#AlternativeSplicing
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jsantoyo.bsky.social
Predicting the structural impact of human alternative splicing. #AlternativeSplicing #GenomeBiology
genomebiology.biomedcentral.com/articles/10....
September 24, 2025 at 9:15 AM
mirimiam.bsky.social
🚨🚨🚨

If you're a bioinformatician who loves:

🧬 #SingleCell #LongReadSequencing & #AlternativeSplicing
🚀 Collaborating and travelling

Apply to work with us at the spectacular BIMSB (@mdc-berlin.bsky.social) in Berlin + @upf.edu-@crg.eu in Barcelona. Qs: www.transdevolab.com

Please RT! 🙏
December 23, 2024 at 3:54 PM
narjournal.bsky.social
⭐ #NARBreakthrough! ⭐
🧬 New study uncovers how #RNAstructures control stochastic exon selection in Dscam1 genes. #Balancer RNA structures and a #multi-subunit RNA architecture coordinate spatial and temporal splicing 🔬✨
Read the full article here: doi.org/10.1093/nar/...
#AlternativeSplicing
March 6, 2026 at 3:54 PM
rnadoctor.bsky.social
🚨 New paper alert! 🚨

Our method paper entitled: "Semi-quantitative RT-PCR Assay for the Analysis of Alternative Splicing of Interleukin Genes" is out now on the volume "Immune Mediators in Cancer"!

🧵 Thread 👇

#AlternativeSplicing
#SpliceVariant
#Interleukins
#Cytokines
January 12, 2026 at 4:05 PM
jsantoyo.bsky.social
Single cell and spatial alternative splicing analysis with Nanopore long read sequencing. #SingleCell #scRNAseq #AlternativeSplicing #LongReads #Sequencing @nanoporetech.com @natcomms.nature.com
www.nature.com/articles/s41...
July 29, 2025 at 5:51 PM
haoyin.bsky.social
#AlternativeSplicing analysis pipeline

MAJIQ v2 - VOILA v2 modulizer

👉Build gene splicegraph including unannotated, complex elements (e.g. de novo intron retention)
👉Quantify AS events & modules
👉Comparative analysis of GTEx v8 all 53 tissues

#NatComm 2023
www.nature.com/articles/s41...
January 24, 2026 at 12:30 PM
haoyin.bsky.social
#AlternativeSplicing

Systematic profiling of AS program & splicing factors (RBPMS, RBFOX2, MBNL1/2, Quaking) in Smooth Muscle Cell

RBPMS, RBFOX2 & MBNL1/2, but not QK, are pro-contractile in PAC1 SMC

#NucAcidRes 2025
academic.oup.com/nar/article/...
December 31, 2025 at 7:51 PM
mixmue.bsky.social
Amazing collaboration powered by the Schlundtlab @lab-nmr.bsky.social with support from @weigandlab.bsky.social, @sophiekorn.bsky.social, the @hummerlab.bsky.social, @imprs-cbp.bsky.social and @scale-cluster-ffm.bsky.social

#SRSF6 #AlternativeSplicing #NMR #iCLIP #MultiDomainRBP #RNARecognition
June 17, 2026 at 2:06 PM
longtrec.bsky.social
Next Up in the #LongTREC Series 📽️ : Yalan Bi!
Yalan is a LongTREC Doctoral Candidate working with Ralf Herwig at @molgen.mpg.de Yalan shares insights into her research project and her experience as part of the LongTREC network. #LongReadsTranscriptomics #AlternativeSplicing #ProteinInteraction
July 12, 2025 at 2:21 PM
ddu-dundee.bsky.social
Good morning Sky-Friends!
Our own @biochemtrix.bsky.social (and occasional poster!) is in Germany at the #Unleash consortium meeting. They are joining us here in the sky @unleash-as.bsky.social so follow along to find out about #AlternativeSplicing!
September 16, 2025 at 7:54 AM
haoyin.bsky.social
Computational workflow to analyze #AlternativeSplicing
vast-tools
Matt
ExOrthist
VastDB (vertebrate database) vastdb.crg.eu/wiki/Main_Page
PastDB (A. thaliana database) pastdb.crg.eu/wiki/About

Manuel Irimia lab #MethodMolBiol 2022
link.springer.com/protocol/10....
September 2, 2025 at 5:58 PM
unleash-as.bsky.social
Well we feel that this is something that needs to be studied closely! How can we possibly understand splicing if the colour palette is wrong!
#alternativesplicing #whatcolourisyoursnrnp
May 12, 2026 at 6:37 PM
plosbiology.org
PRMT5 is a #HistoneMethyltransferase upregulated in various cancer types. This study shows that PRMT5 regulates TCF3 #AlternativeSplicing under #hypoxia and that this promotes #EMT and invasion of #BreastCancer cells @plosbiology.org 🧪 plos.io/48ZbZrT
Schematic model depicting the role of PRMT5-mediated symmetric arginine dimethylation in regulation of TCF3 alternative splicing under normoxia (left) and hypoxia (right). Created in BioRender. Shukla, S.
November 5, 2025 at 8:59 AM
jsantoyo.bsky.social
Machine learning-optimized targeted detection of alternative splicing. #AlternativeSplicing #NAR #Genomics 🧬
academic.oup.com/nar/advance-...
Machine learning-optimized targeted detection of alternative splicing
Abstract. RNA sequencing (RNA-seq) is widely adopted for transcriptome analysis but has inherent biases that hinder the comprehensive detection and quantif
academic.oup.com
January 6, 2025 at 9:34 PM
genomiqueens.bsky.social
🛠️ Resources

All code, datasets, and reproducible pipelines are openly available: github.com/alihamraoui/...

