Blood vessel wall (endothelial) inflammation as a key to multi-organ complications of Covid and #LongCovid
@science.org
science.org/doi/10.1126/...
@science.org
science.org/doi/10.1126/...
Endothelial inflammation in COVID-19
Disrupted endothelial function underlies the multiorgan complications of COVID-19
science.org
November 28, 2024 at 8:33 PM
Blood vessel wall (endothelial) inflammation as a key to multi-organ complications of Covid and #LongCovid
@science.org
science.org/doi/10.1126/...
@science.org
science.org/doi/10.1126/...
Endothelial inflammation in COVID-19
"Disrupted endothelial function underlies the multiorgan complications of COVID-19" with long term effects in #LongCovid @ScienceMagazine
(and yes, endothelial dysfunction in acute and LC was known in 2020-1)
www.science.org/doi/10.1126/...
"Disrupted endothelial function underlies the multiorgan complications of COVID-19" with long term effects in #LongCovid @ScienceMagazine
(and yes, endothelial dysfunction in acute and LC was known in 2020-1)
www.science.org/doi/10.1126/...
Endothelial inflammation in COVID-19
Disrupted endothelial function underlies the multiorgan complications of COVID-19
www.science.org
November 29, 2024 at 12:26 PM
Endothelial inflammation in COVID-19
"Disrupted endothelial function underlies the multiorgan complications of COVID-19" with long term effects in #LongCovid @ScienceMagazine
(and yes, endothelial dysfunction in acute and LC was known in 2020-1)
www.science.org/doi/10.1126/...
"Disrupted endothelial function underlies the multiorgan complications of COVID-19" with long term effects in #LongCovid @ScienceMagazine
(and yes, endothelial dysfunction in acute and LC was known in 2020-1)
www.science.org/doi/10.1126/...
Endothelial inflammation in COVID-19 | Science
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Endothelial inflammation in COVID-19
Disrupted endothelial function underlies the multiorgan complications of COVID-19
www.science.org
November 28, 2024 at 8:40 PM
Endothelial inflammation in COVID-19 | Science
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Endothelial damage and multi-organ damage in Long Covid.
Medsky
Medsky
Endothelial inflammation in COVID-19
Disrupted endothelial function underlies the multiorgan complications of COVID-19
www.science.org
November 28, 2024 at 8:39 PM
Endothelial damage and multi-organ damage in Long Covid.
Medsky
Medsky
🚨New preprint alert 🚨
"Pancreatic cancer cells breach endothelial barriers through protrusion-driven invasion or endothelial retraction"
www.biorxiv.org/content/10.6...
"Pancreatic cancer cells breach endothelial barriers through protrusion-driven invasion or endothelial retraction"
www.biorxiv.org/content/10.6...
September 4, 2026 at 5:51 PM
🚨New preprint alert 🚨
"Pancreatic cancer cells breach endothelial barriers through protrusion-driven invasion or endothelial retraction"
www.biorxiv.org/content/10.6...
"Pancreatic cancer cells breach endothelial barriers through protrusion-driven invasion or endothelial retraction"
www.biorxiv.org/content/10.6...
New important publication in #LongCovid & #MECFS!
After a viral infection, cells lining our blood vessels can become damaged and enter senescence, similar to accelerated aging. These cells are not healthy, but they also don’t disappear. Instead, they send out constant stress & inflammatory signals.
After a viral infection, cells lining our blood vessels can become damaged and enter senescence, similar to accelerated aging. These cells are not healthy, but they also don’t disappear. Instead, they send out constant stress & inflammatory signals.
January 14, 2026 at 3:31 PM
New important publication in #LongCovid & #MECFS!
After a viral infection, cells lining our blood vessels can become damaged and enter senescence, similar to accelerated aging. These cells are not healthy, but they also don’t disappear. Instead, they send out constant stress & inflammatory signals.
After a viral infection, cells lining our blood vessels can become damaged and enter senescence, similar to accelerated aging. These cells are not healthy, but they also don’t disappear. Instead, they send out constant stress & inflammatory signals.
@resiapretorius.bsky.social leading the world in the endothelial pathology in #longcovid
November 15, 2024 at 9:06 AM
@resiapretorius.bsky.social leading the world in the endothelial pathology in #longcovid
New research in human endothelial cells indicates that trifluoroacetic acid (TFA) can impair blood vessel development.
