It is an attempt to recapitulate the myriad pathways involved in signal transduction, protein synthesis, endocytosis, vesicular transport, cell-cell adhesion, apoptosis, and other processes.
April 29, 2026 at 4:05 PM
It is an attempt to recapitulate the myriad pathways involved in signal transduction, protein synthesis, endocytosis, vesicular transport, cell-cell adhesion, apoptosis, and other processes.
How does evolution shape ancient cellular processes? Our new paper uncovers the mosaic evolution of conserved and diverging endocytic traits in fungi!
www.cell.com/current-biol...
www.cell.com/current-biol...
Mosaic evolution of clathrin-mediated endocytosis in fungi
Picco et al. take an evolutionary approach to study clathrin-mediated endocytosis
in a fungal clade and discover that the process is evolving in a mosaic fashion. The
early phase of endocytosis has sh...
www.cell.com
July 10, 2025 at 3:31 PM
How does evolution shape ancient cellular processes? Our new paper uncovers the mosaic evolution of conserved and diverging endocytic traits in fungi!
www.cell.com/current-biol...
www.cell.com/current-biol...
The big one is out! So over the moon to see our latest work with Stéphane Vassilopoulos published in Science. Check out how we reveal the unique architecture of clathrin-coated pits and endocytosis at the axon initial segment: www.science.org/doi/10.1126/...
The actin-spectrin submembrane scaffold restricts endocytosis along proximal axons
Clathrin-mediated endocytosis has characteristic features in neuronal dendrites and presynapses, but how membrane proteins are internalized along the axon shaft remains unclear. We focused on clathrin...
www.science.org
August 22, 2024 at 8:32 PM
The big one is out! So over the moon to see our latest work with Stéphane Vassilopoulos published in Science. Check out how we reveal the unique architecture of clathrin-coated pits and endocytosis at the axon initial segment: www.science.org/doi/10.1126/...
www.biorxiv.org/content/10.6...
Mechanical regulation of endocytosis by protein droplet capillary forces
Mechanical regulation of endocytosis by protein droplet capillary forces
October 3, 2026 at 10:50 AM
www.biorxiv.org/content/10.6...
Mechanical regulation of endocytosis by protein droplet capillary forces
Mechanical regulation of endocytosis by protein droplet capillary forces
Today, our animation synthesizing decades of research on actin-mediated endocytosis in budding yeast was published:
journals.biologists.com/jcs/article/...
The result of a fantastic Iwasa-Drubin lab collaboration.
@margotriggi.bsky.social @jiwasa.bsky.social
movie.biologists.com/video/10.124...
journals.biologists.com/jcs/article/...
The result of a fantastic Iwasa-Drubin lab collaboration.
@margotriggi.bsky.social @jiwasa.bsky.social
movie.biologists.com/video/10.124...
December 2, 2025 at 9:02 PM
Today, our animation synthesizing decades of research on actin-mediated endocytosis in budding yeast was published:
journals.biologists.com/jcs/article/...
The result of a fantastic Iwasa-Drubin lab collaboration.
@margotriggi.bsky.social @jiwasa.bsky.social
movie.biologists.com/video/10.124...
journals.biologists.com/jcs/article/...
The result of a fantastic Iwasa-Drubin lab collaboration.
@margotriggi.bsky.social @jiwasa.bsky.social
movie.biologists.com/video/10.124...
This plant spotted in the Greek mountains absolutely nailed endocytosis aesthetics
January 5, 2025 at 6:51 PM
This plant spotted in the Greek mountains absolutely nailed endocytosis aesthetics
Super happy to announce that together with @stefvass.bsky.social , we will have the honor to join 1st authors Florian Wernert and @moparthisk.bsky.social to present our recent work (www.science.org/doi/10.1126/...) to the French Academy of Sciences @academiesciences.bsky.social!
The actin-spectrin submembrane scaffold restricts endocytosis along proximal axons
Clathrin-mediated endocytosis has characteristic features in neuronal dendrites and presynapses, but how membrane proteins are internalized along the axon shaft remains unclear. We focused on clathrin...
www.science.org
May 23, 2025 at 2:42 PM
Super happy to announce that together with @stefvass.bsky.social , we will have the honor to join 1st authors Florian Wernert and @moparthisk.bsky.social to present our recent work (www.science.org/doi/10.1126/...) to the French Academy of Sciences @academiesciences.bsky.social!
