Engineered receptor-biased IL-2–drug immunoconjugates selectively expand Tregs and suppress effector cells for autoimmune therapy @cp-cellrepmed.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
November 2, 2026 at 10:40 PM
Engineered receptor-biased IL-2–drug immunoconjugates selectively expand Tregs and suppress effector cells for autoimmune therapy @cp-cellrepmed.bsky.social
www.cell.com/cell-reports...
www.cell.com/cell-reports...
In #Microbiome
IL-17A deficiency in HLA-DR3 transgenic mice enriches beneficial Prevotella species in gut to promote Tregs and reduce CNS autoimmunity
Read more ➡️ doi.org/10.1186/s40168-026-02394-w
IL-17A deficiency in HLA-DR3 transgenic mice enriches beneficial Prevotella species in gut to promote Tregs and reduce CNS autoimmunity
Read more ➡️ doi.org/10.1186/s40168-026-02394-w
November 4, 2026 at 10:44 AM
In #Microbiome
IL-17A deficiency in HLA-DR3 transgenic mice enriches beneficial Prevotella species in gut to promote Tregs and reduce CNS autoimmunity
Read more ➡️ doi.org/10.1186/s40168-026-02394-w
IL-17A deficiency in HLA-DR3 transgenic mice enriches beneficial Prevotella species in gut to promote Tregs and reduce CNS autoimmunity
Read more ➡️ doi.org/10.1186/s40168-026-02394-w
Low-dose IL-2 fails to expand Tregs after alemtuzumab: insight into impaired immune tolerance in multiple sclerosis #NeuroDegeneration 🧪🧠
http://doi.org/10.1093/brain/awag171
http://doi.org/10.1093/brain/awag171
November 4, 2026 at 2:04 AM
Low-dose IL-2 fails to expand Tregs after alemtuzumab: insight into impaired immune tolerance in multiple sclerosis #NeuroDegeneration 🧪🧠
http://doi.org/10.1093/brain/awag171
http://doi.org/10.1093/brain/awag171
Engineered Dendritic Cells Imprint Dual Gut-Homing Specificity on Human Tregs for Pan-Intestinal Immunotolerance
www.dl.begellhouse.com/journals/2ff...
#InflammatoryBowelDisease #RegulatoryTCells #DendriticCells
www.dl.begellhouse.com/journals/2ff...
#InflammatoryBowelDisease #RegulatoryTCells #DendriticCells
October 31, 2026 at 7:00 PM
Engineered Dendritic Cells Imprint Dual Gut-Homing Specificity on Human Tregs for Pan-Intestinal Immunotolerance
www.dl.begellhouse.com/journals/2ff...
#InflammatoryBowelDisease #RegulatoryTCells #DendriticCells
www.dl.begellhouse.com/journals/2ff...
#InflammatoryBowelDisease #RegulatoryTCells #DendriticCells
Science Frontiers: CD19 CAR-Tregs persisted >4 months in mouse lupus; local IL-15 let innate cells control brain metastasis in mice; TEM1657 tunes OPA1 in psoriasis models (bioRxiv preprints, not peer reviewed); MedGemma 27B Text: 86.2 on MedQA (Nature Medicine).
inlightbio.com/science/
inlightbio.com/science/
October 31, 2026 at 11:56 AM
Science Frontiers: CD19 CAR-Tregs persisted >4 months in mouse lupus; local IL-15 let innate cells control brain metastasis in mice; TEM1657 tunes OPA1 in psoriasis models (bioRxiv preprints, not peer reviewed); MedGemma 27B Text: 86.2 on MedQA (Nature Medicine).
inlightbio.com/science/
inlightbio.com/science/
Online now: Engineered receptor-biased IL-2–drug immunoconjugates selectively expand Tregs and suppress effector cells for autoimmune therapy
Engineered receptor-biased IL-2–drug immunoconjugates selectively expand Tregs and suppress effector cells for autoimmune therapy
Li et al. identify Y31-20K-KU, a receptor-biased, site-specifically PEGylated IL-2-mTOR inhibitor immunoconjugate that selectively expands Treg cells, suppresses effector T cell activation, and ameliorates autoimmune inflammation in preclinical models.
dlvr.it
October 30, 2026 at 7:19 PM
Online now: Engineered receptor-biased IL-2–drug immunoconjugates selectively expand Tregs and suppress effector cells for autoimmune therapy
Characterization of a novel homozygous CTLA4 variant. new report from Tegan McTaggart, Jing Xuan Lim, Shoba Amarnath @newcastleuni.bsky.social, Ben Carpenter, Arian Laurence @uclh.bsky.social and colleagues:
rupress.org/jhi/article/...
