Did you know there are various types of RNAs on leaf surfaces of corn plants grown in the field? The host RNAs are secreted on the leaf surface and they coexist with the microbiome. @rnasociety.bsky.social #RNA30 #RNA #exRNA
Poster number: 025
Poster number: 025
May 28, 2025 at 5:11 PM
Did you know there are various types of RNAs on leaf surfaces of corn plants grown in the field? The host RNAs are secreted on the leaf surface and they coexist with the microbiome. @rnasociety.bsky.social #RNA30 #RNA #exRNA
Poster number: 025
Poster number: 025
Excited to attend the 30th RNA biology conference, San Diego. As a plant biologist it would be interesting to learn about new technologies in the RNA world and also share our work on maize extracellular RNAs #RNASociety @rnasociety.bsky.social #exRNA
May 28, 2025 at 12:59 AM
Excited to attend the 30th RNA biology conference, San Diego. As a plant biologist it would be interesting to learn about new technologies in the RNA world and also share our work on maize extracellular RNAs #RNASociety @rnasociety.bsky.social #exRNA
Success in the MSCA Doctoral Network! 🇪🇺
In the new EU project nEXt-RNA, the team led by MibiNet spokesperson @mfeldbruegge.bsky.social (@hhu.de) will investigate exRNA communication between U. maydis & corn. 🌽🍄The future ECRs will have the opportunity to associate with #MibiNet!
More info
In the new EU project nEXt-RNA, the team led by MibiNet spokesperson @mfeldbruegge.bsky.social (@hhu.de) will investigate exRNA communication between U. maydis & corn. 🌽🍄The future ECRs will have the opportunity to associate with #MibiNet!
More info
September 16, 2026 at 10:23 AM
Success in the MSCA Doctoral Network! 🇪🇺
In the new EU project nEXt-RNA, the team led by MibiNet spokesperson @mfeldbruegge.bsky.social (@hhu.de) will investigate exRNA communication between U. maydis & corn. 🌽🍄The future ECRs will have the opportunity to associate with #MibiNet!
More info
In the new EU project nEXt-RNA, the team led by MibiNet spokesperson @mfeldbruegge.bsky.social (@hhu.de) will investigate exRNA communication between U. maydis & corn. 🌽🍄The future ECRs will have the opportunity to associate with #MibiNet!
More info
With @amyhbuck we wrote this piece on extracellular RNAs that intends not to give answers but to propose questions that can expand the field in new directions.
Hope you like it! We really enjoyed a lot brainstorming it.
journals.asm.org/doi/10.1128/...
Hope you like it! We really enjoyed a lot brainstorming it.
journals.asm.org/doi/10.1128/...
mGem: Guides or triggers? Extracellular RNAs beyond vesicular miRNAs | mBio
Blood and other extracellular biofluids have a high RNase content. Hence, from its
origins, the exRNA field has focused on extracellular vesicles (EVs) as the main carriers
of RNA molecules that move ...
journals.asm.org
September 17, 2025 at 3:38 AM
With @amyhbuck we wrote this piece on extracellular RNAs that intends not to give answers but to propose questions that can expand the field in new directions.
Hope you like it! We really enjoyed a lot brainstorming it.
journals.asm.org/doi/10.1128/...
Hope you like it! We really enjoyed a lot brainstorming it.
journals.asm.org/doi/10.1128/...
Have you ever wondered how we isolated the RNAs coating Arabidopsis leaf surfaces?
Our new JoVE paper shows the step-by-step protocol + video for isolating leaf surface & apoplastic RNAs!
🎥 Watch the full method here: app.jove.com/v/68406/a-st...
#PlantBiology #exRNA #Arabidopsis #InnesLab
Our new JoVE paper shows the step-by-step protocol + video for isolating leaf surface & apoplastic RNAs!
🎥 Watch the full method here: app.jove.com/v/68406/a-st...
