Join us at this years UK Biomolecular #Condensate Conference!! Register (QR code below) & submit Abstracts:
docs.google.com/forms/d/e/1F...
Places are limited, so secure your place.
Looking forward to seeing you all.
#phaseseparation
docs.google.com/forms/d/e/1F...
Places are limited, so secure your place.
Looking forward to seeing you all.
#phaseseparation
September 26, 2026 at 2:58 PM
Join us at this years UK Biomolecular #Condensate Conference!! Register (QR code below) & submit Abstracts:
docs.google.com/forms/d/e/1F...
Places are limited, so secure your place.
Looking forward to seeing you all.
#phaseseparation
docs.google.com/forms/d/e/1F...
Places are limited, so secure your place.
Looking forward to seeing you all.
#phaseseparation
RESEARCH PAPER: TNK1 is a targetable JAK-independent driver of STAT signaling and inflammation
By López-Palacios et al., and Joshua L. Andersen
➡️ https://genesdev.cshlp.org/content/40/17-18/1408.abstract
Huntsman Cancer Institute
#STAT1 #kinase #inflammation #phaseseparation #biocondensates #IDR
By López-Palacios et al., and Joshua L. Andersen
➡️ https://genesdev.cshlp.org/content/40/17-18/1408.abstract
Huntsman Cancer Institute
#STAT1 #kinase #inflammation #phaseseparation #biocondensates #IDR
September 3, 2026 at 6:00 PM
RESEARCH PAPER: TNK1 is a targetable JAK-independent driver of STAT signaling and inflammation
By López-Palacios et al., and Joshua L. Andersen
➡️ https://genesdev.cshlp.org/content/40/17-18/1408.abstract
Huntsman Cancer Institute
#STAT1 #kinase #inflammation #phaseseparation #biocondensates #IDR
By López-Palacios et al., and Joshua L. Andersen
➡️ https://genesdev.cshlp.org/content/40/17-18/1408.abstract
Huntsman Cancer Institute
#STAT1 #kinase #inflammation #phaseseparation #biocondensates #IDR
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: TNK1 is a targetable JAK-independent driver of STAT signaling and inflammation
By López-Palacios et al., and Joshua L. Andersen
➡️ https://ow.ly/ljPI50ZFk2g
Huntsman Cancer Institute
#STAT1 #kinase #inflammation #phaseseparation #biocondensates #IDR
RESEARCH PAPER: TNK1 is a targetable JAK-independent driver of STAT signaling and inflammation
By López-Palacios et al., and Joshua L. Andersen
➡️ https://ow.ly/ljPI50ZFk2g
Huntsman Cancer Institute
#STAT1 #kinase #inflammation #phaseseparation #biocondensates #IDR
August 26, 2026 at 3:00 PM
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: TNK1 is a targetable JAK-independent driver of STAT signaling and inflammation
By López-Palacios et al., and Joshua L. Andersen
➡️ https://ow.ly/ljPI50ZFk2g
Huntsman Cancer Institute
#STAT1 #kinase #inflammation #phaseseparation #biocondensates #IDR
RESEARCH PAPER: TNK1 is a targetable JAK-independent driver of STAT signaling and inflammation
By López-Palacios et al., and Joshua L. Andersen
➡️ https://ow.ly/ljPI50ZFk2g
Huntsman Cancer Institute
#STAT1 #kinase #inflammation #phaseseparation #biocondensates #IDR
I've had to write about #PhaseSeparation atleast four times now, but I'll be damned if I can make heads or tales of this topic. @philipcball.bsky.social FYI might want to keep an eye on Andrea's thread.
November 29, 2025 at 6:05 PM
I've had to write about #PhaseSeparation atleast four times now, but I'll be damned if I can make heads or tales of this topic. @philipcball.bsky.social FYI might want to keep an eye on Andrea's thread.
November 30, 2025 at 8:57 AM
Hen and egg problem! If you look carefully into biological condensate literature you can find such sharp fronts, which went unnoticed - now we can explain this - and the importance can now be considered in biology.