Exciting new findings: Wnt-receptor endocytosis is required for canonical Wnt activation, yet uptake mechanisms has been controversial. We resolve this by showing that Wnt3a triggers rapid Clathrin- and Fast Endophilin-Mediated LRP6 endocytosis at low concentrations sufficient for Wnt activation.
The Actin regulator Mena promotes Wnt signalosome endocytosis and Wnt signalling
Wnt signaling controls embryonic development and tissue maintenance. Endocytosis of Wnt-receptors is required for signalling, yet uptake mechanisms remain poorly understood. Here, we identify the acti...
www.biorxiv.org
November 27, 2025 at 9:51 AM
Exciting new findings: Wnt-receptor endocytosis is required for canonical Wnt activation, yet uptake mechanisms has been controversial. We resolve this by showing that Wnt3a triggers rapid Clathrin- and Fast Endophilin-Mediated LRP6 endocytosis at low concentrations sufficient for Wnt activation.
Are lipids actively sorted during clathrin mediated endocytosis like proteins? @mathilda95.bsky.social addresses this key open question together with our collaborators from the Honigmann and Modes labs using a new Lipid-STED workflow.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
March 10, 2025 at 11:57 AM
Are lipids actively sorted during clathrin mediated endocytosis like proteins? @mathilda95.bsky.social addresses this key open question together with our collaborators from the Honigmann and Modes labs using a new Lipid-STED workflow.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Published! From a proteomic atlas of the ERECTA signaling network, we show that receptor kinase endocytosis is essential for proper stomatal patterning. Congrats, Pengfei, @edwardmarcotte.bsky.social, @hhmi-science.bsky.social, @texasscience.bsky.social & co-authors!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Comparative proteomic profiling of receptor kinase signaling reveals key trafficking components enforcing plant stomatal development
Proteomic mapping uncovers endocytosis adaptors that drive receptor internalization for robust stomatal development.
www.science.org
March 26, 2026 at 6:59 PM
Published! From a proteomic atlas of the ERECTA signaling network, we show that receptor kinase endocytosis is essential for proper stomatal patterning. Congrats, Pengfei, @edwardmarcotte.bsky.social, @hhmi-science.bsky.social, @texasscience.bsky.social & co-authors!
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
New preprint showing how the membrane-associated periodic skeleton (MPS) restricts endocytosis in neurons: www.biorxiv.org/content/10.6...
It nicely confirms our work from last year (science.org/doi/10.1126/science.ado2032) and extends it to other compartments in more mature neurons
It nicely confirms our work from last year (science.org/doi/10.1126/science.ado2032) and extends it to other compartments in more mature neurons
Membrane-associated periodic skeleton regulates major forms of endocytosis in neurons through a signaling-driven positive feedback loop
Endocytosis enables neurons to internalize molecules, maintaining homeostasis and responsiveness. The neuronal membrane-associated periodic skeleton (MPS), an actin-spectrin-based cytoskeletal lattice...
www.biorxiv.org
December 17, 2025 at 11:48 AM
New preprint showing how the membrane-associated periodic skeleton (MPS) restricts endocytosis in neurons: www.biorxiv.org/content/10.6...
It nicely confirms our work from last year (science.org/doi/10.1126/science.ado2032) and extends it to other compartments in more mature neurons
It nicely confirms our work from last year (science.org/doi/10.1126/science.ado2032) and extends it to other compartments in more mature neurons
Acute remodeling of phosphoinositide lipids promotes endocytosis downstream of RALF/FERONIA signaling: Current Biology www.cell.com/current-biol...
Acute remodeling of phosphoinositide lipids promotes endocytosis downstream of RALF/FERONIA signaling
Serre et al. reveal that RALF peptides rapidly trigger PI4P-to-PI(4,5)P2 conversion
at the plasma membrane downstream of the receptor kinase FERONIA. This acute phosphoinositide
remodeling, mediated b...
www.cell.com
April 3, 2026 at 6:53 AM
Acute remodeling of phosphoinositide lipids promotes endocytosis downstream of RALF/FERONIA signaling: Current Biology www.cell.com/current-biol...
Awesome animation about the molecular complexity of endocytosis!
Today, our animation synthesizing decades of research on actin-mediated endocytosis in budding yeast was published:
journals.biologists.com/jcs/article/...
