Seth Thomas Scanlon
LightNews LightNews
banner
immunoeditor.bsky.social
Seth Thomas Scanlon
@immunoeditor.bsky.social
2.9K followers 260 following 220 posts
Editor, Science Immunology
science.org/journal/sciimmunol

🇺🇸 + 🇳🇱 & based in 🇪🇺

Twitter: x.com/ImmunoEditor
Posts Replies Media Videos
Pinned
immunoeditor.bsky.social
Seth Thomas Scanlon @immunoeditor.bsky.social · Nov 14
At #ScienceImmunology, I lead a fantastic team of #research #editors comprising Chris Fogg (@cnfogg.bsky.social), Claire Olingy (@claireolingy.bsky.social), and Hannah Isles (@hannah-isles.bsky.social)! Be sure to give them a follow!

www.science.org/journal/scii...
The Science Immunology editors in front of AAAS Headquarters in Washington DC. (L to R): Chris Fogg, Claire Olingy, Seth Thomas Scanlon, & Hannah Isles
immunoeditor.bsky.social
My dream of being a … *gulp* … podcast guest has finally come true! Thanks, @boron110.bsky.social for the fun & freewheeling conversation!
boron110.bsky.social Sar Crespi @boron110.bsky.social · Jul 10
Looking back at the first 10 years of Science Immunology—this week on the @science.org podcast. Editor @immunoeditor.bsky.social explores how the field has changed since the inception of the journal and talks about a special series of reviews on immune memory

www.science.org/content/podc...
July 10, 2026 at 5:36 PM
immunoeditor.bsky.social
#Science #Immunology turns 10 years old this month! We celebrate w/ a Special Issue on immune #memory! Check out our 3 outstanding Reviews by Maziar & Kaufmann; @sjturn.bsky.social, Thiele, & @niclag.bsky.social; & @maurogaya.bsky.social & @kimljacobson.bsky.social out this week!

scim.ag/448rEkV
The July 2026 cover of Science Immunology features an illustration depicting an avatar of the immune system playing a memory game, in which previously encountered pathogens are remembered. The scene is framed by an unspooling chromosome, highlighting the critical role that epigenetic reprogramming plays in both innate and adaptive immune memory. (Credit: Ada Zejun Shen)
July 3, 2026 at 7:07 PM
immunoeditor.bsky.social
To celebrate @focisimmunology.bsky.social's annual meeting this week, #Science #Immunology has just released a free sample collection of recent papers with a focus on human & clinical immunology! The collection will be available online to read for the next few weeks! #FOCIS2026

bit.ly/SciImm_free
June 12, 2026 at 3:45 AM
immunoeditor.bsky.social
To mark World #Malaria Day, here are 2 recent Science #Immunology papers highlighting cutting-edge malaria research!

Nideffer & al. (2025)
scim.ag/4izhn63

Gao & al. (2025)
scim.ag/4hN5vOY
April 25, 2026 at 9:50 AM
immunoeditor.bsky.social
So far in March, we've featured papers on:

• how inflammatory #ILC2 migrate
• engineering #CAR-TCells to restore #checkpoint sensitivity
• capturing the earliest events of #TCell #development
• how certain dietary antigens recognized by #Tregs help mediate #OralTolerance

New content every week!
science.org Science Magazine @science.org · Mar 9
The March 2026 issue of #ScienceImmunology is out!

This month's cover highlights how intestinal regulatory T cells in mice recognize food-derived antigens such as the maize protein αZein and suppress immune responses to them.

Learn about this research and more: https://scim.ag/4rL6F1I
This month’s cover features an image of flint corn, a frequently colorful variant of maize (Zea mays), that contains an immunodominant food epitope recognized by Treg cells.
March 13, 2026 at 7:37 PM
immunoeditor.bsky.social
Ghreetings from ghorgeous Ghent, where #Type2Immunity26 co-org by @vibtrainconf.bsky.social & #Science #Immunology is well under way! Check out our free collection of #allergy, #asthma, & #Type2Immunity papers in celebration!

Collection: bit.ly/SciImm_free
Conference: vibbio.tech/3UwmTNk
March 9, 2026 at 2:04 PM
immunoeditor.bsky.social
Out now in #Science #Immunology! 👇
casanovalab.bsky.social Casanova Lab @casanovalab.bsky.social · Mar 2
1/ We are excited to report in @sciimmunology.bsky.social that human complete and selective LFA-1 deficiency causes isolated Epidermodysplasia Verruciformis (EV). This surprising phenotype revealed a surprising mechanism 🙂 www.science.org/doi/10.1126/...
March 4, 2026 at 9:00 AM
immunoeditor.bsky.social
To celebrate next week's #Type2Immunity26 meeting in Ghent co-org by @vibtrainconf.bsky.social & #Science #Immunology, we've selected 8 recent #allergy, #asthma, & #Type2Immunity papers. Free collection available until end April 2026!

