Epigenetics Update - SWI/SNF complexes shape 3D chromatin architecture through CTCF and cohesin www.nature.com/articles/s41...
Cem Meydan, Ari Melnick, & @darkobar.bsky.social in Nature.com
#Epigenetics #Chromatin #CTCF #Cohesin #SWISNF
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Discover the breakthrough at epigenometech.com
Cem Meydan, Ari Melnick, & @darkobar.bsky.social in Nature.com
#Epigenetics #Chromatin #CTCF #Cohesin #SWISNF
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Discover the breakthrough at epigenometech.com
November 4, 2026 at 12:34 PM
Epigenetics Update - SWI/SNF complexes shape 3D chromatin architecture through CTCF and cohesin www.nature.com/articles/s41...
Cem Meydan, Ari Melnick, & @darkobar.bsky.social in Nature.com
#Epigenetics #Chromatin #CTCF #Cohesin #SWISNF
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Discover the breakthrough at epigenometech.com
Cem Meydan, Ari Melnick, & @darkobar.bsky.social in Nature.com
#Epigenetics #Chromatin #CTCF #Cohesin #SWISNF
---
Discover the breakthrough at epigenometech.com
I’ve just published a #PreprintReview of “Genome-wide chromatin reset at the onset of leg regeneration in pancrustaceans” on @prereview.bsky.social
prereview.org/reviews/2388...
prereview.org/reviews/2388...
PREreview of Genome-wide chromatin reset at the onset of leg regeneration in pancrustaceans
Authored by J.P. Flores
prereview.org
November 2, 2026 at 4:13 PM
I’ve just published a #PreprintReview of “Genome-wide chromatin reset at the onset of leg regeneration in pancrustaceans” on @prereview.bsky.social
prereview.org/reviews/2388...
prereview.org/reviews/2388...
Local chromatin, 3D genome folding and transposon cargo shape Sleeping Beauty transposition https://www.biorxiv.org/content/10.64898/2026.11.03.763895v1
November 3, 2026 at 10:31 PM
Local chromatin, 3D genome folding and transposon cargo shape Sleeping Beauty transposition https://www.biorxiv.org/content/10.64898/2026.11.03.763895v1
Epigenetics Update - Evolution of CTCF underlies the establishment of loop extrusion as a predominant chromatin folding mechanism in vertebrates www.biorxiv.org/content/10.6...
Liene Astica and @dariloops.bsky.social in bioRxiv
#Epigenetics #Chromatin #CTCF #LoopExtrusion
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epigenometech.com
Liene Astica and @dariloops.bsky.social in bioRxiv
#Epigenetics #Chromatin #CTCF #LoopExtrusion
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epigenometech.com
November 2, 2026 at 7:28 AM
Epigenetics Update - Evolution of CTCF underlies the establishment of loop extrusion as a predominant chromatin folding mechanism in vertebrates www.biorxiv.org/content/10.6...
Liene Astica and @dariloops.bsky.social in bioRxiv
#Epigenetics #Chromatin #CTCF #LoopExtrusion
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epigenometech.com
Liene Astica and @dariloops.bsky.social in bioRxiv
#Epigenetics #Chromatin #CTCF #LoopExtrusion
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epigenometech.com
Gotta get chromatin data to make it 3D
November 4, 2026 at 4:57 PM
Gotta get chromatin data to make it 3D
Online Now: A TORC1-regulated H3K4me reader preserves promoter chromatin stability, and its degradation promotes meiotic remodeling Online now:
A TORC1-regulated H3K4me reader preserves promoter chromatin stability, and its degradation promotes meiotic remodeling
Yun et al. show that Jmj3 and Lid2 preserve H3K4-methylated promoter chromatin by restricting NuA4-dependent remodeling. Under low-nutrient conditions, TORC1 inactivation drives Ubc14-Dbl4-mediated degradation of Jmj3/Lid2, allowing promoter remodeling that coordinates meiotic gene expression with Rec12-dependent recombination.
dlvr.it
November 4, 2026 at 4:19 PM
Online Now: A TORC1-regulated H3K4me reader preserves promoter chromatin stability, and its degradation promotes meiotic remodeling Online now:
🤝 SWI/SNF was thought to prep chromatin then step aside. #Yeast cryo-EM reveals it stays, forming a 7-megadalton complex with the pre-initiation machinery, Mediator & the promoter nucleosome to actively stabilize transcription initiation
🧬 #YeastResearch 🧪 #SGD 🔬
www.yeastgenome.org/reference/S1...