#softmatter #biomolecularcondensates #DNAnanotech #LLPS #phaseseparation
#softmatter #biomolecularcondensates #DNAnanotech #LLPS #phaseseparation
June 7, 2025 at 4:44 AM
Hen and egg problem! If you look carefully into biological condensate literature you can find such sharp fronts, which went unnoticed - now we can explain this - and the importance can now be considered in biology.
#softmatter #biomolecularcondensates #DNAnanotech #LLPS #phaseseparation
#softmatter #biomolecularcondensates #DNAnanotech #LLPS #phaseseparation
Physics of the perfect cacio e pepe sauce https://arstechni.ca... #phaseseparation #fluiddynamics #Foodscience #rheology #Science #Physics
April 29, 2025 at 5:00 PM
Physics of the perfect cacio e pepe sauce https://arstechni.ca... #phaseseparation #fluiddynamics #Foodscience #rheology #Science #Physics
RNA doesn’t just encode information, it helps build cellular structure. This review explores how RNAs drive the formation of biomolecular condensates, shaping organization, regulation, and function across contexts #RNAbiology #PhaseSeparation #BiomolecularCondensates #CellBiology bit.ly/4mjjI8B
May 11, 2026 at 1:39 PM
RNA doesn’t just encode information, it helps build cellular structure. This review explores how RNAs drive the formation of biomolecular condensates, shaping organization, regulation, and function across contexts #RNAbiology #PhaseSeparation #BiomolecularCondensates #CellBiology bit.ly/4mjjI8B
For those interested in topological analysis of biomolecular condensates!
Article 1: link.springer.com/article/10.1...
Article 2: www.sciencedirect.com/science/arti...
#Topology #Condensate #PhaseSeparation #Aggregation #ChemSky #Biophysics #Polymer #Nanoscience
Article 1: link.springer.com/article/10.1...
Article 2: www.sciencedirect.com/science/arti...
#Topology #Condensate #PhaseSeparation #Aggregation #ChemSky #Biophysics #Polymer #Nanoscience
May 25, 2025 at 10:49 AM
For those interested in topological analysis of biomolecular condensates!
Article 1: link.springer.com/article/10.1...
Article 2: www.sciencedirect.com/science/arti...
#Topology #Condensate #PhaseSeparation #Aggregation #ChemSky #Biophysics #Polymer #Nanoscience
Article 1: link.springer.com/article/10.1...
Article 2: www.sciencedirect.com/science/arti...
#Topology #Condensate #PhaseSeparation #Aggregation #ChemSky #Biophysics #Polymer #Nanoscience
🌟G&D SPOTLIGHT 🌟
REVIEW: RNA granules: functional compartments or incidental condensates?
By Andrea Putnam, Laura Thomas and Geraldine Seydoux
➡️ https://genesdev.cshlp.org/content/37/9-10/354.abstract
#RNAmetabolism #RNAgranules #phaseseparation #RiboNucleoProteins #condensates
REVIEW: RNA granules: functional compartments or incidental condensates?
By Andrea Putnam, Laura Thomas and Geraldine Seydoux
➡️ https://genesdev.cshlp.org/content/37/9-10/354.abstract
#RNAmetabolism #RNAgranules #phaseseparation #RiboNucleoProteins #condensates
November 28, 2025 at 7:00 PM
🌟G&D SPOTLIGHT 🌟
REVIEW: RNA granules: functional compartments or incidental condensates?
By Andrea Putnam, Laura Thomas and Geraldine Seydoux
➡️ https://genesdev.cshlp.org/content/37/9-10/354.abstract
#RNAmetabolism #RNAgranules #phaseseparation #RiboNucleoProteins #condensates
REVIEW: RNA granules: functional compartments or incidental condensates?
