Researchers compared 125 offspring of Holocaust survivors with 31 controls in the independent replication sample and found significantly lower methylation at a particular site in FKBP5, a gene involved in regulation of the stress-response system.
September 28, 2026 at 9:18 PM
Researchers compared 125 offspring of Holocaust survivors with 31 controls in the independent replication sample and found significantly lower methylation at a particular site in FKBP5, a gene involved in regulation of the stress-response system.
Manche Spatzen haben einfach bessere Stressresistenz. Der genetische Grund für seine Frühstücksüberfälle ist gefunden! Spatzen mit höherer FKBP5-Aktivität sind vorsichtiger und meiden eher riskante Situationen.
Wissta Bescheid!^^
Wissta Bescheid!^^
New paper on the link between FKBP5 expression
and risky foraging in house sparrow. Low FKBP5 expression is associated with increased risk taking. Also confirming correlation between blood and HPA axis regulatory region expression with @martinlabusf.bsky.social www.sciencedirect.com/science/arti...
and risky foraging in house sparrow. Low FKBP5 expression is associated with increased risk taking. Also confirming correlation between blood and HPA axis regulatory region expression with @martinlabusf.bsky.social www.sciencedirect.com/science/arti...
FKBP5 expression is related to risky foraging in house sparrows
Responding appropriately to unpredictable challenges requires the ability to match phenotype to current conditions. The hypothalamic-pituitary-adrenal…
www.sciencedirect.com
January 10, 2026 at 1:44 PM
Manche Spatzen haben einfach bessere Stressresistenz. Der genetische Grund für seine Frühstücksüberfälle ist gefunden! Spatzen mit höherer FKBP5-Aktivität sind vorsichtiger und meiden eher riskante Situationen.
Wissta Bescheid!^^
Wissta Bescheid!^^
Bu, beyindeki stres hormonlarını düzenleyen FKBP5 genini hedef alan yeni psikiyatrik tedavilerin geliştirilmesine yol açabilirmiş.
August 26, 2026 at 11:08 AM
Bu, beyindeki stres hormonlarını düzenleyen FKBP5 genini hedef alan yeni psikiyatrik tedavilerin geliştirilmesine yol açabilirmiş.
New paper on the link between FKBP5 expression
and risky foraging in house sparrow. Low FKBP5 expression is associated with increased risk taking. Also confirming correlation between blood and HPA axis regulatory region expression with @martinlabusf.bsky.social www.sciencedirect.com/science/arti...
and risky foraging in house sparrow. Low FKBP5 expression is associated with increased risk taking. Also confirming correlation between blood and HPA axis regulatory region expression with @martinlabusf.bsky.social www.sciencedirect.com/science/arti...
FKBP5 expression is related to risky foraging in house sparrows
Responding appropriately to unpredictable challenges requires the ability to match phenotype to current conditions. The hypothalamic-pituitary-adrenal…
www.sciencedirect.com
January 10, 2026 at 11:14 AM
New paper on the link between FKBP5 expression
and risky foraging in house sparrow. Low FKBP5 expression is associated with increased risk taking. Also confirming correlation between blood and HPA axis regulatory region expression with @martinlabusf.bsky.social www.sciencedirect.com/science/arti...
and risky foraging in house sparrow. Low FKBP5 expression is associated with increased risk taking. Also confirming correlation between blood and HPA axis regulatory region expression with @martinlabusf.bsky.social www.sciencedirect.com/science/arti...
New paper from the lab, where we show how the co-chaperone and psychiatric risk factor FKBP5 acts in CRH-expressing neurons to shape stress- sensitive social behavior. Deep phenotyping using #DLC and #DeepOF was key to unravel these effects. www.nature.com/articles/s41...
Deep phenotyping reveals CRH and FKBP51-dependent behavioral profiles following chronic social stress exposure in male mice - Neuropsychopharmacology
Neuropsychopharmacology - Deep phenotyping reveals CRH and FKBP51-dependent behavioral profiles following chronic social stress exposure in male mice
www.nature.com
November 13, 2024 at 4:37 PM
New paper from the lab, where we show how the co-chaperone and psychiatric risk factor FKBP5 acts in CRH-expressing neurons to shape stress- sensitive social behavior. Deep phenotyping using #DLC and #DeepOF was key to unravel these effects. www.nature.com/articles/s41...
everybody talks about it - we just did it. I'm talking about publishing negative results of course. We showed that adrenal FKBP5 is not involved in HPA axis regulation, so now you don't have to. You're welcome 😊 onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
August 6, 2025 at 8:47 AM
everybody talks about it - we just did it. I'm talking about publishing negative results of course. We showed that adrenal FKBP5 is not involved in HPA axis regulation, so now you don't have to. You're welcome 😊 onlinelibrary.wiley.com/doi/10.1111/...
