This study investigates the expression pattern and regulatory role of NDRG2 during embryonic implantation. Researchers examined NDRG2 expression in human and mouse endometrial tissues across different phases, finding significant upregulation in the secretory phase and at the implantation stage. Functional experiments showed that silencing NDRG2 in mice reduced embryo implantation rates, while in vitro tests revealed NDRG2 knockdown inhibited Ishikawa cell adhesion and suppressed FHL1 expression. The findings suggest NDRG2's involvement in endometrial cell adhesion via FHL1, offering insights into molecular mechanisms critical for successful pregnancy. The research was funded by the National Natural Science Foundation of China and the Hunan Province Natural Science Foundation, with ethical approvals from the Medical Ethics Committee of Xiangya Hospital. The study highlights potential therapeutic targets for improving reproductive outcomes by modulating NDRG2-FHL1 pathways.

During early pregnancy in mice, leukemia inhibitory factor (LIF) regulates embryo implantation by ac