🧬 #YeastResearch 🧪 #SGD 🔬
www.yeastgenome.org/reference/S1...
November 3, 2026 at 5:46 PM
🤝 SWI/SNF was thought to prep chromatin then step aside. #Yeast cryo-EM reveals it stays, forming a 7-megadalton complex with the pre-initiation machinery, Mediator & the promoter nucleosome to actively stabilize transcription initiation
🧬 #YeastResearch 🧪 #SGD 🔬
www.yeastgenome.org/reference/S1...
🧬 #YeastResearch 🧪 #SGD 🔬
www.yeastgenome.org/reference/S1...
I've always suspected that the anterior neural ectoderm and posterior neural ectoderm have fundamentally different chromatin configurations. I think I desrve a Moonpie.
A recent study indicates that our brains are actually two organs. Finally! An explanation for the arguments going on inside my head.
med.stanford.edu/news/all-new...
med.stanford.edu/news/all-new...
Human brain is two separate organs, Stanford Medicine-led research finds
Stanford Health Care delivers the highest levels of care and compassion. SHC treats cancer, heart disease, brain disorders, primary care issues, and many more.
med.stanford.edu
November 2, 2026 at 6:27 PM
I've always suspected that the anterior neural ectoderm and posterior neural ectoderm have fundamentally different chromatin configurations. I think I desrve a Moonpie.
Our three TenK10K papers are out in @nature.com
I am honoured to lead one of the studies addressing the "missing regulation" puzzle for human complex diseases, integrating gene expression and chromatin accessibility of 9M PBMCs from 1925 donors.
www.nature.com/articles/s41...
I am honoured to lead one of the studies addressing the "missing regulation" puzzle for human complex diseases, integrating gene expression and chromatin accessibility of 9M PBMCs from 1925 donors.
www.nature.com/articles/s41...
Genetic variants shape single-cell chromatin accessibility and disease risk - Nature
Single-cell chromatin accessibility profiling identifies cell-type-specific and cell-state-specific genetic effects that link non-coding variants to immune disease risk.
www.nature.com
October 31, 2026 at 12:05 AM
Our three TenK10K papers are out in @nature.com
I am honoured to lead one of the studies addressing the "missing regulation" puzzle for human complex diseases, integrating gene expression and chromatin accessibility of 9M PBMCs from 1925 donors.
www.nature.com/articles/s41...
I am honoured to lead one of the studies addressing the "missing regulation" puzzle for human complex diseases, integrating gene expression and chromatin accessibility of 9M PBMCs from 1925 donors.
www.nature.com/articles/s41...
The DNA demethylase TET1 recognises chromatin via nucleosome engagement of its N-terminal region www.biorxiv.org/content/10.64898/2026.10.31.763349v1 #cryoem
November 3, 2026 at 11:27 AM
The DNA demethylase TET1 recognises chromatin via nucleosome engagement of its N-terminal region www.biorxiv.org/content/10.64898/2026.10.31.763349v1 #cryoem
ChAI-Net learns a regulatory code for chromatin co-accessibility https://www.biorxiv.org/content/10.64898/2026.10.29.762938v1
October 31, 2026 at 6:31 PM
ChAI-Net learns a regulatory code for chromatin co-accessibility https://www.biorxiv.org/content/10.64898/2026.10.29.762938v1
New BioRxiv Preprint from the Soutoglou laboratory + collaborators. "DNA damage at Lamina-Associated Domains triggers nuclear envelope reorganization and chromatin detachment to prevent nuclear envelope blebbing and genome instability". doi.org/10.64898/202...
November 2, 2026 at 1:17 PM
New BioRxiv Preprint from the Soutoglou laboratory + collaborators. "DNA damage at Lamina-Associated Domains triggers nuclear envelope reorganization and chromatin detachment to prevent nuclear envelope blebbing and genome instability". doi.org/10.64898/202...
