Excited to share our new paper!
We identify Wt1 as a transient regulator of cell fate during formative pluripotency and in the early post-implantation epiblast.
We identify Wt1 as a transient regulator of cell fate during formative pluripotency and in the early post-implantation epiblast.
November 5, 2026 at 6:25 PM
Excited to share our new paper!
We identify Wt1 as a transient regulator of cell fate during formative pluripotency and in the early post-implantation epiblast.
We identify Wt1 as a transient regulator of cell fate during formative pluripotency and in the early post-implantation epiblast.
Human pluripotent stem cells often develop differentiation biases in the lab, limiting disease modeling. A new study traces this to epigenetic drift and offers a chemical approach to restore their full differentiation potential.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Restoring pluripotency to pluripotent stem cells - Nature Biotechnology
Human pluripotent cell lines that cannot generate cortical organoids are rescued by an epigenetic reboot.
www.nature.com
November 5, 2026 at 6:00 PM
Human pluripotent stem cells often develop differentiation biases in the lab, limiting disease modeling. A new study traces this to epigenetic drift and offers a chemical approach to restore their full differentiation potential.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
As generalized before, most cancer promoting genes are enriched in embryonic neural/neural stem cells, incl RPS6/Mtor....
They confer cancer cell with neural stemness, which determines tumorigenicity&pluripotency in cells
Conclusion does not only depend on data, but also depend on basic logic.
They confer cancer cell with neural stemness, which determines tumorigenicity&pluripotency in cells
Conclusion does not only depend on data, but also depend on basic logic.
November 8, 2026 at 3:44 AM
As generalized before, most cancer promoting genes are enriched in embryonic neural/neural stem cells, incl RPS6/Mtor....
They confer cancer cell with neural stemness, which determines tumorigenicity&pluripotency in cells
Conclusion does not only depend on data, but also depend on basic logic.
They confer cancer cell with neural stemness, which determines tumorigenicity&pluripotency in cells
Conclusion does not only depend on data, but also depend on basic logic.
p53 is crucial for safely reprogramming human somatic cells to pluripotency, balancing cell identity shifts and ensuring genomic stability during the process. PMID:41999746, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00339-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00339-9
No description available
www.cell.com
November 9, 2026 at 7:00 PM
6/9 We can also use SMFNet to break apart the pluripotency network in silico.
KLF4 and OCT4::SOX2 motifs produce similar accessible fractions, but different spatial patterns: OCT4::SOX2 generates wider accessible regions with less defined nucleosome boundaries.
KLF4 and OCT4::SOX2 motifs produce similar accessible fractions, but different spatial patterns: OCT4::SOX2 generates wider accessible regions with less defined nucleosome boundaries.
November 5, 2026 at 6:18 PM
6/9 We can also use SMFNet to break apart the pluripotency network in silico.
KLF4 and OCT4::SOX2 motifs produce similar accessible fractions, but different spatial patterns: OCT4::SOX2 generates wider accessible regions with less defined nucleosome boundaries.
KLF4 and OCT4::SOX2 motifs produce similar accessible fractions, but different spatial patterns: OCT4::SOX2 generates wider accessible regions with less defined nucleosome boundaries.
GERALT started of as a deceptively simple sketch, born from my PhD on TGFβ signalling in pluripotency, postdoc on developmental gene regulation and growing interest in biomanufacturing. Turning that sketch into reality took years of experiments—and an extraordinary team effort!
November 5, 2026 at 5:29 PM
GERALT started of as a deceptively simple sketch, born from my PhD on TGFβ signalling in pluripotency, postdoc on developmental gene regulation and growing interest in biomanufacturing. Turning that sketch into reality took years of experiments—and an extraordinary team effort!
Basic logic:
The core property of cancer cells is neural stemness
it confers pluripotency/plasticity&tumorigenicty in cancer cells
MYT1L promotes neuronal differentiation to limit cancer cell plasticity&inhibit tumorigencity
doi.org/10.1038/s415... doi.org/10.1038/s415...
