Rachel Van Gelder, a recently minted PhD from the lab, shows IL-2 splices IFNG mRNA introns, increasing protein levels via NF-κB signaling. She uncovers a novel role for cytokine-induced splicing in immunity! 🧬 #RNA #Immunology #Research
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Interleukin-2-mediated NF-κB-dependent mRNA splicing modulates interferon gamma protein production | EMBO reports
imageimageIL-2 stimulation post-transcriptionally enhances splicing of IFNG mRNA in NK cells. Further, NF-κB signaling downstream of the IL-2 receptor is required
for IFNG mRNA processing. IL-12 and ...
www.embopress.org
November 22, 2024 at 4:52 PM
Rachel Van Gelder, a recently minted PhD from the lab, shows IL-2 splices IFNG mRNA introns, increasing protein levels via NF-κB signaling. She uncovers a novel role for cytokine-induced splicing in immunity! 🧬 #RNA #Immunology #Research
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
IFNg is an important discriminator for LC. But be careful, IFNg will be present during many infections and inflammation responses. i.e. IFNg does not mean LC.
It also does not mean IFNg is the cause of LC, not that IFNg causes the symptoms. But, it may and can enhance them.
6/10
It also does not mean IFNg is the cause of LC, not that IFNg causes the symptoms. But, it may and can enhance them.
6/10
February 25, 2025 at 12:10 PM
IFNg is an important discriminator for LC. But be careful, IFNg will be present during many infections and inflammation responses. i.e. IFNg does not mean LC.
It also does not mean IFNg is the cause of LC, not that IFNg causes the symptoms. But, it may and can enhance them.
6/10
It also does not mean IFNg is the cause of LC, not that IFNg causes the symptoms. But, it may and can enhance them.
6/10
Now published @cp-iscience.bsky.social
Work lead by David Lecky & Lozan Sheriff in collaboration with @therad-lab.bsky.social and @cameron-wraith.bsky.social showing how IFNg augments T Cell receptor signal strength to enhance type 1 Regulatory T (Tr1) cell development
www.cell.com/iscience/ful...
Work lead by David Lecky & Lozan Sheriff in collaboration with @therad-lab.bsky.social and @cameron-wraith.bsky.social showing how IFNg augments T Cell receptor signal strength to enhance type 1 Regulatory T (Tr1) cell development
www.cell.com/iscience/ful...
April 11, 2025 at 7:21 AM
Now published @cp-iscience.bsky.social
Work lead by David Lecky & Lozan Sheriff in collaboration with @therad-lab.bsky.social and @cameron-wraith.bsky.social showing how IFNg augments T Cell receptor signal strength to enhance type 1 Regulatory T (Tr1) cell development
www.cell.com/iscience/ful...
Work lead by David Lecky & Lozan Sheriff in collaboration with @therad-lab.bsky.social and @cameron-wraith.bsky.social showing how IFNg augments T Cell receptor signal strength to enhance type 1 Regulatory T (Tr1) cell development
www.cell.com/iscience/ful...
Check out latest work from @bendinglab.bsky.social - new insights into IFNg regulation of TCR signalling! 🧪 #immunosky
Now published @cp-iscience.bsky.social
Work lead by David Lecky & Lozan Sheriff in collaboration with @therad-lab.bsky.social and @cameron-wraith.bsky.social showing how IFNg augments T Cell receptor signal strength to enhance type 1 Regulatory T (Tr1) cell development
www.cell.com/iscience/ful...
Work lead by David Lecky & Lozan Sheriff in collaboration with @therad-lab.bsky.social and @cameron-wraith.bsky.social showing how IFNg augments T Cell receptor signal strength to enhance type 1 Regulatory T (Tr1) cell development
www.cell.com/iscience/ful...
April 11, 2025 at 8:54 AM
Check out latest work from @bendinglab.bsky.social - new insights into IFNg regulation of TCR signalling! 🧪 #immunosky
This paper confirms the increased IFNg in LC patients. IFNg is secreted by CD8 and Th1 cells stimulated by monocytes and MHC (physiological), and actively secreted. Recovery from symptoms correlates with a reduction in IFNg production.
