Kilian Schober
@kischober.bsky.social
MD Microbiology & Virology. Understanding & Engineering Human T Cell Immunity in Erlangen, Germany (www.schoberlab.de). Cycling. BVB. Cinema. Family.
Pinned
Kilian Schober
@kischober.bsky.social
· Oct 8
TCR activation impairs CAR-T cytotoxicity against separate target cells
Chimeric antigen receptor T cells (CAR-T) are effective therapeutics against cancer and autoimmunity, but whether the endogenous T cell receptor (TCR) is beneficial, detrimental or irrelevant for CAR ...
www.biorxiv.org
When a T cell carries both its natural TCR and an engineered CAR, do these two receptors cooperate - or compete?
Our new preprint on bioRxiv shows that TCR activation can enhance CAR-T activation but impairs CAR-mediated killing when targets are on separate cells.
www.biorxiv.org/content/10.1...
Our new preprint on bioRxiv shows that TCR activation can enhance CAR-T activation but impairs CAR-mediated killing when targets are on separate cells.
www.biorxiv.org/content/10.1...
Check out this webinar hosted by @hkoohy.bsky.social (@ox.ac.uk). I am looking forward to speaking about our new findings on the role of EBV-specific T cells in multiple sclerosis (preprint coming soon). More info in the flyer - the link for registration is here, too: us06web.zoom.us/meeting/regi...
September 17, 2026 at 6:47 AM
Check out this webinar hosted by @hkoohy.bsky.social (@ox.ac.uk). I am looking forward to speaking about our new findings on the role of EBV-specific T cells in multiple sclerosis (preprint coming soon). More info in the flyer - the link for registration is here, too: us06web.zoom.us/meeting/regi...
Reposted by Kilian Schober
EBV reactivation priming of the peripheral immune system in multiple sclerosis relapse
www.nature.com/articles/s41...
www.nature.com/articles/s41...
EBV reactivation priming of the peripheral immune system in multiple sclerosis relapse - Nature Medicine
Increased expression of EBV reactivation genes in B cells and MS risk genes targeted by the EBV protein EBNA-2 precedes MS attacks, linking EBV reactivation and genetic risk to the development of MS r...
www.nature.com
September 16, 2026 at 1:57 PM
EBV reactivation priming of the peripheral immune system in multiple sclerosis relapse
www.nature.com/articles/s41...
www.nature.com/articles/s41...
It was an immense honor to receive the Georges Köhler prize yesterday by @dgfi-org.bsky.social. This prize awards young group leaders. I dedicate it to my mentors Dirk Busch and Christian Bogdan and my team, which I also try to support as best as I can. (1/4)
September 16, 2026 at 1:38 PM
It was an immense honor to receive the Georges Köhler prize yesterday by @dgfi-org.bsky.social. This prize awards young group leaders. I dedicate it to my mentors Dirk Busch and Christian Bogdan and my team, which I also try to support as best as I can. (1/4)
Reposted by Kilian Schober
Human inherited RORγT deficiency encompasses genetic heterogeneity, T cell deficiency, and clinical homogeneity. New study from Iris Fagniez, Jean-Laurent Casanova @casanovalab.bsky.social, Rui Yang @ryangrui.bsky.social @rockefeller.edu & colleagues:
rupress.org/jem/article/...
#Immunodeficiency
rupress.org/jem/article/...
#Immunodeficiency
September 11, 2026 at 1:30 PM
Human inherited RORγT deficiency encompasses genetic heterogeneity, T cell deficiency, and clinical homogeneity. New study from Iris Fagniez, Jean-Laurent Casanova @casanovalab.bsky.social, Rui Yang @ryangrui.bsky.social @rockefeller.edu & colleagues:
rupress.org/jem/article/...
#Immunodeficiency
rupress.org/jem/article/...
