##PhaseSeparation
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james-r-barrett.bsky.social
How does molecular valency shape condensate assembly and function? We used the CO2-fixing organelle in algae—the pyrenoid—to find out… 🧵

Preprint here!:
www.biorxiv.org/content/10.6...

@cellarchlab.com @phaips.vd.st @biologyatyork.bsky.social
#Rubisco #PhaseSeparation #Condensates #Pyrenoid
January 30, 2026 at 3:21 PM
brangwynnelab.bsky.social
A tremendous honor! Thrilled & humbled to receive 2025 Keio Medical Science Prize for launching LLPS #phaseseparation field (= #softmatter + #cellbio) w collaborators esp @HymanLab. & Congrats to Akiko Iwasaki @virusesimmunity.bsky.social. www.princeton.edu/news/2025/09...
#KeioMedicalSciencePrize
Bioengineer Clifford Brangwynne wins Keio Medical Science Prize
Japan’s Keio University awards the prize annually to honor contributions in medicine and life sciences. Brangwynne is being recognized for groundbreaking work that has opened up a new field of cell bi...
www.princeton.edu
September 20, 2025 at 6:16 PM
alexis-verger.cpesr.fr
🫣

#LLPS #Droplets #phaseseparation
November 30, 2025 at 8:57 AM
cellarchlab.com
Excited to share this detailed biophysical study of #PhaseSeparation in the Pyrenoid, an algal microcompartment that fixes a third of the Earth's #CO2 🌏. We combine methods across scales, in vitro 🧪 and in vivo 🦠

Thanks for the very fun collaboration! 🤗
#PlantScience 🌾 #TeamTomo 🔬 #LivingPhysics 🧬🧶
james-r-barrett.bsky.social James Barrett @james-r-barrett.bsky.social · Jan 30
How does molecular valency shape condensate assembly and function? We used the CO2-fixing organelle in algae—the pyrenoid—to find out… 🧵

Preprint here!:
www.biorxiv.org/content/10.6...

@cellarchlab.com @phaips.vd.st @biologyatyork.bsky.social
#Rubisco #PhaseSeparation #Condensates #Pyrenoid
January 30, 2026 at 3:50 PM
rnadavid.bsky.social
Biomolecular condensate starter pack!

Trying to compile & to bring together biomolecular condensate enthusiasts & critics!

Please join this non-exhaustive (sorry!) collection & just ping me for addition.

#condensates, #phaseseparation, #granules, #IDPs

go.bsky.app/NFqmffa
November 18, 2024 at 9:44 AM
cellarchlab.com
The KEY🔑 to regulating Rubisco phase separation in the Chlamydomonas algal pyrenoid. Beautiful work by Shan He, @mjonikas.bsky.social, and friends. #PhaseSeparation #CO2 #PlantScience 🧪 🧶🧬 🌾 🌍
mjonikas.bsky.social Martin Jonikas @mjonikas.bsky.social · Oct 12
Algal pyrenoids—condensates that mediate ~1/3 of Earth’s CO2 fixation—change size and number as cells divide. Our data suggest a simple control mechanism: a kinase that continuously ejects material from the condensate! ☀️🌍🔬💧 #Biophysics #Photosynthesis
www.biorxiv.org/content/10.1...
October 12, 2025 at 9:26 PM
brangwynnelab.bsky.social
Congrats to Jing @jesszhiyuezhao.bsky.social‬
& @dnamystrom.bsky.social‬ on cool manuscript!!! Reveals how cell nucleus is a heterogeneous material, w chromatin organization controlling formation & phase behavior of nuclear condensates. #CellBiology #Chromatin #PhaseSeparation rdcu.be/evWxR
Chromatin heterogeneity modulates nuclear condensate dynamics and phase behavior
Nature Communications - Chromatin heterogeneity in the cell nucleus modulates the size, mobility, and formation of biomolecular condensates; decreasing chromatin heterogeneity correlates with...
rdcu.be
July 12, 2025 at 8:33 PM
cp-trendsbiochem.bsky.social
Now online - the Review "Structured protein domains enter the spotlight: modulators of #biomolecularcondensate form and function" from Nathaniel Hess and @jerelleaj.bsky.social.