#PlantBiology #exRNA #Arabidopsis #InnesLab
November 7, 2025 at 1:56 PM
Have you ever wondered how we isolated the RNAs coating Arabidopsis leaf surfaces?
Our new JoVE paper shows the step-by-step protocol + video for isolating leaf surface & apoplastic RNAs!
🎥 Watch the full method here: app.jove.com/v/68406/a-st...
#PlantBiology #exRNA #Arabidopsis #InnesLab
Our new JoVE paper shows the step-by-step protocol + video for isolating leaf surface & apoplastic RNAs!
🎥 Watch the full method here: app.jove.com/v/68406/a-st...
#PlantBiology #exRNA #Arabidopsis #InnesLab
7/
To identify regulators of neuronal exRNA export, we devised a genome-wide CRISPR screening strategy in which secreted sgRNAs link each cell’s genotype to its extracellular RNA phenotype.
The screen revealed thousands of potential exRNA regulators.
To identify regulators of neuronal exRNA export, we devised a genome-wide CRISPR screening strategy in which secreted sgRNAs link each cell’s genotype to its extracellular RNA phenotype.
The screen revealed thousands of potential exRNA regulators.
March 6, 2026 at 9:03 AM
7/
To identify regulators of neuronal exRNA export, we devised a genome-wide CRISPR screening strategy in which secreted sgRNAs link each cell’s genotype to its extracellular RNA phenotype.
The screen revealed thousands of potential exRNA regulators.
To identify regulators of neuronal exRNA export, we devised a genome-wide CRISPR screening strategy in which secreted sgRNAs link each cell’s genotype to its extracellular RNA phenotype.
The screen revealed thousands of potential exRNA regulators.
Bioinformatics workshop on exRNA analysis in Edinburgh May 19-21, apply for funding to attend through COST Action CA20110 by Feb 1. Led by @ceiabreu.bsky.social. Priority for early career researchers - more information and application link here: exrnapath.eu/bioinformati...
BIOINFORMATICS WORKSHOP ON EXTRACELLULAR RNA 19 – 21 May 2025 – exRNAPATH
exrnapath.eu
January 26, 2025 at 3:17 PM
Bioinformatics workshop on exRNA analysis in Edinburgh May 19-21, apply for funding to attend through COST Action CA20110 by Feb 1. Led by @ceiabreu.bsky.social. Priority for early career researchers - more information and application link here: exrnapath.eu/bioinformati...
EVs-exRNA in bladder cancer: progress, challenges & future prospects for clinical application. Read more buff.ly/WX2dUSP
#Oncology #PrecisionMedicine
#Oncology #PrecisionMedicine
December 5, 2025 at 8:15 AM
EVs-exRNA in bladder cancer: progress, challenges & future prospects for clinical application. Read more buff.ly/WX2dUSP
#Oncology #PrecisionMedicine
#Oncology #PrecisionMedicine
What is going to happen to the #flongle after the price markups #OxfordNanoporeTechnologies announced? Are they going to be discontinued ? This is one of the best platforms for exRNA
biomarkers - no barcoding and privacy friendly bioinformatics. Would be very sorry to see it go
biomarkers - no barcoding and privacy friendly bioinformatics. Would be very sorry to see it go
January 15, 2025 at 9:59 PM
What is going to happen to the #flongle after the price markups #OxfordNanoporeTechnologies announced? Are they going to be discontinued ? This is one of the best platforms for exRNA
biomarkers - no barcoding and privacy friendly bioinformatics. Would be very sorry to see it go
biomarkers - no barcoding and privacy friendly bioinformatics. Would be very sorry to see it go
In a VIB Grand Challenge project on liver disease, we determined almost 1000 blood plasma transcriptomes and made the data available in this resource paper #exRNA #liver #fibrosis #cirrhosis #MASLD @franco17ps.bsky.social www.nature.com/articles/s41...