@nature.com
The core property of cancer cells is neural stemness
it confers pluripotency/plasticity&tumorigenicty in cancer cells
MYT1L promotes neuronal differentiation to limit cancer cell plasticity&inhibit tumorigencity
doi.org/10.1038/s415... doi.org/10.1038/s415...
@nature.com
Decoding the regulatory programs governing glioblastoma plasticity - Nature
Multi-omic analyses of cells from patients with glioblastoma (GB) provide insight into the role of non-genetic cellular plasticity in disease progression, showing that state stability in GB cells is c...
doi.org
November 7, 2026 at 3:52 AM
Basic logic:
The core property of cancer cells is neural stemness
it confers pluripotency/plasticity&tumorigenicty in cancer cells
MYT1L promotes neuronal differentiation to limit cancer cell plasticity&inhibit tumorigencity
doi.org/10.1038/s415... doi.org/10.1038/s415...
@nature.com
The core property of cancer cells is neural stemness
it confers pluripotency/plasticity&tumorigenicty in cancer cells
MYT1L promotes neuronal differentiation to limit cancer cell plasticity&inhibit tumorigencity
doi.org/10.1038/s415... doi.org/10.1038/s415...
@nature.com
Efficient protocol transitions human pluripotent stem cells to naive state in just 12 days. Key: chromatin rewiring, increased accessibility at OCT/KLF, and NFκB inhibition. PMID:42414293, Nat Commun 2026, @NatureComms https://doi.org/10.1038/s41467-026-74432-y #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
Delicate inhibition of NFκB/RELA circuitry facilitates efficient transition towards ground-state pluripotency in human | Nature Communications
Rebuilding human naïve pluripotency from primed stem cells is essential for generating pre-implantation epiblast-like cells, a key source for regenerative medicine. Here we present a defined, feeder-free protocol that efficiently converts primed human pluripotent stem cells (hPSCs) to a naïve-like state within 12 days. Integrated ATAC-seq, RNA-seq and miRNA-seq analyses reveal a rapid chromatin rewiring marked by increased accessibility at OCT/KLF motifs, closure at ZIC/RFX/NFκB sites, upregulation of miR-372/373 and miR-182/183, and downregulation of miR-302 and miR-363/106 clusters. Functional assays demonstrate that the inflammatory transcription factor NFκB/RELA blocks naïve induction by activating peri-implantation barrier genes, including IKBKE and VEGFR1. Conversely, enforced miR-372/373 expression accelerates conversion by directly targeting RELA. These data delineate an NFκB/RELA axis that orchestrates the epigenetic switch to human naïve pluripotency, offering a tractable fra
doi.org
November 2, 2026 at 8:00 AM
New research reveals that p53 is crucial for safe and efficient reprogramming of human somatic cells into pluripotency, balancing cell safety and reprogramming efficiency. PMID:41999746, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00339-9 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00339-9
No description available
www.cell.com
November 4, 2026 at 10:00 AM
FRIDAY LECTURE at IGBMC – Pr Austin Smith
He explores pluripotency and the different states of pluripotent stem cells, from naïve to primed, and how these influence their ability to differentiate into specific cell types.
Hosted by Sophie Jarriault.
He explores pluripotency and the different states of pluripotent stem cells, from naïve to primed, and how these influence their ability to differentiate into specific cell types.
Hosted by Sophie Jarriault.
October 30, 2026 at 11:41 AM
FRIDAY LECTURE at IGBMC – Pr Austin Smith
He explores pluripotency and the different states of pluripotent stem cells, from naïve to primed, and how these influence their ability to differentiate into specific cell types.
Hosted by Sophie Jarriault.
He explores pluripotency and the different states of pluripotent stem cells, from naïve to primed, and how these influence their ability to differentiate into specific cell types.
Hosted by Sophie Jarriault.