#Immunodeficiency
Reposted by Kilian Schober
🚀 #OnAIRR 21 is here! Recorded live at the 4th Antwerp TCR meeting, Dr. @hannahvmeyer.bsky.social, Prof. @kischober.bsky.social, and Prof. @hkoohy.bsky.social join the podcast to ask: can we predict which epitope a TCR recognizes? 🎧 Listen in podcast apps or onairr.airr-community.org
#ImmunoSky
#ImmunoSky
September 2, 2026 at 9:55 AM
🚀 #OnAIRR 21 is here! Recorded live at the 4th Antwerp TCR meeting, Dr. @hannahvmeyer.bsky.social, Prof. @kischober.bsky.social, and Prof. @hkoohy.bsky.social join the podcast to ask: can we predict which epitope a TCR recognizes? 🎧 Listen in podcast apps or onairr.airr-community.org
#ImmunoSky
#ImmunoSky
Reposted by Kilian Schober
How often are people infected with malaria?
(This Data Insight was written by @hannahritchie.bsky.social.)
Malaria is an infectious disease that kills over 600,000 people a year. Most of them, children.
(This Data Insight was written by @hannahritchie.bsky.social.)
Malaria is an infectious disease that kills over 600,000 people a year. Most of them, children.
August 29, 2026 at 1:57 PM
How often are people infected with malaria?
(This Data Insight was written by @hannahritchie.bsky.social.)
Malaria is an infectious disease that kills over 600,000 people a year. Most of them, children.
(This Data Insight was written by @hannahritchie.bsky.social.)
Malaria is an infectious disease that kills over 600,000 people a year. Most of them, children.
Reposted by Kilian Schober
Central T cell tolerance from sparse peptide sampling
www.science.org/doi/10.1126/...
@hannahvmeyer.bsky.social @cshlnews.bsky.social
www.science.org/doi/10.1126/...
@hannahvmeyer.bsky.social @cshlnews.bsky.social
August 20, 2026 at 3:54 AM
Central T cell tolerance from sparse peptide sampling
www.science.org/doi/10.1126/...
@hannahvmeyer.bsky.social @cshlnews.bsky.social
www.science.org/doi/10.1126/...
@hannahvmeyer.bsky.social @cshlnews.bsky.social
Reposted by Kilian Schober
Very excited to share my lab's first major paper, led by postdoc Qi Liu @gladstoneinst.bsky.social @ucsanfrancisco.bsky.social executing the first ever genome-wide in vivo screens for genetic modifications to enhance human T cell therapies for solid tumors. www.nature.com/articles/s41...
In vivo genome-wide CRISPR screens of human T cells in solid tumours - Nature
An in vivo model that is able to recover human T cells from solid tumours can identify targets to help improve CAR T cell antitumour activity.
www.nature.com
August 13, 2026 at 5:24 PM
Very excited to share my lab's first major paper, led by postdoc Qi Liu @gladstoneinst.bsky.social @ucsanfrancisco.bsky.social executing the first ever genome-wide in vivo screens for genetic modifications to enhance human T cell therapies for solid tumors. www.nature.com/articles/s41...
Reposted by Kilian Schober
@biorxivpreprint.bsky.social IFNG-producing self-reactive CD4+ T cells drive autoimmune adrenalitis in a mouse model of Addison's disease
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
July 31, 2026 at 8:16 PM
@biorxivpreprint.bsky.social IFNG-producing self-reactive CD4+ T cells drive autoimmune adrenalitis in a mouse model of Addison's disease
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Today is the last day of our postdoc @nipagh.bsky.social who returns to Copenhagen after a 3-year fellowship. Stay tuned for his spectacular EBV T cell story in MS, which we will share as a preprint soon. Thanks, Nikolaj, and all the best!! @fau.de
July 24, 2026 at 2:13 PM
Today is the last day of our postdoc @nipagh.bsky.social who returns to Copenhagen after a 3-year fellowship. Stay tuned for his spectacular EBV T cell story in MS, which we will share as a preprint soon. Thanks, Nikolaj, and all the best!! @fau.de
Eight days ago, our ex PhD student @katharinakocher.bsky.social received a prize for one of three best dissertations at the Faculty of Medicine @fau.de. It was part of a ceremony for all doctorates and jubilees of the past year, a wonderful event. Congrats, Katharina!
July 20, 2026 at 7:15 PM
Eight days ago, our ex PhD student @katharinakocher.bsky.social received a prize for one of three best dissertations at the Faculty of Medicine @fau.de. It was part of a ceremony for all doctorates and jubilees of the past year, a wonderful event. Congrats, Katharina!
