#Endometriotic
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gregoryburns.bsky.social
Our latest publication is now online!

Spatial Transcriptomic Analysis Identifies Epithelium-Macrophage Crosstalk in Endometriotic Lesions: iScience www.cell.com/iscience/ful...
Spatial Transcriptomic Analysis Identifies Epithelium-Macrophage Crosstalk in Endometriotic Lesions
The mechanisms underlying the pathophysiology of endometriosis, characterized by the presence of endometrium-like tissue outside the uterus, remain poorly understood. This study aimed to identify cell...
www.cell.com
January 15, 2025 at 6:37 PM
spillthesoup.bsky.social
I've lost most of my family to various forms of cancer.
Father: colon cancer 1998
Mother: pancreatic cancer 1977
Brother: kidney cancer 1998
Brother: lung cancer 2017
Sister: endometriotic cancer 2006
I truly hate the morons who find it funny that Biden is suffering.
May 20, 2025 at 4:54 AM
d-macphee.bsky.social
And the open access article in iScience
#ReproSky 🧪 #MedSky #ObGynSky
www.cell.com/iscience/ful...
Spatial transcriptomic analysis identifies epithelium-macrophage crosstalk in endometriotic lesions
Reproductive medicine; Integrative aspects of cell biology; Organizational aspects of cell biology; Transcriptomics
www.cell.com
March 23, 2025 at 2:35 AM
profharley.bsky.social
Manuscript Monday with the #harleylab!

So excited for "Matrix Tropism Influences Endometriotic Cell Attachment Patterns" out in #AdvFunctMater:

advanced.onlinelibrary.wiley.com/doi/10.1002/...

Creative work led by Hannah Theriault & Hannah Kimmel. Collab w/ @kateclancy.bsky.social & GregUnderhill
Matrix Tropism Influences Endometriotic Cell Attachment Patterns
The influence of substrate stiffness and multicellular coculture on endometriotic cell attachment to extracellular matrix-laden microarrayed islands is reported. This model investigates early endomet...
advanced.onlinelibrary.wiley.com
June 23, 2025 at 3:39 PM
biorxiv-cellbio.bsky.social
Fibrotic substrate stiffness enhances endometriotic epithelial cell motility https://www.biorxiv.org/content/10.64898/2025.12.31.697209v1
January 2, 2026 at 2:30 AM
petrathepostdoc.bsky.social
me showing up to the con with this as a pin
"is my emotional support endometriotic homunculus"
pixelated doodle of a stickfigure on a light pink background holding their head in pain as there is a flood of dark pink coming out of them and into their abdomen
May 21, 2026 at 12:00 PM
lissaharris.bsky.social
note to all the uterus havers out there who are always going “yeah, everything lowkey hurts, but whatever, I can deal”:

you might have endo so bad all your organs are stuck together. go to the doctor if you can
PROCEDURE FINDINGS: Normal appearing upper abdominal anatomy. Endometriotic implants involving an area 1 x 3 cm in size over the bladder peritoneum which was superficial and not associated with fibrosis. 2 cm superficial area of endometriosis over the anterior abdominal wall adjacent to the obliterated umbilical artery on the left. Bilateral endometriomas approximately 3 cm in size. The ovaries were adherent to the posterior uterine serosa in the midline. The sigmoid colon and rectum were adherent over the posterior uterine serosa, cervicovaginal junction, and vagina. The rectum was adherent laterally to the ovaries. There was significant retroperitoneal fibrosis involving the parametrium bilaterally with endometriotic nodules present within this tissue. On the left this was a 3 cm nodule. On the right, the fibrotic nodule was approximately 2.5 cm. There was a 3 cm nodule of endometriosis involving the rectal serosa which also involved the posterior cervicovaginal junction and vagina. Dense retroperitoneal fibrosis involved the ureters and hypogastric nerves bilaterally over a length of 3 to 4 cm.
February 27, 2025 at 4:03 PM
kcar.me
Researchers are starting to argue that #Endometriosis is like a #Cancer - Reproductive Sciences

