#WeekendRead! #EveryCellsIsAnImmuneCell! Sonnenberg, Chu, Zhou &co show @science.org that a population of gut #fibroblasts produce IGF1, dampening interferon-gamma #IFNg driven CXCL10 by ILC3s & reducing pDC recruitment, restraining gut inflammation in mouse models! This circuit is altered in #IBD!
Fibroblasts restrain gut inflammation by IGF1-dependent regulation of innate lymphocytes
Fibroblasts exhibit phenotypic and functional heterogeneity in chronic inflammatory diseases, but how these changes impact immune outcomes remains poorly understood. We identified that a fibroblast po...
doi.org
October 10, 2026 at 2:53 PM
#WeekendRead! #EveryCellsIsAnImmuneCell! Sonnenberg, Chu, Zhou &co show @science.org that a population of gut #fibroblasts produce IGF1, dampening interferon-gamma #IFNg driven CXCL10 by ILC3s & reducing pDC recruitment, restraining gut inflammation in mouse models! This circuit is altered in #IBD!