Note: CD69 expression indicates effector cells.
5/10
Note: CD69 expression indicates effector cells.
5/10
February 25, 2025 at 12:10 PM
This paper confirms the increased IFNg in LC patients. IFNg is secreted by CD8 and Th1 cells stimulated by monocytes and MHC (physiological), and actively secreted. Recovery from symptoms correlates with a reduction in IFNg production.
Note: CD69 expression indicates effector cells.
5/10
Note: CD69 expression indicates effector cells.
5/10
Changes in IFNg in patients with LC do not correlate with symptom severity.
This paper again shows that LC is an inflammatory disease, with many inflammatory mediators involved, such as the powerful cytokine IFNg. It is not known whether neutralising IFNg will provide symptom relief.
8/10
This paper again shows that LC is an inflammatory disease, with many inflammatory mediators involved, such as the powerful cytokine IFNg. It is not known whether neutralising IFNg will provide symptom relief.
8/10
February 25, 2025 at 12:10 PM
Changes in IFNg in patients with LC do not correlate with symptom severity.
This paper again shows that LC is an inflammatory disease, with many inflammatory mediators involved, such as the powerful cytokine IFNg. It is not known whether neutralising IFNg will provide symptom relief.
8/10
This paper again shows that LC is an inflammatory disease, with many inflammatory mediators involved, such as the powerful cytokine IFNg. It is not known whether neutralising IFNg will provide symptom relief.
8/10
Patients can spontaneously recover from LC, and some can recover after vaccination. This correlates with reductions in IFNg.
This means there is less immune activity and less IFNg production, but still does not reveal the cause and consequence.
7/10
This means there is less immune activity and less IFNg production, but still does not reveal the cause and consequence.
7/10
February 25, 2025 at 12:10 PM
Patients can spontaneously recover from LC, and some can recover after vaccination. This correlates with reductions in IFNg.
This means there is less immune activity and less IFNg production, but still does not reveal the cause and consequence.
7/10
This means there is less immune activity and less IFNg production, but still does not reveal the cause and consequence.
7/10
Now in #Science #Immunology: Philips, O'Shea, &al. made mice w human pathogenic #STAT1 activating mutation. Mice had #IFNg -dependent #autoimmunity, but their innatelike lymphocytes produced suboptimal IFNg during viral infection. Exogenous IFNg🚫virus-induced lethality, suggesting possible therapy!
An activating Stat1 mutant disrupts normal STAT4 innate lymphocyte programs during viral infection
Stat1 gain-of-function mice fail to resolve inflammation in viral infection because of insufficient early STAT4–IFN-γ responses.
www.science.org
May 30, 2025 at 6:36 PM
Now in #Science #Immunology: Philips, O'Shea, &al. made mice w human pathogenic #STAT1 activating mutation. Mice had #IFNg -dependent #autoimmunity, but their innatelike lymphocytes produced suboptimal IFNg during viral infection. Exogenous IFNg🚫virus-induced lethality, suggesting possible therapy!
youtube.com/watch?v=IfNG... Καλό βράδυ ✨🎸👇✨
Edgar Broughton Band - Hotel Room (Lyric video)
YouTube video by T. BERV
youtube.com
April 7, 2026 at 8:35 PM
youtube.com/watch?v=IfNG... Καλό βράδυ ✨🎸👇✨
What mechanisms drive checkpoint inhibitor-associated interstitial nephritis (ICI-AIN)?
In our preprint, we identify CD8 T cells as a central player, inducing a proinflammatory myeloid cell state by IFNg and structuring lymphoid aggregates by CXCL13.
www.biorxiv.org/content/10.1...
1/n
#Nephsky 🧪
In our preprint, we identify CD8 T cells as a central player, inducing a proinflammatory myeloid cell state by IFNg and structuring lymphoid aggregates by CXCL13.
www.biorxiv.org/content/10.1...
1/n
#Nephsky 🧪
November 5, 2025 at 6:24 PM
What mechanisms drive checkpoint inhibitor-associated interstitial nephritis (ICI-AIN)?
In our preprint, we identify CD8 T cells as a central player, inducing a proinflammatory myeloid cell state by IFNg and structuring lymphoid aggregates by CXCL13.
www.biorxiv.org/content/10.1...