By Andrea Putnam, Laura Thomas and Geraldine Seydoux
➡️ https://genesdev.cshlp.org/content/37/9-10/354.abstract
#RNAmetabolism #RNAgranules #phaseseparation #RiboNucleoProteins #condensates
🌟G&D SPOTLIGHT 🌟
RESEARCH PAPER: Nuclear mRNPs are compact particles packaged with a network of proteins promoting RNA–RNA interactions
By Bonneau et al. and Elena Conti
➡️ https://genesdev.cshlp.org/content/37/11-12/505.abstract
#ribonucleoproteins #granules #RNAinteractions #IDR #phaseseparation
RESEARCH PAPER: Nuclear mRNPs are compact particles packaged with a network of proteins promoting RNA–RNA interactions
By Bonneau et al. and Elena Conti
➡️ https://genesdev.cshlp.org/content/37/11-12/505.abstract
#ribonucleoproteins #granules #RNAinteractions #IDR #phaseseparation
November 26, 2025 at 4:01 PM
🌟G&D SPOTLIGHT 🌟
RESEARCH PAPER: Nuclear mRNPs are compact particles packaged with a network of proteins promoting RNA–RNA interactions
By Bonneau et al. and Elena Conti
➡️ https://genesdev.cshlp.org/content/37/11-12/505.abstract
#ribonucleoproteins #granules #RNAinteractions #IDR #phaseseparation
RESEARCH PAPER: Nuclear mRNPs are compact particles packaged with a network of proteins promoting RNA–RNA interactions
By Bonneau et al. and Elena Conti
➡️ https://genesdev.cshlp.org/content/37/11-12/505.abstract
#ribonucleoproteins #granules #RNAinteractions #IDR #phaseseparation
How does molecular valency shape condensate assembly and function? We used the CO2-fixing organelle in algae—the pyrenoid—to find out… 🧵
Preprint here!:
www.biorxiv.org/content/10.6...
@cellarchlab.com @phaips.vd.st @biologyatyork.bsky.social
#Rubisco #PhaseSeparation #Condensates #Pyrenoid
Preprint here!:
www.biorxiv.org/content/10.6...
@cellarchlab.com @phaips.vd.st @biologyatyork.bsky.social
#Rubisco #PhaseSeparation #Condensates #Pyrenoid
January 30, 2026 at 3:21 PM
How does molecular valency shape condensate assembly and function? We used the CO2-fixing organelle in algae—the pyrenoid—to find out… 🧵
Preprint here!:
www.biorxiv.org/content/10.6...
@cellarchlab.com @phaips.vd.st @biologyatyork.bsky.social
#Rubisco #PhaseSeparation #Condensates #Pyrenoid
Preprint here!:
www.biorxiv.org/content/10.6...
@cellarchlab.com @phaips.vd.st @biologyatyork.bsky.social
#Rubisco #PhaseSeparation #Condensates #Pyrenoid
💧🌀 Active matter meets interface physics!
We show how conserved active emulsions form traveling interfacial waves and self-propelling liquid gears, powered by non-reciprocal chemical interactions.
🎥 Gears & belts in motion👇
📄 arxiv.org/abs/2505.20028
#ActiveMatter #PhaseSeparation #PatternFormation
We show how conserved active emulsions form traveling interfacial waves and self-propelling liquid gears, powered by non-reciprocal chemical interactions.
🎥 Gears & belts in motion👇
📄 arxiv.org/abs/2505.20028
#ActiveMatter #PhaseSeparation #PatternFormation
June 3, 2025 at 5:12 PM
💧🌀 Active matter meets interface physics!
We show how conserved active emulsions form traveling interfacial waves and self-propelling liquid gears, powered by non-reciprocal chemical interactions.
🎥 Gears & belts in motion👇
📄 arxiv.org/abs/2505.20028
#ActiveMatter #PhaseSeparation #PatternFormation
We show how conserved active emulsions form traveling interfacial waves and self-propelling liquid gears, powered by non-reciprocal chemical interactions.
🎥 Gears & belts in motion👇
📄 arxiv.org/abs/2505.20028
#ActiveMatter #PhaseSeparation #PatternFormation
Structural studies of the intrinsically disordered regions of human SFPQ reveal that it is capable of swapping dimer partners with itself, potentially contributing to phase separation and impacting disease processes. #PhaseSeparation #Disorder #Flexibility doi.org/10.1107/S205...
July 17, 2025 at 2:30 PM
Structural studies of the intrinsically disordered regions of human SFPQ reveal that it is capable of swapping dimer partners with itself, potentially contributing to phase separation and impacting disease processes. #PhaseSeparation #Disorder #Flexibility doi.org/10.1107/S205...