🔔 New preprint 🔔
We show our previously reported heightened FKBP5 gene expression in psychiatric disorders and with age are likely to be moderated by epigenetic mechanisms. Great work by @katrinazedmond.bsky.social and Dominic Kaul with collaborators Elisabeth Binder and @lieberinstitute.bsky.social
We show our previously reported heightened FKBP5 gene expression in psychiatric disorders and with age are likely to be moderated by epigenetic mechanisms. Great work by @katrinazedmond.bsky.social and Dominic Kaul with collaborators Elisabeth Binder and @lieberinstitute.bsky.social
Lower cortical FKBP5 DNA methylation at key enhancer sites is associated with older age and higher gene expression in schizophrenia https://www.biorxiv.org/content/10.1101/2025.01.28.635384v1
February 1, 2025 at 10:08 AM
🔔 New preprint 🔔
We show our previously reported heightened FKBP5 gene expression in psychiatric disorders and with age are likely to be moderated by epigenetic mechanisms. Great work by @katrinazedmond.bsky.social and Dominic Kaul with collaborators Elisabeth Binder and @lieberinstitute.bsky.social
We show our previously reported heightened FKBP5 gene expression in psychiatric disorders and with age are likely to be moderated by epigenetic mechanisms. Great work by @katrinazedmond.bsky.social and Dominic Kaul with collaborators Elisabeth Binder and @lieberinstitute.bsky.social
A team from the University of Sydney and the Max Planck Institute of Psychiatry found that the brains of people with schizophrenia hold a stress signal that never turns off.
FKBP5: the stress gene that doesn't turn off in the brain with schizophrenia - Sinaptica
A team from the University of Sydney and the Max Planck Institute of Psychiatry found that the brains of people with schizophrenia hold a stress signal that nev
sinapti.ca
September 1, 2026 at 12:16 PM
A team from the University of Sydney and the Max Planck Institute of Psychiatry found that the brains of people with schizophrenia hold a stress signal that never turns off.
Stress can trigger symptoms in #schizophrenia. We've known that for decades, but not why.
We found the chemical tags that keep the key stress gene #FKBP5 in check have worn away, leaving the #stress system switched on.
Our latest in The American Journal of Psychiatry @apajournals.bsky.social 🧠
We found the chemical tags that keep the key stress gene #FKBP5 in check have worn away, leaving the #stress system switched on.
Our latest in The American Journal of Psychiatry @apajournals.bsky.social 🧠
Psychiatry Online
PsychiatryOnline.org is the platform for all American Psychiatric Association Publishing journals, DSM, and bestselling textbooks, as well as APA Practice Guidelines, and continuing medical education.
psychiatryonline.org
August 31, 2026 at 8:51 PM
Stress can trigger symptoms in #schizophrenia. We've known that for decades, but not why.
We found the chemical tags that keep the key stress gene #FKBP5 in check have worn away, leaving the #stress system switched on.
Our latest in The American Journal of Psychiatry @apajournals.bsky.social 🧠
We found the chemical tags that keep the key stress gene #FKBP5 in check have worn away, leaving the #stress system switched on.
