And see: Pleiotropy, epistasis and the genetic architecture of quantitative traits pubmed.ncbi.nlm.nih.gov/38565962/
December 12, 2024 at 6:50 PM
And see: Pleiotropy, epistasis and the genetic architecture of quantitative traits pubmed.ncbi.nlm.nih.gov/38565962/
Arc Institute’s “MULTI-evolve” learns a classical additive model, not epistasis.
Preprint (w/ Gian Marco Visani and Aayush Verma): www.biorxiv.org/content/10.6...
Blog: dewitt-lab.github.io/posts/2026-0...
Preprint (w/ Gian Marco Visani and Aayush Verma): www.biorxiv.org/content/10.6...
Blog: dewitt-lab.github.io/posts/2026-0...
Additivity is all you need?
Arc Institute’s “MULTI-evolve” learns a classical additive model, not epistasis.
dewitt-lab.github.io
April 29, 2026 at 3:36 PM
Arc Institute’s “MULTI-evolve” learns a classical additive model, not epistasis.
Preprint (w/ Gian Marco Visani and Aayush Verma): www.biorxiv.org/content/10.6...
Blog: dewitt-lab.github.io/posts/2026-0...
Preprint (w/ Gian Marco Visani and Aayush Verma): www.biorxiv.org/content/10.6...
Blog: dewitt-lab.github.io/posts/2026-0...
Bio founders need to take more courses to understand quantitative genetics and epistasis
December 12, 2024 at 1:46 PM
Bio founders need to take more courses to understand quantitative genetics and epistasis
New preprint! www.biorxiv.org/content/10.6...
A theory to explain global epistasis in microbial communities
A theory to explain global epistasis in microbial communities
May 17, 2026 at 11:58 PM
New preprint! www.biorxiv.org/content/10.6...
A theory to explain global epistasis in microbial communities
A theory to explain global epistasis in microbial communities
What's the difference between dominance and epistasis? Two physically distinct mutations in a gene interact such that the het is identical to one of the homozygotes. If I define the gene as a locus, we call this dominance. If I define each bp as a locus, we call this epistasis.
September 1, 2025 at 8:06 PM
What's the difference between dominance and epistasis? Two physically distinct mutations in a gene interact such that the het is identical to one of the homozygotes. If I define the gene as a locus, we call this dominance. If I define each bp as a locus, we call this epistasis.
This is an awesome review from @sheppardlab.bsky.social - Epistasis and co-adaptation in bacterial genome #evolution www.nature.com/articles/s41...
Epistasis and co-adaptation in bacterial genome evolution - Nature Reviews Genetics
Bacterial genome evolution is shaped by epistasis, which can constrain or promote specific evolutionary paths. The authors review how integrating the effects of epistatic interactions into population-...
www.nature.com
June 22, 2026 at 7:03 AM
This is an awesome review from @sheppardlab.bsky.social - Epistasis and co-adaptation in bacterial genome #evolution www.nature.com/articles/s41...
I’ve spent a lot of time over the past two years thinking about genome evolution and how recent research revealing complex gene-gene interactions has complicated traditional ‘gene-centric’ genomic approaches to evolution. So here is a review that consolidates these thoughts!
rdcu.be/e6pHY
rdcu.be/e6pHY
Epistasis and co-adaptation in bacterial genome evolution
Nature Reviews Genetics - Bacterial genome evolution is shaped by epistasis, which can constrain or promote specific evolutionary paths. The authors review how integrating the effects of epistatic...
rdcu.be
March 2, 2026 at 3:48 PM
I’ve spent a lot of time over the past two years thinking about genome evolution and how recent research revealing complex gene-gene interactions has complicated traditional ‘gene-centric’ genomic approaches to evolution. So here is a review that consolidates these thoughts!
rdcu.be/e6pHY
rdcu.be/e6pHY
Now in print: tour de force mitonuclear epistasis study in C. elegans.
Start to finish, vision and execution, 100% Tuc Nguyen @tuchmnguyen.bsky.social
Start to finish, vision and execution, 100% Tuc Nguyen @tuchmnguyen.bsky.social
Nguyen et al. used C. elegans as a model to study mitonuclear epistasis, leveraging genetic and phenotypic data to show that mitonuclear epistasis contributed significantly to phenotypic variance across all tested conditions.