Heidar J. Koning et al.: Structural dynamics of IDR interactions in human SFPQ and implications for liquid–liquid phase separation ##PhaseSeparation##Disorder##Flexibility@uwanews@unimelb...##IUCrhttps://journals.iucr.org/paper?S2059798325005303
Structural dynamics of IDR interactions in human SFPQ and implications for liquid–liquid phase separation
SFPQ and NONO are DBHS-family proteins that are essential for transcriptional regulation and the assembly of paraspeckles, which are subnuclear structures built on the long noncoding RNA NEAT1. Through SAXS, SANS and XL-MS analyses, we reveal that the disordered regions of SFPQ surrounding its DBHS domain enable flexible interactions and that the full-length proteins are capable of dimer partner exchange, highlighting how these dynamics may contribute to phase separation and impact disease processes.
journals.iucr.org
June 28, 2025 at 12:00 AM
Heidar J. Koning et al.: Structural dynamics of IDR interactions in human SFPQ and implications for liquid–liquid phase separation ##PhaseSeparation##Disorder##Flexibility@uwanews@unimelb...##IUCrhttps://journals.iucr.org/paper?S2059798325005303
🧬 New review paper!
Our latest article in WIREs Nanomedicine and Nanobiotechnology explores the role of intrinsically disordered protein polymers (IDPPs) in self-assembly and biomaterials.
🔗 Read it here: doi.org/10.1002/wnan...
#Nanobiotech #Biomaterials #PhaseSeparation #Proteins
Our latest article in WIREs Nanomedicine and Nanobiotechnology explores the role of intrinsically disordered protein polymers (IDPPs) in self-assembly and biomaterials.
🔗 Read it here: doi.org/10.1002/wnan...
#Nanobiotech #Biomaterials #PhaseSeparation #Proteins
Spontaneous Self‐Organized Order Emerging From Intrinsically Disordered Protein Polymers
Harnessing the liquid-liquid phase separation (LLPS) properties of intrinsically disordered protein polymers (IDPPs) enables the design and engineering of hierarchically self-assembled protein materi...
doi.org
February 14, 2025 at 11:13 AM
🧬 New review paper!
Our latest article in WIREs Nanomedicine and Nanobiotechnology explores the role of intrinsically disordered protein polymers (IDPPs) in self-assembly and biomaterials.
🔗 Read it here: doi.org/10.1002/wnan...
#Nanobiotech #Biomaterials #PhaseSeparation #Proteins
Our latest article in WIREs Nanomedicine and Nanobiotechnology explores the role of intrinsically disordered protein polymers (IDPPs) in self-assembly and biomaterials.
🔗 Read it here: doi.org/10.1002/wnan...
#Nanobiotech #Biomaterials #PhaseSeparation #Proteins
Luciano has joined our #MSCA Doctoral Network this month and will work on the DC08 project in Rivas' lab: www.comeincell.org/dc08-phase-s...
The project explores how #crowding, surfaces, and #PhaseSeparation affect minimal #divisome function and organization.
Welcome to #ComeInCell, Luciano!
The project explores how #crowding, surfaces, and #PhaseSeparation affect minimal #divisome function and organization.
Welcome to #ComeInCell, Luciano!
May 23, 2025 at 7:44 AM
Luciano has joined our #MSCA Doctoral Network this month and will work on the DC08 project in Rivas' lab: www.comeincell.org/dc08-phase-s...
The project explores how #crowding, surfaces, and #PhaseSeparation affect minimal #divisome function and organization.
Welcome to #ComeInCell, Luciano!
The project explores how #crowding, surfaces, and #PhaseSeparation affect minimal #divisome function and organization.
Welcome to #ComeInCell, Luciano!
