Epitranscriptomics #PhaseSeparation

m6A-modified #EnhancerRNA & YTHDC1-BRD4 assemble transcriptional condensate

MINT-seq detects >3-fold more m6A peaks than MeRIP-seq

Stringtie annotate eRNAs & promoter upstream antisense RNAs, 24% & 48% are m6A+ (MCF7)

#MolCell 2021
www.cell.com/molecular-ce...

RESEARCH PAPER: Multiple human enhancer RNAs contain long translated open reading frames
By Vlasov et al. and James Manley
➡️ https://genesdev.cshlp.org/content/39/23-24/1468.full

#protein #translation #enhancerRNA #openreadingframe #chromatin #DNAdamage #RNAprocessing #nucleus

⏪ G&D RECAP ⏪

🗓️ December 2025
RESEARCH PAPER: Multiple human enhancer RNAs contain long translated open reading frames
By Vlasov et al. and James Manley
➡️ https://genesdev.cshlp.org/content/39/23-24/1468.full

#protein #translation #enhancerRNA #chromatin #DNAdamage #RNAprocessing #nucleus

The LTFe–LTF #enhancerRNA axis is identified as a #ferroptosis-promoting #TumorSuppressor in #ProstateCancer, with AR signaling disrupting LTFe-mediated chromatin looping, and #enzalutamide + RSL3 suppresses #CRPC growth.

#OpenAccess in #STTT: doi.org/10.1038/s413...