I’ve just published a #PreprintReview of “Genome-wide chromatin reset at the onset of leg regeneration in pancrustaceans” on @prereview.bsky.social
prereview.org/reviews/2388...
prereview.org/reviews/2388...
PREreview of Genome-wide chromatin reset at the onset of leg regeneration in pancrustaceans
Authored by J.P. Flores
prereview.org
November 2, 2026 at 4:13 PM
I’ve just published a #PreprintReview of “Genome-wide chromatin reset at the onset of leg regeneration in pancrustaceans” on @prereview.bsky.social
prereview.org/reviews/2388...
prereview.org/reviews/2388...
Our three TenK10K papers are out in @nature.com
I am honoured to lead one of the studies addressing the "missing regulation" puzzle for human complex diseases, integrating gene expression and chromatin accessibility of 9M PBMCs from 1925 donors.
www.nature.com/articles/s41...
I am honoured to lead one of the studies addressing the "missing regulation" puzzle for human complex diseases, integrating gene expression and chromatin accessibility of 9M PBMCs from 1925 donors.
www.nature.com/articles/s41...
Genetic variants shape single-cell chromatin accessibility and disease risk - Nature
Single-cell chromatin accessibility profiling identifies cell-type-specific and cell-state-specific genetic effects that link non-coding variants to immune disease risk.
www.nature.com
October 31, 2026 at 12:05 AM
Our three TenK10K papers are out in @nature.com
I am honoured to lead one of the studies addressing the "missing regulation" puzzle for human complex diseases, integrating gene expression and chromatin accessibility of 9M PBMCs from 1925 donors.
www.nature.com/articles/s41...
I am honoured to lead one of the studies addressing the "missing regulation" puzzle for human complex diseases, integrating gene expression and chromatin accessibility of 9M PBMCs from 1925 donors.
www.nature.com/articles/s41...
Epigenetics Update - Evolution of CTCF underlies the establishment of loop extrusion as a predominant chromatin folding mechanism in vertebrates www.biorxiv.org/content/10.6...
Liene Astica and @dariloops.bsky.social in bioRxiv
#Epigenetics #Chromatin #CTCF #LoopExtrusion
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epigenometech.com
Liene Astica and @dariloops.bsky.social in bioRxiv
#Epigenetics #Chromatin #CTCF #LoopExtrusion
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epigenometech.com
November 2, 2026 at 7:28 AM
Epigenetics Update - Evolution of CTCF underlies the establishment of loop extrusion as a predominant chromatin folding mechanism in vertebrates www.biorxiv.org/content/10.6...
Liene Astica and @dariloops.bsky.social in bioRxiv
#Epigenetics #Chromatin #CTCF #LoopExtrusion
---
epigenometech.com
Liene Astica and @dariloops.bsky.social in bioRxiv
#Epigenetics #Chromatin #CTCF #LoopExtrusion
---
epigenometech.com
I've always suspected that the anterior neural ectoderm and posterior neural ectoderm have fundamentally different chromatin configurations. I think I desrve a Moonpie.
A recent study indicates that our brains are actually two organs. Finally! An explanation for the arguments going on inside my head.
med.stanford.edu/news/all-new...
med.stanford.edu/news/all-new...
Human brain is two separate organs, Stanford Medicine-led research finds
Stanford Health Care delivers the highest levels of care and compassion. SHC treats cancer, heart disease, brain disorders, primary care issues, and many more.
med.stanford.edu
November 2, 2026 at 6:27 PM
I've always suspected that the anterior neural ectoderm and posterior neural ectoderm have fundamentally different chromatin configurations. I think I desrve a Moonpie.
Nature research paper: Genetic variants shape single-cell chromatin accessibility and disease risk
go.nature.com/4swqTxw
go.nature.com/4swqTxw
Genetic variants shape single-cell chromatin accessibility and disease risk - Nature
Single-cell chromatin accessibility profiling identifies cell-type-specific and cell-state-specific genetic effects that link non-coding variants to immune disease risk.
go.nature.com
October 29, 2026 at 9:41 AM
Nature research paper: Genetic variants shape single-cell chromatin accessibility and disease risk
go.nature.com/4swqTxw
go.nature.com/4swqTxw
ChAI-Net learns a regulatory code for chromatin co-accessibility https://www.biorxiv.org/content/10.64898/2026.10.29.762938v1
October 31, 2026 at 6:31 PM
ChAI-Net learns a regulatory code for chromatin co-accessibility https://www.biorxiv.org/content/10.64898/2026.10.29.762938v1
🤝 SWI/SNF was thought to prep chromatin then step aside. #Yeast cryo-EM reveals it stays, forming a 7-megadalton complex with the pre-initiation machinery, Mediator & the promoter nucleosome to actively stabilize transcription initiation
🧬 #YeastResearch 🧪 #SGD 🔬
www.yeastgenome.org/reference/S1...