👀"robust treadmilling requires an optimal phase separation strength to maintain high local concentration while preserving condensate fluidity. A weakened phase separation fails to stabilize the bundles, whereas overly cohesive condensates impede filament dynamics." #actin #phaseseparation
September 19, 2025 at 12:58 PM
👀"robust treadmilling requires an optimal phase separation strength to maintain high local concentration while preserving condensate fluidity. A weakened phase separation fails to stabilize the bundles, whereas overly cohesive condensates impede filament dynamics." #actin #phaseseparation
Captured a very obvious phase separation and fusion process (nuclear localization of tobacco cells)
#LLPS #phaseseparation
#LLPS #phaseseparation
December 17, 2025 at 7:33 PM
Captured a very obvious phase separation and fusion process (nuclear localization of tobacco cells)
#LLPS #phaseseparation
#LLPS #phaseseparation
#ICYMI:
“The insights of [#LaskerAward winners] Görlich & McKnight are being harnessed in medical research.” --Tanja Mittag on how low-complexity domains of proteins impact human health 🧪
#Lasker2025 #phaseseparation #biophysics
MPI for Multidisciplinary Sciences
NEJM.org
https://ow.ly/Fbmy50XUcWn
“The insights of [#LaskerAward winners] Görlich & McKnight are being harnessed in medical research.” --Tanja Mittag on how low-complexity domains of proteins impact human health 🧪
#Lasker2025 #phaseseparation #biophysics
MPI for Multidisciplinary Sciences
NEJM.org
https://ow.ly/Fbmy50XUcWn
January 12, 2026 at 5:50 PM
#ICYMI:
“The insights of [#LaskerAward winners] Görlich & McKnight are being harnessed in medical research.” --Tanja Mittag on how low-complexity domains of proteins impact human health 🧪
#Lasker2025 #phaseseparation #biophysics
MPI for Multidisciplinary Sciences
NEJM.org
https://ow.ly/Fbmy50XUcWn
“The insights of [#LaskerAward winners] Görlich & McKnight are being harnessed in medical research.” --Tanja Mittag on how low-complexity domains of proteins impact human health 🧪
#Lasker2025 #phaseseparation #biophysics
MPI for Multidisciplinary Sciences
NEJM.org
https://ow.ly/Fbmy50XUcWn
“The work of McKnight and Görlich is a testament to curiosity-driven research.”
#ICYMI: William G. Kaelin Jr writes about this year’s Basic Research #LaskerAward winners in the @pnas.org #Lasker2025 collection. 🧪
www.pnas.org/doi/10.1073/...
@mpi-nat.bsky.social
#phaseseparation #biophysics
#ICYMI: William G. Kaelin Jr writes about this year’s Basic Research #LaskerAward winners in the @pnas.org #Lasker2025 collection. 🧪
www.pnas.org/doi/10.1073/...
@mpi-nat.bsky.social
#phaseseparation #biophysics
Making sense of low-complexity domains: The 2025 Lasker Basic Science Award | PNAS
Up to 10 to 20% of the proteome contains regions with much lower amino acid diversity than would be expected by chance. This year’s Lasker Basic Sc...
www.pnas.org
December 9, 2025 at 8:45 PM
“The work of McKnight and Görlich is a testament to curiosity-driven research.”
#ICYMI: William G. Kaelin Jr writes about this year’s Basic Research #LaskerAward winners in the @pnas.org #Lasker2025 collection. 🧪
www.pnas.org/doi/10.1073/...
@mpi-nat.bsky.social
#phaseseparation #biophysics
#ICYMI: William G. Kaelin Jr writes about this year’s Basic Research #LaskerAward winners in the @pnas.org #Lasker2025 collection. 🧪
www.pnas.org/doi/10.1073/...
@mpi-nat.bsky.social
#phaseseparation #biophysics
Why are low-complexity domains (LCDs) in proteins important?
#LaskerAward winners Dirk Görlich & Steven McKnight showed that they are critical for intracellular transport and organization. #Lasker2025 🧪
#structuralbiology #phaseseparation
@mpi-nat.bsky.social
#LaskerAward winners Dirk Görlich & Steven McKnight showed that they are critical for intracellular transport and organization. #Lasker2025 🧪
#structuralbiology #phaseseparation
@mpi-nat.bsky.social
Low-complexity domains: structures & functions
The 2025 Albert Lasker Basic Medical Research Award honors Dirk Görlich and Steven McKnight for discoveries that exposed the structures and functions of low-complexity domains within protein…
www.youtube.com
November 28, 2025 at 1:45 PM
Why are low-complexity domains (LCDs) in proteins important?