link.springer.com/article/10.100…
Text Shot: Endometriosis (EMS) is a non-cancerous invasive condition where tissue resembling the lining of the uterus is found outside of the uterine cavity. Endometriotic lesions have been found in nearly every organ of the body. This review highlights examples of EMS exhibiting all eight established hallmarks of cancer: hyperproliferation (e.g. through estrogen signalling), evasion of growth suppression (e.g. through progesterone resistance), immunosurveillance evasion (e.g. through reduction of natural killer cell cytotoxicity), enabling replicative immortality (e.g. through increased telomere length), invasion (e.g. through epithelial-to-mesenchymal transition), induction of angiogenesis (e.g. through upregulation of hypoxia-inducible factors), resistance to apoptosis (e.g. through increased expression of survivin), and deregulation of cellular metabolism (e.g. through increased production of lactate). Therefore, despite being considered a non-cancerous, benign condition, EMS is…
December 28, 2025 at 12:23 AM
labwaggoner.bsky.social
TSLP modulates the endometriotic lesion microenvironment and promotes a Th2 immune response that could support lesion development @jimmunol.bsky.social
doi.org/10.1093/jimm...
Thymic stromal lymphopoietin contributes to endometriotic lesion proliferation and disease-associated inflammation
Abstract. Endometriosis is a chronic disorder in which endometrial-like tissue presents outside the uterus. Patients with endometriosis have been shown to
doi.org
February 26, 2025 at 8:51 PM
petrathepostdoc.bsky.social
* longest booooooooooooo possible *

tag yourself, i'm lesions covered colon and chocolate cyst
cartoony page from the zine I drew, the colors are dark blue, light blue, yellow, orange, light pink and dark pink. the text is When the uterus tissues go WILD! - ENDOMETRIOSIS- endometrial-like tissue growing outside of the uterus unclear origin (cells escaping fallopian tube at menstruation, immune dysfunction, local estrogen production, circulation, surgery, genetics) Dr. Platypus fact: endometriotic lesions were even found in the brain, which caused neurological and psychiatric symptoms! ~8 years to get diagnosed 1/10 people bleeding outside and inside infertility pelvic PAIN! during intercourse, bowel movement, urination, or for no good reason nausea the middle drawing is of an uterus, guts, kidneys ovaries and bladder covered in pink endometriotic lesions, none of the organs are happy about it, one ovary has a massive pink chocolate cyst on it (a cyst full of endometrial tissue and blood)
April 22, 2026 at 7:27 PM
djmarsh24.bsky.social
First day of the 16th World Congress on Endometriosis listening to Mike Anglesio from Vancouver telling us about challenges working with endometriotic lesions … . Happy to be learning at my first endometriosis conference & in my home town to boot 😊 #WCE2025
May 21, 2025 at 10:53 AM
jimmunol.bsky.social
Scientists investigated the role of thymic stromal lymphopoietin (TSLP) in #endometriosis, finding that TSLP modulated the endometriotic lesion microenvironment and promoted a Th2 immune response that supported lesion development. Read more: ow.ly/F7tP50VIQM4.
April 28, 2025 at 2:09 PM
ferl67.bsky.social
Non-invasive endometriosis scan trial boosts hope for faster diagnosis

globalnews.ca/news/1182397...

#Health #Science #Endometriosis #WomenHealth
Non-invasive endometriosis scan trial boosts hope for faster diagnosis - National | Globalnews.ca
It was found that the specialized CT scans are 'accurately detecting endometriotic lesions' that is often "missed by conventional imaging methods."
globalnews.ca
May 3, 2026 at 2:12 AM
newsmedical.bsky.social
Western diet accelerates endometriosis growth and disrupts gut health 🌱🩺🧬 www.news-medical.net/news/2024111... #Endometriosis #WesternDiet #GutHealth #Microbiome #Akkermansia #Inflammation #WomensHealth #Research #Nutrition
Western diet accelerates endometriosis growth and disrupts gut health
This study found that a Western diet doubles the growth of endometriotic lesions in mice and depletes the gut microbiome's beneficial bacterium, Akkermansia muciniphila, which may exacerbate endometri...
www.news-medical.net
November 12, 2024 at 11:22 PM
angryhacademic.bsky.social
Is this the first disease-modifying treatment for endometriosis?
www.drugdiscoverynews.com/is-this-the-...