August 13, 2026 at 6:50 AM
In a VIB Grand Challenge project on liver disease, we determined almost 1000 blood plasma transcriptomes and made the data available in this resource paper #exRNA #liver #fibrosis #cirrhosis #MASLD @franco17ps.bsky.social www.nature.com/articles/s41...
What a huge effort by Anneleen Decock and Annelien Morlion from the OncoRNALab (@jvdesomp.bsky.social and Pieter Mestdagh), meticulously documenting a completely reproducible exRNA sequencing protocol. www.cell.com/star-protoco...
Protocol for total RNA sequencing analysis of extracellular RNA from biofluids
Extracellular or cell-free RNAs (exRNAs) derived from biofluids are utilized in biomarker
studies to study health and diseases. Here, we present a protocol for total RNA sequencing
analysis of blood p...
www.cell.com
May 19, 2026 at 8:42 AM
What a huge effort by Anneleen Decock and Annelien Morlion from the OncoRNALab (@jvdesomp.bsky.social and Pieter Mestdagh), meticulously documenting a completely reproducible exRNA sequencing protocol. www.cell.com/star-protoco...
It was a pleasure to host the kickoff meeting for the second funding phase of “ex-RNA” (@dfg.de Research Unit 5116) here in Regensburg. No group photo this time – but plenty of exciting ideas, lively discussions, and great science😉
gepris.dfg.de/gepris/proje...
gepris.dfg.de/gepris/proje...
DFG - GEPRIS - FOR 5116: “exRNA”: Kommunikation in der Wirtspflanzen-Mikroben-Interaktion durch extrazelluläre RNA
Aktuelle Studien haben gezeigt, dass extrazelluläre (ex) RNAs zwischen Wirtspflanzen und Mikroben während einer Infektion in beide Richtungen transportiert ...
gepris.dfg.de
August 11, 2025 at 3:04 PM
It was a pleasure to host the kickoff meeting for the second funding phase of “ex-RNA” (@dfg.de Research Unit 5116) here in Regensburg. No group photo this time – but plenty of exciting ideas, lively discussions, and great science😉
gepris.dfg.de/gepris/proje...
gepris.dfg.de/gepris/proje...
🎉Publish in ELSP's Scopus-indexed journals!
📖Welcoming submissions:
• Biofunctional Materials
• Advanced Manufacturing
• Smart Construction
• Law, Ethics & Technology
• ExRNA
Join our international publishing community and share your research. www.elspub.com/journals
#Scopus #OpenAccess #Research
📖Welcoming submissions:
• Biofunctional Materials
• Advanced Manufacturing
• Smart Construction
• Law, Ethics & Technology
• ExRNA
Join our international publishing community and share your research. www.elspub.com/journals
#Scopus #OpenAccess #Research
July 30, 2026 at 7:34 AM
🎉Publish in ELSP's Scopus-indexed journals!
📖Welcoming submissions:
• Biofunctional Materials
• Advanced Manufacturing
• Smart Construction
• Law, Ethics & Technology
• ExRNA
Join our international publishing community and share your research. www.elspub.com/journals
#Scopus #OpenAccess #Research
📖Welcoming submissions:
• Biofunctional Materials
• Advanced Manufacturing
• Smart Construction
• Law, Ethics & Technology
• ExRNA
Join our international publishing community and share your research. www.elspub.com/journals
#Scopus #OpenAccess #Research
🩺 A new, non-invasive test could help predict the quality of embryo used for IVF buff.ly/3U4h0HV
By looking at extracellular RNA (exRNA) from the cell culture fluid used to grow the embryos, the researchers were able to detect embryo quality non-invasively.
By looking at extracellular RNA (exRNA) from the cell culture fluid used to grow the embryos, the researchers were able to detect embryo quality non-invasively.