#chemsky 🧪
#chemsky 🧪
Small, abundant PFAS could impair blood vessel development
Trifluoroacetic acid disrupted energy production in study of endothelial cells
cen.acs.org
September 22, 2026 at 12:25 PM
New research in human endothelial cells indicates that trifluoroacetic acid (TFA) can impair blood vessel development.
#chemsky 🧪
#chemsky 🧪
SARS-CoV-2 harms your vascular system. It disrupts the ACE2 receptors on your endothelial cells, leading to a cascade of harmful effects:
These mechanisms underline how SARS-CoV-2-induced endothelial dysfunction can cause severe cardiovascular complications.
These mechanisms underline how SARS-CoV-2-induced endothelial dysfunction can cause severe cardiovascular complications.
![Citations:
[1] https://www.nature.com/articles/s41598-023-41115-3
[2] https://pmc.ncbi.nlm.nih.gov/articles/PMC9604693/
[3] https://pubmed.ncbi.nlm.nih.gov/33626315/
[4] https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1281263/full
[5] https://academic.oup.com/cardiovascres/article/120/1/34/7504580
[6] https://pmc.ncbi.nlm.nih.gov/articles/PMC7301835/
[7] https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2024.1360364/full
[8] https://www.science.org/doi/10.1126/science.add2962](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:5sz2cdsg4tojqewqh4vjeckg/bafkreibjjfqrbef4uq665c4tfnsemnhixgb2lripgw7e35qnpak7nsxmmq)
February 10, 2025 at 11:46 PM
SARS-CoV-2 harms your vascular system. It disrupts the ACE2 receptors on your endothelial cells, leading to a cascade of harmful effects:
These mechanisms underline how SARS-CoV-2-induced endothelial dysfunction can cause severe cardiovascular complications.
These mechanisms underline how SARS-CoV-2-induced endothelial dysfunction can cause severe cardiovascular complications.
Infection with #SARSCoV2 has highlighted how altered endothelial functions contribute to multiorgan health effects during the acute phase of #COVID19 and potentially to the longer-term consequences associated with #LongCovid.
Learn more in a new #SciencePerspective:
Learn more in a new #SciencePerspective:
Endothelial inflammation in COVID-19
Disrupted endothelial function underlies the multiorgan complications of COVID-19
scim.ag
December 17, 2024 at 7:45 PM
Infection with #SARSCoV2 has highlighted how altered endothelial functions contribute to multiorgan health effects during the acute phase of #COVID19 and potentially to the longer-term consequences associated with #LongCovid.
Learn more in a new #SciencePerspective:
Learn more in a new #SciencePerspective:
Endothelial inflammation in COVID-19
Disrupted endothelial function underlies the multiorgan complications of COVID-19
🙏 @jlerollblues
https://buff.ly/4eQk7dt
Disrupted endothelial function underlies the multiorgan complications of COVID-19
🙏 @jlerollblues
https://buff.ly/4eQk7dt
November 29, 2024 at 5:08 AM
Endothelial inflammation in COVID-19
Disrupted endothelial function underlies the multiorgan complications of COVID-19
🙏 @jlerollblues
https://buff.ly/4eQk7dt
Disrupted endothelial function underlies the multiorgan complications of COVID-19
🙏 @jlerollblues
https://buff.ly/4eQk7dt
3.
Consensus: Long COVID includes dysautonomia (POTS), mast cell activation (MCAS), mitochondrial dysfunction, endothelial damage, & more.
This isn’t one disease. It’s a syndrome of syndromes.
Consensus: Long COVID includes dysautonomia (POTS), mast cell activation (MCAS), mitochondrial dysfunction, endothelial damage, & more.
This isn’t one disease. It’s a syndrome of syndromes.
April 21, 2025 at 2:35 AM
3.
Consensus: Long COVID includes dysautonomia (POTS), mast cell activation (MCAS), mitochondrial dysfunction, endothelial damage, & more.
This isn’t one disease. It’s a syndrome of syndromes.
Consensus: Long COVID includes dysautonomia (POTS), mast cell activation (MCAS), mitochondrial dysfunction, endothelial damage, & more.