Local chromatin, 3D genome folding and transposon cargo shape Sleeping Beauty transposition https://www.biorxiv.org/content/10.64898/2026.11.03.763895v1
November 3, 2026 at 10:31 PM
Local chromatin, 3D genome folding and transposon cargo shape Sleeping Beauty transposition https://www.biorxiv.org/content/10.64898/2026.11.03.763895v1
HOX13 factors shape cell developmental transcriptional program through multiple mechanisms that regulate chromatin accessibility. https://www.biorxiv.org/content/10.64898/2026.11.03.764042v1
November 4, 2026 at 1:31 PM
HOX13 factors shape cell developmental transcriptional program through multiple mechanisms that regulate chromatin accessibility. https://www.biorxiv.org/content/10.64898/2026.11.03.764042v1
Nature research paper: Genetic variants shape single-cell chromatin accessibility and disease risk
go.nature.com/4swqTxw
go.nature.com/4swqTxw
Genetic variants shape single-cell chromatin accessibility and disease risk - Nature
Single-cell chromatin accessibility profiling identifies cell-type-specific and cell-state-specific genetic effects that link non-coding variants to immune disease risk.
go.nature.com
October 29, 2026 at 9:41 AM
Nature research paper: Genetic variants shape single-cell chromatin accessibility and disease risk
go.nature.com/4swqTxw
go.nature.com/4swqTxw
So how is the @asbmb.bsky.social transcription meeting @triggerloop.bsky.social @lucas.farnunglab.com ?
www.asbmb.org/meetings-eve...
www.asbmb.org/meetings-eve...
Transcriptional regulation by chromatin and RNA polymerase
Oct. 29 – Nov. 1, 2026 | Alexandria, VA
www.asbmb.org
October 31, 2026 at 5:54 PM
So how is the @asbmb.bsky.social transcription meeting @triggerloop.bsky.social @lucas.farnunglab.com ?
www.asbmb.org/meetings-eve...
www.asbmb.org/meetings-eve...
Online Now: Structural basis for the non-canonical nucleosome remodeling by ATRX Online now:
Structural basis for the non-canonical nucleosome remodeling by ATRX
Wang et al. show that ATRX remodels chromatin through an unusual mechanism that favors nucleosome disassembly over repositioning. ATRX also captures histones and cooperates with ASF1 for tetrasome assembly, linking chromatin remodeling to histone chaperoning for reassembly and helping explain how ATRX functions at accessible chromatin regions.
dlvr.it
October 30, 2026 at 3:19 PM
Online Now: Structural basis for the non-canonical nucleosome remodeling by ATRX Online now:
Our new paper @cp-cellreports.bsky.social, led by @katsuminami.bsky.social et al.! 🎉🧬🔬
www.cell.com/cell-reports...
Machine learning-assisted Repli-Histo labeling and single-nucleosome imaging reveal distinct transcription-dependent chromatin constraints across euchromatin and heterochromatin.
www.cell.com/cell-reports...
Machine learning-assisted Repli-Histo labeling and single-nucleosome imaging reveal distinct transcription-dependent chromatin constraints across euchromatin and heterochromatin.
October 30, 2026 at 6:32 AM
Our new paper @cp-cellreports.bsky.social, led by @katsuminami.bsky.social et al.! 🎉🧬🔬
www.cell.com/cell-reports...
Machine learning-assisted Repli-Histo labeling and single-nucleosome imaging reveal distinct transcription-dependent chromatin constraints across euchromatin and heterochromatin.
www.cell.com/cell-reports...
Machine learning-assisted Repli-Histo labeling and single-nucleosome imaging reveal distinct transcription-dependent chromatin constraints across euchromatin and heterochromatin.
Looking at histones during optical tweezer manipulation reveals clear deformations of the chromatin.
October 29, 2026 at 9:57 AM
Looking at histones during optical tweezer manipulation reveals clear deformations of the chromatin.
Different transcription systems shape chromatin behavior in distinct nuclear regions
phys.org/news/2026-10...
phys.org/news/2026-10...