January 18, 2024 at 2:07 AM
🩺 A new, non-invasive test could help predict the quality of embryo used for IVF buff.ly/3U4h0HV
By looking at extracellular RNA (exRNA) from the cell culture fluid used to grow the embryos, the researchers were able to detect embryo quality non-invasively.
By looking at extracellular RNA (exRNA) from the cell culture fluid used to grow the embryos, the researchers were able to detect embryo quality non-invasively.
16/
The genetic identification and biochemical validation of this and other mechanisms governing exRNA selection will help uncover the biological functions of extracellular RNAs and ultimately decode the language of RNA-mediated cell-to-cell communication.
The genetic identification and biochemical validation of this and other mechanisms governing exRNA selection will help uncover the biological functions of extracellular RNAs and ultimately decode the language of RNA-mediated cell-to-cell communication.
March 6, 2026 at 9:03 AM
16/
The genetic identification and biochemical validation of this and other mechanisms governing exRNA selection will help uncover the biological functions of extracellular RNAs and ultimately decode the language of RNA-mediated cell-to-cell communication.
The genetic identification and biochemical validation of this and other mechanisms governing exRNA selection will help uncover the biological functions of extracellular RNAs and ultimately decode the language of RNA-mediated cell-to-cell communication.
14/
So how might Ψ drive exRNA export?
One possibility is that RNA-binding proteins recognize Ψ-marked RNAs and channel them into secretory pathways.
Surprisingly, we found that MYL6 (myosin light chain 6) selectively binds Ψ-containing exRNAs and is required for their extracellular transport.
So how might Ψ drive exRNA export?
One possibility is that RNA-binding proteins recognize Ψ-marked RNAs and channel them into secretory pathways.
Surprisingly, we found that MYL6 (myosin light chain 6) selectively binds Ψ-containing exRNAs and is required for their extracellular transport.
March 6, 2026 at 9:03 AM
14/
So how might Ψ drive exRNA export?
One possibility is that RNA-binding proteins recognize Ψ-marked RNAs and channel them into secretory pathways.
Surprisingly, we found that MYL6 (myosin light chain 6) selectively binds Ψ-containing exRNAs and is required for their extracellular transport.
So how might Ψ drive exRNA export?
One possibility is that RNA-binding proteins recognize Ψ-marked RNAs and channel them into secretory pathways.
Surprisingly, we found that MYL6 (myosin light chain 6) selectively binds Ψ-containing exRNAs and is required for their extracellular transport.
10/
When we depleted PUS1, exRNA export was dramatically altered.
When we depleted PUS1, exRNA export was dramatically altered.
March 6, 2026 at 9:03 AM
10/
When we depleted PUS1, exRNA export was dramatically altered.
When we depleted PUS1, exRNA export was dramatically altered.
4/
We know very little about the function of extracellular RNAs (#exRNAs), especially in the context of brain biology.
And even at a more fundamental level, the mechanistic rules governing mammalian exRNA trafficking remain largely obscure.
We know very little about the function of extracellular RNAs (#exRNAs), especially in the context of brain biology.
And even at a more fundamental level, the mechanistic rules governing mammalian exRNA trafficking remain largely obscure.
March 6, 2026 at 9:03 AM
4/
We know very little about the function of extracellular RNAs (#exRNAs), especially in the context of brain biology.
And even at a more fundamental level, the mechanistic rules governing mammalian exRNA trafficking remain largely obscure.
We know very little about the function of extracellular RNAs (#exRNAs), especially in the context of brain biology.
And even at a more fundamental level, the mechanistic rules governing mammalian exRNA trafficking remain largely obscure.
Somebody, @philipcball, set me thinking about RNA, but ouch, I don't think I can, there's mRNA, tRNA, rRNA, lncRNA, exRNA, scRNA, even snoRNA which puts me to sleep I suppose. I can only admire the scientists who are into that stuff!