#LaskerAward winners Dirk Görlich & Steven McKnight showed that they are critical for intracellular transport and organization. #Lasker2025 🧪
#structuralbiology #phaseseparation
@mpi-nat.bsky.social
#LaskerAward winners Dirk Görlich & Steven McKnight showed that they are critical for intracellular transport and organization. #Lasker2025 🧪
#structuralbiology #phaseseparation
@mpi-nat.bsky.social
“The Enigma of Protein Domains of Low-Sequence Complexity”
#LaskerAward winner S. McKnight writes about “these ugly duckling proteins” that turned out to be vital for cellular function. 🧪
#RNAbiology #phaseseparation #Lasker2025 #UTSWMedicalCenter #JAMA
ow.ly/klVz50WY5Hf
#LaskerAward winner S. McKnight writes about “these ugly duckling proteins” that turned out to be vital for cellular function. 🧪
#RNAbiology #phaseseparation #Lasker2025 #UTSWMedicalCenter #JAMA
ow.ly/klVz50WY5Hf
November 11, 2025 at 5:17 PM
“The Enigma of Protein Domains of Low-Sequence Complexity”
#LaskerAward winner S. McKnight writes about “these ugly duckling proteins” that turned out to be vital for cellular function. 🧪
#RNAbiology #phaseseparation #Lasker2025 #UTSWMedicalCenter #JAMA
ow.ly/klVz50WY5Hf
#LaskerAward winner S. McKnight writes about “these ugly duckling proteins” that turned out to be vital for cellular function. 🧪
#RNAbiology #phaseseparation #Lasker2025 #UTSWMedicalCenter #JAMA
ow.ly/klVz50WY5Hf
#ICYMI:
📖 In-depth coverage of the science and significance of the 2025 #LaskerAward(s): laskerfoundation.org/winners/2025...
#LaskerAward #LaskerLaureate #cysticfibrosis #devbio #phaseseparation #RNAbiology #structuralbiology #systemsbiology 🧪
📖 In-depth coverage of the science and significance of the 2025 #LaskerAward(s): laskerfoundation.org/winners/2025...
#LaskerAward #LaskerLaureate #cysticfibrosis #devbio #phaseseparation #RNAbiology #structuralbiology #systemsbiology 🧪
2025 Winners - Lasker Foundation
Dirk Görlich Steven L. McKnight Basic Research Structures and functions of low-complexity domains Learn More > Michael J. Welsh Jesús (Tito) González Paul A. Negulescu Clinical Research…
laskerfoundation.org
September 21, 2025 at 4:45 PM
#ICYMI:
📖 In-depth coverage of the science and significance of the 2025 #LaskerAward(s): laskerfoundation.org/winners/2025...
#LaskerAward #LaskerLaureate #cysticfibrosis #devbio #phaseseparation #RNAbiology #structuralbiology #systemsbiology 🧪
📖 In-depth coverage of the science and significance of the 2025 #LaskerAward(s): laskerfoundation.org/winners/2025...
#LaskerAward #LaskerLaureate #cysticfibrosis #devbio #phaseseparation #RNAbiology #structuralbiology #systemsbiology 🧪
#ICYMI:
📺 Explainers of the #Lasker2025 Award winners and their work: laskerfoundation.org/the-2025-las...
#LaskerAward #LaskerLaureate #cysticfibrosis #devbio #phaseseparation #RNAbiology #biophysics #systemsbiology 🧪
📺 Explainers of the #Lasker2025 Award winners and their work: laskerfoundation.org/the-2025-las...
#LaskerAward #LaskerLaureate #cysticfibrosis #devbio #phaseseparation #RNAbiology #biophysics #systemsbiology 🧪
The 2025 Lasker Award Videos - Lasker Foundation
Watch a series of video shorts, made in collaboration with science journalist Ed Prosser and animator Andrew Khosravani, about the 2025 Lasker Laureates and their work.
laskerfoundation.org
September 20, 2025 at 4:45 PM
#ICYMI:
📺 Explainers of the #Lasker2025 Award winners and their work: laskerfoundation.org/the-2025-las...
#LaskerAward #LaskerLaureate #cysticfibrosis #devbio #phaseseparation #RNAbiology #biophysics #systemsbiology 🧪
📺 Explainers of the #Lasker2025 Award winners and their work: laskerfoundation.org/the-2025-las...
#LaskerAward #LaskerLaureate #cysticfibrosis #devbio #phaseseparation #RNAbiology #biophysics #systemsbiology 🧪