Our latest in The American Journal of Psychiatry @apajournals.bsky.social 🧠
🔔 New lab preprint 🔔
We show the reported heightened FKBP5 gene expression in psychiatric disorders and with age are likely to be moderated by epigenetic mechanisms. Great work by
@katrinazedmond.bsky.social
and Dominic Kaul with collaborators Elisabeth Binder and
@lieberinstitute.bsky.social
We show the reported heightened FKBP5 gene expression in psychiatric disorders and with age are likely to be moderated by epigenetic mechanisms. Great work by
@katrinazedmond.bsky.social
and Dominic Kaul with collaborators Elisabeth Binder and
@lieberinstitute.bsky.social
Lower cortical FKBP5 DNA methylation at key enhancer sites is associated with older age and higher gene expression in schizophrenia https://www.biorxiv.org/content/10.1101/2025.01.28.635384v1
February 4, 2025 at 12:38 AM
🔔 New lab preprint 🔔
We show the reported heightened FKBP5 gene expression in psychiatric disorders and with age are likely to be moderated by epigenetic mechanisms. Great work by
@katrinazedmond.bsky.social
and Dominic Kaul with collaborators Elisabeth Binder and
@lieberinstitute.bsky.social
We show the reported heightened FKBP5 gene expression in psychiatric disorders and with age are likely to be moderated by epigenetic mechanisms. Great work by
@katrinazedmond.bsky.social
and Dominic Kaul with collaborators Elisabeth Binder and
@lieberinstitute.bsky.social
In addition to all the important examples in Luay’s thread, I’d be remiss if I didn’t point out that childhood abuse also changes the epigenome. pubmed.ncbi.nlm.nih.gov/36624283/
February 6, 2025 at 4:14 PM
In addition to all the important examples in Luay’s thread, I’d be remiss if I didn’t point out that childhood abuse also changes the epigenome. pubmed.ncbi.nlm.nih.gov/36624283/
“At the center of this challenge is a stress-regulating gene called FKBP5. In a healthy brain, FKBP5 produces a protein (FKBP51) that acts like a built-in brake, dialing back how neurons react to stress hormones such as cortisol.” #isogg #epigenetics www.technologynetworks.com/genomics/new...
Schizophrenia Linked to Epigenetic Changes in Gene That Regulates Stress
Researchers analyzed postmortem brain tissue and found reduced DNA methylation at key regulatory sites of <i>FKBP5</i> in schizophrenia. The epigenetic changes were linked to increased stress gene act...
www.technologynetworks.com
September 9, 2026 at 7:00 AM
“At the center of this challenge is a stress-regulating gene called FKBP5. In a healthy brain, FKBP5 produces a protein (FKBP51) that acts like a built-in brake, dialing back how neurons react to stress hormones such as cortisol.” #isogg #epigenetics www.technologynetworks.com/genomics/new...
We need to remember a seminal 2013 study published in nature neuroscience that an “allele-specific FKBP5 demethylation mediates gene-childhood interactions” that confer PTSD and Major Depressive Disorder. This important epigenetic interaction confers resilience or susceptibility to the trauma.
May 19, 2025 at 3:16 PM
We need to remember a seminal 2013 study published in nature neuroscience that an “allele-specific FKBP5 demethylation mediates gene-childhood interactions” that confer PTSD and Major Depressive Disorder. This important epigenetic interaction confers resilience or susceptibility to the trauma.
Lower cortical FKBP5 DNA methylation at key enhancer sites is associated with older age and higher gene expression in schizophrenia https://www.biorxiv.org/content/10.1101/2025.01.28.635384v1
January 31, 2025 at 11:15 AM
Lower cortical FKBP5 DNA methylation at key enhancer sites is associated with older age and higher gene expression in schizophrenia https://www.biorxiv.org/content/10.1101/2025.01.28.635384v1
El responsable es un gen llamado FKBP5 , que regula la respuesta hormonal al estrés, y que en estos cerebros pierde las etiquetas químicas que normalmente lo mantienen bajo control.
FKBP5: el gen del estrés que no se apaga en el cerebro con esquizofrenia - Sinaptica
Un equipo de la Universidad de Sídney y el Instituto Max Planck de Psiquiatría encontró que el cerebro de personas con esquizofrenia guarda una señal de estrés
sinapti.ca
September 1, 2026 at 12:17 PM
El responsable es un gen llamado FKBP5 , que regula la respuesta hormonal al estrés, y que en estos cerebros pierde las etiquetas químicas que normalmente lo mantienen bajo control.
How does #rs5522 drive #ME/CFS? It is a genetic vulnerability. While the genes FKBP5 and rs6198 can jam the cell's anti-inflammatory brake, it is like a greedy cortisol magnet. This polygenic cascade triggers fluid leaks that starve the brain of oxygen and suffocate your mitochondrial power plants.