This isn’t one disease. It’s a syndrome of syndromes.
Very cool new paper by @thegulab.bsky.social published in Cell, showing that arterial endothelial coupling via gap junctions determines the speed and spread of vasodilation induced by neuronal activity ! #cerebrovascular #bloodflow #endothelium
Brain endothelial gap junction coupling enables rapid vasodilation propagation during neurovascular coupling
Vasodilatory signals are rapidly communicated across long distances by endothelial-endothelial
gap junctions, enabling coordinated dilation of the arterial network during neurovascular
coupling.
www.cell.com
July 25, 2025 at 7:17 AM
Very cool new paper by @thegulab.bsky.social published in Cell, showing that arterial endothelial coupling via gap junctions determines the speed and spread of vasodilation induced by neuronal activity ! #cerebrovascular #bloodflow #endothelium
Lots of big names co-authored this paper:
David Putrino, Špela Šalamon, David Joffe, Resia Pretorius, & more.
Vascular Pathogenesis in Acute and Long COVID: Current Insights and Therapeutic Outlook
www.thieme-connect.de/products/ejo...
David Putrino, Špela Šalamon, David Joffe, Resia Pretorius, & more.
Vascular Pathogenesis in Acute and Long COVID: Current Insights and Therapeutic Outlook
www.thieme-connect.de/products/ejo...
![Fig. 1 COVID-associated endothelial dysfunction and endothelialitis. Schematic representation of COVID-associated ED and endothelialitis. (1) Under pathological conditions, Type I and Type II endothelial activation—together with endothelial cell injury, such as endothelial cell apoptosis and necrosis—are all involved in ED.[39] (2) Endothelial activation promotes the production of various cytokines, chemokines, and other biomolecules that are involved in coagulation and the immune response.[40] (3) Viral persistence may contribute to ongoing endothelial inflammation or ED in Long COVID.[87] [88] (4) After invasion of the endothelial cells by the virus, P-selectin, TF, ICAM1, VCAM1, and PAI-1 are expressed on these cells and ultra-large VWF multimers are also released.[58] (5) The downregulation of ACE2 favors ED[39] [135] [136] [137] and leads to (6) a dysregulated local RAS with increased levels of Angiotensin II.[55] (7) Capillary rarefication (indicating an inflammatory response) has also been noted in patients suffering from Long COVID.[30] (8) Platelet hyperactivation is a key feature of a hypercoagulable state and has also been noted as a prominent feature in the pathobiology of acute infection[68] [69] and Long COVID.[71] Created with BioRender.com. ACE2, angiotensin-converting enzyme 2; COVID-19, coronavirus disease 2019; ED, endothelial dysfunction; ICAM1, intercellular adhesion molecule 1; PAI-1, plasminogen activator inhibitor 1; RAS, renin–angiotensin system; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; TF, tissue factor; VCAM1, vascular cell adhesion molecule 1; VWF, Von Willebrand factor.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:li6aqouldc2xdd6ohr3tfukn/bafkreihxdkuva4xelv52aiqgbxtvnst6wvte7j56oydh6tc4ytc2x6xuta)
October 22, 2024 at 3:09 AM
Lots of big names co-authored this paper:
David Putrino, Špela Šalamon, David Joffe, Resia Pretorius, & more.
Vascular Pathogenesis in Acute and Long COVID: Current Insights and Therapeutic Outlook
www.thieme-connect.de/products/ejo...
David Putrino, Špela Šalamon, David Joffe, Resia Pretorius, & more.
Vascular Pathogenesis in Acute and Long COVID: Current Insights and Therapeutic Outlook
www.thieme-connect.de/products/ejo...
The primary cells of the neurovascular unit: endothelial cells🔵, pericytes🦑 and astrocytes🟢
November 20, 2024 at 12:00 AM
The primary cells of the neurovascular unit: endothelial cells🔵, pericytes🦑 and astrocytes🟢
Revascularization of coronary endothelial cells during zebrafish heart regeneration. Credit to @harrisonlab.bsky.social. #ZebrafishZunday 🧪
June 1, 2025 at 1:43 PM
Revascularization of coronary endothelial cells during zebrafish heart regeneration. Credit to @harrisonlab.bsky.social. #ZebrafishZunday 🧪
May 17, 2026 at 12:17 PM
[Nutrition, "health foods"]
As a sidebar:
Endothelial cells are often located near mast cells
And they can send signals back and forth to each other
My #MCAS baseline has improved since I started trying to eat specific antioxidants to help endothelial function. YMMV.
