#AlternativeSplicing
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sigtrans-sttt.bsky.social
CDK12/13 inhibition exposes a vulnerability in platinum-resistant #OvarianCancer by disrupting transcription and #AlternativeSplicing, with the CDK12–SFPQ/p54nrb complex driving RNA-processing reprogramming and cytotoxicity.

#STTT #OpenAccess: doi.org/10.1038/s413...
CDK12/13 inhibition overcomes platinum resistance by impairing RNA metabolism
October 3, 2026 at 3:00 AM
genesndiseases.bsky.social
Reliable #AlternativeSplicing detection is key for clinical biomarkers.
This review highlights #RNAsequencing benchmarking, standardization and analytical optimization for reproducible results. #Bioinformatics
#OpenAccess in #GenesAndDiseases: doi.org/10.1016/j.ge...
October 2, 2026 at 4:48 PM
proteomass-sci-soc.bsky.social
Join us at #SPLICING2027 to dig into the mechanisms behind it: from spliceosome biology to translational applications.
📅 11-15 July 2027 |📍Caparica, Portugal
📝 Registration deadline: 1 Dec. 2026
🔗 splicing2027.com
#RNASplicing #DNASplicing #AlternativeSplicing @laqv-requimte.bsky.social
September 29, 2026 at 12:48 PM
sigtrans-sttt.bsky.social
Platinum resistance limits effective treatment for #OvarianCancer.

CDK12i synergizes with Pt-therapy disrupting transcriptional elongation and SFPQ/p54nrb-dependent #AlternativeSplicing, highlighting it as a potent therapeutic strategy.

#STTT #OpenAccess: doi.org/10.1038/s413...
CDK12/13 inhibition overcomes platinum resistance by impairing RNA metabolism
September 7, 2026 at 12:30 PM
genesndiseases.bsky.social
Could one splicing regulator shape #HeartFailure?
This study identifies RBM27 as essential for maintaining Tnnt2 splicing and cardiac function, revealing a promising therapeutic target for heart disease. #AlternativeSplicing
#OpenAccess #GenesAndDiseases: doi.org/10.1016/j.ge...
September 7, 2026 at 10:05 AM
gacatag.bsky.social
An interactive PSI visualization (developed using #RShiny) for the exon inclusion of #OBSCN in our studied pre- and post-natal skeletal and cardiac muscle samples is available at psivis.it.helsinki.fi:3838/OBSCN_PSIVIS/ , #NMD #AlternativeSplicing #RNA #PSIVIS
March 1, 2025 at 8:40 PM
medcomm.bsky.social
#Review in #MedComm
Alternative Splicing: Molecular Mechanisms, Biological Functions, Diseases, and Potential Therapeutic Targets doi.org/10.1002/mco2...

#AlternativeSplicing #BiologicalFunction #disease #MolecularMechanism #TherapeuticTarget
Alternative Splicing: Molecular Mechanisms, Biological Functions, Diseases, and Potential Therapeutic Targets
Alternative splicing (AS) expands proteomic diversity and functional complexity in eukaryotes, regulated by spliceosomal components, RNA elements, and epigenetic modifications. Dysregulated AS contri...
doi.org
December 26, 2025 at 2:27 AM
csbj.org
🔗 Advancing automated cell type annotation with large language models and single-cell isoform sequencing. Computational and Structural Biotechnology Journal, DOI: doi.org/10.1016/j.cs...

📚 CSBJ: www.csbj.org

#LargeLanguageModels #Genomics #CellBiology #AlternativeSplicing #LLMs #SystemsBiology
Advancing automated cell type annotation with large language models and single-cell isoform sequencing. Computational and Structural Biotechnology Journal, DOI: https://doi.org/10.1016/j.csbj.2025.11.008
November 21, 2025 at 9:54 PM
jipb.bsky.social
This exciting issue includes articles on #AI and #Huanglongbing resistance, vertical farming, #reviews on genetic variation in adaptive #evolution, and on #AlternativeSplicing, along with much more research!

Read more great #PlantScience from this issue here: onlinelibrary.wiley.com/toc/17447909...
September 4, 2025 at 2:48 PM
earlhaminst.bsky.social
Thanks to @alperakay.bsky.social from @uniofeastanglia.bsky.social who joined us this morning for our weekly seminar, sharing his research in #alternativesplicing regulation by snRNA modifications.

@norwichrnaclub.bsky.social @whaerty.bsky.social
Dr Alper Akay, UKRI Future Leaders Fellow at the University of East Anglia, standing behind the EI seminar lecturn, next to Dr Wilfried Haerty, Group Leader at EI.
February 11, 2025 at 2:04 PM
crc1678.bsky.social
🥳 Huge congrats to our CRC1678 member @nishahemandhar.bsky.social from the @beyerlab.bsky.social for publishing this amazing work on mapping protein turnover in mice - a fantastic contribution to tissue-specific proteome properties! #CRC1678 #ProteinTurnover #TissueProteomics #SystemsBiology
April 29, 2025 at 2:06 PM
jsantoyo.bsky.social
Predicting the structural impact of human alternative splicing. #AlternativeSplicing #GenomeBiology
genomebiology.biomedcentral.com/articles/10....
September 24, 2025 at 9:15 AM
jsantoyo.bsky.social
Single cell and spatial alternative splicing analysis with Nanopore long read sequencing. #SingleCell #scRNAseq #AlternativeSplicing #LongReads #Sequencing @nanoporetech.com @natcomms.nature.com
www.nature.com/articles/s41...
July 29, 2025 at 5:51 PM
jsantoyo.bsky.social
Machine learning-optimized targeted detection of alternative splicing. #AlternativeSplicing #NAR #Genomics 🧬
academic.oup.com/nar/advance-...
Machine learning-optimized targeted detection of alternative splicing
Abstract. RNA sequencing (RNA-seq) is widely adopted for transcriptome analysis but has inherent biases that hinder the comprehensive detection and quantif
academic.oup.com
January 6, 2025 at 9:34 PM
genomiqueens.bsky.social
🛠️ Resources

All code, datasets, and reproducible pipelines are openly available: github.com/alihamraoui/...

