuracy test meta-analysis - BMC Cardiovascular Disorders
BMC Cardiovascular Disorders - Long noncoding RNAs (lncRNAs) MALAT1 and MIAT modulate atherosclerotic progression and myocardial ischemia injury, through vascular endothelial dysfunction....
link.springer.com
December 14, 2025 at 6:01 AM
#MetaAnalysis reveals that lncRNAs #MALAT1 and #MIAT show moderate diagnostic accuracy for #CoronaryArteryDisease, with MALAT1 also linked to prognosis. Findings highlight their potential but call for standardization in clinical validation. #Biomarker link.springer.com/article/10.1...
The long noncoding RNA Malat1 contains an internal ribosome entry site mediating micropeptide translation https://www.biorxiv.org/content/10.64898/2026.02.11.705401v1
February 12, 2026 at 3:16 PM
The long noncoding RNA Malat1 contains an internal ribosome entry site mediating micropeptide translation https://www.biorxiv.org/content/10.64898/2026.02.11.705401v1
1/
Ever felt your scRNA-seq QC was solid, but something didn’t add up? MALAT1 and NEAT1 might be saying more than you think.
Ever felt your scRNA-seq QC was solid, but something didn’t add up? MALAT1 and NEAT1 might be saying more than you think.
June 10, 2025 at 1:45 PM
1/
Ever felt your scRNA-seq QC was solid, but something didn’t add up? MALAT1 and NEAT1 might be saying more than you think.
Ever felt your scRNA-seq QC was solid, but something didn’t add up? MALAT1 and NEAT1 might be saying more than you think.
Arkhipova & Drukker identified orthologs of NEAT1 and MALAT1 - the only lncRNAs that use the tRNA-processing machinery for maturation - across 545 mammals to investigate differences in function and evolutionary conservation.
🔗 doi.org/10.1093/molbev/msaf265
#evobio #molbio
🔗 doi.org/10.1093/molbev/msaf265
#evobio #molbio
February 27, 2026 at 1:01 PM
Arkhipova & Drukker identified orthologs of NEAT1 and MALAT1 - the only lncRNAs that use the tRNA-processing machinery for maturation - across 545 mammals to investigate differences in function and evolutionary conservation.
🔗 doi.org/10.1093/molbev/msaf265
#evobio #molbio
🔗 doi.org/10.1093/molbev/msaf265
#evobio #molbio
A tour de force. Wonderful stuff! Congrats!
#ncRNA #MALAT1 #RNAExosome #RNaseP #NEXT #DDX59 #RNADecay #RNA #RNAsky
www.nature.com/articles/s41...
#ncRNA #MALAT1 #RNAExosome #RNaseP #NEXT #DDX59 #RNADecay #RNA #RNAsky
www.nature.com/articles/s41...
Identification of human pathways acting on nuclear non-coding RNAs using the Mirror forward genetic approach - Nature Communications
Human pathways acting on nuclear ncRNAs have been refractory to forward genetics. Here, the authors develop a forward genetic approach that identifies such pathways and show DDX59 is required for mino...
www.nature.com
May 22, 2025 at 9:39 PM
A tour de force. Wonderful stuff! Congrats!
#ncRNA #MALAT1 #RNAExosome #RNaseP #NEXT #DDX59 #RNADecay #RNA #RNAsky
www.nature.com/articles/s41...
#ncRNA #MALAT1 #RNAExosome #RNaseP #NEXT #DDX59 #RNADecay #RNA #RNAsky
www.nature.com/articles/s41...
Interesting BMC Genomics paper filters "nucleus-free" low-quality cells using the number of intronic reads. MALAT1 expression may provide a shortcut, but I would be wary of filtering out meaningful data 1/3 🩸🧬 @tmontsay.bsky.social @annaesteveco.bsky.social www.ncbi.nlm.nih.gov/pubmed/39574...
December 4, 2024 at 2:55 PM
Interesting BMC Genomics paper filters "nucleus-free" low-quality cells using the number of intronic reads. MALAT1 expression may provide a shortcut, but I would be wary of filtering out meaningful data 1/3 🩸🧬 @tmontsay.bsky.social @annaesteveco.bsky.social www.ncbi.nlm.nih.gov/pubmed/39574...
Regulation of the lncRNA malat1/Egr1 Axis by Wnt, Notch and TGF-β signaling: A Key Mechanism in Retina Regeneration https://www.biorxiv.org/content/10.1101/2025.01.03.631187v1
January 4, 2025 at 4:30 PM
Regulation of the lncRNA malat1/Egr1 Axis by Wnt, Notch and TGF-β signaling: A Key Mechanism in Retina Regeneration https://www.biorxiv.org/content/10.1101/2025.01.03.631187v1