#InbornErrorsOfImmunity #homozygous #CTLA4 #PID #Tregs
rupress.org/jhi/article/...
#InbornErrorsOfImmunity #homozygous #CTLA4 #PID #Tregs
October 28, 2026 at 2:31 PM
Characterization of a novel homozygous CTLA4 variant. new report from Tegan McTaggart, Jing Xuan Lim, Shoba Amarnath @newcastleuni.bsky.social, Ben Carpenter, Arian Laurence @uclh.bsky.social and colleagues:
rupress.org/jhi/article/...
#InbornErrorsOfImmunity #homozygous #CTLA4 #PID #Tregs
rupress.org/jhi/article/...
#InbornErrorsOfImmunity #homozygous #CTLA4 #PID #Tregs
Can we fix Belatacept’s early rejection problem? This study showed that TIGIT agonism + CTLA-4Ig prolongs graft survival, reduced graft-infiltrating donor-reactive CD8+ T cells, and boosted Tregs in mice. #TXPforAll #Transplantation #Immunology tinyurl.com/wyprxf6a
October 28, 2026 at 12:00 PM
Can we fix Belatacept’s early rejection problem? This study showed that TIGIT agonism + CTLA-4Ig prolongs graft survival, reduced graft-infiltrating donor-reactive CD8+ T cells, and boosted Tregs in mice. #TXPforAll #Transplantation #Immunology tinyurl.com/wyprxf6a
The authors included RRIDs in their in Military Medicine paper! RRIDs improve reproducibility in scientific research. #RRID #OpenResearch #methodsmatter
The Essential Role of Immunomodulatory Tregs in Visual Deficits After Military-Relevant Trauma
Read the full paper: The Essential Role of Immunomodulatory Tregs in Visual Deficits After Military-Relevant Trauma
doi.org
October 28, 2026 at 7:00 AM
The authors included RRIDs in their in Military Medicine paper! RRIDs improve reproducibility in scientific research. #RRID #OpenResearch #methodsmatter
New paper from the #IMMH: ICER restrains glycolytic programming in #Tregs and supports control of inflammatory #colitis. Our team shows that losing ICER in Tregs aggravates intestinal inflammation. #Immunology
Out now in the @eurjimmunol.bsky.social
🔗 doi.org/10.1002/eji.70297
Out now in the @eurjimmunol.bsky.social
🔗 doi.org/10.1002/eji.70297
October 26, 2026 at 10:42 AM
New paper from the #IMMH: ICER restrains glycolytic programming in #Tregs and supports control of inflammatory #colitis. Our team shows that losing ICER in Tregs aggravates intestinal inflammation. #Immunology
Out now in the @eurjimmunol.bsky.social
🔗 doi.org/10.1002/eji.70297
Out now in the @eurjimmunol.bsky.social
🔗 doi.org/10.1002/eji.70297
🧪In Cell Press, UPMC researchers present a mouse model for lifestyle-induced susceptibility to immune related adverse events (irAEs) and show that dietary, microbial, and immune drivers of irAEs can be leveraged to improve immunotherapy responses while minimizing toxicity: https://ow.ly/glCt5101sKe
October 29, 2026 at 7:10 PM
🧪In Cell Press, UPMC researchers present a mouse model for lifestyle-induced susceptibility to immune related adverse events (irAEs) and show that dietary, microbial, and immune drivers of irAEs can be leveraged to improve immunotherapy responses while minimizing toxicity: https://ow.ly/glCt5101sKe
Check out this News & Views article I wrote for @nature.com highlighting an article showing that sympathetic nerves induce endogenous retrovirus activation in hair follicles! www.nature.com/articles/d41... #autoimmunity #Tregs #alopecia
Nerve activity initiates autoimmune hair loss
Understanding the triggers of autoimmunity might lead to better therapies, with hair loss among the conditions for which underpinning factors have come to light.
www.nature.com
October 28, 2026 at 12:33 AM
Check out this News & Views article I wrote for @nature.com highlighting an article showing that sympathetic nerves induce endogenous retrovirus activation in hair follicles! www.nature.com/articles/d41... #autoimmunity #Tregs #alopecia
An article I wrote for @nature.com News & Views came out this week. It highlights exciting research showing that sympathetic nerves activate endogenous retroviruses in hair follicles which promote autoimmune alopecia susceptibility! www.nature.com/articles/d41... #alopecia #Tregs #autoimmune
Nerve activity initiates autoimmune hair loss
Understanding the triggers of autoimmunity might lead to better therapies, with hair loss among the conditions for which underpinning factors have come to light.
www.nature.com
October 28, 2026 at 12:38 AM
An article I wrote for @nature.com News & Views came out this week. It highlights exciting research showing that sympathetic nerves activate endogenous retroviruses in hair follicles which promote autoimmune alopecia susceptibility! www.nature.com/articles/d41... #alopecia #Tregs #autoimmune
Scientists at the University of Porto demonstrated in vitro that the glycoreprogramming of Tregs, mimicking the glycan composition found in #MyastheniaGravis patients, leads to decreased suppression function.