November 7, 2024 at 7:50 PM
Somebody, @philipcball, set me thinking about RNA, but ouch, I don't think I can, there's mRNA, tRNA, rRNA, lncRNA, exRNA, scRNA, even snoRNA which puts me to sleep I suppose. I can only admire the scientists who are into that stuff!
Our thanks to Senator Paoli-Gagin and to the European Cooperation in Science and Technology network exRNA group, who organised the ‘Unleashing Europe’s Next Scientific Revolution’ conference at the Palais Du Luxembourg in October 2024...
January 6, 2025 at 10:28 AM
Our thanks to Senator Paoli-Gagin and to the European Cooperation in Science and Technology network exRNA group, who organised the ‘Unleashing Europe’s Next Scientific Revolution’ conference at the Palais Du Luxembourg in October 2024...
Small RNA Fragments Hold Major Promise in Advancing Cancer Treatment
A groundbreaking review from Universiti Putra Malaysia and its regional partners is challenging the boundaries of cancer diagnosis and treatment by highlighting the transformative potential of extracellular RNA (exRNA) in…
A groundbreaking review from Universiti Putra Malaysia and its regional partners is challenging the boundaries of cancer diagnosis and treatment by highlighting the transformative potential of extracellular RNA (exRNA) in…
Small RNA Fragments Hold Major Promise in Advancing Cancer Treatment
A groundbreaking review from Universiti Putra Malaysia and its regional partners is challenging the boundaries of cancer diagnosis and treatment by highlighting the transformative potential of extracellular RNA (exRNA) in oncology. These minuscule RNA fragments, many of which traverse the body encapsulated within exosomes, are capturing the imagination of researchers due to their dual utility: they are not only biomarkers signaling the presence and progression of malignancies but also vehicles capable of delivering precise therapeutic payloads directly to cancer cells.
scienmag.com
August 4, 2025 at 5:14 PM
Small RNA Fragments Hold Major Promise in Advancing Cancer Treatment
A groundbreaking review from Universiti Putra Malaysia and its regional partners is challenging the boundaries of cancer diagnosis and treatment by highlighting the transformative potential of extracellular RNA (exRNA) in…
A groundbreaking review from Universiti Putra Malaysia and its regional partners is challenging the boundaries of cancer diagnosis and treatment by highlighting the transformative potential of extracellular RNA (exRNA) in…
Optimizing Blood Tubes and RNA Purification for exRNA
In recent years, the exploration of extracellular RNA (exRNA) has surged to the forefront of molecular biology, heralding a new era of biomarker discovery and precision medicine. The exRNAQC Consortium’s latest comprehensive study, published in…
In recent years, the exploration of extracellular RNA (exRNA) has surged to the forefront of molecular biology, heralding a new era of biomarker discovery and precision medicine. The exRNAQC Consortium’s latest comprehensive study, published in…
Optimizing Blood Tubes and RNA Purification for exRNA
In recent years, the exploration of extracellular RNA (exRNA) has surged to the forefront of molecular biology, heralding a new era of biomarker discovery and precision medicine. The exRNAQC Consortium’s latest comprehensive study, published in Nature Communications, offers groundbreaking insights into optimal blood collection and RNA purification protocols, revolutionizing the landscape of extracellular RNA transcriptome profiling. As the scientific community races to harness the diagnostic and therapeutic potential embedded in exRNA signatures, the consortium’s recommendations arrive as both a beacon and a call to standardize methodologies across laboratories worldwide.
scienmag.com
May 15, 2025 at 7:17 PM
Optimizing Blood Tubes and RNA Purification for exRNA
In recent years, the exploration of extracellular RNA (exRNA) has surged to the forefront of molecular biology, heralding a new era of biomarker discovery and precision medicine. The exRNAQC Consortium’s latest comprehensive study, published in…
In recent years, the exploration of extracellular RNA (exRNA) has surged to the forefront of molecular biology, heralding a new era of biomarker discovery and precision medicine. The exRNAQC Consortium’s latest comprehensive study, published in…