Reposted by Kilian Schober
The finding helped establish the idea that an oncogenic herpesvirus can remain latent rather than continuously producing virions.
rdcu.be/fupdl
rdcu.be/fupdl
Presence of EB Virus Nucleic Acid Homology in a “Virus-free” Line of Burkitt Tumour Cells
Nature - Presence of EB Virus Nucleic Acid Homology in a “Virus-free” Line of Burkitt Tumour Cells
rdcu.be
July 18, 2026 at 6:17 PM
The finding helped establish the idea that an oncogenic herpesvirus can remain latent rather than continuously producing virions.
rdcu.be/fupdl
rdcu.be/fupdl
Reposted by Kilian Schober
Elon Musk’s cuts to U.S.A.I.D. led to some 700,000 deaths, Atul Gawande says. www.newyorker.com/news/the-new...
The Human Cost of DOGE’s War on U.S.A.I.D.
Elon Musk, Donald Trump, and the “public man-made death” that they’ve caused.
www.newyorker.com
July 12, 2026 at 8:45 PM
Elon Musk’s cuts to U.S.A.I.D. led to some 700,000 deaths, Atul Gawande says. www.newyorker.com/news/the-new...
Reposted by Kilian Schober
Looking forward to presenting our latest findings on dual receptor T cells!
The next Immune Alliance Lecture is on Wednesday, 15 July, 9 am in Germany / 4 pm in Japan. 😊 You are cordially invited to attend: dgfi.org/immune-allia...
... online and free of charge.
@zielinskilab.bsky.social @efis-immunology.bsky.social @iuis-online.bsky.social @dgfi-yi.bsky.social
... online and free of charge.
@zielinskilab.bsky.social @efis-immunology.bsky.social @iuis-online.bsky.social @dgfi-yi.bsky.social
July 7, 2026 at 9:08 PM
Looking forward to presenting our latest findings on dual receptor T cells!
Reposted by Kilian Schober
Great to share our recent review, written with @niclag.bsky.social and @danielthiele1.bsky.social @monashuniversity.bsky.social #monashBDI
The evolving biology of T cell memory: A dynamic continuum of function and persistence | Science Immunology www.science.org/eprint/95PIC...
The evolving biology of T cell memory: A dynamic continuum of function and persistence | Science Immunology www.science.org/eprint/95PIC...
The evolving biology of T cell memory: A dynamic continuum of function and persistence
Advances in technology continue to refine our understanding of CD8 T cell memory, with major implications for next-generation vaccines and therapies.
www.science.org
July 4, 2026 at 12:32 AM
Great to share our recent review, written with @niclag.bsky.social and @danielthiele1.bsky.social @monashuniversity.bsky.social #monashBDI
The evolving biology of T cell memory: A dynamic continuum of function and persistence | Science Immunology www.science.org/eprint/95PIC...
The evolving biology of T cell memory: A dynamic continuum of function and persistence | Science Immunology www.science.org/eprint/95PIC...
Reposted by Kilian Schober
Thrilled to share our newest study led by @categraca.bsky.social and @yannick-alexandre.bsky.social published in @cp-immunity.bsky.social
Here, we identify B cells as critical helpers for T cells to obtain effector function through enhancing IFN-I 😳
url.au.m.mimecastprotect.com/s/NE67C6X1Py...
Here, we identify B cells as critical helpers for T cells to obtain effector function through enhancing IFN-I 😳
url.au.m.mimecastprotect.com/s/NE67C6X1Py...
July 2, 2026 at 10:09 PM
Thrilled to share our newest study led by @categraca.bsky.social and @yannick-alexandre.bsky.social published in @cp-immunity.bsky.social
Here, we identify B cells as critical helpers for T cells to obtain effector function through enhancing IFN-I 😳
url.au.m.mimecastprotect.com/s/NE67C6X1Py...
Here, we identify B cells as critical helpers for T cells to obtain effector function through enhancing IFN-I 😳
url.au.m.mimecastprotect.com/s/NE67C6X1Py...
We are looking for a PhD student to join our lab in Erlangen (www.schoberlab.de).
Excited about human immunology, T cells, viruses, high-throughput screens, and mechanistic questions?