🔗 https://bit.ly/4zLtPIX
#OpenAccess 🔓 #ImmuneRegulation #RegulatoryTCells
🔗 https://bit.ly/4zLtPIX
#OpenAccess 🔓 #ImmuneRegulation #RegulatoryTCells
October 23, 2026 at 9:31 PM
Scientists at the University of Porto demonstrated in vitro that the glycoreprogramming of Tregs, mimicking the glycan composition found in #MyastheniaGravis patients, leads to decreased suppression function.
🔗 https://bit.ly/4zLtPIX
#OpenAccess 🔓 #ImmuneRegulation #RegulatoryTCells
🔗 https://bit.ly/4zLtPIX
#OpenAccess 🔓 #ImmuneRegulation #RegulatoryTCells
@obbakker.bsky.social from @gosiatrynka.bsky.social lab at #ASHG26, in action for dissecting genetic control of Treg suppression
Developing a primary co-culture system, with CRISPR KO Tregs. The assay captures APC-dependent suppression, enabling functional testing of disease-linked Treg eQTL genes.
Developing a primary co-culture system, with CRISPR KO Tregs. The assay captures APC-dependent suppression, enabling functional testing of disease-linked Treg eQTL genes.
October 22, 2026 at 1:17 PM
@obbakker.bsky.social from @gosiatrynka.bsky.social lab at #ASHG26, in action for dissecting genetic control of Treg suppression
Developing a primary co-culture system, with CRISPR KO Tregs. The assay captures APC-dependent suppression, enabling functional testing of disease-linked Treg eQTL genes.
Developing a primary co-culture system, with CRISPR KO Tregs. The assay captures APC-dependent suppression, enabling functional testing of disease-linked Treg eQTL genes.
McTaggart, Lim, Amarnath, Carpenter, Laurence et al. report on a #CTLA4 homozygous variant identified in a 16-year-old male. CTLA4 expression was severely diminished in CD4+ T cells and T regulatory cells. rupress.org/jhi/article/...
#homozygous #PID #checkpoints #Tregs #InbornErrorsOfImmunity
#homozygous #PID #checkpoints #Tregs #InbornErrorsOfImmunity
October 21, 2026 at 4:45 PM
McTaggart, Lim, Amarnath, Carpenter, Laurence et al. report on a #CTLA4 homozygous variant identified in a 16-year-old male. CTLA4 expression was severely diminished in CD4+ T cells and T regulatory cells. rupress.org/jhi/article/...
#homozygous #PID #checkpoints #Tregs #InbornErrorsOfImmunity
#homozygous #PID #checkpoints #Tregs #InbornErrorsOfImmunity
In @jhumimmunity.org, McTaggart, Lim, Amarnath, Carpenter, Laurence et al. report on a #CTLA4 homozygous variant identified in a 16-year-old male. CTLA4 expression was severely diminished in CD4+ T cells and T regulatory cells. rupress.org/jhi/article/...
#homozygous #PID #checkpoints #Tregs
#homozygous #PID #checkpoints #Tregs
October 21, 2026 at 5:30 PM
In @jhumimmunity.org, McTaggart, Lim, Amarnath, Carpenter, Laurence et al. report on a #CTLA4 homozygous variant identified in a 16-year-old male. CTLA4 expression was severely diminished in CD4+ T cells and T regulatory cells. rupress.org/jhi/article/...
#homozygous #PID #checkpoints #Tregs
#homozygous #PID #checkpoints #Tregs
Stealth CAR-Tregs evade CD3 antibody therapy and skew immune responses toward regulation https://www.biorxiv.org/content/10.64898/2026.10.13.758862v1
October 20, 2026 at 10:15 AM
Stealth CAR-Tregs evade CD3 antibody therapy and skew immune responses toward regulation https://www.biorxiv.org/content/10.64898/2026.10.13.758862v1
New paper from the Hill Lab in The Journal of Immunology (@jimmunol.bsky.social)!
Regulatory T cells usually suppress inflammation, but in a model of eosinophilic esophagitis (EoE), we found that IFNγ signaling reprograms Tregs to promote esophageal inflammation and fibrosis.