RRIDs were included in this in Stem Cells International paper. Thanks for making your methods matter! #methodsmatter #BetterScience #accelerateopenscience
Screening Genes Promoting Exit from Naive Pluripotency Based on Genome-Scale CRISPR-Cas9 Knockout
Read the full paper: Screening Genes Promoting Exit from Naive Pluripotency Based on Genome-Scale CRISPR-Cas9 Knockout
doi.org
October 30, 2026 at 7:05 AM
RRIDs were included in this in Stem Cells International paper. Thanks for making your methods matter! #methodsmatter #BetterScience #accelerateopenscience
The authors included RRIDs in their in Nature Genetics paper! RRIDs improve reproducibility in scientific research. #STMpublishing #ReproducibleResearch #reproducibility
Genome-scale screens identify JNK–JUN signaling as a barrier for pluripotency exit and endoderm differentiation - Nature Genetics
CRISPR screens identify JNK–JUN family genes as repressors of definitive endoderm differentiation in human pluripotent stem cells. JUN co-occupies stem cell enhancers with OCT4, NANOG, SMAD2 and SMAD3 and inhibits the exit from pluripotency.
doi.org
October 30, 2026 at 7:04 AM
The authors included RRIDs in their in Nature Genetics paper! RRIDs improve reproducibility in scientific research. #STMpublishing #ReproducibleResearch #reproducibility
'Human anaplastic thyroid carcinoma shows pluripotency-like features'
Understanding cancer as a systemic disease through comprehension of neural stemness as the core property of cancer cell and the basic rules it dictates
frontiersin.org/journals/cel...
Understanding cancer as a systemic disease through comprehension of neural stemness as the core property of cancer cell and the basic rules it dictates
frontiersin.org/journals/cel...
October 30, 2026 at 10:44 AM
'Human anaplastic thyroid carcinoma shows pluripotency-like features'
Understanding cancer as a systemic disease through comprehension of neural stemness as the core property of cancer cell and the basic rules it dictates
frontiersin.org/journals/cel...
Understanding cancer as a systemic disease through comprehension of neural stemness as the core property of cancer cell and the basic rules it dictates
frontiersin.org/journals/cel...
The authors included RRIDs in their in Nature Communications paper! We value the author's support of reproducibility. #reproducibility #ReproducibleResearch #accelerateopenscience
SS18 regulates pluripotent-somatic transition through phase separation - Nature Communications
Emerging evidence suggests that exit from pluripotency is a regulated, rather than passive process. Here the authors identify a requirement for SS18-mediated Brg/Brahma-associated factors (BAF) chromatin remodeling complex assembly during exit from pluripotency, and that SS18 promotes BAF assembly through liquidliquid phase separation.
doi.org
October 30, 2026 at 7:03 AM
The authors included RRIDs in their in Nature Communications paper! We value the author's support of reproducibility. #reproducibility #ReproducibleResearch #accelerateopenscience
'Human anaplastic thyroid carcinoma shows pluripotency-like features'
Decades later, the pluripotent property of cancer cells was remembered again.
www.cell.com/cell-reports...
Decades later, the pluripotent property of cancer cells was remembered again.
www.cell.com/cell-reports...
Embryonic reprogramming drives anaplastic transformation in thyroid carcinoma
Embryonic reprogramming drives anaplastic transformation in thyroid cancer. Using
human samples and in vivo reprogrammable mouse models, Kawaura et al. show that reprogramming
can induce anaplastic fe...
www.cell.com
October 30, 2026 at 11:05 AM
'Human anaplastic thyroid carcinoma shows pluripotency-like features'
Decades later, the pluripotent property of cancer cells was remembered again.
www.cell.com/cell-reports...
Decades later, the pluripotent property of cancer cells was remembered again.
www.cell.com/cell-reports...