"ENDO-205 is a peptide engineered for selective uptake into endometriotic cells, where it triggers programmed cell death, after which the body’s immune system clears the remaining debris"
Is this the first disease-modifying treatment for endometriosis? | Drug Discovery News
Endometriosis is still largely managed with pain relief, hormones, and surgery, but a new precision peptide therapy seeks to directly target the underlying lesion biology.
www.drugdiscoverynews.com
May 31, 2026 at 8:16 PM
hipecsurvivor.bsky.social
Western diet promotes endometriotic lesion growth in mice and induces depletion of #AkkermansiaMuciniphila in intestinal microbiota.

#microbiome
#gastro
bmcmedicine.biomedcentral.com/articles/10....
Western diet promotes endometriotic lesion growth in mice and induces depletion of Akkermansia muciniphila in intestinal microbiota - BMC Medicine
Background Endometriosis, affecting 10% of women in their reproductive years, remains poorly understood. Both individual and environmental unexplained factors are implicated in this heterogenous condi...
bmcmedicine.biomedcentral.com
November 14, 2024 at 12:27 PM
petrathepostdoc.bsky.social
art train go chooooooo 🚄🦟🦀🎨

tagging:
@loadofolbobbins.bsky.social
@kakapojay.bsky.social
@whistberry.bsky.social
@ascalaphid.com
page from a coloring book of a mosquito holding a mosquito in amber, half of it colored in very bright colors, the other half still uncolored on purpose. redraw of "the horrors persist, but so do I" meme, but with a mosquito in a little pink toy car with pink heart sunglasses. a grid of 3x2 square drawings of crabs (and one shrimp) on a black background, red crab, leopard crab, fluffy crab, orange and purple halloween crab, pipe cleaner red and white shrimp, yellow grey crab with googly eyes cartoony page from the zine I drew, the colors are dark blue, light blue, yellow, orange, light pink and dark pink. the text is When the uterus tissues go WILD! - ENDOMETRIOSIS- endometrial-like tissue growing outside of the uterus unclear origin (cells escaping fallopian tube at menstruation, immune dysfunction, local estrogen production, circulation, surgery, genetics) Dr. Platypus fact: endometriotic lesions were even found in the brain, which caused neurological and psychiatric symptoms! ~8 years to get diagnosed 1/10 people bleeding outside and inside infertility pelvic PAIN! during intercourse, bowel movement, urination, or for no good reason nausea the middle drawing is of an uterus, guts, kidneys ovaries and bladder covered in pink endometriotic lesions, none of the organs are happy about it, one ovary has a massive pink chocolate cyst on it (a cyst full of endometrial tissue and blood)
January 18, 2026 at 7:12 PM
biorxivpreprint.bsky.social
Fibrotic substrate stiffness enhances endometriotic epithelial cell motility https://www.biorxiv.org/content/10.64898/2025.12.31.697209v1
January 2, 2026 at 2:30 AM
ginwilliamsart.bsky.social
Endometriosis and the Hallmarks of Cancer.
Katherine Ellis et al. Reprod Sci. 2026 Jan.

pubmed.ncbi.nlm.nih.gov/41436710/

Endometriosis shares 8 hallmarks of cancer.
Endometriosis and the Hallmarks of Cancer - PubMed
Endometriosis (EMS) is a non-cancerous invasive condition where tissue resembling the lining of the uterus is found outside of the uterine cavity. Endometriotic lesions have been found in nearly every...
pubmed.ncbi.nlm.nih.gov
June 11, 2026 at 3:12 PM
angryhacademic.bsky.social
"But ahh☝🏻💡" they might say, "the inflammation in endometriosis can be localised to endometriotic tissue!"