Collection: bit.ly/SciImm_free
Conference: vibbio.tech/3UwmTNk
General view of the Graslei (Ghent, Belgium) with the Leie river in the foreground. / Photograph by Michiel Hendryckx, distributed under a CC BY-SA 4.0 license.
March 3, 2026 at 10:47 AM
immunoeditor.bsky.social
Check it out! New content each week!!!
science.org Science Magazine @science.org · Feb 9
The February 2026 issue of #ScienceImmunology is out!

This month's cover highlights how the cohesin complex shapes genome organization in dendritic cells to regulate their differentiation and function. https://scim.ag/4agVpT8
This month’s cover illustration depicts the extrusion of DNA loops by cohesin (green) until halted by CCCTC-binding factor (orange).
February 10, 2026 at 11:09 PM
immunoeditor.bsky.social
@science.org is looking for a new research editor to handle papers in the field of next-generation #medicine! Spread the word!!!

bit.ly/4bWOJfn
January 27, 2026 at 6:54 PM
immunoeditor.bsky.social
The January 2026 issue of #Science #Immunology is out now!

Thanks to Rioka Hayama for another fantastic cover!!!
science.org Science Magazine @science.org · Jan 5
The January 2026 issue of #ScienceImmunology is out!

This month's cover depicts the repopulation of resident cardiac macrophages after chemotherapy, protecting the heart against subsequent injury. Learn more about this research and more: https://scim.ag/3NsLjqu
This month’s cover illustration depicts the repopulation of cardiac-resident macrophages with cardioprotective monocyte-derived cells as chemotherapy-guided patchwork mending of the cardiac macrophage pool.
January 8, 2026 at 11:14 AM
immunoeditor.bsky.social
Happy 2026!!!

#Science #Immunology will celebrate its 10th anniversary this year! 🎉 We start with a look back at our Editors’ Choice of articles published in 2025! This free sample collection will be available online to read until the end of February 2026!

bit.ly/SciImm_free

#ScienceImmuno10gy
January 2, 2026 at 3:59 PM
immunoeditor.bsky.social
#Science #Immunology will be sponsoring a prize for the best poster presentation! The abstract deadline is fast approaching though, so don't delay!

I hope to see many of you in marvelous Ghent this coming March!
science.org Science Magazine @science.org · Dec 12
In partnership with @vibtrainconf.bsky.social, #ScienceImmunology is organizing #Type2Immunity26 in Ghent 9–10 March 2026, bringing together leaders in the field of #Type2Immunity.

Check out our lineup here: vibbio.tech/3UwmTNk
🗓️15 DEC: Travel grant deadline
🗓️8 JAN: Abstract deadline
Promotional image for the 3rd edition of the conference titled 'Type 2 Immunity in Homeostasis and Disease (3rd edition)' in Ghent, Belgium, featuring headshots of twelve speakers in a grid format with names and affiliations below each photo. The logo of Science Immunology and VIB are displayed at the top.
December 12, 2025 at 3:50 PM
immunoeditor.bsky.social
The latest issue of #Science #Immunology is out now! This week:

• evaluating large language models ( #LLMs ) / #AI as potential #systems #vaccinology tools

• de novo #thymus #regeneration in the #axolotl!

New content every week!!!
science.org Science Magazine @science.org · Dec 8
The December issue of #ScienceImmunology is out!

This month's cover highlights the juvenile axolotl's ability to regenerate its thymus after complete removal—possibly making it an exception among vertebrates. Learn about this research and more: https://scim.ag/4anWlqv
This month’s cover features the Mexican axolotl Ambystoma mexicanum, which has the ability to regenerate its thymus de novo, an apparent exception among vertebrates.
December 9, 2025 at 9:26 PM
immunoeditor.bsky.social
This week in #Science #Immunology, Lambrecht & Hammad labs (@viblifesciences.bsky.social) use #Danish Nat'l Patient & Prescription Registries + mouse models to show that maternal #allergy & neonatal #RSV infection synergize via FcR-mediated allergen uptake to drive development of early life #asthma!
Maternal allergy and neonatal RSV infection synergize via FcR-mediated allergen uptake to promote the development of asthma in early life
Maternal IgG transfer and neonatal infection synergize via Fc receptor pathways to promote allergic TH2 immunity.
www.science.org
November 28, 2025 at 7:12 PM
immunoeditor.bsky.social
Nov issue of #Science #Immunology out now!

This week: exTH17 cells sustain #IL17 –independent rheumatoid #arthritis; CXCR4+ mesodermal progenitors → rostral blood vessels, prodefinitive hematopoiesis, & postnatal tissue #macrophages; & how #Bcells acquire antigens from #parasites!