1/n
#Nephsky 🧪
In our preprint, we identify CD8 T cells as a central player, inducing a proinflammatory myeloid cell state by IFNg and structuring lymphoid aggregates by CXCL13.
www.biorxiv.org/content/10.1...
1/n
#Nephsky 🧪
I am very excited to share our article on IFNg, stroma and disease tolerance during intestinal helminth infection published today in Cell. This work was lead by the amazing @susanwestfall.bsky.social and supported by many international collaborators.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
A type 1 immune-stromal cell network mediates disease tolerance against intestinal infection
Type 1 immunity mediates host defense through pathogen elimination, but whether this pathway also impacts tissue function is unknown. Here, we demonst…
www.sciencedirect.com
April 22, 2025 at 4:35 PM
I am very excited to share our article on IFNg, stroma and disease tolerance during intestinal helminth infection published today in Cell. This work was lead by the amazing @susanwestfall.bsky.social and supported by many international collaborators.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Although IFNg may not directly be causing symptoms, it can, also indirectly contribute. The cause of more IFNg remains unknown and involves the established hypothesis of latent viral reawakening, viral debris/delay/failure to clear as well as re-awakening or induction of autoimmune activity.
9/10
9/10
February 25, 2025 at 12:11 PM
Although IFNg may not directly be causing symptoms, it can, also indirectly contribute. The cause of more IFNg remains unknown and involves the established hypothesis of latent viral reawakening, viral debris/delay/failure to clear as well as re-awakening or induction of autoimmune activity.
9/10
9/10
Inverted CD4/CD8 ratio persisted during the whole time. But CD8-monocyte comolexes and IFNg + TNF production reduced.
1 patient: causal inference cannot be established. But interesting for follow ups and more investigation.
4/4
1 patient: causal inference cannot be established. But interesting for follow ups and more investigation.
4/4
April 2, 2026 at 8:01 AM
Inverted CD4/CD8 ratio persisted during the whole time. But CD8-monocyte comolexes and IFNg + TNF production reduced.
1 patient: causal inference cannot be established. But interesting for follow ups and more investigation.
4/4
1 patient: causal inference cannot be established. But interesting for follow ups and more investigation.
4/4
and genetic issues such as tight control of cytokines expression such as for IFNg itself, T cells or the antigen-presenting cells.
Many options remain open.
10/10
Many options remain open.
10/10
February 25, 2025 at 12:11 PM
and genetic issues such as tight control of cytokines expression such as for IFNg itself, T cells or the antigen-presenting cells.
Many options remain open.
10/10
Many options remain open.
10/10
@biorxivpreprint.bsky.social IFNG-producing self-reactive CD4+ T cells drive autoimmune adrenalitis in a mouse model of Addison's disease
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
July 31, 2026 at 8:16 PM
@biorxivpreprint.bsky.social IFNG-producing self-reactive CD4+ T cells drive autoimmune adrenalitis in a mouse model of Addison's disease
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
IFNG-producing self-reactive CD4+ T cells induce autoimmune adrenalitis in a mouse model of Addison’s disease: doi.org/10.1172/jci....
JCI Insight - IFNG-producing self-reactive CD4+ T cells induce autoimmune adrenalitis in a mouse model of Addison’s disease
ResearchIn-Press PreviewClinical ResearchEndocrinology Open Access | 10.1172/jci.insight.201704
doi.org
September 22, 2026 at 4:05 PM
IFNG-producing self-reactive CD4+ T cells induce autoimmune adrenalitis in a mouse model of Addison’s disease: doi.org/10.1172/jci....
IFNg stimulation induces SLAMF7 expression on myeloid cells in rheumatoid arthritis. SLAMF7 engagement (with recombinant SLAMF7) then leads to a strong increase in a large number of proinflammatory mediators. SLAMF7+ are found in a number of inflammatory conditions.
1/
1/
November 24, 2024 at 6:23 PM
IFNg stimulation induces SLAMF7 expression on myeloid cells in rheumatoid arthritis. SLAMF7 engagement (with recombinant SLAMF7) then leads to a strong increase in a large number of proinflammatory mediators. SLAMF7+ are found in a number of inflammatory conditions.