#PhaseSeparation #ProteinProteinInteraction #Oligomerization #ProteinRNAInteraction

authors.elsevier.com/sd/article/S...
January 23, 2025 at 3:07 PM
natcellbio.nature.com
🎄Our last issue for 2024 is out!
Cover: #CellDivision in #embryos

👉🏿Comment on the 'Women in #Autophagy' initiative
🔬on: #bone #EmbryoDevelopment #senescence #mitochondria #diabetes #PhaseSeparation #metastasis #sequencing & more!

www.nature.com/ncb/volumes/...
December 18, 2024 at 10:40 PM
laskerfdn.bsky.social
Congratulations to Dirk Görlich and Steven L. McKnight, 2025 #LaskerAward winners! - “for discoveries that exposed the structures and functions of low-complexity domains within protein sequences” 🧪
@mpi-nat.bsky.social
#Lasker2025 #LaskerLaureate #structuralbiology #phaseseparation
September 11, 2025 at 1:07 PM
cp-trendsbiochem.bsky.social
Now online - the Review "Protein quality control machinery: regulators of condensate architecture and functionality" from Anitha Rajendran and Carlos @castanedalab.bsky.social.

#PQC #condensates #phaseseparation #chaperones #therapeutics

Access here 👉 authors.elsevier.com/a/1kNRo3S6Gf...
January 6, 2025 at 5:50 PM
natcellbio.nature.com
🎄Our last issue for 2025 is out!
Cover: human trunk development model

🔬 #EmbryoModels #proteostasis #tRNA #ferroptosis #trogocytosis #mechanobiology #chromatin #TranscriptionFactor #epigenetics #ExtracellularVesicles #hematopoiesis #cancer #PhaseSeparation & more!
www.nature.com/ncb/volumes/...
December 19, 2025 at 7:22 PM
natcellbio.nature.com
☕Lee et al. show that Ca²⁺ triggers condensates enriched with PDIA6, an ER-resident disulfide isomerase and chaperone, along with other protein disulfide isomerase family proteins and some chaperones that in turn enhance folding of #proinsulin. #PhaseSeparation
bit.ly/44mX1bW
Ca2+-driven PDIA6 biomolecular condensation ensures proinsulin folding - Nature Cell Biology
Lee et al. show that Ca²⁺ triggers condensates enriched with PDIA6, an ER-resident disulfide isomerase and chaperone, along with other protein disulfide isomerase family proteins and some chaperones t...
bit.ly
November 27, 2025 at 9:31 AM
natcellbio.nature.com
🎃Our October issue's out!
Cover: mechanoresponsive #microtubules

👉🏼Reviews: #CellularStress ; #NuclearPoreComplex & #mechanobiology
🔬 #StemCells #senescence #cancer #EndoplasmicReticulum #phagocytosis #pyroptosis #autophagy #PhaseSeparation #AMPK #chromatin & more!
www.nature.com/ncb/volumes/...
October 17, 2025 at 10:25 AM
physicsoflifelmu.bsky.social
💧🌀 Active matter meets interface physics!
We show how conserved active emulsions form traveling interfacial waves and self-propelling liquid gears, powered by non-reciprocal chemical interactions.
🎥 Gears & belts in motion👇
📄 arxiv.org/abs/2505.20028
#ActiveMatter #PhaseSeparation #PatternFormation
June 3, 2025 at 5:12 PM
natcellbio.nature.com
👋Our November issue's out!
Cover: Electrostatic forces in condensates

👉🏼Comments: #DEI; #statistics #CellBiology; german #StemCell network
🔬 #ferroptosis #mitochondria #PhaseSeparation #EmbryoModels #transcriptomics #chromatin #cancer #TransposableElements & more!
www.nature.com/ncb/volumes/...
November 14, 2025 at 8:07 PM
natcellbio.nature.com
👋Our February issue's out!
Cover: #glioblastoma

👉🏼Review on #mitochondria #ProteinImport
👉🏻Viewpoint on #LipidMetabolism
🔬 #HumanEmbryos #NuclearSpeckles #PhaseSeparation #autophagy #mitosis #pluripotency #hematopoiesis #LipidDroplets & more!
www.nature.com/ncb/volumes/...
February 14, 2025 at 1:49 PM
natcellbio.nature.com
👋Our April issue is out!
Cover: Visualizing #lipids