🔗 doi.org/10.1093/molbev/msaf300
#evobio #molbio
🔗 doi.org/10.1093/molbev/msaf300
#evobio #molbio
Abundant Recurrent Mitochondrial Mutations and Widespread Mitonuclear Epistasis in Caenorhabditis elegans
Abstract. Coordinated genetic and physical interactions between mitochondrial and nuclear gene products regulate ATP production in the mitochondria. Linkin
doi.org
December 14, 2025 at 12:53 AM
Now in print: tour de force mitonuclear epistasis study in C. elegans.
Start to finish, vision and execution, 100% Tuc Nguyen @tuchmnguyen.bsky.social
Start to finish, vision and execution, 100% Tuc Nguyen @tuchmnguyen.bsky.social
Fantastic study of the evolution of epistasis in paralogs!
How does cryptic genetic variation influence the long-term fate of gene duplicates (paralogs)?
Our new study addresses this question by dissecting the evolutionary potential of redundant myosin paralogs in yeast nature.com/articles/s41... (1/12)
Our new study addresses this question by dissecting the evolutionary potential of redundant myosin paralogs in yeast nature.com/articles/s41... (1/12)
Cryptic genetic variation shapes the fate of gene duplicates in a protein interaction network - Nature Communications
Over time, paralogous genes accumulate changes in their sequences that do not affect their function, which is called cryptic variation. Using paralogous myosins, this study shows how cryptic variation...
nature.com
June 2, 2025 at 11:27 AM
Fantastic study of the evolution of epistasis in paralogs!
What is epistasis?
New preprint Blue-torial!
(Work by the wonderful postdocs Maryn Carlson and Bryan Andrews)
www.biorxiv.org/content/10.1...
New preprint Blue-torial!
(Work by the wonderful postdocs Maryn Carlson and Bryan Andrews)
www.biorxiv.org/content/10.1...
Robust detection of specific epistasis using rank statistics
The phenotypic effect of a mutation may depend on the genetic background in which it occurs, a phenomenon referred to as epistasis. One source of epistasis in proteins is direct interactions between r...
www.biorxiv.org
April 24, 2025 at 6:56 PM
What is epistasis?
New preprint Blue-torial!
(Work by the wonderful postdocs Maryn Carlson and Bryan Andrews)
www.biorxiv.org/content/10.1...
New preprint Blue-torial!
(Work by the wonderful postdocs Maryn Carlson and Bryan Andrews)
www.biorxiv.org/content/10.1...
Lethal epistasis maintains strong linkage disequilibrium between unlinked supergenes https://www.biorxiv.org/content/10.64898/2026.01.08.698410v1
January 9, 2026 at 3:32 AM
Lethal epistasis maintains strong linkage disequilibrium between unlinked supergenes https://www.biorxiv.org/content/10.64898/2026.01.08.698410v1
Check out my first PhD paper on between-species genetic interactions (intergenomic epistasis) with @cbank.bsky.social 🌿↔️🦠✨ We define intergenomic epistasis mathematically and highlight its potential in understanding co-evolution :)
Studying the genetic basis of ecological interactions with intergenomic epistasis
https://doi.org/10.1111/oik.10835
#GxGInteractions #SpeciesInteractions #CoEvolution #HostPathogenInteractions #Epistasis #EcoEvolutionaryDynamics
https://doi.org/10.1111/oik.10835
#GxGInteractions #SpeciesInteractions #CoEvolution #HostPathogenInteractions #Epistasis #EcoEvolutionaryDynamics
April 3, 2025 at 3:03 PM
Check out my first PhD paper on between-species genetic interactions (intergenomic epistasis) with @cbank.bsky.social 🌿↔️🦠✨ We define intergenomic epistasis mathematically and highlight its potential in understanding co-evolution :)
Delighted to see this paper with @anaignatieva.bsky.social now published in Genetics!
academic.oup.com/genetics/adv...
We tackle a thorny issue arising in statistical tests for genetic interactions (epistasis) using ancestral recombination graphs (ARGs)... 🧵
academic.oup.com/genetics/adv...
We tackle a thorny issue arising in statistical tests for genetic interactions (epistasis) using ancestral recombination graphs (ARGs)... 🧵
Phantom epistasis through the lens of genealogies
Abstract. Phantom epistasis arises when, in the course of testing for gene-by-gene interactions, the omission of a causal variant with a purely additive ef
academic.oup.com
September 10, 2025 at 4:31 PM
Delighted to see this paper with @anaignatieva.bsky.social now published in Genetics!
academic.oup.com/genetics/adv...
