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🔬 Explore the frontiers of Reproductive Medicine!

MHR & Bedford Research Foundation present The 2026 Activated Egg Symposium: Unique Human Egg Activation Pathways.

🗓 Nov 6, 2026
📍 MIT Endicott House & Online
🔗 lnkd.in/eyGNJQ4t

#HumanEgg #Embryology #MHRJournal
October 26, 2026 at 8:13 AM
mhr-reprodsci.bsky.social
🧵 For #ThrowbackThursday, #MHRJournal looks back at the review "Molecular mechanisms of ovarian fibrosis" by Beyza Gaye Edepli & Prof. Dr. Aylin Yaba Uçar.

Repeated ovulation causes scarring & severe tissue stiffening 🧱📉
#OvarianFibrosis #MolecularBiology #ExtracellularMatrix
October 22, 2026 at 7:18 AM
mhr-reprodsci.bsky.social
Single-cell proteomics reveals differences in young vs. advanced maternal age (AMA) oocytes:

📉 Decreased proteostasis & meiosis proteins

🔬 Proteasome decline drives poor quality

Read the open-access article: academic.oup.com/molehr/artic...
#MHRJournal #OocyteQuality 2/2
Single-cell proteomics reveals decreased abundance of proteostasis and meiosis proteins in advanced maternal age oocytes
Abstract. Advanced maternal age is associated with a decline in oocyte quality, which often leads to reproductive failure in humans. However, the mechanism
academic.oup.com
October 8, 2026 at 7:33 AM
mhr-reprodsci.bsky.social
Key findings:

🔬 Invasion triggers de novo formation of heterologous tight & adherens junctions, plus desmosomes.

🛑 Blocking desmoglein 2 stalls the invasion!

Read here: academic.oup.com/molehr/advan...

#EmbryoImplantation #MHRJournal 2/2
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academic.oup.com
September 18, 2026 at 10:05 AM
mhr-reprodsci.bsky.social
💡 The results? Adding a sAC inhibitor effectively blocked sperm migration.

This provides strong proof-of-concept for sAC inhibitors as fast-acting contraceptives for both men and women!

🔗 Full open-access study: academic.oup.com/molehr/artic...
#Contraception #MHRJournal #ESHRE
Assessing efficacy of ADCY10 inhibitors in cervical mucus
Abstract. Male fertility depends on sperm motility, which enables sperm to traverse the female reproductive tract to the site of fertilization. Soluble ade
academic.oup.com
July 14, 2026 at 7:08 AM
mhr-reprodsci.bsky.social
📢 New paper in #MHRJournal! 🔬

A study by Carine Munaut at GIGA-ULiège explores the S1P signaling pathway in an #adenomyosis mouse model. S1P modulation decreased tissue invasion & altered uterine immune cells, showing promise for new therapies! 🧬

👉 academic.oup.com/molehr/artic...
Stage-dependent sphingosine-1-phosphate pathway modulation as a therapeutic strategy in a murine model of adenomyosis
Abstract. Adenomyosis is characterized by chronic inflammation, myometrial remodeling, and subfertility, yet therapeutic options that preserve reproductive
academic.oup.com
May 22, 2026 at 10:59 AM
mhr-reprodsci.bsky.social
🔬 New in MHR! Could the liver protein ORM2 hold the key to new #PCOS treatments?

Xu et al. show that while Orm2 KO worsens ovarian pathology, recombinant ORM2 supplementation improves ovarian morphology & Ucp1 expression! 💡

📖 Read the full study: academic.oup.com/molehr/artic...
#MHRJournal #ESHRE
Orosomucoid 2 improves reproductive phenotypes in a mouse model of PCOS induced by letrozole under high-fat diet conditions
Abstract. Polycystic ovary syndrome (PCOS) is the most common reproductive endocrine disorder among women of reproductive age. It is characterized by exces
academic.oup.com
May 12, 2026 at 11:45 AM