🧬 #YeastResearch 🧪 #SGD 🔬
www.yeastgenome.org/reference/S1...
November 3, 2026 at 5:46 PM
🤝 SWI/SNF was thought to prep chromatin then step aside. #Yeast cryo-EM reveals it stays, forming a 7-megadalton complex with the pre-initiation machinery, Mediator & the promoter nucleosome to actively stabilize transcription initiation
🧬 #YeastResearch 🧪 #SGD 🔬
www.yeastgenome.org/reference/S1...
🧬 #YeastResearch 🧪 #SGD 🔬
www.yeastgenome.org/reference/S1...
New BioRxiv Preprint from the Soutoglou laboratory + collaborators. "DNA damage at Lamina-Associated Domains triggers nuclear envelope reorganization and chromatin detachment to prevent nuclear envelope blebbing and genome instability". doi.org/10.64898/202...
November 2, 2026 at 1:17 PM
New BioRxiv Preprint from the Soutoglou laboratory + collaborators. "DNA damage at Lamina-Associated Domains triggers nuclear envelope reorganization and chromatin detachment to prevent nuclear envelope blebbing and genome instability". doi.org/10.64898/202...
Local chromatin, 3D genome folding and transposon cargo shape Sleeping Beauty transposition https://www.biorxiv.org/content/10.64898/2026.11.03.763895v1
November 3, 2026 at 10:31 PM
Local chromatin, 3D genome folding and transposon cargo shape Sleeping Beauty transposition https://www.biorxiv.org/content/10.64898/2026.11.03.763895v1
So how is the @asbmb.bsky.social transcription meeting @triggerloop.bsky.social @lucas.farnunglab.com ?
www.asbmb.org/meetings-eve...
www.asbmb.org/meetings-eve...
Transcriptional regulation by chromatin and RNA polymerase
Oct. 29 – Nov. 1, 2026 | Alexandria, VA
www.asbmb.org
October 31, 2026 at 5:54 PM
So how is the @asbmb.bsky.social transcription meeting @triggerloop.bsky.social @lucas.farnunglab.com ?
www.asbmb.org/meetings-eve...
www.asbmb.org/meetings-eve...
Looking at histones during optical tweezer manipulation reveals clear deformations of the chromatin.
October 29, 2026 at 9:57 AM
Looking at histones during optical tweezer manipulation reveals clear deformations of the chromatin.
Our new paper @cp-cellreports.bsky.social, led by @katsuminami.bsky.social et al.! 🎉🧬🔬
www.cell.com/cell-reports...
Machine learning-assisted Repli-Histo labeling and single-nucleosome imaging reveal distinct transcription-dependent chromatin constraints across euchromatin and heterochromatin.
www.cell.com/cell-reports...
Machine learning-assisted Repli-Histo labeling and single-nucleosome imaging reveal distinct transcription-dependent chromatin constraints across euchromatin and heterochromatin.
October 30, 2026 at 6:32 AM
Our new paper @cp-cellreports.bsky.social, led by @katsuminami.bsky.social et al.! 🎉🧬🔬
www.cell.com/cell-reports...
Machine learning-assisted Repli-Histo labeling and single-nucleosome imaging reveal distinct transcription-dependent chromatin constraints across euchromatin and heterochromatin.
www.cell.com/cell-reports...
Machine learning-assisted Repli-Histo labeling and single-nucleosome imaging reveal distinct transcription-dependent chromatin constraints across euchromatin and heterochromatin.