scim.ag/4qQA6Q6
ONLINE COVERB Cell Help Measures Up Against Parasites. How B cells acquire antigens from large pathogens, including single-celled parasites, to support T cell–driven humoral responses is not well understood. Gao et al. used Ighg2A10 B cells specific for the surface Plasmodium falciparum circumsporozoite protein (PfCSP) to examine the interaction between B cells and Plasmodium berghei sporozoites engineered to express PfCSP. Ighg2A10 B cells could internalize and present cognate and bystander surface antigens, which resulted in both intramolecular and intermolecular CD4 T cell help. This help either suppressed or supported protective B cell responses depending on whether the CD4 T cells recognized cytosolic or surface sporozoite antigens. This month’s cover is a pseudocolored and digitally altered scanning electron microscopy (SEM) micrograph of Plasmodium sporozoites (pale purple) attached to Ighg2A10 B cells (bright pink) at one end. Martin Oeggerli (Micronaut) 2025, with Xin Gao and Ian Cockburn, The John Curtin School of Medicine Research, Australian National University
November 7, 2025 at 10:19 PM
immunoeditor.bsky.social
Now in #Science #Immunology: Hirahara lab reports activated #TH2 cells store LC-UFAs present in inflamed #lung within #lipid droplets. Subsequent catabolism via #microlipophagy induces ST2-hi effector & memory TH2 cell phenotypes, exacerbating #type2 #airway #inflammation!
#asthma #immunometabolism
Lipolysis-microlipophagy cascade regulated by adipose triglyceride lipase drives pathogenic adaptive type 2 immunity
Enzymatic and autophagic catabolism of lipid droplets after unsaturated fatty acid uptake induces pathogenic TH2 cells.
www.science.org
October 24, 2025 at 6:54 PM
immunoeditor.bsky.social
Recently in #Science #Immunology: Kalinichenko, Huemer, @boztugk.bsky.social, & colleagues report than #sphingolipid #metabolism & protein #palmitoylation play critical roles in the killing of target cells by #cytotoxic #lymphocytes!
Protein palmitoylation and sphingolipid metabolism control regulated exocytosis in cytotoxic lymphocytes
Protein palmitoylation and sphingolipid metabolism control lytic granule release in cytotoxic lymphocytes via membrane targeting of SNAP23.
www.science.org
October 24, 2025 at 5:26 PM
immunoeditor.bsky.social
Last week in #Science #Immunology: two papers from Bill Schief, Facundo Batista, @profshanecrotty.bsky.social, & al. provide evidence that simultaneous #immunization with multiple #bnAb #immunogens could be a viable #HIV #vaccine strategy!

Xie & al.
scim.ag/3W7wfQl

Sutton & al.
scim.ag/4ofvKQa
October 24, 2025 at 5:19 PM
immunoeditor.bsky.social
I'm so excited to be in stunning Stockholm for the 50th annual meeting of the #Scandinavian Society for #Immunology!

swimm.se/ssi-2025/

@finnsocimm.bsky.social @swimm-immuno.bsky.social @yssi-immunology.bsky.social @ki.se
Main stage of the Aula Medica auditorium in Stockholm, Sweden. Three people are standing near the lectern on stage. Text on the screen above the stage reads "50th annual meeting of the Scandinavian Society for Immunology" and features the SSI logo.
October 15, 2025 at 7:38 AM
immunoeditor.bsky.social
To celebrate this year’s #NobelPrize in #Medicine, awarded for the discovery of regulatory #TCells, we have selected 8 papers recently published in #Science #Immunology that highlight recent advances in #Treg biology! The collection will be online until the end of Oct 2025!

bit.ly/SciImm_free
October 9, 2025 at 5:43 PM
immunoeditor.bsky.social
Thanks, @natrevimmunol.nature.com, for highlighting this exciting recent paper in #Science #Immunology!
October 6, 2025 at 10:04 AM
immunoeditor.bsky.social
This week in #Science #Immunology! 👇
kischober.bsky.social Kilian Schober @kischober.bsky.social · Oct 3
If the immune system is an army...
...
would you rather rely on one “super warrior” — or on a diverse team of fighters, even if none of them is the single strongest?

I’d go with the team.

Why? Check out our new study, just published in Science Immunology: www.science.org/doi/10.1126/...
October 4, 2025 at 10:45 AM
immunoeditor.bsky.social
The October issue of #Science #Immunology is out now! This week: how #TCR avidity shapes #CD8 #TCell responses to #mRNA #vaccines and the latest research on the immunology of #brain #tumors reviewed! New content added every week!

scim.ag/46TGooP
Decoding the Brain Tumor Immune Microenvironment. Brain tumors originate either from within the brain or as metastases from other tissues and pose major clinical challenges because of their heterogenous and aggressive nature. Bunse et al. review the cellular and molecular determinants of brain tumor antigenicity and factors that contribute to the immunosuppressive brain tumor microenvironment (TME). This month’s cover illustration depicts distinct malignant glioma (upper left) and metastatic (bottom right) TMEs as collages of aperiodic penrose tiles overlaid on a stylized positron emission tomography (PET) scan of the brain. Credit: Rioka Hayama
October 3, 2025 at 8:08 PM
immunoeditor.bsky.social
David Baker & colleagues develop an #IL21 mimic (21h10) that is more stable & shows x-reactivity against both human & murine #IL21R. 21h10 promotes potent antitumor responses in mice and in human #melanoma tumor explants, expanding low-affinity CD8 #TCells & #TH1 cells & reducing #Tregs in #tumors!
Design of a potent interleukin-21 mimic for cancer immunotherapy
A de novo IL-21 mimic, 21h10, exhibits improved stability and potent antitumor activity in vivo compared with native IL-21.
www.science.org
September 29, 2025 at 9:13 PM