Apply here: www.karriere.uk-erlangen.de/en/job/phd-s...
Please share with candidates.
Excited about human immunology, T cells, viruses, high-throughput screens, and mechanistic questions?
Apply here: www.karriere.uk-erlangen.de/en/job/phd-s...
Please share with candidates.
July 2, 2026 at 2:11 PM
We are looking for a PhD student to join our lab in Erlangen (www.schoberlab.de).
Excited about human immunology, T cells, viruses, high-throughput screens, and mechanistic questions?
Apply here: www.karriere.uk-erlangen.de/en/job/phd-s...
Please share with candidates.
Excited about human immunology, T cells, viruses, high-throughput screens, and mechanistic questions?
Apply here: www.karriere.uk-erlangen.de/en/job/phd-s...
Please share with candidates.
Reposted by Kilian Schober
“It’s just a microscopic water droplet surrounded by a fatty membrane and stuffed with chemicals and snippets of DNA encoding a mere 36 genes. But it’s also arguably the closest researchers have come to building a living cell from scratch.”🧪
My story in @science.org on a fascinating preprint:
My story in @science.org on a fascinating preprint:
Lab-created ‘SpudCell’ marks ‘stunning’ step toward building life from scratch
A synthetic cell can now grow and divide—but it’s still far from alive
www.science.org
July 1, 2026 at 4:45 PM
“It’s just a microscopic water droplet surrounded by a fatty membrane and stuffed with chemicals and snippets of DNA encoding a mere 36 genes. But it’s also arguably the closest researchers have come to building a living cell from scratch.”🧪
My story in @science.org on a fascinating preprint:
My story in @science.org on a fascinating preprint:
What are our blind spots in human T cell immunology?
In "Current Opinion in Immunology", M. Hiltensperger and I argue that we lack a coherent understanding of epitope-specific responses in secondary lymphoid organs.
www.sciencedirect.com/science/arti...
Grazie, Marco & Matteo, for the invite!
In "Current Opinion in Immunology", M. Hiltensperger and I argue that we lack a coherent understanding of epitope-specific responses in secondary lymphoid organs.
www.sciencedirect.com/science/arti...
Grazie, Marco & Matteo, for the invite!
A blind spot of human T cell immunology: epitope specificity in secondary lymphoid organs
The fate of T cells is determined through the expression of a unique T cell receptor (TCR). TCR epitope specificity drives spatial localization, pheno…
www.sciencedirect.com
June 29, 2026 at 6:47 PM
What are our blind spots in human T cell immunology?
In "Current Opinion in Immunology", M. Hiltensperger and I argue that we lack a coherent understanding of epitope-specific responses in secondary lymphoid organs.
www.sciencedirect.com/science/arti...
Grazie, Marco & Matteo, for the invite!
In "Current Opinion in Immunology", M. Hiltensperger and I argue that we lack a coherent understanding of epitope-specific responses in secondary lymphoid organs.
www.sciencedirect.com/science/arti...
Grazie, Marco & Matteo, for the invite!
Reposted by Kilian Schober
An interesting finding: for medical questions, specialized large language models might perform worse than general-purpose LLMs such as chatGPT:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
General-purpose large language models outperform specialized clinical AI tools on medical benchmarks - Nature Medicine
In an independent evaluation, frontier large language models outperformed specialized clinical artificial intelligence tools on medical knowledge, clinician alignment and real-world clinical queries.
www.nature.com
June 13, 2026 at 10:37 AM
An interesting finding: for medical questions, specialized large language models might perform worse than general-purpose LLMs such as chatGPT:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Kilian Schober
The T Cell Receptor: Molecular Sensor, Therapeutic Mediator and Probabilistic Driver of Adaptive Immunity
@kischober.bsky.social
onlinelibrary.wiley.com/doi/10.1111/...
@kischober.bsky.social
onlinelibrary.wiley.com/doi/10.1111/...
The T Cell Receptor: Molecular Sensor, Therapeutic Mediator and Probabilistic Driver of Adaptive Immunity
Advances in high-throughput sequencing, single-cell profiling, and genome engineering have transformed the study of T cell receptors (TCRs), enabling the identification and functional interrogation o...
onlinelibrary.wiley.com
June 5, 2026 at 2:32 PM
The T Cell Receptor: Molecular Sensor, Therapeutic Mediator and Probabilistic Driver of Adaptive Immunity
@kischober.bsky.social
onlinelibrary.wiley.com/doi/10.1111/...