#bioinformatics #RNAseq #singlecell #alternativesplicing #benchmark #opensource #scRNAseq #MinION

cc @fr-genomics.bsky.social @mthomaschollier.bsky.social
GitHub - alihamraoui/scKenver
Contribute to alihamraoui/scKenver development by creating an account on GitHub.
github.com
July 30, 2025 at 12:00 PM
plosbiology.org
PRMT5 is a #HistoneMethyltransferase upregulated in various cancer types. This study shows that PRMT5 regulates TCF3 #AlternativeSplicing under #hypoxia and that this promotes #EMT and invasion of #BreastCancer cells @plosbiology.org 🧪 plos.io/48ZbZrT
Schematic model depicting the role of PRMT5-mediated symmetric arginine dimethylation in regulation of TCF3 alternative splicing under normoxia (left) and hypoxia (right). Created in BioRender. Shukla, S.
November 5, 2025 at 5:30 PM
earlhaminst.bsky.social
Thanks to @alperakay.bsky.social from @uniofeastanglia.bsky.social who joined us this morning for our weekly seminar, sharing his research in #alternativesplicing regulation by snRNA modifications.

@norwichrnaclub.bsky.social @whaerty.bsky.social
Dr Alper Akay, UKRI Future Leaders Fellow at the University of East Anglia, standing behind the EI seminar lecturn, next to Dr Wilfried Haerty, Group Leader at EI.
February 11, 2025 at 2:04 PM
jipb.bsky.social
This exciting issue includes articles on #AI and #Huanglongbing resistance, vertical farming, #reviews on genetic variation in adaptive #evolution, and on #AlternativeSplicing, along with much more research!

Read more great #PlantScience from this issue here: onlinelibrary.wiley.com/toc/17447909...
September 4, 2025 at 2:48 PM
crc1678.bsky.social
🥳 Huge congrats to our CRC1678 member @nishahemandhar.bsky.social from the @beyerlab.bsky.social for publishing this amazing work on mapping protein turnover in mice - a fantastic contribution to tissue-specific proteome properties! #CRC1678 #ProteinTurnover #TissueProteomics #SystemsBiology
April 29, 2025 at 2:06 PM
rnadoctor.bsky.social
4/4 Undergrad students Christopher Beauvil, Damyan Dekajlo, and Katelyn Cheung presented a poster on molecular tools to study RNA splicing in neurons.

#RNAsplicing
#AlternativeSplicing
#RNA
#neuron
April 14, 2026 at 7:30 PM
slefkopoulos.bsky.social
#NCB2024
In July, @tamraogilvie.bsky.social, Taylor, @olivier-saulnier.bsky.social & co reported a noncanonical role for OTX2 in regulating #AlternativeSplicing and a stem cell and pro-tumorigenic splicing program in group 3 #medulloblastoma.
www.nature.com/articles/s41...
A group 3 medulloblastoma stem cell program is maintained by OTX2-mediated alternative splicing - Nature Cell Biology
Werbowetski-Ogilvie, Taylor and colleagues report a noncanonical role for OTX2 in regulating alternative splicing and controlling a stem cell and pro-tumorigenic splicing program in group 3 medullobla...
www.nature.com
December 20, 2024 at 11:25 PM
plosbiology.org
Protein #kinase dysregulation is often implicated in #cancer. This study shows that casein kinase 2-mediated phosphorylation of splicing factor SF3B2 enhances its #deubiquitination & stability, driving aberrant #AlternativeSplicing & promoting ESCC progression @plosbiology.org 🧪 plos.io/4tjuKgI
A working model of CK2-mediated SF3B3 phosphorylation in promoting ESCC progression. In ESCC, aberrantly activated CK2 phosphorylates SF3B3 at Thr1200, enhancing its interaction with the deubiquitinase USP7. This interaction leads to deubiquitination and stabilization of SF3B3, ultimately promoting a large cohort of alternative splicing events, including the inclusion of exon 4 in EXOSC2, and thereby driving ESCC progression. Targeting both CK2 and USP7, either individually or in combination, using CX-4945 and P5091, respectively, effectively suppresses ESCC progression.
April 14, 2026 at 8:00 AM
rnadoctor.bsky.social
📢 #PaperAlert

Review article in @WIREs_Reviews on #AlternativeSplicing, voltage-gated #calcium #channels, and #channelopathies. #IonChannels

Alternative Splicing and CaV‐Associated Channelopathies - Munyao - 2025 - WIREs RNA - Wiley Online Library wires.onlinelibrary.wiley.com/doi/10.1002/...
Alternative Splicing and CaV‐Associated Channelopathies
Voltage-gated calcium channels control vital cellular processes through complex alternative splicing mechanisms, and their dysfunction contributes to neurological, cardiac, endocrine, oncogenic, and ...
wires.onlinelibrary.wiley.com
June 11, 2025 at 8:16 PM
plosbiology.org
PRMT5 is a #HistoneMethyltransferase upregulated in various cancer types. This study shows that PRMT5 regulates TCF3 #AlternativeSplicing under #hypoxia and that this promotes #EMT and invasion of #BreastCancer cells @plosbiology.org 🧪 plos.io/48ZbZrT
Schematic model depicting the role of PRMT5-mediated symmetric arginine dimethylation in regulation of TCF3 alternative splicing under normoxia (left) and hypoxia (right). Created in BioRender. Shukla, S.
November 5, 2025 at 2:04 PM
andrewj27.bsky.social
Sad to hear about the lurg.

🎉 #alternativesplicing 🎉
May 10, 2026 at 5:51 PM