And that is exactly the point - inflammation can be localised! For example, *in* the central nervous system, or around tissues directly being targeted by autoantibodi
es
July 13, 2025 at 4:21 PM
drdeepaknmodi.bsky.social
March is Endometriosis Awareness Month
Here are some papers on endometriosis in mouse

Steroid receptors
pmc.ncbi.nlm.nih.gov/articles/PMC...

Estrogen
doi.org/10.1007/s120...
Inflamation
doi.org/10.1007/s120...
Hox genes
journals.lww.com/fsar/fulltex...

#ReproductiveBiology
Spatial and temporal changes in the expression of steroid hormone receptors in mouse model of endometriosis
Endometriosis is recognized as a steroid hormone-dependent disorder. However, controversies exist regarding the status of the steroid hormone receptor expression in endometriotic tissues. The purpose of this study was to determine the ontogeny of ...
pmc.ncbi.nlm.nih.gov
March 29, 2026 at 6:30 AM
kateclancy.bsky.social
One day people will want me to collect endometriotic menstrual blood and put it into 3D scaffolds to better understand variablity in endometrial function and lesion invasion. Last Monday was not that day.
June 24, 2024 at 2:41 PM
petrathepostdoc.bsky.social
the culmination of one year of collaborative work on a #SciArt zine discussing gynecological issues, finally in print form!

from a lovely team from the @sangerinstitute.bsky.social with special thanks to Dr @talkswithdrsesay.bsky.social and Dr Gioia Canciani for reviewing the contents! 🥼🩸
cover of a zine that looks like a corkboard, with various gynaecological organ pictures connected by red string, some pills pinned to it, a callendar, a page saying gyn app the title is Pelvic Matters A collaborative zine on gynaecological health last page of the corkboard zine, with the various sponsors, a qr code for the zine website, a DO NOT SCRAPE anti AI sticker, the 5 artists involved, the 6 writers involved and the two reviewers involved the artists Antonio Garcia (Scientific illustrator and designer, Founder of Bio-Graphics. Explore his work at www.bio-graphics.es) Petra Korlević (Staff scientist at the Wellcome Sanger Insitute. Find more of her silly doodles at petrathepostdoc.bsky.social, and SciArt and crafts at theintrovertebrates.etsy.com) Megan Gozzard (Post-Doctoral Researcher in Human Genetics at Wellcome Sanger Insitute. Explore her portfolio at www.megangozzard.co.uk) Lia Bote (PhD student at the Wellcome Sanger Insitute, Parasites and Microbes Programme. See more of her art and science at @liabote.bsky.social!) Isabelle Zane (PhD student, Sanger Institute. Find scientific cartoons and live sketches of conferences @isabellease on X, @isabellease.bsky.social or isabellezane.bio) The writers Valentina Lorenzi Charlotte Cassie Marie Moullet Ana Paredes Garcia Christina Kim Rina Sakata The reviewers Dr Gioia Canciani Dr Aziza Sesay cartoony page from the zine I drew, the colors are dark blue, light blue, yellow, orange, light pink and dark pink. the text is When the uterus tissues go WILD! - ENDOMETRIOSIS- endometrial-like tissue growing outside of the uterus unclear origin (cells escaping fallopian tube at menstruation, immune dysfunction, local estrogen production, circulation, surgery, genetics) Dr. Platypus fact: endometriotic lesions were even found in the brain, which caused neurological and psychiatric symptoms! ~8 years to get diagnosed 1/10 people bleeding outside and inside infertility pelvic PAIN! during intercourse, bowel movement, urination, or for no good reason nausea the middle drawing is of an uterus, guts, kidneys ovaries and bladder covered in pink endometriotic lesions, none of the organs are happy about it, one ovary has a massive pink chocolate cyst on it (a cyst full of endometrial tissue and blood) photo of seven of the eleven zine authors under a giant oak tree without any leaves (it is winter) each holding one zine.
November 17, 2025 at 9:25 PM
petrathepostdoc.bsky.social
my section was all about uterine tissues creating happy little "benign" tumors that make your life hell but since they are not cancerous it takes forever to diagnose and find a treatment that works for YOU!