As a sidebar:
Endothelial cells are often located near mast cells
And they can send signals back and forth to each other
My #MCAS baseline has improved since I started trying to eat specific antioxidants to help endothelial function. YMMV.
September 23, 2026 at 5:33 PM
[Nutrition, "health foods"]
As a sidebar:
Endothelial cells are often located near mast cells
And they can send signals back and forth to each other
My #MCAS baseline has improved since I started trying to eat specific antioxidants to help endothelial function. YMMV.
As a sidebar:
Endothelial cells are often located near mast cells
And they can send signals back and forth to each other
My #MCAS baseline has improved since I started trying to eat specific antioxidants to help endothelial function. YMMV.
Infection with SARS-CoV-2 has highlighted how altered endothelial functions contribute to multiorgan health effects during the acute phase of COVID-19 and potentially to the longer-term consequences associated with #LongCovid.
Learn more in a new #SciencePerspective: scim.ag/3OOaaCM
Learn more in a new #SciencePerspective: scim.ag/3OOaaCM
Endothelial inflammation in COVID-19
Disrupted endothelial function underlies the multiorgan complications of COVID-19
scim.ag
December 9, 2024 at 9:03 PM
Infection with SARS-CoV-2 has highlighted how altered endothelial functions contribute to multiorgan health effects during the acute phase of COVID-19 and potentially to the longer-term consequences associated with #LongCovid.
Learn more in a new #SciencePerspective: scim.ag/3OOaaCM
Learn more in a new #SciencePerspective: scim.ag/3OOaaCM
Science: 'Endothelial inflammation in COVID-19'
'..highlighted how altered endothelial functions contribute to multiorgan health effects during the acute phase of COVID-19 and potentially to the longer-term consequences associated with Long Covid'
www.science.org/doi/10.1126/...
'..highlighted how altered endothelial functions contribute to multiorgan health effects during the acute phase of COVID-19 and potentially to the longer-term consequences associated with Long Covid'
www.science.org/doi/10.1126/...
Endothelial inflammation in COVID-19
Disrupted endothelial function underlies the multiorgan complications of COVID-19
www.science.org
November 30, 2024 at 2:54 PM
Science: 'Endothelial inflammation in COVID-19'
'..highlighted how altered endothelial functions contribute to multiorgan health effects during the acute phase of COVID-19 and potentially to the longer-term consequences associated with Long Covid'
www.science.org/doi/10.1126/...
'..highlighted how altered endothelial functions contribute to multiorgan health effects during the acute phase of COVID-19 and potentially to the longer-term consequences associated with Long Covid'
www.science.org/doi/10.1126/...
8/
If you claim COVID is like the flu, yet can’t explain endothelial dysfunction or microclots, you’ve confused vibes with science.
If you claim COVID is like the flu, yet can’t explain endothelial dysfunction or microclots, you’ve confused vibes with science.
August 25, 2025 at 6:28 PM
8/
If you claim COVID is like the flu, yet can’t explain endothelial dysfunction or microclots, you’ve confused vibes with science.
If you claim COVID is like the flu, yet can’t explain endothelial dysfunction or microclots, you’ve confused vibes with science.
#WeekendRead! #EveryCellIsAnImmuneCell! Peng Bai Marichal &co show @ Science Immunology that endothelial cells produce TGFb to differentiate monocytes into #lung interstitial macrophages preventing aging & fibrosis
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Endothelial-driven TGFβ signaling supports lung interstitial macrophage development from monocytes
Endothelial Tgfβ1 shapes the development and functional identity of lung interstitial macrophages.
www.science.org
April 27, 2025 at 2:59 PM
#WeekendRead! #EveryCellIsAnImmuneCell! Peng Bai Marichal &co show @ Science Immunology that endothelial cells produce TGFb to differentiate monocytes into #lung interstitial macrophages preventing aging & fibrosis
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...