#bioinformatics #RNAseq #singlecell #alternativesplicing #benchmark #opensource #scRNAseq #MinION

cc @fr-genomics.bsky.social @mthomaschollier.bsky.social
GitHub - alihamraoui/scKenver
Contribute to alihamraoui/scKenver development by creating an account on GitHub.
github.com
July 30, 2025 at 12:00 PM
haoyin.bsky.social
#AlternativeSplicing analysis pipeline

MAJIQ v2 - VOILA v2 modulizer

👉Build gene splicegraph including unannotated, complex elements (e.g. de novo intron retention)
👉Quantify AS events & modules
👉Comparative analysis of GTEx v8 all 53 tissues

#NatComm 2023
www.nature.com/articles/s41...
January 24, 2026 at 12:30 PM
haoyin.bsky.social
#AlternativeSplicing

Systematic profiling of AS program & splicing factors (RBPMS, RBFOX2, MBNL1/2, Quaking) in Smooth Muscle Cell

RBPMS, RBFOX2 & MBNL1/2, but not QK, are pro-contractile in PAC1 SMC

#NucAcidRes 2025
academic.oup.com/nar/article/...
December 31, 2025 at 7:51 PM
haoyin.bsky.social
Computational workflow to analyze #AlternativeSplicing
vast-tools
Matt
ExOrthist
VastDB (vertebrate database) vastdb.crg.eu/wiki/Main_Page
PastDB (A. thaliana database) pastdb.crg.eu/wiki/About

Manuel Irimia lab #MethodMolBiol 2022
link.springer.com/protocol/10....
September 2, 2025 at 5:58 PM
haoyin.bsky.social
#AlternativeSplicing #SmoothMuscleCell

RBPMS, coordinating with RBFOX2, mediates splicing events of SMC contractile, focal adhesion & actin cytoskeleton genes

234 skipped exon events shared by high-level RBPMS overexpression in hESC adult aorta

#CardiovascRes 2024
academic.oup.com/cardiovascre...
October 17, 2024 at 6:56 PM
haoyin.bsky.social
Patho-DBiT
Spatial #RNAWorld on FFPE section👹
Now tissues can be mapped by RNA variants or non-coding RNAs

Whole transcriptome seq covers
mRNA
LincRNA
microRNA
sn/snoRNA
#AlternativeSplicing
#RNAEditing
RNA #SingleNucleotideVariation

In situ polyA

bioRxiv 2024
www.biorxiv.org/content/10.1...
February 9, 2024 at 1:06 PM
haoyin.bsky.social
Genome-wide #AlternativeSplicing variation in #SmoothMuscleCell phenotypic plasticity

#Nanopore long-read RNAseq

Cultured👤aortic SMC
TGFβ/PDGFBB/miR-221

When your targets don't vary at the gene level, take a look at their AS variants

#CommsBio 2023
www.nature.com/articles/s42...
December 22, 2023 at 7:54 PM
slefkopoulos.bsky.social
#NCB2024
In July, @tamraogilvie.bsky.social, Taylor, @olivier-saulnier.bsky.social & co reported a noncanonical role for OTX2 in regulating #AlternativeSplicing and a stem cell and pro-tumorigenic splicing program in group 3 #medulloblastoma.
www.nature.com/articles/s41...
A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing - Nature Cell Biology
Werbowetski-Ogilvie, Taylor and colleagues report a noncanonical role for OTX2 in regulating alternative splicing and controlling a stem cell and pro-tumorigenic splicing program in group 3 medullobla...
www.nature.com
December 20, 2024 at 11:25 PM
cosybio-uhh.bsky.social
#AlternativeSplicing is key to understanding disease, but high-depth data is limited. We tested #DeepLearning tools to bridge the gap and show their added value in analysis pipelines, e.g. for initial hypothesis development.

🔗https://academic.oup.com/bib/article/27/1/bbaf705/8419938
April 13, 2026 at 12:22 PM
cosybio-uhh.bsky.social
While reaching for cookies, we stumbled on a treat of a different kind: DIGGER 2.0 for exploring the functional role of protein interactions in #AlternativeSplicing! ☃️🍪
Now supporting the mouse interactome and the functional enrichment tool NEASE #CoSyAdventcalender

👉 exbio.wzw.tum.de/digger/
Home | DIGGER
exbio.wzw.tum.de
December 23, 2025 at 12:28 PM
cosybio-uhh.bsky.social
Presenting DIGGER 2.0: we extended our #AlternativeSplicing software DIGGER with new functionalities, including support of the mouse interactome and NEASE for #EnrichmentAnalysis! Check it out here: exbio.wzw.tum.de/digger/
August 21, 2025 at 11:32 AM