Institute for Bioengineering of Catalonia (IBEC) is hiring:
Postdoctoral Researcher in Pluripotency for Organ Regeneration
#postdoc #biologicalsciences
Postdoctoral Researcher in Pluripotency for Organ Regeneration
#postdoc #biologicalsciences
October 27, 2026 at 10:32 AM
Institute for Bioengineering of Catalonia (IBEC) is hiring:
Postdoctoral Researcher in Pluripotency for Organ Regeneration
#postdoc #biologicalsciences
Postdoctoral Researcher in Pluripotency for Organ Regeneration
#postdoc #biologicalsciences
KLF17 acts as a dual reporter for tracking naive pluripotency and 8-cell-like states https://www.biorxiv.org/content/10.64898/2026.10.23.761375v1
October 27, 2026 at 10:31 AM
KLF17 acts as a dual reporter for tracking naive pluripotency and 8-cell-like states https://www.biorxiv.org/content/10.64898/2026.10.23.761375v1
KLF17 acts as a dual reporter for tracking naive pluripotency and 8-cell-like states https://www.biorxiv.org/content/10.64898/2026.10.23.761375v1
October 27, 2026 at 10:31 AM
KLF17 acts as a dual reporter for tracking naive pluripotency and 8-cell-like states https://www.biorxiv.org/content/10.64898/2026.10.23.761375v1
At #SEDB2026 we also welcome Hannah Stuart as invited speaker. A new PI at @embl.org Barcelona, her research explores pluripotency, early lineage specification, and epigenetic reprogramming, uncovering how embryonic stem cells transition between states maintaining genomic integrity #DevBio
October 26, 2026 at 2:57 PM
Extract: The Pluripotency for organ regeneration Group at IBEC seeks a Junior Post-doctoral Researcher to develop advanced human organoid platforms for disease modeling and drug screening.
October 27, 2026 at 10:32 AM
Extract: The Pluripotency for organ regeneration Group at IBEC seeks a Junior Post-doctoral Researcher to develop advanced human organoid platforms for disease modeling and drug screening.
p53 is crucial for safely reprogramming human somatic cells to pluripotency, balancing genome stability and Yamanaka factors. Key insights reveal its essential role in efficient reprogramming while preventing… PMID:41999746, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00339-9
https://www.cell.com/cell/fulltext/S0092-8674(26)00339-9
No description available
www.cell.com
October 26, 2026 at 10:00 PM
p53 is crucial for safely reprogramming human somatic cells to pluripotency, balancing genome stability and Yamanaka factors. Key insights reveal its essential role in efficient reprogramming while preventing… PMID:41999746, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00339-9
p53 is crucial for safe chemical reprogramming of human somatic cells to pluripotency, balancing genome stability and efficient reprogramming. A fine-tuned approach enhances cell fate manipulation. PMID:41999746, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00339-9 #Medsky 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00339-9
No description available
www.cell.com
October 25, 2026 at 5:00 AM
p53 is crucial for safe chemical reprogramming of human somatic cells to pluripotency, balancing genome stability and efficient reprogramming. A fine-tuned approach enhances cell fate manipulation. PMID:41999746, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00339-9 #Medsky 🧪
Shin Kiriki, Xiaolong Li, Kodai Yamamoto: Pluripotency and Anosov Dynamics https://arxiv.org/abs/2610.30636 https://arxiv.org/pdf/2610.30636 https://arxiv.org/html/2610.30636
October 23, 2026 at 6:47 AM
Shin Kiriki, Xiaolong Li, Kodai Yamamoto: Pluripotency and Anosov Dynamics https://arxiv.org/abs/2610.30636 https://arxiv.org/pdf/2610.30636 https://arxiv.org/html/2610.30636
p53 is crucial for safe reprogramming of human somatic cells to pluripotency, balancing genome stability against oncogenic activation. Key for efficient cell fate manipulation! PMID:41999746, Cell 2026, @Cell https://www.cell.com/cell/fulltext/S0092-8674(26)00339-9 #Medsky #Pharmsky #RNA #ASHG 🧪
https://www.cell.com/cell/fulltext/S0092-8674(26)00339-9
No description available
www.cell.com
October 21, 2026 at 3:00 PM