Different transcription systems shape chromatin behavior in distinct nuclear regions
Inside the cell nucleus, DNA is wrapped around histone proteins to form nucleosomes, which are further organized into chromatin. Chromatin has traditionally been divided into transcriptionally active ...
phys.org
November 2, 2026 at 8:38 PM
Different transcription systems shape chromatin behavior in distinct nuclear regions
phys.org/news/2026-10...
phys.org/news/2026-10...
🚨 🚨 NEW PREPRINT 🚨 🚨 "ChAI-Net learns a regulatory code for chromatin co-accessibility" from the Pollard and Ramani labs at Gladstone.
@vram142.bsky.social
@biorxivpreprint.bsky.social
@vram142.bsky.social
@biorxivpreprint.bsky.social
ChAI-Net learns a regulatory code for chromatin co-accessibility
The regulation of chromatin accessibility is critical for cell function and identity. Advances in single-molecule long-read footprinting have enabled near-nucleotide-resolution readout of chromatin fiber organization, capturing both coordination of tran...
www.biorxiv.org
November 5, 2026 at 12:09 AM
🚨 🚨 NEW PREPRINT 🚨 🚨 "ChAI-Net learns a regulatory code for chromatin co-accessibility" from the Pollard and Ramani labs at Gladstone.
@vram142.bsky.social
@biorxivpreprint.bsky.social
@vram142.bsky.social
@biorxivpreprint.bsky.social
Self-organization of Drosophila chromatin architecture in a cell-free system
#Drosophila
#Drosophila
Self-organization of Drosophila chromatin architecture in a cell-free system
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
November 3, 2026 at 11:23 AM
Self-organization of Drosophila chromatin architecture in a cell-free system
#Drosophila
#Drosophila
Blocking Pol II increased chromatin movement in several chromatin classes. Blocking Pol I selectively increased movement in one heterochromatin population around nucleoli. doi.org/hcqthq
Different transcription systems shape chromatin behavior in distinct nuclear regions
Inside the cell nucleus, DNA is wrapped around histone proteins to form nucleosomes, which are further organized into chromatin.
phys.org
October 30, 2026 at 5:00 PM
Blocking Pol II increased chromatin movement in several chromatin classes. Blocking Pol I selectively increased movement in one heterochromatin population around nucleoli. doi.org/hcqthq
Epigenetics Update - Inflammatory memory primes the intestine for enhanced regenerative potential www.nature.com/articles/s41...
Borja Arozamena and guiulab.bsky.social in Nat Commun
#Epigenetics #Inflammation #Chromatin #Regeneration
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High-resolution insights; epigenometech.com
Borja Arozamena and guiulab.bsky.social in Nat Commun
#Epigenetics #Inflammation #Chromatin #Regeneration
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High-resolution insights; epigenometech.com
November 3, 2026 at 4:58 PM
Epigenetics Update - Inflammatory memory primes the intestine for enhanced regenerative potential www.nature.com/articles/s41...
Borja Arozamena and guiulab.bsky.social in Nat Commun
#Epigenetics #Inflammation #Chromatin #Regeneration
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High-resolution insights; epigenometech.com
Borja Arozamena and guiulab.bsky.social in Nat Commun
#Epigenetics #Inflammation #Chromatin #Regeneration
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High-resolution insights; epigenometech.com
Epigenetics Update - Genetic variants shape single-cell chromatin accessibility and disease risk www.nature.com/articles/s41...
anglixue.bsky.social and Joseph E. Powell (Garvan Institute of Medical Research) in nature.com
#Epigenetics #Chromatin #SingleCell #DiseaseRisk
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epigenometech.com
anglixue.bsky.social and Joseph E. Powell (Garvan Institute of Medical Research) in nature.com
#Epigenetics #Chromatin #SingleCell #DiseaseRisk
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epigenometech.com
November 4, 2026 at 3:46 PM
Epigenetics Update - Genetic variants shape single-cell chromatin accessibility and disease risk www.nature.com/articles/s41...
anglixue.bsky.social and Joseph E. Powell (Garvan Institute of Medical Research) in nature.com
#Epigenetics #Chromatin #SingleCell #DiseaseRisk
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epigenometech.com
anglixue.bsky.social and Joseph E. Powell (Garvan Institute of Medical Research) in nature.com
#Epigenetics #Chromatin #SingleCell #DiseaseRisk
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epigenometech.com