The result of a fantastic Iwasa-Drubin lab collaboration.
@margotriggi.bsky.social @jiwasa.bsky.social
movie.biologists.com/video/10.124...
journals.biologists.com/jcs/article/...
The result of a fantastic Iwasa-Drubin lab collaboration.
@margotriggi.bsky.social @jiwasa.bsky.social
movie.biologists.com/video/10.124...
December 2, 2025 at 10:52 PM
Awesome animation about the molecular complexity of endocytosis!
Latest paper from my lab !! New insight into transporter endocytosis in plants using TurboID. Proud of liza-pellegrin.bsky.social for the great work and @julnev.bsky.social for driving this.
doi.org/10.1111/nph....
@lrsv-toulouse.bsky.social @cnrsbiologie.bsky.social
doi.org/10.1111/nph....
@lrsv-toulouse.bsky.social @cnrsbiologie.bsky.social
<fc>TurboID</fc>‐based proteomic profiling reveals proxitome of the <fc>IRT1</fc> metal transporter and new insight into <fc>IRT1</fc> endocytosis
Identification of new regulators of Arabidopsis IRT1 endocytosis and metal transport using TurboID. TurboID proximity labeling of the Arabidopsis IRT1 root metal transporter identified new IRT1-inter....
doi.org
September 14, 2026 at 6:39 AM
Latest paper from my lab !! New insight into transporter endocytosis in plants using TurboID. Proud of liza-pellegrin.bsky.social for the great work and @julnev.bsky.social for driving this.
doi.org/10.1111/nph....
@lrsv-toulouse.bsky.social @cnrsbiologie.bsky.social
doi.org/10.1111/nph....
@lrsv-toulouse.bsky.social @cnrsbiologie.bsky.social
Beautiful quantitative superresolution imaging study using clickable bifunctional lipid probes to figure out lipid sorting in endocytosis from @nadlerlab.bsky.social! #lipidtime
Are lipids actively sorted during clathrin mediated endocytosis like proteins? @mathilda95.bsky.social addresses this key open question together with our collaborators from the Honigmann and Modes labs using a new Lipid-STED workflow.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
March 14, 2025 at 3:26 PM
Beautiful quantitative superresolution imaging study using clickable bifunctional lipid probes to figure out lipid sorting in endocytosis from @nadlerlab.bsky.social! #lipidtime
We wrote a review article on ultrafast endocytosis and its mechanisms and relevance to diseases. Enjoy! pubmed.ncbi.nlm.nih.gov/40062769/
Beyond Clathrin: Decoding the Mechanism of Ultrafast Endocytosis - PubMed
Endocytosis in nonneuronal cells requires gradual recruitment of proteins to endocytic sites for inducing membrane curvature and forming scaffolds around the neck of endocytic pits. This recruitment p...
pubmed.ncbi.nlm.nih.gov
June 21, 2025 at 11:11 AM
We wrote a review article on ultrafast endocytosis and its mechanisms and relevance to diseases. Enjoy! pubmed.ncbi.nlm.nih.gov/40062769/
Study today in @natcellbio.nature.com by @mathilda95.bsky.social @nadlerlab.bsky.social @mpi-cbg.de, Honigmann group @biotec-tud.bsky.social & @carldmodes.bsky.social reveals that clathrin-mediated endocytosis sorts proteins but not lipids. Lipids use different routes. www.mpi-cbg.de/news-outreac...
September 29, 2026 at 11:55 AM
Study today in @natcellbio.nature.com by @mathilda95.bsky.social @nadlerlab.bsky.social @mpi-cbg.de, Honigmann group @biotec-tud.bsky.social & @carldmodes.bsky.social reveals that clathrin-mediated endocytosis sorts proteins but not lipids. Lipids use different routes. www.mpi-cbg.de/news-outreac...
What brings clathrin adaptors, phase separation & membrane trafficking together? 🧬🔬
Our new paper in Communications Biology explores just that!
Discover how clathrin adaptors drive LLPS during endocytosis—and what we found 👇
www.nature.com/articles/s42...
@embl.org @cssbhamburg.bsky.social
Our new paper in Communications Biology explores just that!
Discover how clathrin adaptors drive LLPS during endocytosis—and what we found 👇
www.nature.com/articles/s42...
