The central dogma of biology relies on numerous regulatory events to define the expression profile of any given cell. Created in https://BioRender.com.

mRNA synthesis requires extensive pre-mRNA maturation, the organisation of which remains unclear. Here, we directly sequence pre-mRNA without metabolic labelling or amplification to resolve transcript...

Abstract. Upon stresses, cellular compartments initiate adaptive programs meant to restore homeostasis. Dedicated to the resolution of transient perturbati

Reprogramming of aged donor tissue cells into induced pluripotent stem cells (A-iPSC) preserved the epigenetic memory of aged-donor tissue, defined as genomic instability and poor tissue differentiati...

Focus on the molecular consequence described in the question — a mutation in the SMN1 gene causing defective snRNP assembly. Recall the cellular processes each component is involved in. Use this analysis to determine which process is directly impaired. This approach strengthens your ability to link gene mutations to cellular dysfunction.

HEMIFUSOME : THE EXCITING DISCOVERY OF A BRAND-NEW ORGANELLE INSIDE OUR CELLS You might already know about organelles like the mitochondria (our cell’s “power plants”) or the nucleus (the “control c...