#Immunology #EoE
Regulatory T cells usually suppress inflammation, but in a model of eosinophilic esophagitis (EoE), we found that IFNγ signaling reprograms Tregs to promote esophageal inflammation and fibrosis.
#Immunology #EoE
October 20, 2026 at 1:52 PM
New paper from the Hill Lab in The Journal of Immunology (@jimmunol.bsky.social)!
Regulatory T cells usually suppress inflammation, but in a model of eosinophilic esophagitis (EoE), we found that IFNγ signaling reprograms Tregs to promote esophageal inflammation and fibrosis.
#Immunology #EoE
Regulatory T cells usually suppress inflammation, but in a model of eosinophilic esophagitis (EoE), we found that IFNγ signaling reprograms Tregs to promote esophageal inflammation and fibrosis.
#Immunology #EoE
Stealth CAR-Tregs evade CD3 antibody therapy and skew immune responses toward regulation https://www.biorxiv.org/content/10.64898/2026.10.13.758862v1
October 20, 2026 at 10:15 AM
Stealth CAR-Tregs evade CD3 antibody therapy and skew immune responses toward regulation https://www.biorxiv.org/content/10.64898/2026.10.13.758862v1
Importantly, Tregs from these individuals also suppressed T cells better in the presence of CD80/CD86-expressing dendritic cells. Also, the frequency of Tregs in the peripheral blood of these individuals was increased.
🧵5/7
🧵5/7
October 19, 2026 at 11:10 AM
Importantly, Tregs from these individuals also suppressed T cells better in the presence of CD80/CD86-expressing dendritic cells. Also, the frequency of Tregs in the peripheral blood of these individuals was increased.
🧵5/7
🧵5/7
Exciting progress in translating Treg biology into innovative therapies! From S/F iTregs to immunometabolic targeting and CARTregs, combining these approaches could yield next-gen “super-suppressor” Tregs with greater stability and function: bringing more precise therapies closer!
October 18, 2026 at 8:37 PM
Exciting progress in translating Treg biology into innovative therapies! From S/F iTregs to immunometabolic targeting and CARTregs, combining these approaches could yield next-gen “super-suppressor” Tregs with greater stability and function: bringing more precise therapies closer!
Current MS treatments suppress the immune system. Federico Fondelli’s project aims to retrain it.
Supported by the #CaixaImpulse Innovation call, his project uses educator cells to turn patients' immune cells into Tregs, natural protectors that stop autoimmune attacks.
https://tinyurl.com/466x2tke
Supported by the #CaixaImpulse Innovation call, his project uses educator cells to turn patients' immune cells into Tregs, natural protectors that stop autoimmune attacks.
https://tinyurl.com/466x2tke
October 19, 2026 at 1:20 PM
Current MS treatments suppress the immune system. Federico Fondelli’s project aims to retrain it.
Supported by the #CaixaImpulse Innovation call, his project uses educator cells to turn patients' immune cells into Tregs, natural protectors that stop autoimmune attacks.
https://tinyurl.com/466x2tke
Supported by the #CaixaImpulse Innovation call, his project uses educator cells to turn patients' immune cells into Tregs, natural protectors that stop autoimmune attacks.
https://tinyurl.com/466x2tke
Intestinal Epithelial NF-κB isn't just pro-inflammatory. It deploys a CCL22 secretome to recruit & reprogram protective Tregs driving crypt epithelial cell repair. Future IBD therapies must aim to preserve or transiently trigger the protective epithelial NF-κB pathway.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Epithelial NF-κB shapes protective Treg cell responses to restrain intestinal inflammation - Nature Communications
Inflammation and recovery from ulcerative colitis (UC) involves various immune cells and mediators. Here the authors examine the function of NFκB using patient samples and reporter mice to show that N...
www.nature.com
October 20, 2026 at 12:33 PM
Intestinal Epithelial NF-κB isn't just pro-inflammatory. It deploys a CCL22 secretome to recruit & reprogram protective Tregs driving crypt epithelial cell repair. Future IBD therapies must aim to preserve or transiently trigger the protective epithelial NF-κB pathway.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
How does this affect Treg function? We next demonstrated, that Tregs from carriers of the protective rs3087243-A variant express higher storage levels of CTLA-4, and are able to mobilize it faster to the cell surface upon activation.
🧵4/7
🧵4/7
October 19, 2026 at 11:10 AM
How does this affect Treg function? We next demonstrated, that Tregs from carriers of the protective rs3087243-A variant express higher storage levels of CTLA-4, and are able to mobilize it faster to the cell surface upon activation.
🧵4/7
🧵4/7