#EXOSC2
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milofasken.bsky.social
Interesting!
#RNAExosome #EXOSC2 #RNADecay #RNAprocessing #Aging #Cancer

www.biorxiv.org/content/10.1...
Aging-dependent dysregulation of EXOSC2 is maintained in cancer as a dependency
Reprogramming of aged donor tissue cells into induced pluripotent stem cells (A-iPSC) preserved the epigenetic memory of aged-donor tissue, defined as genomic instability and poor tissue differentiati...
www.biorxiv.org
April 17, 2025 at 3:48 PM
plosbiology.org
Protein #kinase dysregulation is often implicated in #cancer. This study shows that casein kinase 2-mediated phosphorylation of splicing factor SF3B2 enhances its #deubiquitination & stability, driving aberrant #AlternativeSplicing & promoting ESCC progression @plosbiology.org 🧪 plos.io/4tjuKgI
A working model of CK2-mediated SF3B3 phosphorylation in promoting ESCC progression. In ESCC, aberrantly activated CK2 phosphorylates SF3B3 at Thr1200, enhancing its interaction with the deubiquitinase USP7. This interaction leads to deubiquitination and stabilization of SF3B3, ultimately promoting a large cohort of alternative splicing events, including the inclusion of exon 4 in EXOSC2, and thereby driving ESCC progression. Targeting both CK2 and USP7, either individually or in combination, using CX-4945 and P5091, respectively, effectively suppresses ESCC progression.
April 14, 2026 at 8:00 AM
plosbiology.org
Protein #kinase dysregulation is often implicated in #cancer. This study shows that casein kinase 2-mediated phosphorylation of splicing factor SF3B2 enhances its #deubiquitination & stability, driving aberrant #AlternativeSplicing & promoting ESCC progression @plosbiology.org 🧪 plos.io/4tjuKgI
A working model of CK2-mediated SF3B3 phosphorylation in promoting ESCC progression. In ESCC, aberrantly activated CK2 phosphorylates SF3B3 at Thr1200, enhancing its interaction with the deubiquitinase USP7. This interaction leads to deubiquitination and stabilization of SF3B3, ultimately promoting a large cohort of alternative splicing events, including the inclusion of exon 4 in EXOSC2, and thereby driving ESCC progression. Targeting both CK2 and USP7, either individually or in combination, using CX-4945 and P5091, respectively, effectively suppresses ESCC progression.
April 13, 2026 at 4:45 PM
plosbiology.org
Protein #kinase dysregulation is often implicated in #cancer. This study shows that casein kinase 2-mediated phosphorylation of splicing factor SF3B2 enhances its #deubiquitination & stability, driving aberrant #AlternativeSplicing & promoting ESCC progression @plosbiology.org 🧪 plos.io/4tjuKgI
A working model of CK2-mediated SF3B3 phosphorylation in promoting ESCC progression. In ESCC, aberrantly activated CK2 phosphorylates SF3B3 at Thr1200, enhancing its interaction with the deubiquitinase USP7. This interaction leads to deubiquitination and stabilization of SF3B3, ultimately promoting a large cohort of alternative splicing events, including the inclusion of exon 4 in EXOSC2, and thereby driving ESCC progression. Targeting both CK2 and USP7, either individually or in combination, using CX-4945 and P5091, respectively, effectively suppresses ESCC progression.
April 14, 2026 at 1:03 PM
rridrobot.bsky.social
A preprint using: EXOSC2 antibody (RRID:AB_2101837) from @proteintech.bsky.social was published.

SciScore made a table with this resource, see “Automated Services” module (download as csv, xml or #jats) #methodsmatter #STMpublishing
Hierarchical assembly and functional resilience of the mammalian RNA exosome
www.biorxiv.org
March 23, 2025 at 12:01 PM
biorxiv-cellbio.bsky.social
Aging-dependent dysregulation of EXOSC2 is maintained in cancer as a dependency https://www.biorxiv.org/content/10.1101/2025.04.04.647279v1
April 7, 2025 at 1:30 PM
biorxivpreprint.bsky.social
Aging-dependent dysregulation of EXOSC2 is maintained in cancer as a dependency https://www.biorxiv.org/content/10.1101/2025.04.04.647279v1
April 7, 2025 at 1:30 PM