We tackle a thorny issue arising in statistical tests for genetic interactions (epistasis) using ancestral recombination graphs (ARGs)... 🧵
academic.oup.com/genetics/adv...
We tackle a thorny issue arising in statistical tests for genetic interactions (epistasis) using ancestral recombination graphs (ARGs)... 🧵
Pleiotropy and epistasis are pervasive - just because you can average them out across a population does not mean you can predict (or control) their effects in an individual
June 9, 2026 at 10:56 AM
Pleiotropy and epistasis are pervasive - just because you can average them out across a population does not mean you can predict (or control) their effects in an individual
I wrote about gene-gene interactions (epistasis) and the implications for heritability, trait definitions, natural selection, and therapeutic interventions. Biology is clearly full of causal interactions, so why don't we see them in the data? A 🧵:
Beneath the surface of the sum
When genetic interactions matter and when they don't
open.substack.com
August 27, 2025 at 8:41 PM
I wrote about gene-gene interactions (epistasis) and the implications for heritability, trait definitions, natural selection, and therapeutic interventions. Biology is clearly full of causal interactions, so why don't we see them in the data? A 🧵:
Studying the genetic basis of ecological interactions with intergenomic epistasis
https://doi.org/10.1111/oik.10835
#GxGInteractions #SpeciesInteractions #CoEvolution #HostPathogenInteractions #Epistasis #EcoEvolutionaryDynamics
https://doi.org/10.1111/oik.10835
#GxGInteractions #SpeciesInteractions #CoEvolution #HostPathogenInteractions #Epistasis #EcoEvolutionaryDynamics
March 6, 2025 at 5:06 PM
Studying the genetic basis of ecological interactions with intergenomic epistasis
https://doi.org/10.1111/oik.10835
#GxGInteractions #SpeciesInteractions #CoEvolution #HostPathogenInteractions #Epistasis #EcoEvolutionaryDynamics
https://doi.org/10.1111/oik.10835
#GxGInteractions #SpeciesInteractions #CoEvolution #HostPathogenInteractions #Epistasis #EcoEvolutionaryDynamics
Our latest work on drug resistance and epistasis. We performed comparative deep mutational scanning of two fungal orthologs to estimate how much data on one can help predict the impact of mutations on the other. We dissect the source of epistasis at the atomic level. www.biorxiv.org/content/10.6...
Epistasis limits but does not prevent the transfer of mutation-drug resistance mapping across 600 million years of fungal evolution
Whether different pathogens acquire resistance to antimicrobials through the same mutations is a major question in evolution and microbiology. Most antifungal drugs are used to treat infections caused...
www.biorxiv.org
July 8, 2026 at 10:31 PM
Our latest work on drug resistance and epistasis. We performed comparative deep mutational scanning of two fungal orthologs to estimate how much data on one can help predict the impact of mutations on the other. We dissect the source of epistasis at the atomic level. www.biorxiv.org/content/10.6...
Thanks to replies—thank you!—I searched YouTube for epistasis, and got this: youtu.be/YJHGfbW55l0?...
I feel like this one 7 minute video beat up my high school biology class and took its lunch money.
That might not be fair, it HAS been a long time, but it sure feels that way 😅
I feel like this one 7 minute video beat up my high school biology class and took its lunch money.
That might not be fair, it HAS been a long time, but it sure feels that way 😅
Incomplete Dominance, Codominance, Polygenic Traits, and Epistasis!
YouTube video by Amoeba Sisters
youtu.be
October 12, 2025 at 7:06 PM
Thanks to replies—thank you!—I searched YouTube for epistasis, and got this: youtu.be/YJHGfbW55l0?...
I feel like this one 7 minute video beat up my high school biology class and took its lunch money.
That might not be fair, it HAS been a long time, but it sure feels that way 😅
I feel like this one 7 minute video beat up my high school biology class and took its lunch money.
That might not be fair, it HAS been a long time, but it sure feels that way 😅
This paper by @skryazhi.bsky.social et al is amazing. www.science.org/doi/10.1126/...
I find the evidence of global diminishing returns epistasis compelling- it fundamentally changes how I think about the dynamics of adaptation. Very well worth a read!
I find the evidence of global diminishing returns epistasis compelling- it fundamentally changes how I think about the dynamics of adaptation. Very well worth a read!