@kischober.bsky.social
onlinelibrary.wiley.com/doi/10.1111/...
"The T Cell Receptor: Molecular Sensor, Therapeutic Mediator and Probabilistic Driver of Adaptive Immunity."
My personal perspective on TCR (repertoires).
Immunological Reviews: onlinelibrary.wiley.com/doi/epdf/10....
This is part of a special issue with contributions from great TCR colleagues.
My personal perspective on TCR (repertoires).
Immunological Reviews: onlinelibrary.wiley.com/doi/epdf/10....
This is part of a special issue with contributions from great TCR colleagues.
The T Cell Receptor: Molecular Sensor, Therapeutic Mediator and Probabilistic Driver of Adaptive Immunity
Advances in high-throughput sequencing, single-cell profiling, and genome engineering have transformed the study of T cell receptors (TCRs), enabling the identification and functional interrogation o...
onlinelibrary.wiley.com
June 5, 2026 at 7:29 AM
"The T Cell Receptor: Molecular Sensor, Therapeutic Mediator and Probabilistic Driver of Adaptive Immunity."
My personal perspective on TCR (repertoires).
Immunological Reviews: onlinelibrary.wiley.com/doi/epdf/10....
This is part of a special issue with contributions from great TCR colleagues.
My personal perspective on TCR (repertoires).
Immunological Reviews: onlinelibrary.wiley.com/doi/epdf/10....
This is part of a special issue with contributions from great TCR colleagues.
"Integrating complementary approaches reveals antigen-reactive CD4+ T cell states after SARS-CoV-2 vaccination"
New paper from our lab, just out in @cp-iscience.bsky.social. It is, for the time being, our last work on SARS-CoV-2 T cell responses.
www.cell.com/iscience/ful...
New paper from our lab, just out in @cp-iscience.bsky.social. It is, for the time being, our last work on SARS-CoV-2 T cell responses.
www.cell.com/iscience/ful...
Integrating complementary approaches reveals antigen-reactive CD4+ T cell states after SARS-CoV-2 vaccination
Therapeutics; Immunology; Virology
www.cell.com
June 5, 2026 at 7:25 AM
"Integrating complementary approaches reveals antigen-reactive CD4+ T cell states after SARS-CoV-2 vaccination"
New paper from our lab, just out in @cp-iscience.bsky.social. It is, for the time being, our last work on SARS-CoV-2 T cell responses.
www.cell.com/iscience/ful...
New paper from our lab, just out in @cp-iscience.bsky.social. It is, for the time being, our last work on SARS-CoV-2 T cell responses.
www.cell.com/iscience/ful...
Reposted by Kilian Schober
Ein Team von Studierenden der FAU hat bei der diesjährigen Asian Supercomputer Challenge einen herausragenden Erfolg erzielt.
Das Team „FAUltier“ überzeugte beim Finale des weltweit größten studentischen Supercomputerwettbewerbs als bestes internationales Team.
www.fau.de/2026/06/news...
Das Team „FAUltier“ überzeugte beim Finale des weltweit größten studentischen Supercomputerwettbewerbs als bestes internationales Team.
www.fau.de/2026/06/news...
FAU-Team gewinnt bei weltweit größtem Studierenden-Supercomputerwettbewerb
Team „FAUltier“ überzeugt bei der Asian Supercomputer Challenge mit Spitzenleistung…
www.fau.de
June 3, 2026 at 2:32 PM
Ein Team von Studierenden der FAU hat bei der diesjährigen Asian Supercomputer Challenge einen herausragenden Erfolg erzielt.
Das Team „FAUltier“ überzeugte beim Finale des weltweit größten studentischen Supercomputerwettbewerbs als bestes internationales Team.
www.fau.de/2026/06/news...
Das Team „FAUltier“ überzeugte beim Finale des weltweit größten studentischen Supercomputerwettbewerbs als bestes internationales Team.
www.fau.de/2026/06/news...