👉2 Perspectives: #embryo models
👉Comment on #mitochondria DNA
🔬 #telomeres #leukemia #ferroptosis #pyroptosis #PhaseSeparation #CellAdhesion #BreastCancer #lncRNA #metabolism #autophagy #microscopy & more!
www.nature.com/ncb/volumes/...
April 17, 2026 at 6:05 PM
natcellbio.nature.com
👋Our May issue's out!
Cover: #medulloblastoma #metastasis

👉🏼Comment on #autophagy in #aging
👉🏼Review on #lipid signaling & #CellMigration
👉🏼Review on #fibroblasts
🔬 #trophectoderm #NuclearEnvelope #lysosomes #PhaseSeparation #chromatin in #cancer & more!
www.nature.com/ncb/volumes/...
Chromosomes in rainbow colors inside blue nuclei on a black background
May 19, 2025 at 12:30 PM
natcellbio.nature.com
☀️Our July issue's out!
Cover: #lysosome #metabolite

👉Editorial: #StemCell #embryo models
👉Perspective: #proteomics in #oocytes & embryo
👉Review: #ferroptosis in glial #tumors
🔬 #mitochondria #cytoskeleton #chromatin #BreastCancer #PhaseSeparation #lipids & more!

www.nature.com/ncb/volumes/...
July 13, 2026 at 6:03 PM
natcellbio.nature.com
🏖️Our July issue's out!
Cover: Droplets in meiotic crossovers

👉🏼Comment on #Alzheimers
👉🏼Reviews on #aging and #EndoplasmicReticulum -associated degradation
🔬 #BreastCancer #autophagy #neurodegeneration #amnion #chromatin #meiosis #PhaseSeparation #healthspan & more!
www.nature.com/ncb/volumes/...
July 18, 2025 at 8:09 PM
cellarchlab.com
#PhaseSeparation 💧🧪 #ProteinCosmos 🧶🧬 #NMR 🧲
August 11, 2025 at 12:31 PM
natcellbio.nature.com
💫NEW: Wei et al. report that MBD2 forms condensates through #PhaseSeparation in diverse cancers where it assembles the NuRD complex. MBD2 condensates are redox-sensitive and mediate transcriptional repression in #cancer cells.
👉https://rdcu.be/elKdU
go.nature.com/4iW4nrd
Targeting redox-sensitive MBD2–NuRD condensate in cancer cells - Nature Cell Biology
Wei et al. report that MBD2 forms condensates through phase separation in diverse cancers where it assembles the NuRD complex. MBD2 condensates are redox-sensitive and mediate transcriptional repressi...
go.nature.com
May 12, 2025 at 8:48 PM
sfb1551.bsky.social
🎉 Congrats to @kgaurav.bsky.social, Lukas Stelzl & @reneketting.bsky.social (SFB1551) on their new Biophysical Journal paper! #MUT16 #PhaseSeparation #MutatorFoci #SmallRNA #GeneRegulation #Celegans #ProteinAssembly #RNAResearch #MultiscaleSimulations Great teamwork👏👏👏 www.cell.com/biophysj/ful....
Multi-scale Simulations of MUT-16 Scaffold Protein Phase Separation and Client Recognition
Phase separation of proteins plays a critical role in cellular organisation. How phase separated protein condensates underpin biological function and how condensates achieve specificity remain elusive...
www.cell.com
August 14, 2025 at 12:28 PM
natcellbio.nature.com
☕Wang, Wang, Pan et al uncover a C864–C869 disulfide linkage stimulated by viral RNA that drives RIG-I activation, #PhaseSeparation and stimulates downstream innate #immune signaling.
👉https://rdcu.be/ekiGB
bit.ly/4cVF6Mu
Targeting a key disulfide linkage to regulate RIG-I condensation and cytosolic RNA-sensing - Nature Cell Biology
Wang, Wang, Pan and colleagues uncover a C864–C869 disulfide linkage stimulated by viral RNA that drives RIG-I activation, phase separation and stimulates downstream innate immune signalling.
bit.ly
May 1, 2025 at 6:07 PM