July 19, 2026 at 6:09 PM
Nesiller boyu süren travma, stres genleri NR3C1 ve FKBP5'i etkilemektedir. Bir çalışma, Holokost, Hollanda Açlık Kışı ve Ruanda'daki soykırımdan kurtulanların torunlarında DNA metilasyonunda değişiklikler olduğunu gösteriyor.
www.mdpi.com/1422-0067/26...
www.mdpi.com/1422-0067/26...
August 27, 2025 at 9:47 AM
Nesiller boyu süren travma, stres genleri NR3C1 ve FKBP5'i etkilemektedir. Bir çalışma, Holokost, Hollanda Açlık Kışı ve Ruanda'daki soykırımdan kurtulanların torunlarında DNA metilasyonunda değişiklikler olduğunu gösteriyor.
www.mdpi.com/1422-0067/26...
www.mdpi.com/1422-0067/26...
natgeo.nikkeibp.co.jp/atcl/news/24...
これはちょっと面白い研究ですね
不安作用に影響があるFKBP5遺伝子のDNAメチル化が次世代にまで影響をもたらす、端的にいうとPTSDの症状が子孫にも受け継がれているかもしれない、という話
これはちょっと面白い研究ですね
不安作用に影響があるFKBP5遺伝子のDNAメチル化が次世代にまで影響をもたらす、端的にいうとPTSDの症状が子孫にも受け継がれているかもしれない、という話
トラウマは遺伝する、研究続々、ただし影響を元に戻せる可能性も
人生を変えるほどのトラウマは一代では消えず、子孫に受け継がれることを示唆する研究が積み重なってきている。
natgeo.nikkeibp.co.jp
June 18, 2024 at 1:29 AM
natgeo.nikkeibp.co.jp/atcl/news/24...
これはちょっと面白い研究ですね
不安作用に影響があるFKBP5遺伝子のDNAメチル化が次世代にまで影響をもたらす、端的にいうとPTSDの症状が子孫にも受け継がれているかもしれない、という話
これはちょっと面白い研究ですね
不安作用に影響があるFKBP5遺伝子のDNAメチル化が次世代にまで影響をもたらす、端的にいうとPTSDの症状が子孫にも受け継がれているかもしれない、という話
So cortisol, HPA axis, and FKBP5 are all related...and can lead to suicide
December 14, 2024 at 7:11 PM
So cortisol, HPA axis, and FKBP5 are all related...and can lead to suicide
FKBP5 expression is related to risky foraging in house sparrows HormBehav
FKBP5 expression is related to risky foraging in house sparrows
Publication date: February 2026
Source: Hormones and Behavior, Volume 178
Author(s): C. Zimmer, K.M. McCain, H.E. Hanson, L.B. Martin
dlvr.it
January 10, 2026 at 5:57 PM
FKBP5 expression is related to risky foraging in house sparrows HormBehav
FKBP5 expression is related to risky foraging in house sparrows HormBehav
FKBP5 expression is related to risky foraging in house sparrows
Publication date: February 2026
Source: Hormones and Behavior, Volume 178
Author(s): C. Zimmer, K.M. McCain, H.E. Hanson, L.B. Martin
dlvr.it
January 12, 2026 at 12:58 AM
FKBP5 expression is related to risky foraging in house sparrows HormBehav
FKBP5/FKBP51-Mediated Signaling Pathways in Neuropsychiatric diseases
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
FKBP5/FKBP51-Mediated Signaling Pathways in Neuropsychiatric diseases: Insights for Biomarker Development and Targeted Therapies
The FK506-binding protein 5 gene encodes FKBP51, a molecular chaperone linked to the pathogenesis of neuropsychiatric diseases. Recent evidence shows …
www.sciencedirect.com
September 18, 2025 at 10:37 AM
FKBP5/FKBP51-Mediated Signaling Pathways in Neuropsychiatric diseases
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
The authors included RRIDs in their paper! We value the author's support of reproducibility. #reproducibility #ReproducibleResearch #OpenScience
Loss of noradrenergic Fkbp5 disrupts social behavior and norepinephrine dynamics in the basolateral amygdala
doi.org
December 26, 2025 at 8:00 AM
The authors included RRIDs in their paper! We value the author's support of reproducibility. #reproducibility #ReproducibleResearch #OpenScience