Online Now: Structural basis for the non-canonical nucleosome remodeling by ATRX Online now:
Structural basis for the non-canonical nucleosome remodeling by ATRX
Wang et al. show that ATRX remodels chromatin through an unusual mechanism that favors nucleosome disassembly over repositioning. ATRX also captures histones and cooperates with ASF1 for tetrasome assembly, linking chromatin remodeling to histone chaperoning for reassembly and helping explain how ATRX functions at accessible chromatin regions.
dlvr.it
October 30, 2026 at 3:19 PM
Online Now: Structural basis for the non-canonical nucleosome remodeling by ATRX Online now:
Local chromatin, 3D genome folding and transposon cargo shape Sleeping Beauty transposition https://www.biorxiv.org/content/10.64898/2026.11.03.763895v1
November 3, 2026 at 10:31 PM
Local chromatin, 3D genome folding and transposon cargo shape Sleeping Beauty transposition https://www.biorxiv.org/content/10.64898/2026.11.03.763895v1
The DNA demethylase TET1 recognises chromatin via nucleosome engagement of its N-terminal region www.biorxiv.org/content/10.64898/2026.10.31.763349v1 #cryoem
November 3, 2026 at 11:27 AM
The DNA demethylase TET1 recognises chromatin via nucleosome engagement of its N-terminal region www.biorxiv.org/content/10.64898/2026.10.31.763349v1 #cryoem
Blocking Pol II increased chromatin movement in several chromatin classes. Blocking Pol I selectively increased movement in one heterochromatin population around nucleoli. doi.org/hcqthq
Different transcription systems shape chromatin behavior in distinct nuclear regions
Inside the cell nucleus, DNA is wrapped around histone proteins to form nucleosomes, which are further organized into chromatin.
phys.org
October 30, 2026 at 5:00 PM
Blocking Pol II increased chromatin movement in several chromatin classes. Blocking Pol I selectively increased movement in one heterochromatin population around nucleoli. doi.org/hcqthq
Different transcription systems shape chromatin behavior in distinct nuclear regions
phys.org/news/2026-10...
phys.org/news/2026-10...
Different transcription systems shape chromatin behavior in distinct nuclear regions
Inside the cell nucleus, DNA is wrapped around histone proteins to form nucleosomes, which are further organized into chromatin. Chromatin has traditionally been divided into transcriptionally active ...
phys.org
November 2, 2026 at 8:38 PM
Different transcription systems shape chromatin behavior in distinct nuclear regions
phys.org/news/2026-10...
phys.org/news/2026-10...
Self-organization of Drosophila chromatin architecture in a cell-free system
#Drosophila
#Drosophila
Self-organization of Drosophila chromatin architecture in a cell-free system
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
November 3, 2026 at 11:23 AM
Self-organization of Drosophila chromatin architecture in a cell-free system
#Drosophila
#Drosophila
This PhD project, with @sproullab.bsky.social, @hannahlong.bsky.social and Marcus Wilson at @edinburgh-uni.bsky.social, would suit those with a strong interest and background in gene regulation, chromatin and epigenetics with quantitative skills. Find out more and apply here 👉 edin.ac/4yIe5Fx
November 3, 2026 at 10:30 AM
This PhD project, with @sproullab.bsky.social, @hannahlong.bsky.social and Marcus Wilson at @edinburgh-uni.bsky.social, would suit those with a strong interest and background in gene regulation, chromatin and epigenetics with quantitative skills. Find out more and apply here 👉 edin.ac/4yIe5Fx
We compared spindles across 25 eukaryotic species, from yeasts to plants and animals: Metaphase plate width scales with genome size to the 1/3 power. A vast range of genomes, handled by a small change in spindles. Surprisingly, chromatin amount counts, not chromosome number.
October 30, 2026 at 9:25 AM
We compared spindles across 25 eukaryotic species, from yeasts to plants and animals: Metaphase plate width scales with genome size to the 1/3 power. A vast range of genomes, handled by a small change in spindles. Surprisingly, chromatin amount counts, not chromosome number.
We put this idea to the test. From polyploid human cells and patient-derived cancer organoids to physical compression of cells, experiments showed that changing chromatin content or crowding changes spindle geometry as predicted.
October 30, 2026 at 9:25 AM
We put this idea to the test. From polyploid human cells and patient-derived cancer organoids to physical compression of cells, experiments showed that changing chromatin content or crowding changes spindle geometry as predicted.
Joanna gave a keynote today at ASBMB Txn and Chromatin meeting, speaking about this recent preprint. The talk was AMAZING and this is exceptionally cool preprint. So people in NYC should see this upcoming talk!! www.biorxiv.org/content/10.6...