@embl.org @cssbhamburg.bsky.social
Clathrin adaptors drive phase separation in endocytosis and trafficking - Communications Biology
Communications Biology - Clathrin adaptors drive phase separation in endocytosis and trafficking
www.nature.com
September 28, 2026 at 8:49 AM
What brings clathrin adaptors, phase separation & membrane trafficking together? 🧬🔬
Our new paper in Communications Biology explores just that!
Discover how clathrin adaptors drive LLPS during endocytosis—and what we found 👇
www.nature.com/articles/s42...
@embl.org @cssbhamburg.bsky.social
Our new paper in Communications Biology explores just that!
Discover how clathrin adaptors drive LLPS during endocytosis—and what we found 👇
www.nature.com/articles/s42...
@embl.org @cssbhamburg.bsky.social
Delighted to share our latest preprint "Filopodia-mediated trans-endocytosis"
www.biorxiv.org/content/10.6...
Work driven by many people including Hanna, Marcela, Sujan, Marie-Catherine, Anna and Monika. Fantastic collaboration with Johanna Englund, Emilia Peuhu, and Eija Jokitalo
www.biorxiv.org/content/10.6...
Work driven by many people including Hanna, Marcela, Sujan, Marie-Catherine, Anna and Monika. Fantastic collaboration with Johanna Englund, Emilia Peuhu, and Eija Jokitalo
February 11, 2026 at 2:20 PM
Delighted to share our latest preprint "Filopodia-mediated trans-endocytosis"
www.biorxiv.org/content/10.6...
Work driven by many people including Hanna, Marcela, Sujan, Marie-Catherine, Anna and Monika. Fantastic collaboration with Johanna Englund, Emilia Peuhu, and Eija Jokitalo
www.biorxiv.org/content/10.6...
Work driven by many people including Hanna, Marcela, Sujan, Marie-Catherine, Anna and Monika. Fantastic collaboration with Johanna Englund, Emilia Peuhu, and Eija Jokitalo
Cell jamming transition is regulated by mitochondrial pyruvate transport and endocytosis | PNAS www.pnas.org/doi/10.1073/...
Cell jamming transition is regulated by mitochondrial pyruvate transport and endocytosis | PNAS
Epithelial tissues undergo dynamic transitions between fluid-like collective motion
and mechanically jammed states during development, injury repai...
www.pnas.org
October 8, 2026 at 2:20 PM
Cell jamming transition is regulated by mitochondrial pyruvate transport and endocytosis | PNAS www.pnas.org/doi/10.1073/...
Clathrin mediated endocytosis regulates microvilli growth!
the @tyskalabactual.bsky.social strikes again with more beautiful work on MV growth!
Apical clathrin-coated pits control the location, timing, and scale of microvillar growth
www.biorxiv.org/content/10.1...
Apical clathrin-coated pits control the location, timing, and scale of microvillar growth
www.biorxiv.org/content/10.1...
Apical clathrin-coated pits control the location, timing, and scale of microvillar growth
Epithelial cells from diverse contexts assemble apical specializations to serve tissue-specific functions. In virtually all cases, these features consist of arrays of microvilli: micron-scale, actin b...
www.biorxiv.org
December 18, 2024 at 1:37 AM
Clathrin mediated endocytosis regulates microvilli growth!
When my lab moved from UNC to UM, one of our major experiments stopped working.
We had found that acute glucose starvation-induced endocytosis at UNC, and ppl at JHU and U.Utah had repeated it. But dammit in Michigan, glucose starvation didn't induce endocytosis.
We had found that acute glucose starvation-induced endocytosis at UNC, and ppl at JHU and U.Utah had repeated it. But dammit in Michigan, glucose starvation didn't induce endocytosis.
October 14, 2023 at 11:44 PM
When my lab moved from UNC to UM, one of our major experiments stopped working.
We had found that acute glucose starvation-induced endocytosis at UNC, and ppl at JHU and U.Utah had repeated it. But dammit in Michigan, glucose starvation didn't induce endocytosis.
We had found that acute glucose starvation-induced endocytosis at UNC, and ppl at JHU and U.Utah had repeated it. But dammit in Michigan, glucose starvation didn't induce endocytosis.
polyniigo absorb Honami endocytosis style
September 11, 2025 at 7:37 PM
polyniigo absorb Honami endocytosis style