1/
1/
This week in #Science #Immunology: Boisson-Dupuis, @casanovalab.bsky.social, & colleagues identify in 3 unrelated individuals w/ #tuberculosis a rare autosomal recessive complete deficiency in #LY9 linked to impaired #IFNg production by CCR4−CCR6+CXCR3+T-bet+RORγT+ TH1* cells (aka TH1/17 cells)!
Human LY9 governs CD4+ T cell IFN-γ immunity to Mycobacterium tuberculosis
Impaired CD4+ T cell–dependent IFN-γ immunity in humans with LY9 deficiency underlies tuberculosis.
www.science.org
May 30, 2025 at 6:23 PM
This week in #Science #Immunology: Boisson-Dupuis, @casanovalab.bsky.social, & colleagues identify in 3 unrelated individuals w/ #tuberculosis a rare autosomal recessive complete deficiency in #LY9 linked to impaired #IFNg production by CCR4−CCR6+CXCR3+T-bet+RORγT+ TH1* cells (aka TH1/17 cells)!
Beautiful talk by @ikinglab.bsky.social today @nyulangone.bsky.social talking IFNg, type 2, parasites, disease tolerance and gut:stroma axis. gorgeous microscopy and insightful new Frontiers in Hpb infections. 👏👏
October 2, 2025 at 4:09 PM
Beautiful talk by @ikinglab.bsky.social today @nyulangone.bsky.social talking IFNg, type 2, parasites, disease tolerance and gut:stroma axis. gorgeous microscopy and insightful new Frontiers in Hpb infections. 👏👏
A Jak/Stat inhibitor, #Tofacitinib, can suppress IFNg production from ILCs and T cells, reducing tissue damage during ameliorates #Campylobacter www.mucosalimmunology.org/article/S193...
July 21, 2025 at 2:55 PM
A Jak/Stat inhibitor, #Tofacitinib, can suppress IFNg production from ILCs and T cells, reducing tissue damage during ameliorates #Campylobacter www.mucosalimmunology.org/article/S193...
CD8+GZMK+IFNG+ T cells are a key immune population in cutaneous Lyme disease @insight.jci.org
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
February 24, 2026 at 5:48 PM
CD8+GZMK+IFNG+ T cells are a key immune population in cutaneous Lyme disease @insight.jci.org
insight.jci.org/articles/vie...
insight.jci.org/articles/vie...
ICYMI: earlier this month in #Science #Immunology, Ping Chih-Ho & Cheng Lung-Ku labs engineered #CAART cells bearing truncated #IFNg mutant bait to eliminate #Bcells expressing anti-IFN neutralizing #autoantibodies (nAIGAs) in both mouse models & in ex vivo cultures of PBMCs from patients w/ nAIGAs!
Chimeric autoantibody receptor T cells clonally eliminate B cells producing autoantibodies against IFN-γ
Interferon-γ chimeric autoantibody receptor T cells broadly deplete autoreactive B cells against interferon-γ.
www.science.org
May 26, 2025 at 9:54 PM
ICYMI: earlier this month in #Science #Immunology, Ping Chih-Ho & Cheng Lung-Ku labs engineered #CAART cells bearing truncated #IFNg mutant bait to eliminate #Bcells expressing anti-IFN neutralizing #autoantibodies (nAIGAs) in both mouse models & in ex vivo cultures of PBMCs from patients w/ nAIGAs!
A recurrent observation in #LongCovid patients is the increase in immune activity, including the production of IFNg from T cells. Much in opposite to any claims of "exhaustion", these cells express activation markers, such as CD69, PD-1.
IFNg has many effects on other immune cells, such as
3/10
IFNg has many effects on other immune cells, such as
3/10
February 25, 2025 at 12:10 PM
A recurrent observation in #LongCovid patients is the increase in immune activity, including the production of IFNg from T cells. Much in opposite to any claims of "exhaustion", these cells express activation markers, such as CD69, PD-1.
IFNg has many effects on other immune cells, such as
3/10
IFNg has many effects on other immune cells, such as
3/10