Environment-independent distribution of mutational effects emerges from microscopic epistasis
Predicting how new mutations alter phenotypes is difficult because mutational effects vary across genotypes and environments. Recently discovered global epistasis, in which the fitness effects of muta...
www.science.org
October 24, 2024 at 5:57 PM
This paper by @skryazhi.bsky.social et al is amazing. www.science.org/doi/10.1126/...
I find the evidence of global diminishing returns epistasis compelling- it fundamentally changes how I think about the dynamics of adaptation. Very well worth a read!
I find the evidence of global diminishing returns epistasis compelling- it fundamentally changes how I think about the dynamics of adaptation. Very well worth a read!
Nguyen et al. used C. elegans as a model to study mitonuclear epistasis, leveraging genetic and phenotypic data to show that mitonuclear epistasis contributed significantly to phenotypic variance across all tested conditions.
🔗 doi.org/10.1093/molbev/msaf300
#evobio #molbio
🔗 doi.org/10.1093/molbev/msaf300
#evobio #molbio
Abundant Recurrent Mitochondrial Mutations and Widespread Mitonuclear Epistasis in Caenorhabditis elegans
Abstract. Coordinated genetic and physical interactions between mitochondrial and nuclear gene products regulate ATP production in the mitochondria. Linkin
doi.org
December 12, 2025 at 11:50 AM
Nguyen et al. used C. elegans as a model to study mitonuclear epistasis, leveraging genetic and phenotypic data to show that mitonuclear epistasis contributed significantly to phenotypic variance across all tested conditions.
🔗 doi.org/10.1093/molbev/msaf300
#evobio #molbio
🔗 doi.org/10.1093/molbev/msaf300
#evobio #molbio
A student in my undergrad genetics class asked me about my favorite example of epistasis and I totally blanked. Does anyone have any favorites to share?
September 4, 2025 at 2:46 PM
A student in my undergrad genetics class asked me about my favorite example of epistasis and I totally blanked. Does anyone have any favorites to share?
New perspective paper with the amazing @asanchezlab.bsky.social @javierdelafuente.bsky.social and Juan Diaz-Colunga.
Can we use global epistasis patterns to predict/understand plasmid-mediated AMR evolution? www.embopress.org/doi/full/10....
Can we use global epistasis patterns to predict/understand plasmid-mediated AMR evolution? www.embopress.org/doi/full/10....
Global epistasis in plasmid-mediated antimicrobial resistance | Molecular Systems Biology
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
www.embopress.org
February 26, 2024 at 4:02 PM
New perspective paper with the amazing @asanchezlab.bsky.social @javierdelafuente.bsky.social and Juan Diaz-Colunga.
Can we use global epistasis patterns to predict/understand plasmid-mediated AMR evolution? www.embopress.org/doi/full/10....
Can we use global epistasis patterns to predict/understand plasmid-mediated AMR evolution? www.embopress.org/doi/full/10....
From diminishing returns to entrenchment: a unifying theory of epistasis along adaptive walks revealed by Fisher's geometric model https://www.biorxiv.org/content/10.64898/2026.05.07.723117v1
May 12, 2026 at 3:33 AM
From diminishing returns to entrenchment: a unifying theory of epistasis along adaptive walks revealed by Fisher's geometric model https://www.biorxiv.org/content/10.64898/2026.05.07.723117v1
Epistasis and co-adaptation in bacterial genome evolution www.nature.com/articles/s41... #jcampubs
Epistasis and co-adaptation in bacterial genome evolution - Nature Reviews Genetics
Bacterial genome evolution is shaped by epistasis, which can constrain or promote specific evolutionary paths. The authors review how integrating the effects of epistatic interactions into population-...
www.nature.com
March 3, 2026 at 5:17 PM
Epistasis and co-adaptation in bacterial genome evolution www.nature.com/articles/s41... #jcampubs
Nature research paper: Cryptic variation fuels plant phenotypic change through hierarchical epistasis
go.nature.com/4lLtajx
go.nature.com/4lLtajx
Cryptic variation fuels plant phenotypic change through hierarchical epistasis - Nature
Gene regulatory network architecture and complex dosage effects from paralogue diversification converge to shape phenotypic space, producing the potential for both strongly buffered phenotypes and sudden bursts of phenotypic change.
go.nature.com
July 14, 2025 at 9:57 AM
Nature research paper: Cryptic variation fuels plant phenotypic change through hierarchical epistasis
go.nature.com/4lLtajx
go.nature.com/4lLtajx