#SciArt #endometriosis #fibroids #adenomyosis
cartoony page from the zine I drew, the colors are dark blue, light blue, yellow, orange, light pink and dark pink. the text is When the uterus tissues go WILD! - FIBROIDS- non-cancerous abnormal growths of muscle tissue extremely common, 2/3, ~50% asymptomatic unclear origin, estrogen? progesterone? at higher risk: African Caribbean, family history, early periods, obesity heavy bleeds, anemia, back pain infertility constipation, frequent urination Dr. Platypus fact: one of the biggest fibroid was 28kg in a 53 year old Singaporean patient! the middle drawing is of an uterus absolutely covered in pink blobs representing the different type of fibroids: pedunculate (outside), pedunculate (inside), subserosal, submucosal, utnramural cartoony page from the zine I drew, the colors are dark blue, light blue, yellow, orange, light pink and dark pink. the text is When the uterus tissues go WILD! - ENDOMETRIOSIS- endometrial-like tissue growing outside of the uterus unclear origin (cells escaping fallopian tube at menstruation, immune dysfunction, local estrogen production, circulation, surgery, genetics) Dr. Platypus fact: endometriotic lesions were even found in the brain, which caused neurological and psychiatric symptoms! ~8 years to get diagnosed 1/10 people bleeding outside and inside infertility pelvic PAIN! during intercourse, bowel movement, urination, or for no good reason nausea the middle drawing is of an uterus, guts, kidneys ovaries and bladder covered in pink endometriotic lesions, none of the organs are happy about it, one ovary has a massive pink chocolate cyst on it (a cyst full of endometrial tissue and blood) cartoony page from the zine I drew, the colors are dark blue, light blue, yellow, orange, light pink and dark pink. the text is When the uterus tissues go WILD! - ADENOMYOSIS- endometrial tissue frowing inside the muscles of the uterus 1/10 people, and they might not even have symptoms (one figure sayinh you telling me WHAT??) unclear origin... shocking i know... estrogen?? other hormones? most likely in: +30 years, abdominal surgery, given birth heavy abnormal bleeding, anemia, pain bloating, fullness infertility Dr. Platypus fact:you can have endometriosis, adenomyosis, and firboids ALL AT ONCE!... and they all have similar symptoms the middle drawing is of an uterus absolutely covered in pink blobs representing the endometrial tissue growing within the muscle: focal (adenomyoma), diffuse, enlarged uterus cartoony page from the zine I drew, the colors are dark blue, light blue, yellow, orange, light pink and dark pink. the text is When the uterus tissues go WILD! - MANAGING- there is no one-size-fits-all treatment, care ranges from less to more invasive first you need to diagnose the problem: ultrasound, blood markers, Magnetic Resonanse Imaging (MRI), surgery etc. PAIN CONTROL: painkillers and anti-inflammatory drugs, physiotherapy, heating pads or hot water bottles, transcutaneous electrical nerve stimulation (TENS) HORMONAL MEDICATION: IUS, mini pill, implants (progestogen only), combined pill, patches (progestogen + estrogen), hypothalamus pills injections (GnRH agonists and antagonists) SURGERY (diagnostic, to alleviate symptoms, and curative) laparoscopy, transvaginal hysteroscopy, abdominal (all biopsied) diseased tissue removal by laser or surgical hysterectomy: curative for adenomyosis and fibroids, but harder to access if <45 Dr. Platypus fact: platypuses don't have a uterus*(long oviduct, sometimes called the "uterus") so don't need to worry about any of this
November 27, 2025 at 10:47 PM
petrathepostdoc.bsky.social
we are all endometriosis covered kidneys
doodle of an orange kidney screaming covered in pink endometriotic blobs
December 11, 2025 at 3:31 PM