November 1, 2026 at 10:55 PM
Joanna gave a keynote today at ASBMB Txn and Chromatin meeting, speaking about this recent preprint. The talk was AMAZING and this is exceptionally cool preprint. So people in NYC should see this upcoming talk!! www.biorxiv.org/content/10.6...
Beyond thrilled that the first paper from our lab is out today in @nature.com! We show that SWI/SNF loss results in gain-of-function for CTCF and cohesin, reshaping the 3D genome, and an unexpected switch between chromatin remodeling complexes.
Full thread below.
www.nature.com/articles/s41...
Full thread below.
www.nature.com/articles/s41...
SWI/SNF complexes shape 3D chromatin architecture through CTCF and cohesin - Nature
Loss of function of canonical BAF induces gain of CTCF and cohesin binding that alters 3D genome architecture and reprograms transcription.
www.nature.com
October 28, 2026 at 5:05 PM
Beyond thrilled that the first paper from our lab is out today in @nature.com! We show that SWI/SNF loss results in gain-of-function for CTCF and cohesin, reshaping the 3D genome, and an unexpected switch between chromatin remodeling complexes.
Full thread below.
www.nature.com/articles/s41...
Full thread below.
www.nature.com/articles/s41...
CRV Science Labs ⚗️
🧬 Giant Virus Chromatin and Pre-LECA Phylogenomics: How Viral Histone Doublets, Family B Polymerases, and Captured tRNA Synthetases Illuminate Eukaryotic Chromatin Evolution — Across 1.50 Mb and 64 taxa, Mars…
https://crvscience.com/labs/discoveries/ncldv-histone-chromatin-tier3
🧬 Giant Virus Chromatin and Pre-LECA Phylogenomics: How Viral Histone Doublets, Family B Polymerases, and Captured tRNA Synthetases Illuminate Eukaryotic Chromatin Evolution — Across 1.50 Mb and 64 taxa, Mars…
https://crvscience.com/labs/discoveries/ncldv-histone-chromatin-tier3
CRV Science Labs ⚗️
🧬 Giant Virus Chromatin and Pre-LECA Phylogenomics: How Viral Histone Doublets, Family B Polymerases, and Captured tRNA Synthetases Illuminate Eukaryotic Chromatin Evolution — Across 1.50 Mb and 64 taxa, Marseilleviridae fused H4-H3/H2B-H2A histone doublets (121 bp wrap) and Med…
crvscience.com
November 3, 2026 at 7:10 AM
CRV Science Labs ⚗️
🧬 Giant Virus Chromatin and Pre-LECA Phylogenomics: How Viral Histone Doublets, Family B Polymerases, and Captured tRNA Synthetases Illuminate Eukaryotic Chromatin Evolution — Across 1.50 Mb and 64 taxa, Mars…
https://crvscience.com/labs/discoveries/ncldv-histone-chromatin-tier3
🧬 Giant Virus Chromatin and Pre-LECA Phylogenomics: How Viral Histone Doublets, Family B Polymerases, and Captured tRNA Synthetases Illuminate Eukaryotic Chromatin Evolution — Across 1.50 Mb and 64 taxa, Mars…
https://crvscience.com/labs/discoveries/ncldv-histone-chromatin-tier3
🧬 Excited to share our new paper, out today in Nature Cell Biology!
📄 www.nature.com/articles/s41...
This work started with a very simple and intriguing question: how can microtubules apply sufficient force in the nucleus to promote chromatin mobility, in particular DNA double stand breaks? 🤔 🧵
📄 www.nature.com/articles/s41...
This work started with a very simple and intriguing question: how can microtubules apply sufficient force in the nucleus to promote chromatin mobility, in particular DNA double stand breaks? 🤔 🧵
October 28, 2026 at 5:14 PM
🧬 Excited to share our new paper, out today in Nature Cell Biology!
📄 www.nature.com/articles/s41...
This work started with a very simple and intriguing question: how can microtubules apply sufficient force in the nucleus to promote chromatin mobility, in particular DNA double stand breaks? 🤔 🧵
📄 www.nature.com/articles/s41...
This work started with a very simple and intriguing question: how can microtubules apply sufficient force in the nucleus to promote chromatin mobility, in particular DNA double stand breaks? 🤔 🧵